Accelerated intimai hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia

British Journal of Pharmacology

Volumn 126, Issue 1, 1999, Pages 211-218

  Masuda, Hiroshi ^a   Goto, Moritaka ^a   Tamaoki, Satoru ^a   Azuma, Hiroshi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Accelerated intimai hyperplasia; ADMA; Alloxan; Endothelial denudation; Hyperglycaemia; L NMMA; No production

Indexed keywords

ALLOXAN; CYCLIC GMP; GLUCOSE; N(G) METHYLARGININE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTERY MEDIA; ARTICLE; CAROTID ARTERY; CONCENTRATION RESPONSE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HYPERGLYCEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; VASCULAR ENDOTHELIUM;

ALLOXAN; ANIMALS; ARGININE; BLOOD GLUCOSE; BODY WEIGHT; CAROTID ARTERIES; CYCLIC GMP; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HYPERGLYCEMIA; HYPERPLASIA; MALE; NITRIC OXIDE; OMEGA-N-METHYLARGININE; RABBITS; TUNICA INTIMA; TUNICA MEDIA; WEIGHT GAIN;

EID: 0032893051     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702298     Document Type: Article

References (45)

1. ALIPUI, C..TENNER, T.E. & RAMOS, K. (1991). Rabbit aortic smooth muscle cell culture. A model for the pharmacological study of diabetes-induced alterations in cell proliferation. J. Pliarmacol. Methods, 26,211-222.
2. AZUMA, H., FUNAYAMA, N., KUBOTA, T. & ISHIKAWA, M. (1990). Regeneration of endothelial cells after balloon denudation of the rabbit carotid artery and changes in responsiveness. Jpn. J. PharmacoL, 52, 541-552.
3. AZUMA, H., HAMASAKI, H., NIIMI, Y., TERADA, T. & MATSUBARA, O. (1994). Role of endothelin-l in neointima formation after endothelial removal in rabbit carotid arteries. Am. J. Physiol., 267, H2259-H2267.
4. AZUMA, H., ISHIKAWA, M. & SEKIZAKI, S. (1986). Endotheliumdependent inhibition of platelet aggregation. Br. J. PhnrmacoL, 88,411-415.
5. AZUMA, H., MASUDA, H., SATO, J., NIWA, K. & TOKORO, T. (1997). A possible role of endogenous inhibitor for nitric oxide synthesis in the bovine ciliary muscle. Exp. Eye Res., 64, 823-830.
6. AZUMA, H., NIIMI, Y. & HAMASAKI, H. (1992). Prevention of intimai thickening after endothelial removal by a nonpeptide angiotensin II receptor antagonist, losartan. Br. J. PharmacoL. 106,655-671.
7. AZUMA, H., SATO, J., HAMASAKI, H., SUGIMOTO, A., ISOTANI, E. & OBAYASHI, S. (1995). Accumulation of endogenous inhibitors for nitric oxide synthesis and decreased content of L-arginine in regenerated endothelial cells. Br. J. Pliarmacol., 115, 1001 -1004.
8. BAYDOUN, A.R., EMERY, P.W., PEARSON, J.D. & MANN, O.E. (1990). Substrate-dependent regulation of intracellular amino acid concentration in cultured bovine aortic endothelial cells. Biochem. Biopliys. Res. Commun., 173, 940-948.
9. BÖGER, R.H., BODE-BÖGER, S.M., THIELE, V., JUNKER, W., ALEXANDER, K. & FRÖLICH, J.C. (1997). Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease. Circulation, 95, 2068-2074.
10. BOGLE, R.G., MACALLISTER, R.J., WHITLEY, G.ST.J. & VALLANCE, P. (1995). Induction of NG-monomethyl-L-arginine, uptake: a mechanism for differential inhibition of synthase? Am. J. Physiol., 269, C750-C756.
11. CAMERON, N.E. & COTTER, M.A. (1992). Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: role of polyol pathway. Diabetologia, 35, 1011-1019.
12. CHINKERS, M. & GARBERS, D.L. (1991). Signal transduction by guanylyl cyclase. Ann. Rev. Biochem, 60, 553-575.
13. CHRISTLIEB, A.R., JANKA, H., KRAUS, B GLEASON, R.E., ICASASCABRAL, E.A., AIELLO, L.M., CABRAL, B.V. & SOLANG, A. (1976). Vascular reactivity to Angiotensin II and to norepinephrine in diabetic subjects. Diabetes, 25, 268-274.
14. FÖRSTERMANN, U., CLOSS, E.I., POLLOCK, J.S., NAKANE, M., SHVVARZ, P., GATH, L, KLEINERT, H. (1994). Nitric oxide synthase isoenzymes: characterization, purification, molecular cloning, and functions. Hypertension, 23, 1121-1131.
15. FURCHGOTT, R.F. & ZAWADZKI, J.V. (1980). The obligatory role of endothelial cells in the relaxation of arterial muscle by acetylcholine. Nature. 288, 373-376.
16. GARG, U.C. & HASSID, A. (1989). Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J. Clin. Invest.. 83, 1774-1777.
17. HAMASAKI, H., SATO, J., MASUDA, H., TAMAOKI, S., ISOTANI, E., OBAYASHI, S., UDAGAWA, T. & AZUMA, H. (1997). Effect of nicotine on the intimai hyperplasia after endothelial removal of the rabbit carotid artery. Gen. Pliarmacol.. 28, 653-659.
18. IGNARRO, L.J. (1990a). Biosynthesis and metabolism of endothelium-derived nitric oxide. Ann. Rev. Pliarmacol. Toxicol., 30, 535-560.
19. IGNARRO, L.J. (1990b). Nitric oxide: A novel signal transduction mechanism for transcellular communication. Hypertension, 16, 477-483.
20. KAMATA, K., MIYATA, N. & KASUYA, Y. (1989). Impairment of endothelium-dependent relaxation and changes in levels of cGMP in aorta from STZ-induced diabetic rats. Br. J. P/iarmacol.,91,64-6l&.
21. KAMIKAWATOKO, S., TOKORO, T., ISHIDA, A., MASUDA, H., HAMASAKI, H., SATO, J. & AZUMA, H. (1998). Nitric oxide relaxes bovine ciliary muscle contracted by carbachol through elevation of cyclic GMP. Exp. Eye Res., 66, 1 -7.
22. KANZAKI, T., SHINOMIYA, M., UEDA, S., MORISAKI, N., SAITO, T. & YOSHIDA, S. (1994). Enhanced arterial intimai thickening after balloon catheter injury in diabetic animals accompanied by PDGF /?-receptor overexpression of aortic media. Eur. J. din. Invest.. 24, 377-381.
23. KAWANO, M., KOSHIKAWA, T., KANZAKI, T., MORFSAKI, N., SAITO, Y. & YOSHIDA, S. (1993). Diabetes mellitus induces accelerated growth of aortic smooth muscle cells: association with overexpression of PDGF -receptors. Eur. J. Clin. Invest., 23,84-90.
24. KISSANE, J.M. & ROBINS, E. (1958). The fluorometric measurement of deoxyribonucleic acid in animal tissue with special reference to the central nervous system. J. Biol. Cliem., 233, 184- 188.
25. KOBAYASHI, Y. & HATTORI, K. (1990). Nitroarginine inhibits endothelium-derived relaxation. Jpn. J. Pharmacol., 52, 167169.
26. LÜSCHER, T.F., BOCK, H.A., YANG, Z. & DIEDER1CH, D. (1990). Endothelium-derived relaxing and contracting factors: Perspective in nephrology. Kidney Int., 39, 575-590.
27. MACALLISTER, R.J., PARRY, H., KIMOTO, M., OGAWA, T., RUSSELL, R.J., HUDSON, IL, WHITLEY, G.ST.J. & VALLANCE, P. (1996). Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase. Br. J. Pharniacol, 119, 15331540.
28. MASUDA, H., TAMAOKI, S., GOTO, M., 1SH1DA, A., KAMIKAWATOKO, S., TOKORO, T. & AZUMA, 11. (1997). Nitric oxide-induced relaxation during the contraction with endothelin-I is mediated through elevation of cyclic GMP. Curr. Eye Res., 16, 1245-1251.
29. MILLER, R.A. & WILSON, R.B. (1984). Atherosclerosis and myocardial ischémie lesions in alloxan-diabetic rabbits fed a low cholesterol diet. Arteriosclerosis, 4, 586-591.
30. MONCADA, S. & HIGGS, E.A. (1993). The L-arginine-nitric oxide pathway. N. Engl. J. Mal. 329, 2002-2012.
31. MONCADA, S., PALMER, R.M.J. & HIGGS, E.A. (1988). The discovery of nitric oxide as the endogenous nitrosovasodilator. Hypertension, 12,365-372.
32. MONCADA, S., PALMER, R.M.J. & HIGGS, E.A. (1991). Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev., 43, 109-142.
33. NIIMI, Y., AZUMA, H. & HIRAKAWA, K. (I994). Repeated endothelial removal augments intimai thickening and attenuates EDRF release. Am. J. Physio!.. 266, H1348-HI356.
34. OBAYASHI, S., ASO, T., SATO, J., HAMASAKI, H. & AZUMA, H. (1996). Intimai hyperplasia in human uterine arteries accompanied by impaired synergism between prostaglandin Ij and ntiric oxide. Br. J. Pharmacol., 119, 1072-1078.
35. OGAWA, T., KIMOTO, M. & SASAOKA, K. (19S9). Purification and properties of a new enzyme, NG, NG-dimethyIarginine dimethylaminohydrolase, from rat kidney. J. Biol. Chem., 264, 1020510209.
36. POSTON, L. & TAYLOR, P.D. (1995). Endothelium-mediated vascular function in insulin-dependent diabetes mellitus. Clin. Sei., 88, 245-255.
37. RADOMSKI, M.W., PALMER, R.M.J. & MONCADA, S. (1987). The antiaggregating properties of vascular endothelium: interaction between prostacyclin and nitric oxide. Br. J. Pharmacol., 92, 639-646.
38. ROSS, R. (1986). The pathogenesis of atherosclerosis-an update. N. Engl. J. Med., 314, 488-500.
39. SCHWARTZ, S.M., GAJDUSEK, CM. & SELDEN, S.C. (1981). Vascular wall growth control: the role of endothelium. Arteriosclerosis, 1, 107-171.
40. SOBREVIA, L., YUDILEVICH, D.L. & MANN, O.E. (1998). Elevated D glucose induces insulin insensitivity in human umbilical endothelial cells isolated from gestational diabetic pregnancies. J. Physiol., 506, 219-230.
41. TAYLOR, P.D., MCCARTHY, A.L., THOMAS, C.R. & POSTON, L. (1992). Endothelium-dependent relaxation and noradrenaline sensitivity in mesenteric resistance arteries of streptozotocininduced diabetic rat. Br. J. Pharmacol.. 107, 393-399.
42. TAYLOR, P.D., WICKENDEN, A.D., MIRRLEES, D.J. & POSTON, L. (1994). Endothelial function in the isolated perfused mesentery and aorta of rats with streptozotocin-induced diabetes: effect of treatment with the aldose rcductase inhibitor ponalrestat. Br. J. Pharmacol., 111,42-48.
43. TESFAMARIAM, B., JAKUBOWSKI, J.A. & COHEN, R.A. (1989). Contraction of diabetic rabbit aorta due to endothelium-derived PGH2/TXA2. Am. J. Physiol., 257, H1327-H1333.
44. VALLANCE, P., LEONE, A., CALVER, A., COLLIER, J. & MONCADA, S. (1992). Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J. Cardiovasc. PhannacoL, 20, S60-S62.
45. ZHAO, Z.H., WATZCHINGER, B., BROWN, C.D., BEYER, M.M. & FRIEDMAN, E.A. (1987). Variations of susceptibility to alloxan induced diabetes in the rabbit. Harm. Metabol. Res., 19, 534537.