Antisense oligonucleotides targeting protein kinase C-α, -βI, or -σ but not -η inhibit lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 Macrophages: Involvement of a nuclear factor κB- dependent mechanism

Journal of Immunology

Volumn 161, Issue 11, 1998, Pages 6206-6214

  Chen, Ching Chow ^a   Wang, Jia Kae ^a   Lin, Shwu Bin ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE INHIBITOR;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; DRUG RECEPTOR BINDING; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME SPECIFICITY; GENE TARGETING; LONG TERM POTENTIATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; CELL NUCLEUS; ENZYME INDUCTION; ENZYME INHIBITORS; ISOENZYMES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MOLECULAR WEIGHT; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN KINASE C-DELTA; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE;

EID: 0032403566     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Moncada, S., R. H. J. Palmer, and E. A. Higgs. 1991. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43:109.
2. Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:3051.
3. Lowenstein, C. J., J. L. Dinerman, and S. H. Snyder. 1994. Nitric oxide: a physiologic messenger. Ann. Intern. Med. 120:227.
4. Leone, A. M., R. M. Palmer, R. G. Knowles, P. L. Francis, D. S. Ashton, and S. Moncada. 1991. Constitutive and inducible nitric oxide synthases incorporate molecular oxygen in both nitric oxide and L-citrulline. J. Biol. Chem. 266:23790.
5. White, K. A., and M. A. Marietta. 1992. Nitric oxide synthase is a cytochrome p-450 type hemoprotein. Biochemistry 31:6627.
6. Knowles, R. G., and S. Moncada. 1994. Nitric oxide synthase in mammals. Biochem. J. 298:249.
7. Nathan, C., and Q. Xie. 1994. Regulation of biosynthesis of nitric oxide. J. Biol. Chem. 269:13725.
8. Forstermann, U., I. Gath, P. Schwarz, E. I. Closs, and H. Kleinert. 1995. Isoforms of nitric oxide synthase. Biochem. Pharmacol. 50:1321.
9. Bredt, D. S., P. M. Hwang, C. E. Glatt, C. Lowenstein, R. R. Reed, and S. H. Snyder. 1991. Cloned and expressed nitric oxide synthase structurally resemble cytochrome p-450 reductase. Nature 351:714.
10. Xie, Q. W., H. J. Cho, J. Calaycay, R. A. Mumford, K. M. Swiderek, T. D. Lee, A. Ding, T. Troso, and C. Nathan. 1992. Cloning and characterization of inducible nitric oxide synthase from mouse macrophage. Science 256:225.
11. Lamas, S., P. A. Marsden, G. K. Li, P. Tempst, and T. Michel. 1992. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc. Natl. Acad. Sci. USA 89:6348.
12. Knowles, R. G., and S. Moncada. 1992. Nitric oxide as a signal in blood vessels. Trends Biochem. Sci. 17:399.
13. Lowenstein, C. J., E. W. Alley, P. Raval, A. M. Snowwan, S. H. Synder, S. W. Russell, and W. J. Murphy. 1993. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon γ and lipopolysaccharide. Proc. Natl. Acad. Sci. USA 90:9730.
14. Xie, Q. W., R. Wishnan, and C. Nathan. 1993. Promotor of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide. J. Exp. Med. 177:1779.
15. Chartrain, N. A., D. A. Geller, P. P. Koty, N. F. Sitrin, A. K. Nussler, E. P. Hoffman, T. R. Billiar, N. I. Hutchinson, and J. S. Mudgett. 1994. Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene. J. Biol. Chem. 269:6765.
16. Xie, Q. W., Y. Kashiwabara, and C. Nathan. 1994. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269:4705.
17. Sherman, M. P., E. E. Aeberhard, V. Z. Wong, J. M. Griscavage, and L. J. Ignarro. 1993. Pyrrolidine dithiocarbamate inhibits the induction of NOS in rat alveolar macrophages. Biochem. Biophys. Res. Commun. 191:1301.
18. Thanos, D., and T. Maniatis. 1995. NF-κB: a lesson in family values. Cell 80: 529.
19. Lyons, C. R., G. J. Orloff, and J. M. Cumningham. 1992. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J. Biol. Chem. 267:6370.
20. MacMicking, J., Q. W. Xie, and C. Nathan. 1997. Nitric oxide and macrophage function. Annu. Rev. Immunol. 15:323.
21. Weinstein, S. L., M. R. Gold, and A. L. DeFranco. 1991. Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages. Proc. Natl. Acad. Sci. USA 88:4148.
22. Paul, A., R. H. Pendreigh, and R. Plevin. 1995. Protein kinase C and tyrosine kinase pathways regulate lipopolysaccharide-induced nitrite oxide synthase activity in RAW 264.7 murine macrophage. Br. J. Pharmacol. 114:482.
23. Severn, A., M. J. O. Wakelam, and F. Y. Liew. 1992. The role of protein kinase C in the induction of nitrix oxide synthase by murine macrophages. Biochem. Biophys. Res. Commun. 188:997.
24. Sands, W. A., J. S. Clark, and F. Y. Liew. 1994. The role of a phosphatidylcholine specific phospholipase C in the production of diacylglycerol for nitric oxide synthesis in macrophages activated by IFN-γ and LPS. Biochem. Biophys. Res. Commun. 199:461.
25. Tschaikowsky, K., M. Meisner, F. Schonhuber, and E. Rugheimer. 1994. Induction of nitric oxide synthase activity in phagocytic cells inhibited by ticyclodecan-9-yl-xanthogenate (D609). Br. J. Pharmacol. 113:664.
26. Fujihara, M., N. Connolly, N. Ito, and T. Suzuki. 1994. Properties of protein kinase C isoforms (βII, ∈, and ζ) in a macrophage cell line (J774) and their roles in LPS-induced nitric oxide production. J. Immunol. 152:1898.
27. Paul, A., K. Doherty, and R. Plevin. 1997. Differential regulation by protein kinase C isoforms of nitric oxide synthase induction in RAW 264.7 macrophages and rat aortic smooth muscle cells. Br. J. Pharmacol. 120:940.
28. Chen, C. C. 1993. Protein kinase α, δ, ∈ and ζ in C6 glioma cells: TPA induces translocation and down-regulation of conventional and new PKC isoforms but not atypical PKCζ. FEBS Lett. 332:169.
29. Chen, C. C., J. Chang, and W. C. Chen. 1995. Role of protein kinase C subtypes α and δ in the regulation of bradykinin stimulated phosphoinositide breakdown in astrocytes. Mol. Pharmacol. 48:39.
30. Chen, C. C. 1994. Pentylenetrazole-induced chemshock affect protein kinase C and substrate proteins in mouse brain. J. Neurochem. 62:2308.
31. Lin, S. B., S. S. Huang, K. B. Choo, P. J. Chen, and L. C. Au. 1995. Inhibition of α-fetoprotein production in a hepatoma cell line by antisense oligonucleotide analogues. J. Biochem. 117:1100.
32. Lin, S. B., G. W. Chang, G. W. Teh, K. I. Lin, and L. C. Au. 1993. A simple and rapid method for the purification of oligodeoxynucleoside methylphosphonates. Biotechniques 14:795.
33. Chen, C. C., J. K. Wang, and W. C. Chen. 1997. TPA induces translocation but not down-regulation of new PKC isoform η in macrophages, MDCK cells and astrocytes. FEBS Lett. 412:30.
34. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Anna. Rev. Immunol. 12:141.
35. Schumann, R. R., S. R. Leong, G. W. Flaggs, P. W. Gray, S. D. Wright, J. C. Mathison, P. S. Tobias, and R. J. Ulevitch. 1990. Structure and function of lipopolysaccharide binding protein. Science 249:1429.
36. Martin, T. R., J. C. Mathison, P. S. Tobias, D. J. Leturco, A. M. Moriarty, R. J. Maunder, and R. J. Ulevitch. 1992. Lipopolysaccharide binding protein enhances the responsiveness for alveolar macrophages to bacteria lipopolysaccharides. J. Clin. Invest. 90:2209.
37. Wright, S. D., R. A. Ramos, P. S. Tobias, R. J. Ulevitch, and J. Mathison. 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431.
38. Ulevitch, R. J., and P. S. Tobias. 1995. Receptor-dependent mechanisms by bacterial endotoxin. Annu. Rev. Immunol. 13:437.
39. Lee, J. D., V. Kravchenko, T. N. Kirkland, J. Han, N. Mackman, A. Moriarty, D. Letureq, P. S. Tobias, and R. J. Ulevitch. 1993. GPI-anchored or integral membrane forms of CD14 mediated identical cellular responses to endotoxin. Proc. Natl. Acad. Sci. USA 90:9930.
40. Dentener, M. A., V. Bazil, E. J. U. Von Asmuth, M. Ceska, and W. A Buurman. 1993. Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-α, IL-6 and IL-8 release by human monocytes and alveolar macrophages. J. Immunol. 150:2285.
41. Nishizuka, Y. 1995. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9:484.
42. Exton, J. H. 1994. Phosphatidylcholine breakdown and signal transduction. Biochim. Biophys. Acta 1212:26.
43. Schlessinger, J. 1994. SH2/SH3 signaling proteins. Curr. Opin. Genet. Dev. 4:25.
44. Yamamoto, H., K. Hanada, and M. Nishijima. 1997. Involvement of diacylglycerol production in activation of nuclear factor κB by a CD14-mediated lipopolysaccharide stimulus. Biochem. J. 325:223.
45. Choudhury, G. G., V. L. Sylvia, L. M. Wang, J. Pierce, and A. Y. Sakaguchi. 1991. The kinase insert domain of colony stimulating factor-1 receptor is dispensable for CSF-1 induced phosphatidylcholine hydrolysis. FEBS Lett. 282:351.
46. lyn. J. Biol. Chem. 268:20725.
47. Beaty, C. D., T. L. Franklin, Y. Uehara, and C. B. Wilson. 1994. Lipopolysaccharide-induced cytokine production in human monocytes: role of tyrosine phosphorylation in transmembrane signal transduction. Eur. J. Immunol. 24:1278.
48. Diaz-Guerra, M. J. M., O. G. Bolelon, M. Velasco, R. Whelan, P. J. Parker, and L. Bosca. 1996. Up-regulation of protein kinase C-∈ promotes the expression of cytokine-inducible nitric oxide synthase in RAW 264.7 cells. J. Biol. Chem. 271:32028.
49. Hortelano, S., A. M. Genaro, and L. Bosca. 1993. Phorbol esters induce nitric oxide synthase and increase arginine influx in cultured peritoneal macrophages. FEBS Lett. 320:135.
50. Diaz-Guerra, M. J. M., M. Velasco, P. Martin-Sanz, and L. Bosca. 1996. Evidence for common mechanism in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes. J. Biol. Chem. 271:30114.
51. Johnson, D. R., I. Douglas, A. Jahnke, S. Ghosh, and J. S. Pober. 1996. A sustained reduction in IκB-β may contribute to persistent NF-κB activation in human endothelial cells. J. Biol. Chem. 271:16317.
52. Chen, C. C., J. K. Wang, W. C. Chen, and S. B. Lin. 1998. Protein kinase C η mediates lipopolysaccharide-induced nitric oxide synthase expression in primary astrocytes. J. Biol. Chem. 273:19424.
53. Lozano, J., E. Berra, M. M. Municio, M. T. Diaz-Meco, I. Dominguez, L. Sanz, and J. Moscat. 1994. Protein kinase C ζ isoform is critical for κB-dependent promotor activation by sphingomyelinase. J. Biol. Chem. 269:19200.
54. Chen, C. C., and J. K. Wang, 1998. p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lippolysaccharide in RAW 264.7 macrophages. Mol. Parmacol. In press.