Experimental study on the effects of 7-nitroindazol, a selective inhibitor of neuronal nitric oxide synthase (nNOS), on some brain and hepatic biochemical parameters

Farmacia

Volumn 59, Issue 6, 2011, Pages 803-808

  Vitcheva, Vessela ^a   Simeonova, Rumyana ^a   Mitcheva, Mitka ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

7 nitroindazole; Anilinehydroxilase (AH); Ethylmorphine N demethylase (EMND); Metabolism; nNOS; Rat

Indexed keywords

7 NITROINDAZOLE; CYTOCHROME P450; ETHYLMORPHINE N DEMETHYLASE; GLUTATHIONE; NEURONAL NITRIC OXIDE SYNTHASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL CELL; ARTICLE; BIOCHEMICAL COMPOSITION; BRAIN HOMOGENATE; DRUG EFFECT; ENZYME ACTIVITY; EXPERIMENTAL STUDY; HUMAN; LIPID PEROXIDATION; LIVER HOMOGENATE; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; RAT;

EID: 83455177527     PISSN: 00148237     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Ali S.F., Itzhak Y. Effects of 7-nitroindazole, an NOS inhibitor on methamphetamine-induced dopaminergic and serotonergic neurotoxicity in mice. Ann NY Acad Sci., 1998, 884: 122-130
2. Bump E.A., Taylor Y.C., Brown M.J. Role of glutathione in the hypoxic cell cytotoxicity of misonidazole. Cancer Res., 1983, 43: 997-1002.
3. Cohen L.H., van Leeuwen R.E.W., van Thiel G.C.F., van Pelt J.F., Yap S.H. Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P 450 enzymes. Biopharm Drug Dispos., 2000, 21: 353-364.
4. Council of Europe. European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes. CETS No. 123, 1991.
5. Guengerich F.P. Microsomal enzymes involved in toxicology. Analysis and separation. In: Heis AW (ed) Principals and Methods of Toxicology, Raven Press, New York, 1987, pp 609-634
6. Itzhak Y., Ali S.F. Role of nitrergic system in behavioral and neurotoxic effects of amphetamine analogs. Pharmacol Ther., 2006, 109:246-62.
7. Itzhak Y. Modification of cocaine- and methamphetamine-induced behavioral sensitization by inhibition of brain nitric oxide synthase. J Pharmacol Exp Ther., 1997, 282: 521-527.
8. Knowles R.G., Moncada S. Nitric oxide synthases in mammals. Biochem J., 1994, 298: 249-258.
9. Lowry O.H. Protein measurement with the Folin phenol reagent. J Biol Chem., 1951, 193: 265-75.
10. Lue W.M., Su M.T., Lin W.B., Tao P.L. The role of nitric oxide in the development of morphine tolerance in rat hippocampal slices. Eur J Pharmacol., 1999, 383: 129-35.
11. Marletta M.A. Nitric oxide synthase: aspects concerning structure and catalysis. Cell (Cambridge, Mass.) 1994, 78: 927-93.
12. Merino G., Alvarez A., Prieto J.G., Kim R.B. The antihelmintic agent albendazole does not interect with P-glycoprotein. Drug Metab Dispos., 2002, 30: 365-369.
13. Omura T., Sato R. The carbon-monoxide-binding pigment of liver microsomes. J Biol Chem., 1964, 239: 2370-2385.
14. Polizio A.H., Pena C. Effects of angiotensin II type 1 receptor blockade on the oxidative stress in spontaneously hypertensive rat tissues. Regulatory Peptides 2005, 128: 1-5.
15. Pramyothin P., Janthasoot W., Pongnimitprasert N., Phrukudom S., Ruangrungsi N. Hepatotoxic effect of (+) usnic acid from Usnea siamensis Wainio in rats, isolated rat hepatocytes and isolated rat liver mitochondria. J Ethnopharmacol., 2004, 90: 381-387.
16. Rawden H.C., Kokwaro G.O., Ward S.A., Edwards G. Relative contribution of cytochrome P 450 and flavin-containing momooxygenases to the metabolism of albendazole by human liver microsomes. Br J Clin Pharmacol., 2000, 49: 313-322.
17. rd Edition, Taylor and Francis, London 2000, 164-165.
18. Uzbay I.T., Erden B.F., Tapanygit E.E., Kayaalp S.O. Nitric oxide synthase inhibition attenuates signs of ethanol withdrawal in rats. Life Sci., 1997, 61: 2197-2209.
19. Wittwveen F.B., Giovanelli J., Kaufman S. Reduction of quinonoid dihydrobiopterin to tetrahydrobiopterin by nitric oxide synthase. J Biol Chem., 1996, 271: 4143-4147.