Slc10a2-null mice uncover colon cancer-promoting actions of endogenous fecal bile acids

Carcinogenesis

Volumn 36, Issue 10, 2015, Pages 1193-1200

  Jean Pierre, Rauor ^a   Dawson, Paul A ^b   Rao, Anuradha ^b   Drachenberg, Cinthia B ^a   Heath, Jonathon ^a   Shang, Aaron C ^a   Hu, Shien ^a   Zhan, Min ^a   Polli, James E ^c   Cheng, Kunrong ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZOXYMETHANE; BILE ACID; CASPASE 3; DEXTRAN SULFATE; DRINKING WATER; KI 67 ANTIGEN; METHYLENE BLUE; SLC10A2 PROTEIN; SODIUM BILE ACID COTRANSPORTER; UNCLASSIFIED DRUG; COTRANSPORTER; ORGANIC ANION TRANSPORTER; SODIUM-BILE ACID COTRANSPORTER;

ABERRANT CRYPT FOCUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; CELL PROLIFERATION; COLON ADENOCARCINOMA; COLON CANCER; CONTROLLED STUDY; ENTEROHEPATIC CIRCULATION; ENZYME PHOSPHORYLATION; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR PROMOTION; WILD TYPE MOUSE; ANIMAL; COLONIC NEOPLASMS; DISEASE MODEL; DRUG EFFECTS; FECES; GENETICS; HUMAN; ILEUM; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; BILE ACIDS AND SALTS; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; FECES; HUMANS; ILEUM; MICE; MICE, KNOCKOUT; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; SIGNAL TRANSDUCTION; SYMPORTERS;

EID: 84943756789     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgv107     Document Type: Article

References (26)

1. Dawson, P. (2012) Bile formation and the enterohepatic circulation. In Johnson, L.R. (ed) Physiology of the Gastrointestinal Tract. Academic Press, Oxford, pp. 1461-1484.
2. Dawson, P.A. et al. (2003) Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. J. Biol. Chem 278, 33920-33927.
3. Flynn, C. et al. (2007) Deoxycholic acid promotes the growth of colonic aberrant crypt foci. Mol. Carcinog 46, 60-70.
4. Wang, W. et al. (2001) An association between genetic polymorphisms in the ileal sodium-dependent bile acid transporter gene and the risk of colorectal adenomas. Cancer Epidemiol. Biomarkers Prev 10, 931-936.
5. Grünhage, F. et al. (2008) Effects of common haplotypes of the ileal sodium dependent bile acid transporter gene on the development of sporadic and familial colorectal cancer: a case control study. BMC Med. Genet 9, 70.
6. Raufman, J.P. et al. (2008) Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia. Cancer Res 68, 3573-3578.
7. Xie, G. et al. (2009) Acetylcholine-induced activation of M3 muscarinic receptors stimulates robust matrix metalloproteinase gene expression in human colon cancer cells. Am. J. Physiol. Gastrointest. Liver Physiol 296, G755-G763.
8. Bernstein, C. et al. (2011) Carcinogenicity of deoxycholate, a secondary bile acid. Arch. Toxicol 85, 863-871.
9. Scudamore, C.H. et al. (1983) Effects of small bowel transection, resection, or bypass in 1,2-dimethylhydrazine-induced rat intestinal neoplasia. Gastroenterology, 84, 725-731.
10. Williamson, R.C. et al. (1978) Promotion of azoxymethane-induced colonic neoplasia by resection of the proximal small bowel. Cancer Res 38, 3212-3217.
11. Vivian, D. et al. (2014) Design and evaluation of a novel trifluorinated imaging agent for assessment of bile acid transport using fluorine magnetic resonance imaging. J. Pharm. Sci 103, 3782-3792.
12. Vivian, D. et al. (2014) In vivo performance of a novel fluorinated magnetic resonance imaging agent for functional analysis of bile acid transport. Mol. Pharm 11, 1575-1582.
13. Boivin, G.P. et al. (2003) Pathology of mouse models of intestinal cancer: consensus report and recommendations. Gastroenterology, 124, 762-777.
14. Holt, P.R. et al. (1997) Is Ki-67 a better proliferative marker in the colon than proliferating cell nuclear antigen? Cancer Epidemiol. Biomarkers Prev 6, 131-135.
15. Cheng, K. et al. (2005) Bile acid-induced proliferation of a human colon cancer cell line is mediated by transactivation of epidermal growth factor receptors. Biochem. Pharmacol 70, 1035-1047.
16. Bongers, G. et al. (2012) A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans. Gastroenterology, 143, 730-740.
17. Dawson, P.A. (2011) Role of the intestinal bile acid transporters in bile acid and drug disposition. Handb. Exp. Pharmacol 201, 169-203.
18. De Gottardi, A. et al. (2004) The bile acid nuclear receptor FXR and the bile acid binding protein IBABP are differently expressed in colon cancer. Dig. Dis. Sci 49, 982-989.
19. Raufman, J.P. et al. (2011) Muscarinic receptor subtype-3 gene ablation and scopolamine butylbromide treatment attenuate small intestinal neoplasia in Apcmin/+ mice. Carcinogenesis, 32, 1396-1402.
20. Song, P. et al. (2008) Activated cholinergic signaling provides a target in squamous cell lung carcinoma. Cancer Res 68, 4693-4700.
21. Peng, Z. et al. (2013) Cholinergic muscarinic receptor activation augments murine intestinal epithelial cell proliferation and tumorigenesis. BMC Cancer, 13, 204.
22. Cheng, K. et al. (2007) Matrix metalloproteinase-7-catalyzed release of HB-EGF mediates deoxycholyltaurine-induced proliferation of a human colon cancer cell line. Biochem. Pharmacol 73, 1001-1012.
23. Belcheva, A. et al. (2014) Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells. Cell, 158, 288-299.
24. Donohoe, D.R. et al. (2014) A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota-and butyrate-dependent manner. Cancer Discov 4, 1387-1397.
25. Louis, P. et al. (2014) The gut microbiota, bacterial metabolites and colorectal cancer. Nat. Rev. Microbiol 12, 661-672.
26. Zheng, X. et al. (2009) Computational models for drug inhibition of the human apical sodium-dependent bile acid transporter. Mol. Pharm 6, 1591-1603.