메뉴 건너뛰기




Volumn 13, Issue 4, 2012, Pages

Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis

Author keywords

Arginine; Carnitine; Intensive care units; Nitric oxide; Nitric oxide synthase; Pediatric; Sepsis

Indexed keywords

ACYLCARNITINE; ARGININE; CARNITINE; CITRULLINE; DIMETHYLARGININE; INTERLEUKIN 8; ORNITHINE; UNCLASSIFIED DRUG;

EID: 84864283156     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0b013e318238b5cd     Document Type: Article
Times cited : (21)

References (49)
  • 3
    • 0027752805 scopus 로고
    • The L-arginine-nitric oxide pathway
    • DOI 10.1056/NEJM199312303292706
    • Moncada S, Higgs A: The l-arginine-nitric oxide pathway. N Engl J Med 1993; 329: 2002-2012 (Pubitemid 24015045)
    • (1993) New England Journal of Medicine , vol.329 , Issue.27 , pp. 2002-2012
    • Moncada, S.1    Higgs, A.2
  • 4
    • 0031892252 scopus 로고    scopus 로고
    • Prolonged inhibition of nitric oxide synthesis in severe septic shock: A clinical study
    • DOI 10.1097/00003246-199804000-00012
    • Avontuur JA, Tutein Nolthenius RP, van Bodegom JW, et al: Prolonged inhibition of nitric oxide synthesis in severe septic shock: A clinical study. Crit Care Med 1998; 26: 660-667 (Pubitemid 28201411)
    • (1998) Critical Care Medicine , vol.26 , Issue.4 , pp. 660-667
    • Avontuur, J.A.M.1    Tutein Nolthenius, R.P.2    Van Bodegom, J.W.3    Bruining, H.A.4
  • 5
    • 0034222910 scopus 로고    scopus 로고
    • Tissue oxygenation and hemodynamic response to NO synthase inhibition in septic shock
    • Broccard A, Hurni JM, Eckert P, et al: Tissue oxygenation and hemodynamic response to NO synthase inhibition in septic shock. Shock 2000; 14: 35-40
    • (2000) Shock , vol.14 , pp. 35-40
    • Broccard, A.1    Hurni, J.M.2    Eckert, P.3
  • 7
    • 44049093984 scopus 로고    scopus 로고
    • Resuscitating the microcirculation in sepsis: The central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials
    • Trzeciak S, Cinel I, Phillip Dellinger R, et al: Resuscitating the microcirculation in sepsis: The central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med 2008; 15: 399-413
    • (2008) Acad Emerg Med , vol.15 , pp. 399-413
    • Trzeciak, S.1    Cinel, I.2    Phillip Dellinger, R.3
  • 9
    • 58149379390 scopus 로고    scopus 로고
    • Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production
    • Luiking YC, Poeze M, Ramsay G, et al: Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production. Am J Clin Nutr 2009; 89: 142-152
    • (2009) Am J Clin Nutr , vol.89 , pp. 142-152
    • Luiking, Y.C.1    Poeze, M.2    Ramsay, G.3
  • 10
    • 79251572569 scopus 로고    scopus 로고
    • Is plasma arginine concentration decreased in patients with sepsis? A systematic review and meta-analysis
    • Davis JS, Anstey NM: Is plasma arginine concentration decreased in patients with sepsis? A systematic review and meta-analysis. Crit Care Med 2011; 39: 380-385
    • (2011) Crit Care Med , vol.39 , pp. 380-385
    • Davis, J.S.1    Anstey, N.M.2
  • 11
    • 33746096538 scopus 로고    scopus 로고
    • L-Arginine supplementation in sepsis: Beneficial or harmful?
    • DOI 10.1097/01.ccx.0000235206.92697.bf, PII 0007519820060800000005
    • Kalil AC, Danner RL: l-Arginine supplementation in sepsis: Beneficial or harmful? Curr Opin Crit Care 2006; 12: 303-308 (Pubitemid 44078141)
    • (2006) Current Opinion in Critical Care , vol.12 , Issue.4 , pp. 303-308
    • Kalil, A.C.1    Danner, R.L.2
  • 13
    • 79951972996 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis
    • Davis JS, Darcy CJ, Yeo TW, et al: Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis. PLoS One 2011; 6: e17260
    • (2011) PLoS One , vol.6
    • Davis, J.S.1    Darcy, C.J.2    Yeo, T.W.3
  • 15
    • 34447628068 scopus 로고    scopus 로고
    • Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: A prospective observational study
    • O'Dwyer MJ, Dempsey F, Crowley V, et al: Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: A prospective observational study. Crit Care 2006; 10: R139
    • (2006) Crit Care , vol.10
    • O'dwyer, M.J.1    Dempsey, F.2    Crowley, V.3
  • 16
    • 66449112861 scopus 로고    scopus 로고
    • Low arginine/asymmetric dimethylarginine ratio deteriorates systemic hemodynamics and organ blood flow in a rat model
    • Richir MC, van Lambalgen AA, Teerlink T, et al: Low arginine/asymmetric dimethylarginine ratio deteriorates systemic hemodynamics and organ blood flow in a rat model. Crit Care Med 2009; 37: 2010-2017
    • (2009) Crit Care Med , vol.37 , pp. 2010-2017
    • Richir, M.C.1    Van Lambalgen, A.A.2    Teerlink, T.3
  • 17
    • 1242273844 scopus 로고    scopus 로고
    • ADMA and oxidative stress
    • DOI 10.1016/S1567-5688(03)00033-3
    • Sydow K, Munzel T: ADMA and oxidative stress. Atheroscler Suppl 2003; 4: 41-51 (Pubitemid 38234494)
    • (2003) Atherosclerosis Supplements , vol.4 , Issue.4 , pp. 41-51
    • Sydow, K.1    Munzel, T.2
  • 18
    • 0036892452 scopus 로고    scopus 로고
    • Bench-to-bedside review: Cytopathic hypoxia
    • DOI 10.1186/cc1824
    • Fink MP: Bench-to-bedside review: Cytopathic hypoxia. Crit Care 2002; 6: 491-499 (Pubitemid 35414580)
    • (2002) Critical Care , vol.6 , Issue.6 , pp. 491-499
    • Fink, M.P.1
  • 19
    • 77950916518 scopus 로고    scopus 로고
    • Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: Role of asymmetric dimethylarginine
    • Sharma S, Smith A, Kumar S, et al: Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: Role of asymmetric dimethylarginine. Vascul Pharmacol 2009; 52: 182-190
    • (2009) Vascul Pharmacol , vol.52 , pp. 182-190
    • Sharma, S.1    Smith, A.2    Kumar, S.3
  • 20
    • 47249137061 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: Role of mitochondrial dysfunction
    • Sud N, Wells SM, Sharma S, et al: Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: Role of mitochondrial dysfunction. Am J Physiol Cell Physiol 2008; 294: C1407-1418
    • (2008) Am J Physiol Cell Physiol , vol.294
    • Sud, N.1    Wells, S.M.2    Sharma, S.3
  • 22
    • 33644849567 scopus 로고    scopus 로고
    • Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry after hypoxia-ischemia in newborn rats
    • DOI 10.1161/01.STR.0000198892.15269.f7, PII 0000767020060200000081
    • Wainwright MS, Kohli R, Whitington PF, et al: Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry after hypoxia-ischemia in newborn rats. Stroke 2006; 37: 524-530 (Pubitemid 43732018)
    • (2006) Stroke , vol.37 , Issue.2 , pp. 524-530
    • Wainwright, M.S.1    Kohli, R.2    Whitington, P.F.3    Chace, D.H.4
  • 23
    • 21644438082 scopus 로고    scopus 로고
    • International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics
    • Goldstein B, Giroir B, Randolph A: International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005; 6: 2-8
    • (2005) Pediatr Crit Care Med , vol.6 , pp. 2-8
    • Goldstein, B.1    Giroir, B.2    Randolph, A.3
  • 24
    • 77949458090 scopus 로고    scopus 로고
    • Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass
    • Gaies MG, Gurney JG, Yen AH, et al: Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatr Crit Care Med 2010; 11: 234-238
    • (2010) Pediatr Crit Care Med , vol.11 , pp. 234-238
    • Gaies, M.G.1    Gurney, J.G.2    Yen, A.H.3
  • 25
    • 0037302945 scopus 로고    scopus 로고
    • PIM2: A revised version of the Paediatric Index of Mortality
    • Slater A, Shann F, Pearson G: PIM2: A revised version of the Paediatric Index of Mortality. Intensive Care Med 2003; 29: 278-285 (Pubitemid 36384419)
    • (2003) Intensive Care Medicine , vol.29 , Issue.2 , pp. 278-285
    • Slater, A.1    Shann, F.2    Pearson, G.3
  • 26
    • 0038783334 scopus 로고    scopus 로고
    • Validation of the paediatric logistic organ dysfunction (PELOD) score: Prospective, observational, multicentre study
    • Leteurtre S, Martinot A, Duhamel A, et al: Validation of the Paediatric Logistic Organ Dysfunction (PELOD) score: Prospective, observational, multicentre study. Lancet2003; 362: 192-197
    • Lancet2003 , vol.362 , pp. 192-197
    • Leteurtre, S.1    Martinot, A.2    Duhamel, A.3
  • 27
    • 70349437005 scopus 로고    scopus 로고
    • Hemodialysis acutely reduces the plasma levels of asymmetric dimethylarginine (ADMA) without reversing impaired nitric oxide dependent vasodilation
    • Engelberger RP, Teta D, Henry H, et al: Hemodialysis acutely reduces the plasma levels of asymmetric dimethylarginine (ADMA) without reversing impaired nitric oxide dependent vasodilation. Clin Sci (Lond) 2009; 117: 293-303
    • (2009) Clin Sci (Lond) , vol.117 , pp. 293-303
    • Engelberger, R.P.1    Teta, D.2    Henry, H.3
  • 28
    • 35048878172 scopus 로고    scopus 로고
    • Measurement of arginine derivatives in pediatric patients with chronic kidney disease using high-performance liquid chromatography-tandem mass spectrometry
    • DOI 10.1515/CCLM.2007.277
    • Wang S, Vicente FB, Miller A, et al: Measurement of arginine derivatives in pediatric patients with chronic kidney disease using high-performance liquid chromatography-tandem mass spectrometry. Clin Chem Lab Med 2007; 45: 1305-1312 (Pubitemid 47557069)
    • (2007) Clinical Chemistry and Laboratory Medicine , vol.45 , Issue.10 , pp. 1305-1312
    • Wang, S.1    Vicente, F.B.2    Miller, A.3    Brooks, E.R.4    Price, H.E.5    Smith, F.A.6
  • 30
    • 0034734956 scopus 로고    scopus 로고
    • Increased l-citrulline/l-arginine plasma ratio in severe preeclampsia
    • Benedetto C, Marozio L, Neri I, et al: Increased l-citrulline/l-arginine plasma ratio in severe preeclampsia. ObstetGynecol 2000; 96: 395-399
    • (2000) ObstetGynecol , vol.96 , pp. 395-399
    • Benedetto, C.1    Marozio, L.2    Neri, I.3
  • 33
    • 12244283055 scopus 로고    scopus 로고
    • The asymmetrical dimethylarginine (ADMA) - Multiple organ failure hypothesis
    • DOI 10.1054/clnu.2002.0614
    • Nijveldt RJ, Teerlink T, van Leeuwen PA: The asymmetrical dimethylarginine (ADMA)-multiple organ failure hypothesis. Clin Nutr 2003; 22: 99-104 (Pubitemid 36193187)
    • (2003) Clinical Nutrition , vol.22 , Issue.1 , pp. 99-104
    • Nijveldt, R.J.1    Teerlink, T.2    Van Leeuwen, P.A.M.3
  • 34
    • 27744604586 scopus 로고    scopus 로고
    • Elevated levels of asymmetric dimethylarginine (ADMA) as a marker for cardiovascular disease and mortality
    • DOI 10.1515/CCLM.2005.196
    • Boger RH, Maas R, Schulze F, et al: Elevated levels of asymmetric dimethylarginine (ADMA) as a marker of cardiovascular disease and mortality. Clin Chem Lab Med 2005; 43: 1124-1129 (Pubitemid 41581972)
    • (2005) Clinical Chemistry and Laboratory Medicine , vol.43 , Issue.10 , pp. 1124-1129
    • Boger, R.H.1    Maas, R.2    Schulze, F.3    Schwedhelm, E.4
  • 35
    • 68349147783 scopus 로고    scopus 로고
    • Dimethylarginine levels in cerebrospinal fluid of hyperacute ischemic stroke patients are associated with stroke severity
    • Brouns R, Marescau B, Possemiers I, et al: Dimethylarginine levels in cerebrospinal fluid of hyperacute ischemic stroke patients are associated with stroke severity. Neurochem Res 2009; 34: 1642-1649
    • (2009) Neurochem Res , vol.34 , pp. 1642-1649
    • Brouns, R.1    Marescau, B.2    Possemiers, I.3
  • 36
    • 33747397670 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine is an independent risk factor for coronary heart disease
    • Results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study
    • Schulze F, Lenzen H, Hanefeld C, et al: Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: Results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study. Am Heart J 2006; 152: 493 e491-e498
    • (2006) Am Heart J , vol.152 , Issue.493
    • Schulze, F.1    Lenzen, H.2    Hanefeld, C.3
  • 37
    • 77954061745 scopus 로고    scopus 로고
    • Increased asymmetric dimethylarginine in severe falciparum malaria: Association with impaired nitric oxide bioavailability and fatal outcome
    • Yeo TW, Lampah DA, Tjitra E, et al: Increased asymmetric dimethylarginine in severe falciparum malaria: Association with impaired nitric oxide bioavailability and fatal outcome. PLoS Pathog 2010; 6: e1000868
    • (2010) PLoS Pathog , vol.6
    • Yeo, T.W.1    Lampah, D.A.2    Tjitra, E.3
  • 38
    • 34447252828 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) in vascular, renal and hepatic disease and the regulatory role of l-arginine on its metabolism
    • DOI 10.1016/j.ymgme.2007.04.017, PII S1096719207001412
    • Wilcken DE, Sim AS, Wang J, et al: Asymmetric dimethylarginine (ADMA) in vascular, renal and hepatic disease and the regulatory role of l-arginine on its metabolism. Mol GenetMetab 2007; 91: 309-317; discussion 318 (Pubitemid 47043511)
    • (2007) Molecular Genetics and Metabolism , vol.91 , Issue.4 , pp. 309-317
    • Wilcken, D.E.L.1    Sim, A.S.2    Wang, J.3    Wang, X.L.4
  • 39
    • 2942752473 scopus 로고    scopus 로고
    • Acute Escherichia coli endotoxaemia decreases the plasma L-arginine/asymmetrical dimethylarginine ratio in humans
    • DOI 10.1042/CS20030363
    • Mittermayer F, Namiranian K, Pleiner J, et al: Acute Escherichia coli endotoxaemia decreases the plasma l-arginine/asymmetrical dimethylarginine ratio in humans. Clin Sci (Lond) 2004; 106: 577-581 (Pubitemid 38797569)
    • (2004) Clinical Science , vol.106 , Issue.6 , pp. 577-581
    • Mittermayer, F.1    Namiranian, K.2    Pleiner, J.3    Schaller, G.4    Wolzt, M.5
  • 40
    • 36849013997 scopus 로고    scopus 로고
    • Dimethylarginine dimethylaminohydrolase (DDAH): Expression, regulation, and function in the cardiovascular and renal systems
    • DOI 10.1152/ajpheart.00998.2007
    • Palm F, Onozato ML, Luo Z, et al: Dimethylarginine dimethylaminohydrolase (DDAH): Expression, regulation, and function in the cardiovascular and renal systems. Am J Physiol Heart Circ Physiol 2007; 293: H3227-H3245 (Pubitemid 350230862)
    • (2007) American Journal of Physiology - Heart and Circulatory Physiology , vol.293 , Issue.6
    • Palm, F.1    Onozato, M.L.2    Luo, Z.3    Wilcox, C.S.4
  • 41
    • 0033594888 scopus 로고    scopus 로고
    • Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase
    • Ito A, Tsao PS, Adimoolam S, et al: Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999; 99: 3092-3095 (Pubitemid 29289071)
    • (1999) Circulation , vol.99 , Issue.24 , pp. 3092-3095
    • Ito, A.1    Tsao, P.S.2    Adimoolam, S.3    Kimoto, M.4    Ogawa, T.5    Cooke, J.P.6
  • 44
    • 77954676829 scopus 로고    scopus 로고
    • Time course of endogenous nitric oxide inhibitors in severe sepsis in humans
    • Iapichino G, Umbrello M, Albicini M, et al: Time course of endogenous nitric oxide inhibitors in severe sepsis in humans. Minerva Anestesiol 2010; 76: 325-333
    • (2010) Minerva Anestesiol , vol.76 , pp. 325-333
    • Iapichino, G.1    Umbrello, M.2    Albicini, M.3
  • 46
    • 0028978350 scopus 로고
    • L-Arginine depletion by arginase reduces nitric oxide production in endotoxic shock: An electron paramagnetic resonance study
    • Bune AJ, Shergill JK, Cammack R, et al: l-Arginine depletion by arginase reduces nitric oxide production in endotoxic shock: An electron paramagnetic resonance study. FEBS Lett 1995; 366: 127-130
    • (1995) FEBS Lett , vol.366 , pp. 127-130
    • Bune, A.J.1    Shergill, J.K.2    Cammack, R.3
  • 47
    • 0031081462 scopus 로고    scopus 로고
    • Relation between pro- and anti-inflammatory cytokines and the production of nitric oxide (NO) in severe sepsis
    • DOI 10.1006/cyto.1996.0147
    • Groeneveld PH, Kwappenberg KM, Langermans JA, et al: Relation between pro- and anti-inflammatory cytokines and the production of nitric oxide (NO) in severe sepsis. Cytokine 1997; 9: 138-142 (Pubitemid 27116889)
    • (1997) Cytokine , vol.9 , Issue.2 , pp. 138-142
    • Groeneveld, P.H.P.1    Kwappenberg, K.M.C.2    Langermans, J.A.M.3    Nibbering, P.H.4    Curtis, L.5
  • 48
    • 0028962444 scopus 로고
    • Plasma nitrate concentrations in neutropenic and non-neutropenic patients with suspected septicaemia
    • Neilly IJ, Copland M, Haj M, et al: Plasma nitrate concentrations in neutropenic and non-neutropenic patients with suspected septicaemia. Br J Haematol 1995; 89: 199-202
    • (1995) Br J Haematol , vol.89 , pp. 199-202
    • Neilly, I.J.1    Copland, M.2    Haj, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.