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Volumn 22, Issue 1, 2003, Pages 17-22

The liver is an important organ in the metabolism of asymmetrical dimethylarginine (ADMA)

Author keywords

Asymmetrical dimethylarginine; Kidney; Liver; Symmetrical dimethylarginine

Indexed keywords

DIMETHYLARGININASE; MICROSPHERE; N(G),N(G) DIMETHYLARGININE;

EID: 12244269690     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1054/clnu.2002.0612     Document Type: Article
Times cited : (151)

References (41)
  • 2
    • 0031019697 scopus 로고    scopus 로고
    • Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension
    • Matsuoka H, Itoh S, Kimoto M, Kohno K, Tamai O, Wada Y et al. Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension. Hypertension 1997; 29: 242-247.
    • (1997) Hypertension , vol.29 , pp. 242-247
    • Matsuoka, H.1    Itoh, S.2    Kimoto, M.3    Kohno, K.4    Tamai, O.5    Wada, Y.6
  • 3
    • 0029093320 scopus 로고
    • Accumulation of endogenous inhibitors for nitric oxide synthesis and decreased content of L-arginine in regenerated endothelial cells
    • Azuma H, Sato J, Hamasaki H, Sugimoto A, Isotani E, Obayashi S. Accumulation of endogenous inhibitors for nitric oxide synthesis and decreased content of L-arginine in regenerated endothelial cells. Br J Pharmacol 1995; 115: 1001-1004
    • (1995) Br. J. Pharmacol. , vol.115 , pp. 1001-1004
    • Azuma, H.1    Sato, J.2    Hamasaki, H.3    Sugimoto, A.4    Isotani, E.5    Obayashi, S.6
  • 4
    • 0026548912 scopus 로고
    • Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
    • Vallance P, Leone A, Calver A, Collier J, Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992; 339: 572-575
    • (1992) Lancet , vol.339 , pp. 572-575
    • Vallance, P.1    Leone, A.2    Calver, A.3    Collier, J.4    Moncada, S.5
  • 6
    • 0031464899 scopus 로고    scopus 로고
    • Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney
    • Tojo A, Welch W J, Bremer V, Kimoto M, Kimura K, Omata M, Ogawa T et al. Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney. Kidney Int 1997; 52: 1593-1601
    • (1997) Kidney Int. , vol.52 , pp. 1593-1601
    • Tojo, A.1    Welch, W.J.2    Bremer, V.3    Kimoto, M.4    Kimura, K.5    Omata, M.6    Ogawa, T.7
  • 9
    • 0033813512 scopus 로고    scopus 로고
    • Does ADMA cause endothelial dysfunction?
    • Cooke J P. Does ADMA cause endothelial dysfunction? Arterioscler Thromb Vasc Biol 2000; 20: 2032-2037.
    • (2000) Arterioscler Thromb. Vasc. Biol. , vol.20 , pp. 2032-2037
    • Cooke, J.P.1
  • 10
    • 0017355945 scopus 로고
    • Urinary excretion of methylarginine in human disease
    • Carnegie P R, Fellows F C, Symington G R. Urinary excretion of methylarginine in human disease. Metabolism 1977; 26: 531-537
    • (1977) Metabolism , vol.26 , pp. 531-537
    • Carnegie, P.R.1    Fellows, F.C.2    Symington, G.R.3
  • 11
    • 0021147261 scopus 로고
    • Urinary excretion of dimethylarginines in premature infants
    • Yudkoff M, Nissim I, Pereira G, Segal S. Urinary excretion of dimethylarginines in premature infants. Biochem Med 1984; 32: 242-251
    • (1984) Biochem. Med. , vol.32 , pp. 242-251
    • Yudkoff, M.1    Nissim, I.2    Pereira, G.3    Segal, S.4
  • 12
    • 0027338342 scopus 로고
    • G-dimethylarginine dimethylaminohydrolase in the nitric oxide-generating systems of rats using monoclonal antibody
    • G-dimethylarginine dimethylaminohydrolase in the nitric oxide-generating systems of rats using monoclonal antibody. Arch Biochem Biophys 1993; 300: 657-662
    • (1993) Arch. Biochem. Biophys. , vol.300 , pp. 657-662
    • Kimoto, M.1    Tsuji, H.2    Ogawa, T.3    Sasaoka, K.4
  • 13
    • 0028987629 scopus 로고
    • G-dimethylarginine dimethylaminohydrolase in human tissues using a monoclonal antibody
    • G-dimethylarginine dimethylaminohydrolase in human tissues using a monoclonal antibody. J Biochem (Tokyo) 1995; 117: 237-238
    • (1995) J. Biochem. (Tokyo) , vol.117 , pp. 237-238
    • Kimoto, M.1    Whitley, G.S.2    Tsuji, H.3    Ogawa, T.4
  • 14
    • 0033594888 scopus 로고    scopus 로고
    • Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase
    • Ito A, Tsao P S, Adimoolam S, Kimoto M, Ogawa T, Cooke J P. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999; 99: 3092-3095
    • (1999) Circulation , vol.99 , pp. 3092-3095
    • Ito, A.1    Tsao, P.S.2    Adimoolam, S.3    Kimoto, M.4    Ogawa, T.5    Cooke, J.P.6
  • 15
    • 0242322346 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA): A novel risk factor for endothelial dysfunction: Its role in hypercholesterolemia
    • Böger R H, Bode-Böger S M, Szuba A et al. Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation 1998; 98: 1842-1847
    • (1998) Circulation , vol.98 , pp. 1842-1847
    • Böger, R.H.1    Bode-Böger, S.M.2    Szuba, A.3
  • 16
    • 0024340138 scopus 로고
    • G-dimethylarginine dimethylaminohydrolase, from rat kidney
    • G-dimethylarginine dimethylaminohydrolase, from rat kidney. J Biol Chem 1989; 264: 10 205-10 209
    • (1989) J. Biol. Chem. , vol.264
    • Ogawa, T.1    Kimoto, M.2    Sasaoka, K.3
  • 17
    • 0032533159 scopus 로고    scopus 로고
    • Arginine metabolism: Nitric oxide and beyond
    • Wu G, Morris S M J. Arginine metabolism: nitric oxide and beyond. Biochem J 1998; 336: 1-17
    • (1998) Biochem. J. , vol.336 , pp. 1-17
    • Wu, G.1    Morris, S.M.J.2
  • 18
    • 0033063539 scopus 로고    scopus 로고
    • Cationic amino acid transporter gene expression in cultured vascular smooth muscle cells and in rats
    • Hattori Y, Kasai K, Gross S S. Cationic amino acid transporter gene expression in cultured vascular smooth muscle cells and in rats. Am J Physiol 1999; 276: H2020-H2028
    • (1999) Am. J. Physiol. , vol.276
    • Hattori, Y.1    Kasai, K.2    Gross, S.S.3
  • 19
    • 0018581060 scopus 로고
    • Evaluation of the microsphere method for determination of cardiac output and flow distribution in the rat
    • Idvall J, Aronsen K F, Nilsson L, Nosslin B. Evaluation of the microsphere method for determination of cardiac output and flow distribution in the rat. Eur Surg Res 1979; 11: 423-433
    • (1979) Eur. Surg. Res. , vol.11 , pp. 423-433
    • Idvall, J.1    Aronsen, K.F.2    Nilsson, L.3    Nosslin, B.4
  • 21
    • 0028558390 scopus 로고
    • Glutamine-enriched enteral dietincreases splanchnic blood flow in the rat
    • Houdijk A P J, van Leeuwen P A M, Boermeester M A et al. Glutamine-enriched enteral dietincreases splanchnic blood flow in the rat. Am J Physiol 1994; 267: G1035-G1040
    • (1994) Am. J. Physiol. , vol.267
    • Houdijk, A.P.J.1    van Leeuwen, P.A.M.2    Boermeester, M.A.3
  • 22
    • 0017262388 scopus 로고
    • Reference sample method for cardiac output and regional blood flow determinations in the rat
    • Malik A B, Kaplan J E, Saba T M. Reference sample method for cardiac output and regional blood flow determinations in the rat. J Appl Physiol 1976; 40: 472-475
    • (1976) J. Appl. Physiol. , vol.40 , pp. 472-475
    • Malik, A.B.1    Kaplan, J.E.2    Saba, T.M.3
  • 23
    • 0037089509 scopus 로고    scopus 로고
    • Determination of arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in human plasma and other biological samples by high-performance liquid chromatography
    • Teerlink T, Nijveldt R J, de Jong S, van Leeuwen P A M. Determination of arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in human plasma and other biological samples by high-performance liquid chromatography. Anal Biochem 2002; 303: 131-137
    • (2002) Anal. Biochem. , vol.303 , pp. 131-137
    • Teerlink, T.1    Nijveldt, R.J.2    de Jong, S.3    van Leeuwen, P.A.M.4
  • 24
    • 0344791653 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: Relationship to treatment method and atherosclerotic disease
    • Kielstein J T, Böger R H, Bode-Böger S M, Schaffer J, Barbey M, Koch K M, Frolich J C. Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: relationship to treatment method and atherosclerotic disease. J Am Soc Nephrol 1999; 10: 594-600
    • (1999) J. Am. Soc. Nephrol. , vol.10 , pp. 594-600
    • Kielstein, J.T.1    Böger, R.H.2    Bode-Böger, S.M.3    Schaffer, J.4    Barbey, M.5    Koch, K.M.6    Frolich, J.C.7
  • 25
    • 0035129041 scopus 로고    scopus 로고
    • Serum concentrations of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine in renal failure patients
    • Fleck C, Janz A, Schweitzer F, Karge E, Schwertfeger M, Stein G. Serum concentrations of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine in renal failure patients. Kidney Int 2001; 59 (Suppl) 78: S14-S18
    • (2001) Kidney Int. , vol.59 , Issue.SUPPL. 78
    • Fleck, C.1    Janz, A.2    Schweitzer, F.3    Karge, E.4    Schwertfeger, M.5    Stein, G.6
  • 26
    • 0035128310 scopus 로고    scopus 로고
    • Relationship of asymmetric dimethylarginine to dialysis treatment and atherosclerotic disease
    • Kielstein J T, Bode-Böger S M, Frolich J C, Haller H, Böger R H. Relationship of asymmetric dimethylarginine to dialysis treatment and atherosclerotic disease. Kidney Int 2001; 59 (Suppl) 78: S9-S13
    • (2001) Kidney Int. , vol.59 , Issue.SUPPL. 78
    • Kielstein, J.T.1    Bode-Böger, S.M.2    Frolich, J.C.3    Haller, H.4    Böger, R.H.5
  • 27
    • 0033861894 scopus 로고    scopus 로고
    • Total nitric oxide production is low in patients with chronic renal disease
    • Schmidt R J, Baylis C. Total nitric oxide production is low in patients with chronic renal disease. Kidney Int 2000; 58: 1261-1266
    • (2000) Kidney Int. , vol.58 , pp. 1261-1266
    • Schmidt, R.J.1    Baylis, C.2
  • 29
    • 0034001963 scopus 로고    scopus 로고
    • Study on the relationship between plasma nitrite and nitrate level and salt sensitivity in human hypertension : Modulation of nitric oxide synthesis by salt intake
    • Fujiwara N, Osanai T, Kamada T, Katoh T, Takahashi K, Okumura K. Study on the relationship between plasma nitrite and nitrate level and salt sensitivity in human hypertension : modulation of nitric oxide synthesis by salt intake. Circulation 2000; 101: 856-861
    • (2000) Circulation , vol.101 , pp. 856-861
    • Fujiwara, N.1    Osanai, T.2    Kamada, T.3    Katoh, T.4    Takahashi, K.5    Okumura, K.6
  • 30
    • 0031978591 scopus 로고    scopus 로고
    • Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia
    • Holden D P, Fickling S A, Whitley G S, Nussey S S. Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia. Am J Obstet Gynecol 1998; 178: 551-556
    • (1998) Am. J. Obstet. Gynecol. , vol.178 , pp. 551-556
    • Holden, D.P.1    Fickling, S.A.2    Whitley, G.S.3    Nussey, S.S.4
  • 31
    • 0032912757 scopus 로고    scopus 로고
    • Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension
    • Surdacki A, Nowicki M, Sandmann J et al. Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension. J Cardiovasc Pharmacol 1999; 33: 652-658
    • (1999) J. Cardiovasc. Pharmacol. , vol.33 , pp. 652-658
    • Surdacki, A.1    Nowicki, M.2    Sandmann, J.3
  • 32
    • 0032557388 scopus 로고    scopus 로고
    • Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure
    • Usui M, Matsuoka H, Miyazaki H, Ueda S, Okuda S, Imaizumi T. Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure. Life Sci 1998; 62: 2425-2430
    • (1998) Life Sci. , vol.62 , pp. 2425-2430
    • Usui, M.1    Matsuoka, H.2    Miyazaki, H.3    Ueda, S.4    Okuda, S.5    Imaizumi, T.6
  • 33
    • 0029670349 scopus 로고    scopus 로고
    • Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits
    • Bode-Böger S M, Böger R H, Kienke S, Junker W, Frolich J C. Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits. Biochem Biophys Res Commun 1996; 219: 598-603
    • (1996) Biochem. Biophys. Res. Commun. , vol.219 , pp. 598-603
    • Bode-Böger, S.M.1    Böger, R.H.2    Kienke, S.3    Junker, W.4    Frolich, J.C.5
  • 34
    • 0028219077 scopus 로고
    • Increase of an endogenous inhibitor of nitric oxide synthesis in serum of high cholesterol fed rabbits
    • Yu X J, Li Y J, Xiong Y. Increase of an endogenous inhibitor of nitric oxide synthesis in serum of high cholesterol fed rabbits. Life Sci 1994; 54: 753-758
    • (1994) Life Sci. , vol.54 , pp. 753-758
    • Yu, X.J.1    Li, Y.J.2    Xiong, Y.3
  • 36
    • 0025607080 scopus 로고
    • Dimethylarginine: Pyruvate aminotransferase in rats. Purification, properties, and identity with alanine: Glyoxylate aminotransferase 2
    • Ogawa T, Kimoto M, Sasaoka K. Dimethylarginine: pyruvate aminotransferase in rats. Purification, properties, and identity with alanine: glyoxylate aminotransferase 2. J Biol Chem 1990; 265: 20 938-20 945
    • (1990) J. Biol. Chem. , vol.265
    • Ogawa, T.1    Kimoto, M.2    Sasaoka, K.3
  • 37
    • 0014940650 scopus 로고
    • Isolation and identification of N-G,N-G- and N-G,N'-G-dimethyl-arginine, N-epsilon-mono-, di-, and trimethyllysine, and glucosylgalactosyl- and galactosyl-delta-hydroxylysine from human urine
    • Kakimoto Y, Akazawa S. Isolation and identification of N-G,N-G- and N-G,N'-G-dimethyl-arginine, N-epsilon-mono-, di-, and trimethyllysine, and glucosylgalactosyl- and galactosyl-delta-hydroxylysine from human urine. J Biol Chem 1970; 245: 5751-5758
    • (1970) J. Biol. Chem. , vol.245 , pp. 5751-5758
    • Kakimoto, Y.1    Akazawa, S.2
  • 38
    • 0016412452 scopus 로고
    • Protein methylation: Chemical, enzymological, and biological significance
    • Paik W K, Kim S. Protein methylation: chemical, enzymological, and biological significance. Adv Enzymol Relat Areas Mol Biol 1975; 42: 227-286
    • (1975) Adv. Enzymol. Relat. Areas Mol. Biol. , vol.42 , pp. 227-286
    • Paik, W.K.1    Kim, S.2
  • 39
    • 0027156138 scopus 로고
    • Peptides with sequences similar to glycine, arginine-rich motifs in proteins interacting with RNA are efficiently recognized by methyltransferase(s) modifying arginine in numerous proteins
    • Najbauer J, Johnson B A, Young A L, Aswad D W. Peptides with sequences similar to glycine, arginine-rich motifs in proteins interacting with RNA are efficiently recognized by methyltransferase(s) modifying arginine in numerous proteins. J Biol Chem 1993; 268: 10 501-10 509
    • (1993) J. Biol. Chem. , vol.268
    • Najbauer, J.1    Johnson, B.A.2    Young, A.L.3    Aswad, D.W.4
  • 40
    • 12244262222 scopus 로고    scopus 로고
    • Asymmetrical dimethylarginine (ADMA) in critically ill patients: High plasma ADMA concentration is an independent risk factor of ICU mortality
    • doi: 10.1054/clnu.2002.0613
    • Nijveldt R J, Teerlink T, van der Hoven B, Siroen M P C, Kuik D J, Rauwerda J A, van Leeuwen P A M. Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality. Clin Nutr 2003 doi: 10.1054/clnu.2002.0613
    • (2003) Clin. Nutr.
    • Nijveldt, R.J.1    Teerlink, T.2    van der Hoven, B.3    Siroen, M.P.C.4    Kuik, D.J.5    Rauwerda, J.A.6    van Leeuwen, P.A.M.7
  • 41
    • 0034885255 scopus 로고    scopus 로고
    • Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase
    • Murray-Rust J, Leiper J, McAlister M et al. Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase. Nat Struct Biol 2001; 8: 679-683.
    • (2001) Nat. Struct. Biol. , vol.8 , pp. 679-683
    • Murray-Rust, J.1    Leiper, J.2    McAlister, M.3


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