메뉴 건너뛰기




Volumn 100, Issue 10, 2015, Pages E1319-E1327

FGF21 response to critical illness: Effect of blood glucose control and relation with cellular stress and survival

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 21; GLUCOSE; INSULIN; SOMATOMEDIN C; FIBROBLAST GROWTH FACTOR; GLUCOSE BLOOD LEVEL;

EID: 84943740629     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-2700     Document Type: Article
Times cited : (33)

References (40)
  • 2
    • 29144479953 scopus 로고    scopus 로고
    • Impact of admission hyperglycemia on hospital mortality in various intensive care unit populations
    • Whitcomb BW, Pradhan EK, Pittas AG, Roghmann MC, Perencevich EN. Impact of admission hyperglycemia on hospital mortality in various intensive care unit populations. Crit Care Med. 2005;33:2772-2777.
    • (2005) Crit Care Med. , vol.33 , pp. 2772-2777
    • Whitcomb, B.W.1    Pradhan, E.K.2    Pittas, A.G.3    Roghmann, M.C.4    Perencevich, E.N.5
  • 3
    • 0035829852 scopus 로고    scopus 로고
    • Intensive insulin therapy in critically ill patients
    • Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345:1359-1367.
    • (2001) N Engl J Med. , vol.345 , pp. 1359-1367
    • Van Den Berghe, G.1    Wouters, P.2    Weekers, F.3
  • 4
    • 11444259403 scopus 로고    scopus 로고
    • Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients
    • Vanhorebeek I, De Vos R, Mesotten D, Wouters PJ, De Wolf-Peeters C, Van den Berghe G. Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet. 2005;365:53-59.
    • (2005) Lancet. , vol.365 , pp. 53-59
    • Vanhorebeek, I.1    De Vos, R.2    Mesotten, D.3    Wouters, P.J.4    De Wolf-Peeters, C.5    Van Den Berghe, G.6
  • 5
    • 68949206301 scopus 로고    scopus 로고
    • Hyperglycemic kidney damage in an animal model of prolonged critical illness
    • Vanhorebeek I, Gunst J, Ellger B, et al. Hyperglycemic kidney damage in an animal model of prolonged critical illness. Kidney Int. 2009;76:512-520.
    • (2009) Kidney Int. , vol.76 , pp. 512-520
    • Vanhorebeek, I.1    Gunst, J.2    Ellger, B.3
  • 6
    • 67650472358 scopus 로고    scopus 로고
    • Tissue-specific glucose toxicity induces mitochondrial damage in a burn injury model of critical illness
    • Vanhorebeek I, Ellger B, De Vos R, et al. Tissue-specific glucose toxicity induces mitochondrial damage in a burn injury model of critical illness. Crit Care Med. 2009;37:1355-1364.
    • (2009) Crit Care Med. , vol.37 , pp. 1355-1364
    • Vanhorebeek, I.1    Ellger, B.2    De Vos, R.3
  • 7
    • 84891655634 scopus 로고    scopus 로고
    • The role of mitochondrial dysfunction in sepsis-induced multi-organ failure
    • Singer M. The role of mitochondrial dysfunction in sepsis-induced multi-organ failure. Virulence. 2014;5:66-72.
    • (2014) Virulence. , vol.5 , pp. 66-72
    • Singer, M.1
  • 9
    • 63849189712 scopus 로고    scopus 로고
    • Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity
    • Mraz M, Bartlova M, Lacinova Z, et al. Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity. Clin Endocrinol (Oxf). 2009;71:369-375.
    • (2009) Clin Endocrinol (Oxf). , vol.71 , pp. 369-375
    • Mraz, M.1    Bartlova, M.2    Lacinova, Z.3
  • 10
    • 84906928425 scopus 로고    scopus 로고
    • FGF21 as a stress hormone: The roles of FGF21 in stress adaptation and the treatment of metabolic diseases
    • Kim KH, Lee MS. FGF21 as a stress hormone: The roles of FGF21 in stress adaptation and the treatment of metabolic diseases. Diabetes Metab J. 2014;38:245-251.
    • (2014) Diabetes Metab J. , vol.38 , pp. 245-251
    • Kim, K.H.1    Lee, M.S.2
  • 11
    • 84883151328 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in db/db mice
    • KimHW,Lee JE, Cha JJ, et al. Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in db/db mice. Endocrinology. 2013;154:3366-3376.
    • (2013) Endocrinology. , vol.154 , pp. 3366-3376
    • Kim, H.W.1    Lee, J.E.2    Cha, J.J.3
  • 12
    • 33846418834 scopus 로고    scopus 로고
    • The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
    • Kharitonenkov A, Wroblewski VJ, Koester A, et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology. 2007;148:774-781.
    • (2007) Endocrinology. , vol.148 , pp. 774-781
    • Kharitonenkov, A.1    Wroblewski, V.J.2    Koester, A.3
  • 13
    • 84872057896 scopus 로고    scopus 로고
    • Autophagy deficiency leads to protection from obesity and insulin resistance by inducing FGF21 as a mitokine
    • Kim KH, Jeong YT, Oh H, et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing FGF21 as a mitokine. Nat Med. 2013;19:83-92.
    • (2013) Nat Med. , vol.19 , pp. 83-92
    • Kim, K.H.1    Jeong, Y.T.2    Oh, H.3
  • 14
    • 84870568785 scopus 로고    scopus 로고
    • Circulating fibroblast growth factors as metabolic regulators-A critical appraisal
    • Angelin B, Larsson TE, Rudling M. Circulating fibroblast growth factors as metabolic regulators-A critical appraisal. Cell Metab. 2012;16:693-705.
    • (2012) Cell Metab. , vol.16 , pp. 693-705
    • Angelin, B.1    Larsson, T.E.2    Rudling, M.3
  • 15
    • 48949092388 scopus 로고    scopus 로고
    • Prevalence, incidence, and clinical resolution of insulin resistance in critically ill patients: An observational study
    • Saberi F, Heyland D, Lam M, Rapson D, Jeejeebhoy K. Prevalence, incidence, and clinical resolution of insulin resistance in critically ill patients: an observational study. JPEN J Parenter Enteral Nutr. 2008;32:227-235.
    • (2008) JPEN J Parenter Enteral Nutr. , vol.32 , pp. 227-235
    • Saberi, F.1    Heyland, D.2    Lam, M.3    Rapson, D.4    Jeejeebhoy, K.5
  • 16
    • 0037142987 scopus 로고    scopus 로고
    • Association between mitochondrial dysfunction and severity and outcome of septic shock
    • Brealey D, Brand M, Hargreaves I, et al. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet. 2002;360:219-223.
    • (2002) Lancet. , vol.360 , pp. 219-223
    • Brealey, D.1    Brand, M.2    Hargreaves, I.3
  • 17
    • 0036170768 scopus 로고    scopus 로고
    • A novel in vivo rabbit model of hypercatabolic critical illness reveals a biphasic neuroendocrine stress response
    • Weekers F, Van Herck E, Coopmans W, et al. A novel in vivo rabbit model of hypercatabolic critical illness reveals a biphasic neuroendocrine stress response. Endocrinology. 2002;143:764-774.
    • (2002) Endocrinology. , vol.143 , pp. 764-774
    • Weekers, F.1    Van Herck, E.2    Coopmans, W.3
  • 18
    • 84872066457 scopus 로고    scopus 로고
    • Insufficient autophagy contributes to mitochondrial dysfunction, organ failure, and adverse outcome in an animal model of critical illness
    • Gunst J, Derese I, Aertgeerts A, et al. Insufficient autophagy contributes to mitochondrial dysfunction, organ failure, and adverse outcome in an animal model of critical illness. Crit Care Med. 2013; 41:182-194.
    • (2013) Crit Care Med. , vol.41 , pp. 182-194
    • Gunst, J.1    Derese, I.2    Aertgeerts, A.3
  • 19
    • 33745320589 scopus 로고    scopus 로고
    • Survival benefits of intensive insulin therapy in critical illness: Impact of maintaining normoglycemia versus glycemia-independent actions of insulin
    • Ellger B, Debaveye Y, Vanhorebeek I, et al. Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin. Diabetes. 2006;55:1096-1105.
    • (2006) Diabetes. , vol.55 , pp. 1096-1105
    • Ellger, B.1    Debaveye, Y.2    Vanhorebeek, I.3
  • 20
    • 23644461209 scopus 로고    scopus 로고
    • Intensive insulin therapy protects the endothelium of critically ill patients
    • Langouche L, Vanhorebeek I, Vlasselaers D, et al. Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest. 2005;115:2277-2286.
    • (2005) J Clin Invest. , vol.115 , pp. 2277-2286
    • Langouche, L.1    Vanhorebeek, I.2    Vlasselaers, D.3
  • 21
    • 84899516860 scopus 로고    scopus 로고
    • Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine
    • Keipert S, Ost M, Johann K, et al. Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine. Am J Physiol Endocrinol Metab. 2014;306: E469-E482.
    • (2014) Am J Physiol Endocrinol Metab. , vol.306 , pp. E469-E482
    • Keipert, S.1    Ost, M.2    Johann, K.3
  • 22
    • 84858311217 scopus 로고    scopus 로고
    • Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
    • De Sousa-Coelho AL, Marrero PF, Haro D. Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation. Biochem J. 2012;443:165-171.
    • (2012) Biochem J. , vol.443 , pp. 165-171
    • De Sousa-Coelho, A.L.1    Marrero, P.F.2    Haro, D.3
  • 23
    • 84905394061 scopus 로고    scopus 로고
    • FGF21 as a hepatokine, adipokine, and myokine in metabolism and diseases
    • Itoh N. FGF21 as a hepatokine, adipokine, and myokine in metabolism and diseases. Front Endocrinol (Lausanne). 2014;5:107.
    • (2014) Front Endocrinol (Lausanne). , vol.5 , pp. 107
    • Itoh, N.1
  • 24
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response byPPAR-mediated induction of fibroblast growth factor 21
    • Inagaki T, Dutchak P, Zhao G, et al. Endocrine regulation of the fasting response byPPAR-mediated induction of fibroblast growth factor 21. Cell Metab. 2007;5:415-425.
    • (2007) Cell Metab. , vol.5 , pp. 415-425
    • Inagaki, T.1    Dutchak, P.2    Zhao, G.3
  • 25
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPAR and is a key mediator of hepatic lipid metabolism in ketotic states
    • Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPAR and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007;5:426-437.
    • (2007) Cell Metab. , vol.5 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 26
    • 77957359658 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
    • Li H, Fang Q, Gao F, et al. Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. J Hepatol. 2010;53:934-940.
    • (2010) J Hepatol. , vol.53 , pp. 934-940
    • Li, H.1    Fang, Q.2    Gao, F.3
  • 27
    • 84906487180 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1-mediated antioxidant capacity in mice
    • Ye D, Wang Y, Li H, et al. Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1-mediated antioxidant capacity in mice. Hepatology. 2014;60:977-989.
    • (2014) Hepatology. , vol.60 , pp. 977-989
    • Ye, D.1    Wang, Y.2    Li, H.3
  • 28
    • 78349310229 scopus 로고    scopus 로고
    • SerumFGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients
    • Domingo P, Gallego-Escuredo JM, Domingo JC, et al. SerumFGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients. AIDS. 2010;24:2629-2637.
    • (2010) AIDS. , vol.24 , pp. 2629-2637
    • Domingo, P.1    Gallego-Escuredo, J.M.2    Domingo, J.C.3
  • 29
    • 84907015381 scopus 로고    scopus 로고
    • FGF21 is an endocrine signal of protein restriction
    • Laeger T, Henagan TM, Albarado DC, et al. FGF21 is an endocrine signal of protein restriction. J Clin Invest. 2014;124:3913-3922.
    • (2014) J Clin Invest. , vol.124 , pp. 3913-3922
    • Laeger, T.1    Henagan, T.M.2    Albarado, D.C.3
  • 31
    • 79953875974 scopus 로고    scopus 로고
    • Insufficient activation of autophagy allows cellular damage to accumulate in critically ill patients
    • Vanhorebeek I, Gunst J, Derde S, et al. Insufficient activation of autophagy allows cellular damage to accumulate in critically ill patients. J Clin Endocrinol Metab. 2011;96:E633-E645.
    • (2011) J Clin Endocrinol Metab. , vol.96 , pp. E633-E645
    • Vanhorebeek, I.1    Gunst, J.2    Derde, S.3
  • 33
    • 84892162004 scopus 로고    scopus 로고
    • Stressed liver and muscle call on adipocytes with FGF21
    • Luo Y, McKeehan WL. Stressed liver and muscle call on adipocytes with FGF21. Front Endocrinol (Lausanne). 2013;4:194.
    • (2013) Front Endocrinol (Lausanne). , vol.4 , pp. 194
    • Luo, Y.1    McKeehan, W.L.2
  • 34
    • 84861324386 scopus 로고    scopus 로고
    • FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis
    • Feingold KR, Grunfeld C, Heuer JG, et al. FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis. Endocrinology. 2012;153:2689-2700.
    • (2012) Endocrinology. , vol.153 , pp. 2689-2700
    • Feingold, K.R.1    Grunfeld, C.2    Heuer, J.G.3
  • 36
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • Kroemer G, Mariño G, Levine B. Autophagy and the integrated stress response. Mol Cell. 2010;40:280-293.
    • (2010) Mol Cell. , vol.40 , pp. 280-293
    • Kroemer, G.1    Mariño, G.2    Levine, B.3
  • 37
    • 0035947778 scopus 로고    scopus 로고
    • Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2
    • Novoa I, Zeng H, Harding HP, Ron D. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2. J Cell Biol. 2000; 153: 1011-1022.
    • (2000) J Cell Biol. , vol.153 , pp. 1011-1022
    • Novoa, I.1    Zeng, H.2    Harding, H.P.3    Ron, D.4
  • 39
    • 84883481988 scopus 로고    scopus 로고
    • The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
    • Gaich G, Chien JY, Fu H, et al. The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell Metab. 2013;18:333-340.
    • (2013) Cell Metab. , vol.18 , pp. 333-340
    • Gaich, G.1    Chien, J.Y.2    Fu, H.3
  • 40
    • 48349127924 scopus 로고    scopus 로고
    • The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPAR activation in man
    • Gälman C, Lundasen T, Kharitonenkov A, et al. The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPAR activation in man. Cell Metab. 2008;8:169-174.
    • (2008) Cell Metab. , vol.8 , pp. 169-174
    • Gälman, C.1    Lundasen, T.2    Kharitonenkov, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.