Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis

PLoS Pathogens

Volumn 11, Issue 9, 2015, Pages

  Chertow, Jessica H ^a   Alkaitis, Matthew S ^a,b   Nardone, Glenn ^a   Ikeda, Allison K ^a   Cunnington, Aubrey J ^c   Okebe, Joseph ^d   Ebonyi, Augustine O ^d   Njie, Madi ^d   Correa, Simon ^d   Jayasooriya, Shamanthi ^d   Casals Pascual, Climent ^e   Billker, Oliver ^f   Conway, David J ^d,g   Walther, Michael ^d   Ackerman, Hans ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d MRC Unit   (Gambia)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^g LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DIMETHYLARGININASE; LACTIC ACID; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; AMIDASE; NITRIC OXIDE;

ANIMAL MODEL; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; GAMBIAN; HOMEOSTASIS; HUMAN; MAJOR CLINICAL STUDY; MALARIA; MOUSE; NONHUMAN; ANIMAL; BLOOD; CASE CONTROL STUDY; DISEASE MODEL; ENZYMOLOGY; GAMBIA; LIVER; METABOLISM; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

AMIDOHYDROLASES; ANIMALS; ARGININE; CASE-CONTROL STUDIES; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; GAMBIA; HOMEOSTASIS; HUMANS; LIVER; MALARIA; MICE; NITRIC OXIDE;

EID: 84943550981     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005119     Document Type: Article

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