Geldanamycin Reduces Aβ-Associated Anxiety and Depression, Concurrent with Autophagy Provocation

Journal of Molecular Neuroscience

Volumn 57, Issue 3, 2015, Pages 317-324

  Zare, Nayereh ^a   Khalifeh, Solmaz ^b   Khodagholi, Fariba ^a   Shahamati, Shima Zareh ^a   Motamedi, Fereshteh ^a   Maghsoudi, Nader ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

Amyloid ; Anxiety; Autophagy; Depression; Geldanamycin; HSP90

Indexed keywords

AMYLOID BETA PROTEIN; AUTOPHAGY PROTEIN 12; AUTOPHAGY PROTEIN 7; CATALASE; GELDANAMYCIN; MALONALDEHYDE; PROTEIN; PROTEIN LIGHT CHAIN 3; UNCLASSIFIED DRUG; BENZOQUINONE DERIVATIVE; BIOLOGICAL MARKER; HEAT SHOCK PROTEIN 90; MACROCYCLIC LACTAM; NERVE PROTEIN; NEUROPROTECTIVE AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DEPRESSION; ENZYME ACTIVITY; FORCED SWIM TEST; HIPPOCAMPUS; IMMOBILITY; LOCOMOTION; MALE; MAZE TEST; NEUROPROTECTION; NONHUMAN; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYMOLOGY; EXPLORATORY BEHAVIOR; FATIGUE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; OXIDATIVE STRESS; PRECLINICAL STUDY; PREMEDICATION; RANDOMIZATION; SWIMMING; WISTAR RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; ANXIETY; AUTOPHAGY; BENZOQUINONES; BIOMARKERS; CATALASE; DEPRESSION; DRUG EVALUATION, PRECLINICAL; EXPLORATORY BEHAVIOR; FATIGUE; HIPPOCAMPUS; HSP90 HEAT-SHOCK PROTEINS; INJECTIONS, INTRAVENTRICULAR; LACTAMS, MACROCYCLIC; MALE; MALONDIALDEHYDE; MAZE LEARNING; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PREMEDICATION; RANDOM ALLOCATION; RATS; RATS, WISTAR; SWIMMING;

EID: 84944277278     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-015-0619-1     Document Type: Article

References (49)

1. Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121–126
2. Barth S, Glick D, Macleod KF (2010) Autophagy: assays and artifacts. J Pathol 221(2):117–124
3. Bilici M, Efe H, Köroğlu MA, Uydu HA, Bekaroğlu M, Değer O (2001) Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. J Affect Disord 64(1):43–51
4. Borsini F, Meli A (1988) Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology 94(2):147–160
5. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1):248–254
6. Crews F, Nixon K, Kim D, Joseph J, Shukitt‐Hale B, Qin L, Zou J (2006) BHT blocks NF‐κB activation and ethanol‐induced brain damage. Alcohol Clin Exp Res 30(11):1938–1949
7. Dawson GR, Tricklebank MD (1995) Use of the elevated plus maze in the search for novel anxiolytic agents. Trends Pharmacol Sci 16(2):33–36
8. Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Xu H (2003) Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci 100(2):721–726
9. Draper HH, Hadley M (1989) Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 186:421–431
10. Einat H, Yuan P, Manji HK (2005) Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders. Behav Brain Res 165(2):172–180
11. Eren İ, Nazıroğlu M, Demirdaş A (2007) Protective effects of lamotrigine, aripiprazole and escitalopram on depression-induced oxidative stress in rat brain. Neurochem Res 32(7):1188–1195
12. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Mizushima N (2006) Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441(7095):885–889
13. Harkany T, O’Mahony S, Keijser J, Kelly JP, Kónya C, Borostyánkői ZA, Luiten PG (2001) β-Amyloid (1-42)-induced cholinergic lesions in rat nucleus basalis bidirectionally modulate serotonergic innervation of the basal forebrain and cerebral cortex. Neurobiol Dis 8(4):667–678
14. He C, Klionsky DJ (2006) Autophagy and neurodegeneration. ACS Chem Biol 1(4):211–213
15. Kadiiska MB, Gladen BC, Baird DD, Germolec D, Graham LB, Parker CE, Barrett JC (2005) Biomarkers of oxidative stress study ii: are oxidation products of lipids, proteins, and DNA markers of CCl 4 poisoning? Free Radic Biol Med 38(6):698–710
16. Kamper EF, Chatzigeorgiou A, Tsimpoukidi O, Kamper M, Dalla C, Pitychoutis PΜ, Papadopoulou-Daifoti Z (2009) Sex differences in oxidant/antioxidant balance under a chronic mild stress regime. Physiol Behav 98(1):215–222
17. Kara NZ, Toker L, Agam G, Anderson GW, Belmaker RH, Einat H (2013) Trehalose induced antidepressant-like effects and autophagy enhancement in mice. Psychopharmacology 229(2):367–375
18. Kelly BL, Ferreira A (2006) β-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons. J Biol Chem 281(38):28079–28089
19. Khalifeh S, Oryan S, Digaleh H, Shaerzadeh F, Khodagholi F, Maghsoudi N, Zarrindast MR (2015) Involvement of Nrf2 in development of anxiety-like behavior by linking Bcl2 to oxidative phosphorylation: estimation in rat hippocampus, amygdala, and prefrontal cortex. J Mol Neurosci 55(2):492–499
20. Kundu M, Thompson CB (2008) Autophagy: basic principles and relevance to disease. Annu Rev Pathmechdis Mech Dis 3:427–455
21. Leliveld SR, Bader V, Hendriks P, Prikulis I, Sajnani G, Requena JR, Korth C (2008) Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease. J Neurosci 28(15):3839–3845
22. Lemasters JJ (2005) Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res 8(1):3–5
23. Lu A, Ran R, Parmentier‐Batteur S, Nee A, Sharp FR (2002) Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia. J Neurochem 81(2):355–364
24. Maccioni RB, Muñoz JP, Barbeito L (2001) The molecular bases of Alzheimer’s disease and other neurodegenerative disorders. Arch Med Res 32(5):367–381
25. McLean PJ, Klucken J, Shin Y, Hyman BT (2004) Geldanamycin induces Hsp70 and prevents α-synuclein aggregation and toxicity in vitro. Biochem Biophys Res Commun 321(3):665–669
26. Merenlender-Wagner A, Malishkevich A, Shemer Z, Udawela M, Gibbons A, Scarr E, Gozes I (2013) Autophagy has a key role in the pathophysiology of schizophrenia. Mol Psychiatr
27. Mirakhur A, Craig D, Hart DJ, McLlroy SP, Passmore AP (2004) Behavioural and psychological syndromes in Alzheimer’s disease. Int J Geriatr Psychiatr 19(11):1035–1039
28. Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y (2009) Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol 10(7):458–467
29. Namekawa Y, Baba H, Maeshima H, Nakano Y, Satomura E, Takebayashi N, Arai H (2013) Heterogeneity of elderly depression: increased risk of Alzheimer’s disease and Aβ protein metabolism. Prog Neuro-Psychopharmacol Biol Psychiatr 43:203–208
30. Paxinos G, Watson CR (2007) The rat brain in stereotaxic coordinates. Elsevier Academic Press, San Diego
31. Pellow S, Chopin P, File SE, Briley M (1985) Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14(3):149–167
32. Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, Wyss-Coray T (2008) The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice. J Clin Invest 118(6):2190
33. Pomara N, Bruno D, Sarreal AS, Hernando RT, Nierenberg J, Petkova E, Blennow K (2014) Lower CSF amyloid beta peptides and higher F2-isoprostanes in cognitively intact elderly individuals with major depressive disorder. Am J Psychiatr
34. Porsolt RD, Le Pichon M, Jalfre ML (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266(5604):730–732
35. Potter GG, Steffens DC (2007) Contribution of depression to cognitive impairment and dementia in older adults. Neurologist 13(3):105–117
36. Rodrigues R, Petersen RB, Perry G (2014) Parallels between major depressive disorder and Alzheimer’s disease: role of oxidative stress and genetic vulnerability. Cell Mol Neurobiol 34(7):925–949
37. Salam JN, Fox JH, DeTroy EM, Guignon MH, Wohl DF, Falls WA (2009) Voluntary exercise in C57 mice is anxiolytic across several measures of anxiety. Behav Brain Res 197(1):31–40
38. Sarkaki A, Farbood Y, Badavi M, Khalaj L, Khodagholi F, Ashabi G (2015) Metformin improves anxiety-like behaviors through AMPK-dependent regulation of autophagy following transient forebrain ischemia. Metab Brain Dis 1–12
39. Sarkar S, Korolchuk VI, Renna M, Imarisio S, Fleming A, Williams A, Rubinsztein DC (2011) Complex inhibitory effects of nitric oxide on autophagy. Mol Cell 43(1):19–32
40. Shaerzadeh F, Motamedi F, Minai-Tehrani D, Khodagholi F (2014) Monitoring of neuronal loss in the hippocampus of Aβ-injected rat: autophagy, mitophagy, and mitochondrial biogenesis stand against apoptosis. Neruomol Med 16(1):175–190
41. Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Selkoe DJ (2008) Amyloid-β protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory. Nat Med 14(8):837–842
42. Shehata M, Matsumura H, Okubo-Suzuki R, Ohkawa N, Inokuchi K (2012) Neuronal stimulation induces autophagy in hippocampal neurons that is involved in AMPA receptor degradation after chemical long-term depression. J Neurosci 32(30):10413–10422
43. Shen HY, He JC, Wang Y, Huang QY, Chen JF (2005) Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice. J Biol Chem 280(48):39962–39969
44. Stebbins CE, Russo AA, Schneider C, Rosen N, Hartl FU, Pavletich NP (1997) Crystal structure of an Hsp90–geldanamycin complex: targeting of a protein chaperone by an antitumor agent. Cell 89(2):239–250
45. Sun X, Steffens DC, Au R, Folstein M, Summergrad P, Yee J, Qiu WQ (2008) Amyloid-associated depression: a prodromal depression of Alzheimer disease? Arch Gen Psychiatry 65(5):542–550
46. Taylor JP, Hardy J, Fischbeck KH (2002) Toxic proteins in neurodegenerative disease. Science 296(5575):1991–1995
47. Teri L, Ferretti LE, Gibbons LE, Logsdon RG, McCurry SM, Kukull WA, Larson EB (1999) Anxiety in Alzheimer’s disease: prevalence and comorbidity. J Gerontol A: Biol Med Sci 54(7):M348–M352
48. Wong E, Cuervo AM (2010) Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 13(7):805–811
49. Zare N, Motamedi F, Digaleh H, Khodagholi F, Maghsoudi N (2015) Collaboration of geldanamycin-activated P70S6K and Hsp70 against beta-amyloid-induced hippocampal apoptosis: an approach to long-term memory and learning. Cell Stress Chaperones 20(2):309–319