Activated cholinergic signaling provides a target in squamous cell lung carcinoma

Cancer Research

Volumn 68, Issue 12, 2008, Pages 4693-4700

  Song, Pingfang ^a   Sekhon, Harmanjatinder S ^a   Xiao, Wen Fu ^a   Maier, Michelle ^a   Jia, Yibing ^a   Duan, Jie ^a   Proskosil, Becky J ^a   Gravett, Courtney ^a   Lindstrom, Jon ^b   Mark, Gregory P ^c   Saha, Saurabh ^d   Spindel, Eliot R ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA5 NICOTINIC RECEPTOR; BETA3 NICOTINIC RECEPTOR; CHOLINE ACETYLTRANSFERASE; CHOLINESTERASE; DARIFENACIN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINE; NICOTINIC RECEPTOR; PROTEIN LYNX1; UNCLASSIFIED DRUG; ACETYLCHOLINE; BENZOFURAN DERIVATIVE; CALCIUM; LYNX1 PROTEIN, HUMAN; MESSENGER RNA; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; PYRROLIDINE DERIVATIVE; SLC18A3 PROTEIN, HUMAN; VESICULAR ACETYLCHOLINE TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; HUMAN; HUMAN CELL; LUNG CARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; UPREGULATION; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECT; ELECTROPHYSIOLOGY; GENETICS; LUNG; LUNG TUMOR; METABOLISM; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACETYLCHOLINE; ANIMALS; BENZOFURANS; BLOTTING, WESTERN; CALCIUM; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; CELLS, CULTURED; CHOLINE O-ACETYLTRANSFERASE; ELECTROPHYSIOLOGY; HUMANS; LUNG; LUNG NEOPLASMS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, NUDE; MUSCARINIC ANTAGONISTS; NICOTINE; PHOSPHORYLATION; PYRROLIDINES; RECEPTOR, MUSCARINIC M3; RECEPTORS, NICOTINIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS;

EID: 49649125178     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-0183     Document Type: Article

References (49)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43-66.
2. Ginsburgh PJ, Voles EE, Rosenzweig K. Non-small cell lung cancer. In: DeVita VT, Hellman S, Rosenberg SA, editors. Cancer: principles and practice of oncology. 7th ed. Philadelphia: Lippincott, Williams and Wilkins; 2005. p. 925-83.
3. Subramanian J, Govindan R. Lung cancer in never smokers: a review. J Clin Oncol 2007;25:561-70.
4. West KA, Brognard J, Clark AS, et al. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J Clin Invest 2003;111:81-90.
5. Nakayama H, Numakawa T, Ikeuchi T. Nicotine-induced phosphorylation of Akt through epidermal growth factor receptor and Src in PC12h cells. J Neurochem 2002;83:1372-9.
6. Cattaneo MG, D'atri F, Vicentini LM. Mechanisms of mitogen-activated protein kinase activation by nicotine in small-cell lung carcinoma cells. Biochem J 1997;328:499-503.
7. Jull BA, Plummer HK III, Schuller HM. Nicotinic receptor-mediated activation by the tobacco-specific nitrosamine NNK of a Raf-1/MAP kinase pathway, resulting in phosphorylation of c-myc in human small cell lung carcinoma cells and pulmonary neuroendocrine cells. J Cancer Res Clin Oncol 2001;127:707-17.
8. Schuller HM, Plummer HK III, Jull BA. Receptor-mediated effects of nicotine and its nitrosated derivative NNK on pulmonary neuroendocrine cells. Anat Rec 2003;270:51-8.
9. Heusch WL, Maneckjee R. Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis 1998;19:551-6.
10. Lam DC, Girard L, Ramirez R, et al. Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer Res 2007;67:4638-47.
11. Song P, Sekhon HS, Jia Y, et al. Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma. Cancer Res 2003;63:214-21.
12. Plummer HK III, Dhar M, Schuller HM. Expression of the α7 nicotinic acetylcholine receptor in human lung cells. Respir Res 2005;6:29.
13. Proskocil BJ, Sekhon HS, Jia Y, et al. Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Endocrinology 2004;145:2498-506.
14. Wessler IK, Kirkpatrick CJ. The non-neuronal cholinergic system: an emerging drug target in the airways. Pulm Pharmacol Ther 2001;14:423-34.
15. Sekhon HS, Jia Y, Raab R, et al. Prenatal nicotine increases pulmonary α7 nicotinic receptor expression and alters fetal lung development in monkeys. J Clin Invest 1999;103:637-47.
16. Reinheimer T, Bernedo P, Klapproth H, et al. Acetylcholine in isolated airways of rat, guinea pig, and human: species differences in role of airway mucosa. Am J Physiol 1996;270:L722-8.
17. Ma W, Maric D, Li BS, et al. Acetylcholine stimulates cortical precursor cell proliferation in vitro via muscarinic receptor activation and MAP kinase phosphorylation. Eur J Neurosci 2000;12:1227-40.
18. Arredondo J, Hall LL, Ndoye A, Chernyavsky AI, Jolkovsky DL, Grando SA. Muscarinic acetylcholine receptors regulating cell cycle progression are expressed in human gingival keratinocytes. J Periodontal Res 2003;38:79-89.
19. Jimenez E, Montiel M. Activation of MAP kinase by muscarinic cholinergic receptors induces cell proliferation and protein synthesis in human breast cancer cells. J Cell Physiol 2005;204:678-6.
20. Schuller HM, Nylen ES, Park P, Becker KL. Nicotine, acetylcholine and bombesin are trophic growth factors in neuroendocrine cell lines derived from experimental hamster lung tumors. Life Sci 1990;47:571-8.
21. Tsurutani J, Castillo SS, Brognard J, et al. Tobacco components stimulate Akt-dependent proliferation and NFκB-dependent survival in lung cancer cells. Carcinogenesis 2005;26:1182-95.
22. Song P, Sekhon HS, Lu A, et al. M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion. Cancer Res 2007;67:3936-44.
23. Dasgupta P, Rastogi S, Pillai S, et al. Nicotine induces cell proliferation by β-arrestin-mediated activation of Src and Rb-Raf-1 pathways. J Clin Invest 2006;116:2208-17.
24. Zheng Y, Ritzenthaler JD, Roman J, Han S. Nicotine stimulates human lung cancer cell growth by inducing fibronectin expression. Am J Respir Cell Mol Biol 2007;37:681-90.
25. Sekhon HS, Song P, Jia Y, Lindstrom J, Spindel ER. Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure. Cell Tissue Res 2005;320:287-97.
26. Buchli R, Ndoye A, Rodriguez JG, Zia S, Webber RJ, Grando SA. Human skin fibroblasts express m2, m4, and m5 subtypes of muscarinic acetylcholine receptors. J Cell Biochem 1999;74:264-77.
27. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981;391:85-100.
28. Schuller HM. Cell type specific, receptor-mediated modulation of growth kinetics in human lung cancer cell lines by nicotine and tobacco-related nitrosamines. Biochem Pharmacol 1989;38:3439-42.
29. Maneckjee R, Minna JD. Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines. Proc Natl Acad Sci U S A 1990;87:3294-8.
30. Kim JY, Yang MS, Oh CD, et al. Signalling pathway leading to an activation of mitogen-activated protein kinase by stimulating M3 muscarinic receptor. Biochem J 1999;337:275-80.
31. Martinez-Moreno P, Nieto-Ceron S, Torres-Lanzas J, et al. Cholinesterase activity of human lung tumours varies according to their histological classification. Carcinogenesis 2006;27:429-36.
32. Cabello G, Valenzuela M, Vilaxa A, et al. A rat mammary tumor model induced by the organophosphorous pesticides parathion and malathion, possibly through acetylcholinesterase inhibition. Environ Health Perspect 2001;109:471-9.
33. Ibanez-Tallon I, Miwa JM, Wang HL, et al. Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1. Neuron 2002;33:893-903.
34. Chimienti F, Hogg RC, Plantard L, et al. Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda. Hum Mol Genet 2003;12:3017-24.
35. Arredondo J, Chernyavsky AI, Grando SA. Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells. Biochem Pharmacol 2007;74:1315-9.
36. Miwa JM, Stevens TR, King SL, et al. The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo. Neuron 2006;51:587-600.
37. Sgard F, Charpantier E, Bertrand S, et al. A novel human nicotinic receptor subunit, α10, that confers functionality to the α9-subunit. Mol Pharmacol 2002;61:150-9.
38. Zhu BQ, Heeschen C, Sievers RE, et al. Second hand smoke stimulates tumor angiogenesis and growth. Cancer Cell 2003;4:191-6.
39. Song P, Sekhon HS, Duan J, Mark GP, Spindel ER. Inhibitory regulation by M2 muscarinic acetylcholine receptors is decreased in lung cancers. Am J Respir Crit Care Med 2004;169:A290.
40. Sun S, Schiller JH, Gazdar AF. Lung cancer in never smokers - a different disease. Nat Rev Cancer 2007;7:778-90.
41. Quick MW, Lester RA. Desensitization of neuronal nicotinic receptors. J Neurobiol 2002;53:457-78.
42. Buisson B, Bertrand D. Nicotine addiction: the possible role of functional upregulation. Trends Pharmacol Sci 2002;23:130-6.
43. Kuryatov A, Luo J, Cooper J, Lindstrom J. Nicotine acts as a pharmacological chaperone to up-regulate human α4β2 acetylcholine receptors. Mol Pharmacol 2005;68:1839-51.
44. Videtic GM, Stitt LW, Dar AR, et al. Continued cigarette smoking by patients receiving concurrent chemoradiotherapy for limited-stage small-cell lung cancer is associated with decreased survival. J Clin Oncol 2003;21:1544-9.
45. Tammemagi CM, Neslund-Dudas C, Simoff M, Kvale P. Smoking and lung cancer survival: the role of comorbidity and treatment. Chest 2004;125:27-37.
46. Sardari NP, Weyler J, Colpaert C, Vermeulen P, Van Marck E, Van Schil P. Prognostic value of smoking status in operated non-small cell lung cancer. Lung Cancer 2005;47:351-9.
47. Trombino S, Cesario A, Margaritora S, et al. α7-Nicotinic acetylcholine receptors affect growth regulation of human mesothelioma cells: role of mitogen-activated protein kinase pathway. Cancer Res 2004;64:135-45.
48. Hegde SS. Muscarinic receptors in the bladder: from basic research to therapeutics. Br J Pharmacol 2006;147 Suppl 2:S80-7.
49. Gross NJ. Anticholinergic agents in asthma and COPD. Eur J Pharmacol 2006;533:36-9.