Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells

Cancer Science

Volumn 94, Issue 7, 2003, Pages 593-597

  Taki, Masayuki ^a   Kamata, Nobuyuki ^a   Yokoyama, Kazuhiro ^a   Fujimoto, Ryoichi ^a   Tsutsumi, Satoshi ^a   Nagayama, Masaru ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

UVOMORULIN; VIMENTIN; WNT PROTEIN;

CANCER CELL CULTURE; CARCINOGENESIS; CELL STRAIN; CELL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; EXPRESSION VECTOR; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KERATINOCYTE; MALIGNANT NEOPLASTIC DISEASE; MESENCHYME CELL; MOLECULAR CLONING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SPINDLE CELL; SQUAMOUS CELL CARCINOMA; UPREGULATION;

CARCINOMA, SQUAMOUS CELL; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KERATINOCYTES; MESODERM; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; TUMOR CELLS, CULTURED; WNT PROTEINS;

EID: 0043063969     PISSN: 13479032     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2003.tb01488.x     Document Type: Review

References (54)

1. Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 1998; 14: 59-88.
2. Cadigan KM, Nusse R. Wnt signaling: a common theme in animal development. Genes Dev 1997; 11: 3286-305.
3. 2+ pathways. Oncogene 1999; 18: 7860-72.
4. Boutros M, Paricio N, Strutt DI, Mlodzik M. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 1998; 94: 109-18.
5. Tada M, Smith JC. Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. Development 2000; 127: 2227-38.
6. Heisenberg CP, Tada M, Rauch GJ, Saude L, Concha ML, Geisler R, Stemple DL, Smith JC, Wilson SW. Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature 2000; 405: 76-81.
7. 2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet 2000; 16: 279-83.
8. Roelink H, Wagenaar E, Lopes da Silva S, Nusse R. Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/ Wnt-1 and is normally expressed in mouse embryos and adult brain. Proc Natl Acad Sci USA 1990; 87: 4519-23.
9. Nusse R, Theunissen H, Wagenaar E, Rijsewijk F, Gennissen A, Otte A, Schuuring E, van Ooyen A. The Wnt-1 (int-1) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the mouse mammary tumor virus. Mol Cell Biol 1990; 10: 4170-9.
10. Jue SF, Bradley RS, Rudnicki JA, Varmus HE, Brown AM. The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. Mol Cell Biol 1992; 12: 321-8.
11. Wong GT, Gavin BJ, McMahon AP. Differential transformation of mammary epithelial cells by Wnt genes. Mol Cell Biol 1994; 14: 6278-86.
12. Huguet EL, McMahon JA, McMahon AP, Bicknell R, Harris AL. Differential expression of human Wnt genes 2, 3, 4 and 7b in human breast cell lines and normal and disease states of human breast cancer tissue. Cancer Res 1994; 54: 2615-21.
13. Vider BZ, Zimber A, Chastre E, Prevot S, Gespach C, Estlein D, Wolloch Y, Tronick SR, Gazit A, Yaniv A. Evidence for the involvement of the Wnt 2 gene in human colorectal cancer. Oncogene 1996; 12: 153-8.
14. Iozzo RV, Eichstetter I, Danielson KG. Aberrant expression of the growth factor Wnt-5A in human malignancy. Cancer Res 1995; 55: 3495-9.
15. Bui TD, O'Brien T, Crew J, Cranston D, Harris AL. High expression of Wnt7b in human superficial bladder cancer vs invasive bladder cancer. Br J Cancer 1998; 77: 319-24.
16. Bui TD, Zhang L, Rees MCP, Bicknell R, Harris AL. Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. Br J Cancer 1997; 75: 1131-6.
17. Jönsson M, Dejmek J, Bendahl P, Andersson T. Loss of wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas. Cancer Res 2002; 62: 409-16.
18. Müller T, Bain G, Wang X, Papkoff J. Regulation of epithelial cell migration and tumor formation by beta-catenin signaling. Exp Cell Res 2002; 280: 119-33.
19. Kim K, Lu Z, Hay ED. Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT. Cell Biol Int 2002; 26: 463-76.
20. Kawasaki Y, Sato R, Akiyama T. Mutated APC and Asef are involved in the migration of colorectal tumour cells. Nat Cell Biol 2003; 5: 211-5.
21. Weeraratna AT, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M, Trent JM. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 2002; 1: 279-88.
22. Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, Garcia De Herreros A. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000; 2: 84-9.
23. Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, Portillo F, Nieto MA. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000; 2: 76-83.
24. Nieto MA, Bennett MF, Sargent MG, Wilkinson DG. Cloning and developmental expression of Sna, a murine homologue of the Drosophila snail gene. Development 1992; 116: 227-37.
25. Smith DE, Flanco del Amo F, Gridley T. Isolation of Sna, a mouse gene homologous to Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development. Development 1992; 116: 1033-9.
26. Kamata N, Chida K, Rikimaru K, Horikoshi M, Enomoto S, Kuroki T. Growth inhibitory effects of epidermal growth factor and overexpression of its receptors on human squamous cell carcinomas in culture. Cancer Res 1986; 46: 1648-53.
27. Akanuma D, Uzawa N, Yoshida MA, Negishi A, Amagasa T, Ikeuchi T. Inactivation patterns of the p16 (INK4a) gene in oral squamous cell carcinoma cell lines. Oral Oncol 1999; 35: 476-83.
28. Hoteiya T, Hayashi E, Satomura K, Kamata N, Nagayama N. Expression of E-cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo. J Oral Pathol Med 1999; 28: 107 -11.
29. Yokoyama K, Kamata N, Hayashi E, Hoteiya T, Ueda N, Fujimoto R, Nagayama M. Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro. Oral Oncol 2001; 37: 65-71.
30. Kamata N, Yokoyama K, Fujimoto R, Ueda N, Hayashi E, Nakanishi H, Nagayama, M. Growth of normal oral keratinocytes and squamous cell carcinoma cells in a novel protein-free defined medium. In Vitro Cell Dev Biol 1999; 35: 635-41.
31. Fujimoto R, Kamata N, Yokoyama K, Ueda N, Satomura K, Hayashi E, Nagayama M. Expression of telomerase components in oral keratinocytes and squamous cell carcinomas. Oral Oncol 2001; 37: 132-40.
32. Yokoyama K, Kamata N, Fujimoto R, Tsutsumi S, Tomonari M, Taki M, Hosokawa H, Nagayama M. Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas. Int J Oncol 2003; 22: 891-8.
33. Remacle JE, Kraft H, Lerchner W, Wuytens G, Collart C, Verschueren K, Smith JC, Huylebroeck D. New mode of DNA binding of multi-zinc finger transcription factors: deltaEF1 family members bind with two hands to two target sites. EMBO J 1999; 18: 5073-84.
34. Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, Garcia De Herreros A, Baulida J. Snail induction of epithelial-tomesenchymal transition in tumor cells is accompanied by MUC-1 repression and ZEB1 expression. J Biol Chem 2002; 277: 39209-16.
35. Poser I, Dominguez D, Herreros AG, Varnai A, Buettner R, Bosserhoff A. Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail. J Biol Chem 2001; 276: 24661-6.
36. Jiao K, Miyazaki K, Kitajima Y. Inverse correlation between E-cadherin and Snail expression in hepatocellular cell lines in vitro and in vivo. Br J Cancer 2002; 86: 98-101.
37. Blanco MJ, Moreno-Bueno G, Sarrio D, Locascio A, Cano A, Palacios J, Nieto MA. Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene 2002; 21: 3241-6.
38. Rosivatz E, Becker I, Specht K, Fricke E, Luber B, Busch R, Hofler H, Becker KF. Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol 2002; 161: 1881-91.
39. Shimizu H, Julius MA, Giarre M, Zheng Z, Brown AM, Kitajewski J. Transformation by Wnt family proteins correlates with regulation of beta-catenin. Cell Growth Differ 1997; 8: 1349-58.
40. Du SJ, Purcell SM, Christian JL, McGrew LL, Moon RT. Identification of distinct classes and functional domains of Wnts through expression of wildtype and chimeric proteins in Xenopus embryos. Mol Cell Biol 1995; 15: 2625-34.
41. Torres MA, Yang-Snyder JA, Purcell SM, DeMarais AA, McGrew LL, Moon RT. Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. Cell Biol 1996; 133: 1123-37.
42. Saneyoshi T, Kume S, Amasaki Y, Mikoshiba K. The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature 2002; 417: 295-9.
43. Cohen ED, Mariol MC, Wallace RM, Weyers J, Kamberov YG, Pradel J, Wilder EL. DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis. Dev Cell 2002; 2: 437-48.
44. Saitoh A, Hansen LA, Vogel JC, Udey MC. Characterization of Wnt gene expression in murine skin: possible involvement of epidermis-derived Wnt-4 in cutaneous epithelial-mesenchymal interactions. Exp Cell Res 1998; 243: 150-60.
45. Stark K, Vainio S, Vassileva G, McMahon AP. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 1994; 372: 679-83.
46. Sarkar L, Sharpe PT. Expression of Wnt signaling pathway genes during tooth development. Mech Dev 1999; 85: 197-200.
47. Reddy S, Andl T, Bagasra A, Lu MM, Epstein DJ, Morrisey EE, Millar SE. Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev 2001; 107: 69-82.
48. Rhee CS, Sen M, Lu D, Wu C, Leoni L, Rubin J, Corr M, Carson DA. Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene 2002; 21: 6598-605.
49. Yamamoto E, Kohama G, Sunakawa H, Iwai M, Hiratsuka H. Mode of invasion, bleomycin sensitivity, and clinical course in squamous cell carcinoma of the oral cavity. Cancer 1983; 51: 2175-80.
50. Yamamoto E, Miyakawa A, Kohama G. Mode of invasion and lymph node metastasis in squamous cell carcinoma of oral cavity. Head Neck Surg 1984; 5: 938-47.
51. Bui TD, Tortora G. Ciardiello F, Harris AL. Expression of Wnt5a is down-regulated by extracellular matrix and mutated c-Ha-ras in the human mammary epithelial cell line MCF-10A. Biochem Biophys Res Commun 1997; 239: 911-7.
52. Lejeune S, Huguet EL, Hamby A, Poulsom R, Harris AL. Wnt5a cloning, expression, and up-regulation in human primary breast cancers. Clin Cancer Res 1995; 1: 215-22.
53. Olson DJ, Gibo DM, Saggers G, Debinski W, Kumar R. Reversion of uroepithelial cell tumorigenesis by the ectopic expression of human wnt-5a. Cell Growth Differ 1997; 8: 417-23.
54. Bittner M, Meltzer P, Chen Y, Jiang Y, Seftor E, Hendrix M, Radmacher M, Simon R, Yakhini Z, Ben-Dor A, Sampas N, Dougherty E, Wang E, Marincola F, Gooden C, Lueders J, Glatfelter A, Pollock P, Carpten J, Gillanders E, Leja D, Dietrich K, Beaudry C, Berens M, Alberts D, Sondak V. Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 2000; 406: 536-40.