IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression

Oncotarget

Volumn 6, Issue 29, 2015, Pages 27146-27159

  Lee, Sang Chul ^a   Kim, Ok Hee ^a   Lee, Sang Kuon ^a   Kim, Say June ^a  

^a Daejeon St Mary's Hospital   (South Korea)

Author keywords

Colorectal cancer; Epithelial mesenchymal transition (EMT); IWR 1; Survivin; Wnt catenin signaling

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; GELATINASE A; GELATINASE B; IWR 1; NERVE CELL ADHESION MOLECULE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SURVIVIN; TRANSCRIPTION FACTOR SNAIL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; WNT PROTEIN; AKT1 PROTEIN, HUMAN; BIRC5 PROTEIN, HUMAN; CTNNB1 PROTEIN, HUMAN; IMIDE; INHIBITOR OF APOPTOSIS PROTEIN; IWR-1 COMPOUND; QUINOLINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER MODEL; CELL STIMULATION; CLINICAL ARTICLE; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; EX VIVO STUDY; HCT116 CELL LINE; HT29 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; METASTASIS INHIBITION; MIGRATION INHIBITION; MOLECULAR DYNAMICS; PROMOTER REGION; PROTEIN EXPRESSION; TUMOR INVASION; ANTAGONISTS AND INHIBITORS; CELL MOTION; CELL PROLIFERATION; COLORECTAL TUMOR; DOSE RESPONSE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENE SILENCING; HCT 116 CELL LINE; HT-29 CELL LINE; IMMUNOHISTOCHEMISTRY; METABOLISM; METASTASIS; TUMOR CELL LINE; WNT SIGNALING PATHWAY;

BETA CATENIN; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HCT116 CELLS; HT29 CELLS; HUMANS; IMIDES; IMMUNOHISTOCHEMISTRY; INHIBITOR OF APOPTOSIS PROTEINS; MICROSCOPY, FLUORESCENCE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; QUINOLINES; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84944474640     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4354     Document Type: Article

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