The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes

Free Radical Biology and Medicine

Volumn 89, Issue , 2015, Pages 750-757

  Banerjee, Sudip ^a   Melnyk, Stepan B ^b   Krager, Kimberly J ^c   Aykin Burns, Nukhet ^c   Letzig, Lynda G ^b   James, Laura P ^a,b   Hinson, Jack A ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b ARKANSAS CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Acetaminophen; Hepatotoxicity 3 nitrotyrosine; Mitochondria; Nitric Oxide; Reactive nitrogen and oxygen species; S nitrosoglutathione

Indexed keywords

3 NITROTYROSINE; ENZYME INHIBITOR; GLUTATHIONE; GLUTATHIONE DISULFIDE; NEURONAL NITRIC OXIDE SYNTHASE; N[(4) 4 AMINO 5 [(2 AMINOETHYL)AMINO]PENTYL]N' NITROGUANIDINETRIS(TRIFLUOROACETATE); PARACETAMOL; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG; ANALGESIC AGENT; GUANIDINE DERIVATIVE; N-(4-AMINO-5-((2-AMINOETHYL)AMINO)PENTYL)-N'-NITROGUANIDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER CELL; MALE; METABOLIC ACTIVATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NITRATION; NONHUMAN; PRIORITY JOURNAL; SPECTROFLUOROMETRY; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; LIVER MITOCHONDRION; METABOLISM; OXIDATIVE STRESS; OXYGEN CONSUMPTION; TOXIC HEPATITIS;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; CHEMICAL AND DRUG INDUCED LIVER INJURY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; GUANIDINES; HEPATOCYTES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA, LIVER; NAD; NITRIC OXIDE SYNTHASE TYPE I; OXIDATIVE STRESS; OXYGEN CONSUMPTION; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES;

EID: 84944390436     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.09.022     Document Type: Article

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