Synthesis of marine-derived 3-alkylpyridinium alkaloids with potent antiprotozoal activity

ACS Medicinal Chemistry Letters

Volumn 2, Issue 12, 2011, Pages 901-906

  Rodenko, Boris ^a,b   Al Salabi, Mohammed I ^b   Teka, Ibrahim A ^b   Ho, William ^b   El Sabbagh, Nasser ^b   Ali, Juma A M ^b   Ibrahim, Hasan M S ^b   Wanner, Martin J ^a   Koomen, Gerrit Jan ^a   De Koning, Harry P ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Alkylpyridinium alkaloids; antileishmanial activity; antiplasmodial activity; antitrypanosomal activity; cytotoxicity; synthesis

Indexed keywords

ALKALOID DERIVATIVE; ALKYL GROUP; ANTIPROTOZOAL AGENT; ARSENOSOBENZENE; CHLOROQUINE; DIMINAZENE; MELARSOMINE; MONOMER; OLIGOMER; PENTAMIDINE; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG; VISCOSAMINE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; LEISHMANIA; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI;

EID: 83455216164     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200160k     Document Type: Article

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