-
1
-
-
77649273272
-
Nrf2 the rescue: Effects of the an-tioxidative/electrophilic response on the liver
-
Klaassen CD, Reisman SA. Nrf2 the rescue: effects of the an-tioxidative/electrophilic response on the liver. Toxicol Appl Pharmacol 2010;244:57-65.
-
(2010)
Toxicol Appl Pharmacol
, vol.244
, pp. 57-65
-
-
Klaassen, C.D.1
Reisman, S.A.2
-
2
-
-
84878704486
-
Nrf2 protection against liver injury produced by various hepatotoxicants
-
Liu J, Wu KC, Lu YF, Ekuase E, Klaassen CD. Nrf2 protection against liver injury produced by various hepatotoxicants. Oxid Med Cell Longev 2013;2013:305861.
-
(2013)
Oxid Med Cell Longev
, vol.2013
, pp. 305861
-
-
Liu, J.1
Wu, K.C.2
Lu, Y.F.3
Ekuase, E.4
Klaassen, C.D.5
-
3
-
-
34250359779
-
Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease
-
Aleksunes LM, Manautou JE. Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease. Toxicol Pathol 2007;35:459-473.
-
(2007)
Toxicol Pathol
, vol.35
, pp. 459-473
-
-
Aleksunes, L.M.1
Manautou, J.E.2
-
4
-
-
84878703659
-
Role of the Nrf2-ARE pathway in liver diseases
-
Shin SM, Yang JH, Ki SH. Role of the Nrf2-ARE pathway in liver diseases. Oxid Med Cell Longev 2013;2013:763257.
-
(2013)
Oxid Med Cell Longev
, vol.2013
, pp. 763257
-
-
Shin, S.M.1
Yang, J.H.2
Ki, S.H.3
-
5
-
-
84880422286
-
Nuclear erythroid 2-related factor 2: A novel potential therapeutic target for liver fbrosis
-
Yang JJ, Tao H, Huang C, Li J. Nuclear erythroid 2-related factor 2: a novel potential therapeutic target for liver fbrosis. Food Chem Toxicol 2013;59:421-427.
-
(2013)
Food Chem Toxicol
, vol.59
, pp. 421-427
-
-
Yang, J.J.1
Tao, H.2
Huang, C.3
Li, J.4
-
6
-
-
77958125017
-
Discovery of the negative regulator of Nrf2, Keap1: A historical overview
-
Itoh K, Mimura J, Yamamoto M. Discovery of the negative regulator of Nrf2, Keap1: a historical overview. Antioxid Redox Signal 2010;13:1665-1678.
-
(2010)
Antioxid Redox Signal
, vol.13
, pp. 1665-1678
-
-
Itoh, K.1
Mimura, J.2
Yamamoto, M.3
-
7
-
-
78751703950
-
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
-
Taguchi K, Motohashi H, Yamamoto M. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 2011;16:123-140.
-
(2011)
Genes Cells
, vol.16
, pp. 123-140
-
-
Taguchi, K.1
Motohashi, H.2
Yamamoto, M.3
-
8
-
-
84863763926
-
Effect of graded Nrf2 activation on phase-I and-II drug metabolizing enzymes and transporters in mouse liver
-
Wu KC, Cui JY, Klaassen CD. Effect of graded Nrf2 activation on phase-I and-II drug metabolizing enzymes and transporters in mouse liver. PLoS One 2012;7:e39006.
-
(2012)
PLoS One
, vol.7
, pp. e39006
-
-
Wu, K.C.1
Cui, J.Y.2
Klaassen, C.D.3
-
9
-
-
77951860160
-
Effect of blueberry on hepatic and immunological functions in mice
-
Wang YP, Cheng ML, Zhang BF, Mu M, Zhou MY, Wu J, et al. Effect of blueberry on hepatic and immunological functions in mice. Hepatobiliary Pancreat Dis Int 2010;9:164-168.
-
(2010)
Hepatobiliary Pancreat Dis Int
, vol.9
, pp. 164-168
-
-
Wang, Y.P.1
Cheng, M.L.2
Zhang, B.F.3
Mu, M.4
Zhou, M.Y.5
Wu, J.6
-
10
-
-
78649549021
-
Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease
-
Hardwick RN, Fisher CD, Canet MJ, Lake AD, Cherrington NJ. Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease. Drug Metab Dispos 2010;38:2293-2301.
-
(2010)
Drug Metab Dispos
, vol.38
, pp. 2293-2301
-
-
Hardwick, R.N.1
Fisher, C.D.2
Canet, M.J.3
Lake, A.D.4
Cherrington, N.J.5
-
11
-
-
77954101086
-
Enhanced hepatic Nrf2 activation after ur-sodeoxycholic acid treatment in patients with primary biliary cirrhosis
-
Kawata K, Kobayashi Y, Souda K, Kawamura K, Sumiyoshi S, Takahashi Y, et al. Enhanced hepatic Nrf2 activation after ur-sodeoxycholic acid treatment in patients with primary biliary cirrhosis. Antioxid Redox Signal 2010;13:259-268.
-
(2010)
Antioxid Redox Signal
, vol.13
, pp. 259-268
-
-
Kawata, K.1
Kobayashi, Y.2
Souda, K.3
Kawamura, K.4
Sumiyoshi, S.5
Takahashi, Y.6
-
12
-
-
84892601947
-
Does hepatic oxidative stress enhance activation of nuclear factor-E2-related factor in patients with nonalcoholic steatohepatitis?
-
Takahashi Y, Kobayashi Y, Kawata K, Kawamura K, Sumiyoshi S, Noritake H, et al. Does hepatic oxidative stress enhance activation of nuclear factor-E2-related factor in patients with nonalcoholic steatohepatitis? Antioxid Redox Signal 2014;20: 538-543.
-
(2014)
Antioxid Redox Signal
, vol.20
, pp. 538-543
-
-
Takahashi, Y.1
Kobayashi, Y.2
Kawata, K.3
Kawamura, K.4
Sumiyoshi, S.5
Noritake, H.6
-
13
-
-
84858989085
-
Nuclear factor erythroid 2-like 2 (Nrf2) expression in end-stage liver disease
-
Kurzawski M, Dziedziejko V, Urasinska E, Post M, Wójcicki M, Mietkiewski J, et al. Nuclear factor erythroid 2-like 2 (Nrf2) expression in end-stage liver disease. Environ Toxicol Pharmacol 2012;34:87-95.
-
(2012)
Environ Toxicol Pharmacol
, vol.34
, pp. 87-95
-
-
Kurzawski, M.1
Dziedziejko, V.2
Urasinska, E.3
Post, M.4
Wójcicki, M.5
Mietkiewski, J.6
-
14
-
-
84904382729
-
Expression of P450 and nuclear receptors in normal and end-stage Chinese livers
-
Chen H, Shen ZY, Xu W, Fan TY, Li J, Lu YF, et al. Expression of P450 and nuclear receptors in normal and end-stage Chinese livers. World J Gastroenterol 2014;20:8681-8690.
-
(2014)
World J Gastroenterol
, vol.20
, pp. 8681-8690
-
-
Chen, H.1
Shen, Z.Y.2
Xu, W.3
Fan, T.Y.4
Li, J.5
Lu, Y.F.6
-
15
-
-
84864133163
-
Nrf2 activation prevents cadmium-induced acute liver injury
-
Wu KC, Liu JJ, Klaassen CD. Nrf2 activation prevents cadmium-induced acute liver injury. Toxicol Appl Pharmacol 2012;263:14-20.
-
(2012)
Toxicol Appl Pharmacol
, vol.263
, pp. 14-20
-
-
Wu, K.C.1
Liu, J.J.2
Klaassen, C.D.3
-
16
-
-
84863824650
-
Role of Nrf2 in preventing etha-nol-induced oxidative stress and lipid accumulation
-
Wu KC, Liu J, Klaassen CD. Role of Nrf2 in preventing etha-nol-induced oxidative stress and lipid accumulation. Toxicol Appl Pharmacol 2012;262:321-329.
-
(2012)
Toxicol Appl Pharmacol
, vol.262
, pp. 321-329
-
-
Wu, K.C.1
Liu, J.2
Klaassen, C.D.3
-
17
-
-
84911916049
-
Protection against phalloi-din-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2
-
Lu YF, Liu J, Wu KC, Klaassen CD. Protection against phalloi-din-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2. Toxicol Lett 2014;232:326-332.
-
(2014)
Toxicol Lett
, vol.232
, pp. 326-332
-
-
Lu, Y.F.1
Liu, J.2
Wu, K.C.3
Klaassen, C.D.4
-
18
-
-
0035153227
-
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
-
Enomoto A, Itoh K, Nagayoshi E, Haruta J, Kimura T, O'Connor T, et al. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci 2001;59:169-177.
-
(2001)
Toxicol Sci
, vol.59
, pp. 169-177
-
-
Enomoto, A.1
Itoh, K.2
Nagayoshi, E.3
Haruta, J.4
Kimura, T.5
O'Connor, T.6
-
19
-
-
52649098886
-
The Nrf2 transcription factor protects from toxin-induced liver injury and fbrosis
-
Xu W, Hellerbrand C, Köhler UA, Bugnon P, Kan YW, Werner S, et al. The Nrf2 transcription factor protects from toxin-induced liver injury and fbrosis. Lab Invest 2008;88:1068-1078.
-
(2008)
Lab Invest
, vol.88
, pp. 1068-1078
-
-
Xu, W.1
Hellerbrand, C.2
Köhler, U.A.3
Bugnon, P.4
Kan, Y.W.5
Werner, S.6
-
20
-
-
69749108385
-
Nrf2 protects against As(III)-induced damage in mouse liver and bladder
-
Jiang T, Huang Z, Chan JY, Zhang DD. Nrf2 protects against As(III)-induced damage in mouse liver and bladder. Toxicol Appl Pharmacol 2009;240:8-14.
-
(2009)
Toxicol Appl Pharmacol
, vol.240
, pp. 8-14
-
-
Jiang, T.1
Huang, Z.2
Chan, J.Y.3
Zhang, D.D.4
-
21
-
-
77954067512
-
Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity
-
Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Sheik Mohideen S, et al. Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity. Toxicol Sci 2010;115: 596-606.
-
(2010)
Toxicol Sci
, vol.115
, pp. 596-606
-
-
Liu, F.1
Ichihara, S.2
Valentine, W.M.3
Itoh, K.4
Yamamoto, M.5
Sheik Mohideen, S.6
-
22
-
-
41349119138
-
Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury
-
Lamlé J, Marhenke S, Borlak J, von Wasielewski R, Eriksson CJ, Geffers R, et al. Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury. Gastroenterology 2008;134:1159-1168.
-
(2008)
Gastroenterology
, vol.134
, pp. 1159-1168
-
-
Lamlé, J.1
Marhenke, S.2
Borlak, J.3
Von Wasielewski, R.4
Eriksson, C.J.5
Geffers, R.6
-
23
-
-
77952952816
-
Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine-and choline-defcient diet
-
Zhang YK, Yeager RL, Tanaka Y, Klaassen CD. Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine-and choline-defcient diet. Toxicol Appl Pharmacol 2010;245:326-334.
-
(2010)
Toxicol Appl Pharmacol
, vol.245
, pp. 326-334
-
-
Zhang, Y.K.1
Yeager, R.L.2
Tanaka, Y.3
Klaassen, C.D.4
-
24
-
-
76749149157
-
Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice
-
Sugimoto H, Okada K, Shoda J, Warabi E, Ishige K, Ueda T, et al. Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice. Am J Physiol Gastrointest Liver Physiol 2010;298:G283-294.
-
(2010)
Am J Physiol Gastrointest Liver Physiol
, vol.298
, pp. G283-294
-
-
Sugimoto, H.1
Okada, K.2
Shoda, J.3
Warabi, E.4
Ishige, K.5
Ueda, T.6
-
25
-
-
72649103895
-
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis
-
Chowdhry S, Nazmy MH, Meakin PJ, Dinkova-Kostova AT, Walsh SV, Tsujita T, et al. Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. Free Radic Biol Med 2010;48: 357-371.
-
(2010)
Free Radic Biol Med
, vol.48
, pp. 357-371
-
-
Chowdhry, S.1
Nazmy, M.H.2
Meakin, P.J.3
Dinkova-Kostova, A.T.4
Walsh, S.V.5
Tsujita, T.6
-
26
-
-
84886745810
-
Nrf2 deletion causes "benign" simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet
-
Wang C, Cui Y, Li C, Zhang Y, Xu S, Li X, et al. Nrf2 deletion causes "benign" simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet. Lipids Health Dis 2013;12:165.
-
(2013)
Lipids Health Dis
, vol.12
, pp. 165
-
-
Wang, C.1
Cui, Y.2
Li, C.3
Zhang, Y.4
Xu, S.5
Li, X.6
-
27
-
-
84865429068
-
Nrf2: A potential target for new therapeutics in liver disease
-
Bataille AM, Manautou JE. Nrf2: a potential target for new therapeutics in liver disease. Clin Pharmacol Ther 2012;92:340-348.
-
(2012)
Clin Pharmacol Ther
, vol.92
, pp. 340-348
-
-
Bataille, A.M.1
Manautou, J.E.2
-
28
-
-
84867570924
-
Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepa-titis
-
Okada K, Warabi E, Sugimoto H, Horie M, Tokushige K, Ueda T, et al. Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepa-titis. J Gastroenterol 2012;47:924-935.
-
(2012)
J Gastroenterol
, vol.47
, pp. 924-935
-
-
Okada, K.1
Warabi, E.2
Sugimoto, H.3
Horie, M.4
Tokushige, K.5
Ueda, T.6
-
29
-
-
84885344699
-
Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steato-sis
-
Zhou R, Lin J, Wu D. Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steato-sis. Biochim Biophys Acta 2014;1840:209-218.
-
(2014)
Biochim Biophys Acta
, vol.1840
, pp. 209-218
-
-
Zhou, R.1
Lin, J.2
Wu, D.3
-
30
-
-
84862786878
-
Somatic mutations of the KEAP1 gene in common solid cancers
-
Yoo NJ, Kim HR, Kim YR, An CH, Lee SH. Somatic mutations of the KEAP1 gene in common solid cancers. Histopathology 2012;60:943-952.
-
(2012)
Histopathology
, vol.60
, pp. 943-952
-
-
Yoo, N.J.1
Kim, H.R.2
Kim, Y.R.3
Ch, A.4
Lee, S.H.5
-
31
-
-
33645996345
-
Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury
-
Aleksunes LM, Goedken M, Manautou JE. Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury. World J Gastroenterol 2006;12:1937-1940.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 1937-1940
-
-
Aleksunes, L.M.1
Goedken, M.2
Manautou, J.E.3
-
32
-
-
0027268350
-
NAD(P)H: Quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues
-
Belinsky M, Jaiswal AK. NAD(P)H: quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues. Cancer Metastasis Rev 1993;12:103-117.
-
(1993)
Cancer Metastasis Rev
, vol.12
, pp. 103-117
-
-
Belinsky, M.1
Jaiswal, A.K.2
-
33
-
-
56649083534
-
Dual roles of Nrf2 in cancer
-
Lau A, Villeneuve NF, Sun Z, Wong PK, Zhang DD. Dual roles of Nrf2 in cancer. Pharmacol Res 2008;58:262-270.
-
(2008)
Pharmacol Res
, vol.58
, pp. 262-270
-
-
Lau, A.1
Villeneuve, N.F.2
Sun, Z.3
Wong, P.K.4
Zhang, D.D.5
-
34
-
-
46949099638
-
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
-
Wang XJ, Sun Z, Villeneuve NF, Zhang S, Zhao F, Li Y, et al. Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis 2008;29:1235-1243.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1235-1243
-
-
Wang, X.J.1
Sun, Z.2
Villeneuve, N.F.3
Zhang, S.4
Zhao, F.5
Li, Y.6
-
35
-
-
84855475121
-
The multiple functions of heme oxygenase-1 in the liver
-
Sass G, Barikbin R, Tiegs G. The multiple functions of heme oxygenase-1 in the liver. Z Gastroenterol 2012;50:34-40.
-
(2012)
Z Gastroenterol
, vol.50
, pp. 34-40
-
-
Sass, G.1
Barikbin, R.2
Tiegs, G.3
-
37
-
-
81855183855
-
Heme oxy-genase-1: A molecular brake on hepatocellular carcinoma cell migration
-
Zou C, Zhang H, Li Q, Xiao H, Yu L, Ke S, et al. Heme oxy-genase-1: a molecular brake on hepatocellular carcinoma cell migration. Carcinogenesis 2011;32:1840-1848.
-
(2011)
Carcinogenesis
, vol.32
, pp. 1840-1848
-
-
Zou, C.1
Zhang, H.2
Li, Q.3
Xiao, H.4
Yu, L.5
Ke, S.6
-
38
-
-
4344599417
-
Immu-nohistochemical analysis of heme oxygenase-1 in preneoplastic and neoplastic lesions during chemical hepatocarcinogenesis
-
Caballero F, Meiss R, Gimenez A, Batlle A, Vazquez E. Immu-nohistochemical analysis of heme oxygenase-1 in preneoplastic and neoplastic lesions during chemical hepatocarcinogenesis. Int J Exp Pathol 2004;85:213-222.
-
(2004)
Int J Exp Pathol
, vol.85
, pp. 213-222
-
-
Caballero, F.1
Meiss, R.2
Gimenez, A.3
Batlle, A.4
Vazquez, E.5
-
39
-
-
84872418223
-
Proteomics in HepG2 hepatocarcinoma cells with stably silenced expression of PRDX1
-
Aguilar-Melero P, Prieto-álamo MJ, Jurado J, Holmgren A, Pu-eyo C. Proteomics in HepG2 hepatocarcinoma cells with stably silenced expression of PRDX1. J Proteomics. 2013;79:161-171.
-
(2013)
J Proteomics.
, vol.79
, pp. 161-171
-
-
Aguilar-Melero, P.1
Prieto-Álamo, M.J.2
Jurado, J.3
Holmgren, A.4
Pu-Eyo, C.5
-
40
-
-
77949269486
-
Nrf2 in toxicology and pharmacology: The good, the bad and the ugly?
-
Pi J, Freeman ML, Yamamoto M. Nrf2 in toxicology and pharmacology: the good, the bad and the ugly? Toxicol Appl Pharmacol 2010;244:1-3.
-
(2010)
Toxicol Appl Pharmacol
, vol.244
, pp. 1-3
-
-
Pi, J.1
Freeman, M.L.2
Yamamoto, M.3
-
41
-
-
34548380363
-
Keap1 eye on the target: Chemopreven-tion of liver cancer
-
Yates MS, Kensler TW. Keap1 eye on the target: chemopreven-tion of liver cancer. Acta Pharmacol Sin 2007;28:1331-1342.
-
(2007)
Acta Pharmacol Sin
, vol.28
, pp. 1331-1342
-
-
Yates, M.S.1
Kensler, T.W.2
|