Deoxycholic acid promotes the growth of colonic aberrant crypt foci

Molecular Carcinogenesis

Volumn 46, Issue 1, 2007, Pages 60-70

  Flynn, Christopher ^a   Montrose, David C ^a   Swank, Daniel L ^a   Nakanishi, Masako ^a   Ilsley, Jillian N M ^a   Rosenberg, Daniel W ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

catenin; Aberrant crypt foci; AKR J; Deoxycholic acid

Indexed keywords

AZOXYMETHANE; BETA CATENIN; DEOXYCHOLIC ACID; TUMOR PROMOTER; UVOMORULIN;

ABERRANT CRYPT FOCUS; AKR MOUSE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER RESEARCH; CANCER RESISTANCE; CARCINOGENESIS; CARCINOGENIC ACTIVITY; CELL MEMBRANE; COLON TUMOR; CONTROLLED STUDY; DIET; DYSPLASIA; EXPOSURE; GENETIC RESISTANCE; IMMUNOHISTOCHEMISTRY; INTESTINE CRYPT; MALE; MOUSE; NONHUMAN; PRECANCER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SENSITIZATION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TUMOR GROWTH;

ANIMALS; AZOXYMETHANE; BETA CATENIN; CADHERINS; CARCINOGENS; CELL NUCLEUS; COLON; COLONIC NEOPLASMS; DEOXYCHOLIC ACID; DETERGENTS; HYPERPLASIA; MALE; MICE; MICE, INBRED AKR; PRECANCEROUS CONDITIONS; PROTEIN TRANSPORT;

MUS;

EID: 33846238160     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20253     Document Type: Article

References (60)

1. Jemal A, Murray T, Ward E, et al. Cancer statistics, 2005. CA Cancer J Clin 2005;55:10-30.
2. Heavey PM, McKenna D, Rowland IR. Colorectal cancer and the relationship between genes and the environment. Nutr Cancer 2004;48:124-141.
3. Nagengast FM, Grubben MJ, van Munster IP. Role of bile acids in colorectal carcinogenesis. Eur J Cancer 1995;31A: 1067-1070.
4. Reddy BS, Hanson D, Mangat S, et al. Effect of high-fat, high-beef diet and of mode of cooking of beef in the diet on fecal bacterial enzymes and fecal bile acids and neutral sterols. J Nutr 1980;110:1880-1887.
5. Stadler J, Yeung KS, Furrer R, Marcon N, Himal HS, Bruce WR. Proliferative activity of rectal mucosa and soluble fecal bile acids in patients with normal colons and in patients with colonic polyps or cancer. Cancer Lett 1988;38:315-320.
6. Reddy BS, Wynder EL. Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps. Cancer 1977;39:2533-2539.
7. Reddy BS, Wynder EL. Large-bowel carcinogenesis: Fecal constituents of populations with diverse incidence rates of colon cancer. J Natl Cancer Inst 1973;50:1437-1442.
8. Reddy BS, Hedges A, Laakso K, Wynder EL. Fecal constituents of a high-risk North American and a low-risk Finnish population for the development of large bowel cancer. Cancer Lett 1978;4:217-222.
9. Hill MJ, Drasar BS, Hawksworth G, Aries V, Crowther JS, Williams RE. Bacteria and aetiology of cancer of large bowel. Lancet 1971;1:95-100.
10. Domellof L, Darby L, Hanson D, Mathews L, Simi B, Reddy BS. Fecal sterols and bacterial beta-glucuronidase activity: A preliminary metabolic epidemiology study of healthy volunteers from Umea, Sweden, and metropolitan New York. Nutr Cancer 1982;4:120-127.
11. McKeigue PM, Adelstein AM, Marmot MG, et al. Diet and fecal steroid profile in a South Asian population with a low colon-cancer rate. Am J Clin Nutr 1989;50:151-154.
12. Narisawa T, Magadia NE, Weisburger JH, Wynder EL. Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N′-nitro-N-nitrosoguanidine in rats. J Natl Cancer Inst 1974;53:1093-1097.
13. Reddy BS, Narasawa T, Weisburger JH, Wynder EL. Promoting effect of sodium deoxycholate on colon adenocarcinomas in germfree rats. J Natl Cancer Inst 1976;56: 441-442.
14. Reddy BS, Watanabe K. Effect of cholesterol metabolites and promoting effect of lithocholic acid in colon carcinogenesis in germ-free and conventional F344 rats. Cancer Res 1979; 39:1521-1524.
15. Reddy BS, Watanabe K, Weisburger JH, Wynder EL. Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats. Cancer Res 1977; 37:3238-3242.
16. Baijal PK, Clow EP, Fitzpatrick DW, Bird RP. Tumor-enhancing effects of cholic acid are exerted on the early stages of colon carcinogenesis via induction of aberrant crypt foci with an enhanced growth phenotype. Can J Physiol Pharmacol 1998;76:1095-1102.
17. Baijal PK, Fitzpatrick DW, Bird RP. Comparative effects of secondary bile acids, deoxycholic and lithocholic acids, on aberrant crypt foci growth in the postinitiation phases of colon carcinogenesis. Nutr Cancer 1998;31:81-89.
18. Sutherland LA, Bird RP. The effect of chenodeoxycholic acid on the development of aberrant crypt foci in the rat colon. Cancer Lett 1994;76:101-107.
19. Seraj MJ, Umemoto A, Kajikawa A, et al. Effects of dietary bile acids on formation of azoxymethane-induced aberrant crypt foci in F344 rats. Cancer Lett 1997;115:97-103.
20. Ueyama Y, Monden Y, He XB, et al. Effects of bile acids on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced aberrant crypt foci and DNA adduct formation in the rat colon. J Exp Clin Cancer Res 2002;21:577-583.
21. +-dependent bile acid transporter from small intestine by ileum resection increases [correction of increase] colonic tumorigenesis in the rat fed deoxycholic acid. Cancer Lett 1999;145:115-120.
22. Debruyne PR, Bruyneel EA, Li X, Zimber A, Gespach C, Mareel MM. The role of bile acids in carcinogenesis. Mutat Res 2001;480-481:359-369.
23. Rosenberg DW, Liu Y. Induction of aberrant crypts in murine colon with varying sensitivity to colon carcinogenesis. Cancer Lett 1995;92:209-214.
24. Papanikolaou A, Wang QS, Delker DA, Rosenberg DW. Azoxymethane-induced colon tumors and aberrant crypt foci in mice of different genetic susceptibility. Cancer Lett 1998;130:29-34.
25. Delker DA, Wang QS, Papanikolaou A, Whiteley HE, Rosenberg DW. Quantitative assessment of azoxymethane-induced aberrant crypt foci in inbred mice. Exp Mol Pathol 1999;65:141-149.
26. Bolt AB, Papanikolaou A, Delker DA, Wang QS, Rosenberg DW. Azoxymethane induces KI-ras activation in the tumor resistant AKR/J mouse colon. Mol Carcinog 2000;27:210-218.
27. Papanikolaou A, Wang QS, Mulherkar R, Bolt A, Rosenberg DW. Expression analysis of the group HA secretory phospholipase A(2) in mice with differential susceptibility to azoxymethane-induced colon tumorigenesis. Carcinogenesis 2000;21:133-138.
28. Papanikolaou A, Wang QS, Papanikolaou D, Whiteley HE, Rosenberg DW. Sequential and morphological analyses of aberrant crypt foci formation in mice of differing susceptibility to azoxymethane-induced colon carcinogenesis. Carcinogenesis 2000;21:1567-1572.
29. Nambiar PR, Giardina C, Guda K, Aizu W, Raja R, Rosenberg DW. Role of the alternating reading frame (P19)-p53 pathway in an in vivo murine colon tumor model. Cancer Res 2002;62:3667-3674.
30. Nambiar PR, Girnun G, Lillo NA, Guda K, Whiteley HE, Rosenberg DW. Preliminary analysis of azoxymethane induced colon tumors in inbred mice commonly used as transgenic/knockout progenitors. Int J Oncol 2003;22:145-150.
31. Nambiar PR, Nakanishi M, Gupta R, et al. Genetic signatures of high- and low-risk aberrant crypt foci in a mouse model of sporadic colon cancer. Cancer Res 2004;64:6394-6401.
32. Siu IM, Pretlow TG, Amini SB, Pretlow TP. Identification of dysplasia in human colonic aberrant crypt foci. Am J Pathol 1997;150:1805-1813.
33. Roncucci L, Stamp D, Medline A, Cullen JB, Bruce WR. Identification and quantification of aberrant crypt foci and microadenomas in the human colon. Hum Pathol 1991; 22:287-294.
34. Wang QS, Papanikolaou A, Nambiar PR, Rosenberg DW. Differential expression of p16(INK4a) in azoxymethane-induced mouse colon tumorigenesis. Mol Carcinog 2000; 28:139-147.
35. Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 2003;1653: 1-24.
36. Wong NA, Pignatelli M. Beta-catenin-a linchpin in colorectal carcinogenesis? Am J Pathol 2002;160:389-401.
37. Kolligs FT, Bommer G, Goke B. Wnt/beta-catenin/tcf signaling: A critical pathway in gastrointestinal tumorigenesis. Digestion 2002;66:131-144.
38. Hao XP, Pretlow TG, Rao JS, Pretlow TP. Beta-catenin expression is altered in human colonic aberrant crypt foci. Cancer Res 2001;61:8085-8088.
39. Roca F, Mauro LV, Morandi A, et al. Prognostic value of E-cadherin, beta-catenin, MMPs (7 and 9), and TIMPs (1 and 2) in patients with colorectal carcinoma. J Surg Oncol 2006;93: 151-160.
40. Wali RK, Khare S, Tretiakova M, et al. Ursodeoxycholic acid and F(6)-D(3) inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: Roles of cyclin D1 and E-cadherin. Cancer Epidemiol Biomarkers Prev 2002;11: 1653-1662.
41. Hardy RG, Tselepis C, Hoyland J, et al. Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon. Gut 2002;50:513-519.
42. Wargovich MJ, Chang P, Velasco M, Sinicrope F, Eisenbrodt E, Sellin J. Expression of cellular adhesion proteins and abnormal glycoproteins in human aberrant crypt foci. Appl Immunohistochem Mol Morphol 2004;12:350-355.
43. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-170.
44. Brabletz T, Hlubek F, Spaderna S, et al. Invasion and metastasis in colorectal cancer: Epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. Cells Tissues Organs 2005;179:56-65.
45. Prange W, Breuhahn K, Fischer F, et al. Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes. J Pathol 2003;201:250-259.
46. Reichling T, Goss KH, Carson DJ, et al. Transcriptional profiles of intestinal tumors in Apc(Min) mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors. Cancer Res 2005;65:166-176.
47. McMillan L, Butcher S, Wallis Y, Neoptolemos JP, Lord JM. Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: Implications for colon carcinogenesis. Biochem Biophys Res Commun 2000;273:45-49.
48. Qiao D, Stratagouleas ED, Martinez JD. Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis. Carcinogenesis 2001;22:35-41.
49. Milovic V, Stein J, Odera G, Gilani S, Murphy GM. Low-dose deoxycholic acid stimulates putrescine uptake in colon cancer cells (Caco-2). Cancer Lett 2000;154:195-200.
50. Pai R, Tarnawski AS, Tran T. Deoxycholic acid activates beta-catenin signaling pathway and increases colon cell cancer growth and invasiveness. Mol Biol Cell 2004;15:2156-2163.
51. Bartram HP, Scheppach W, Schmid H, et al. Proliferation of human colonic mucosa as an intermediate biomarker of carcinogenesis: Effects of butyrate, deoxycholate, calcium, ammonia, and pH. Cancer Res 1993;53:3283-3288.
52. Stadler J, Stern HS, Yeung KS, et al. Effect of high fat consumption on cell proliferation activity of colorectal mucosa and on soluble faecal bile acids. Gut 1988;29:1326-1331.
53. Robblee NM, McLellan EA, Bird RP. Measurement of the proliferative status of colonic epithelium as a risk marker for colon carcinogenesis: Effect of bile acid and dietary fiber. Nutr Cancer 1989;12:301-310.
54. Bird RP, Schneider R, Stamp D, Bruce WR. Effect of dietary calcium and cholic acid on the proliferative indices of murine colonic epithelium. Carcinogenesis 1986;7:1657-1661.
55. Azuma N, Kanaya M, Kanamoto R, Iwami K. Feeding soybean resistant protein to rats raises fecal bile acid excretion but counteracts a deoxycholate-caused decrease in colonic aberrant crypt foci. J Nutr Sci Vitaminol (Tokyo) 1999;45:183-192.
56. Narahara H, Tatsuta M, Iishi H, et al. K-ras point mutation is associated with enhancement by deoxycholic acid of colon carcinogenesis induced by azoxymethane, but not with its attenuation by all-trans-retinoic acid. Int J Cancer 2000; 88:157-161.
57. Guda K, Upender MB, Belinsky G, et al. Carcinogen-induced colon tumors in mice are chromosomally stable and are characterized by low-level microsatellite instability. Oncogene 2004;23:3813-3821.
58. De Filippo C, Caderni G, Bazzicalupo M, et al. Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats. Br J Cancer 1998; 77:2148-2151.
59. Weinstein IB. Disorders in cell circuitry during multistage carcinogenesis: The role of homeostasis. Carcinogenesis 2000;21:857-864.
60. Garte SJ. The c-myc oncogene in tumor progression. Crit Rev Oncog 1993;4:435-449.