Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27

Cell Research

Volumn 25, Issue 10, 2015, Pages 1121-1136

  Zheng, Qingliang ^a   Hou, Jin ^b   Zhou, Ye ^b   Yang, Yingyun ^c   Xie, Bing ^a   Cao, Xuetao ^a,b,c  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

innate immune response; Siglec1; TBK1; TRIM27; type I interferon

Indexed keywords

DNA BINDING PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 3; IRF3 PROTEIN, MOUSE; NUCLEAR PROTEIN; PROTEIN SERINE THREONINE KINASE; SIALOADHESIN; SIGLEC1 PROTEIN, MOUSE; TBK1 PROTEIN, MOUSE; TRIM27 PROTEIN, MOUSE;

ANIMAL; C57BL MOUSE; CELL LINE; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; MACROPHAGE; METABOLISM; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; UBIQUITINATION; VIROLOGY; VIRUS INFECTION;

ANIMALS; CELL LINE; DNA-BINDING PROTEINS; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-3; INTERFERON TYPE I; MACROPHAGES; MICE, INBRED C57BL; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTEOLYSIS; SIALIC ACID BINDING IG-LIKE LECTIN 1; SIGNAL TRANSDUCTION; UBIQUITINATION; VIRUS DISEASES;

EID: 84943454247     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2015.108     Document Type: Article

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