Protein nitration is mediated by heme and free metals through Fenton-type chemistry: An alternative to the NO/O2- reaction

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 20, 2002, Pages 12691-12696

  Thomas, Douglas D ^a   Espey, Michael Graham ^a   Vitek, Michael P ^b   Miranda, Katrina M ^a   Wink, David A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Hemin; Nitric oxide; Nitrotyrosine; Oxidation; Peroxynitrite

Indexed keywords

COPPER ION; FERRIC ION; FERROUS GLUCONATE; FERROUS ION; HEMATIN; HEME; HYDROGEN PEROXIDE; METAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEROXIDASE; PEROXYNITRITE; SPERMINE; SUPEROXIDE; SUPEROXIDE DISMUTASE; TYROSINE; XANTHINE OXIDASE;

ARTICLE; CATALYST; CONCENTRATION (PARAMETERS); ENZYME ACTIVITY; HOMEOSTASIS; NITRATION; PRIORITY JOURNAL;

BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; HEME; HEMIN; HUMANS; HYDROGEN PEROXIDE; IMMUNOBLOTTING; IRON; METALS; MODELS, CHEMICAL; NITRIC OXIDE; OXIDATION-REDUCTION; OXYGEN; SPECTROPHOTOMETRY; SUPEROXIDES; TUMOR CELLS, CULTURED; ULTRAVIOLET RAYS;

EID: 0036790992     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.202312699     Document Type: Article

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