Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality

Nature Communications

Volumn 6, Issue , 2015, Pages

  Alvarez, Silvia ^a   Diáz, Marcos ^a   Flach, Johanna ^b   Rodriguez Acebes, Sara ^a   López Contreras, Andrés J ^a,d   Martínez, Dolores ^a   Canãmero, Marta ^a,e   Fernández Capetillo, Oscar ^a   Isern, Joan ^c   Passegué, Emmanuelle ^b   Méndez, Juan ^a  

^a Structural Biology and Biocomputing Programme   (Spain)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MINICHROMOSOME MAINTENANCE PROTEIN 3; CHECKPOINT KINASE 1; PROTEIN KINASE;

ADULT; ANEMIA; CELLS AND CELL COMPONENTS; CHROMOSOME; DIFFERENTIATION; EMBRYONIC DEVELOPMENT; GENE EXPRESSION; GENETIC ANALYSIS; HEMATOLOGY; MATURATION; RODENT;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; DNA DAMAGE CHECKPOINT; DNA REPLICATION; EMBRYO; EMBRYO DEVELOPMENT; ERYTHROCYTE; ERYTHROPOIESIS; FEMALE; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN DEFICIENCY; ANIMAL; C57BL MOUSE; DISEASE PREDISPOSITION; DNA DAMAGE; GENETICS; HEMATOLOGIC DISEASE; KNOCKOUT MOUSE; LETHAL GENE; LIVER; MAMMALIAN EMBRYO; METABOLISM; PHYSIOLOGY;

ANIMALS; CHECKPOINT KINASE 1; DISEASE SUSCEPTIBILITY; DNA DAMAGE; DNA REPLICATION; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; ERYTHROPOIESIS; FEMALE; GENES, LETHAL; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELLS; LIVER; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MINICHROMOSOME MAINTENANCE COMPLEX COMPONENT 3; PROTEIN KINASES;

EID: 84943803541     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9548     Document Type: Article

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