메뉴 건너뛰기




Volumn 39, Issue 10, 2015, Pages 1523-1530

MiR-26b modulates insulin sensitivity in adipocytes by interrupting the PTEN/PI3K/AKT pathway

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER 4; INSULIN; MICRORNA; MICRORNA 26B; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; MIRN26 MICRORNA, RAT; PTEN PROTEIN, HUMAN; PTEN PROTEIN, RAT;

EID: 84943450164     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2015.95     Document Type: Article
Times cited : (77)

References (48)
  • 1
    • 78650614006 scopus 로고    scopus 로고
    • World Health Organization. Obesity and Overweight. World Health Organization: Geneva Switzerland
    • World Health Organization. Office of Helath Communications and Public Relations. Obesity and Overweight. World Health Organization: Geneva, Switzerland, 2006.
    • (2006) Office of Helath Communications and Public Relations
  • 2
    • 51849146897 scopus 로고    scopus 로고
    • Global burden of obesity in 2005 and projections to 2030
    • Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) 2008; 32: 1431-1437.
    • (2008) Int J Obes (Lond , vol.32 , pp. 1431-1437
    • Kelly, T.1    Yang, W.2    Chen, C.S.3    Reynolds, K.4    He, J.5
  • 3
    • 84857845479 scopus 로고    scopus 로고
    • Childhood obesity in developing countries: Epidemiology, determinants, and prevention
    • Gupta N, Goel K, Shah P, Misra A. Childhood obesity in developing countries: epidemiology, determinants, and prevention. Endocr Rev. 2012; 33: 48-70.
    • (2012) Endocr Rev , vol.33 , pp. 48-70
    • Gupta, N.1    Goel, K.2    Shah, P.3    Misra, A.4
  • 4
    • 84891897906 scopus 로고    scopus 로고
    • Cohort profile: The fangshan cohort study of cardiovascular epidemiology in Beijing, China
    • Wu N, Tang X, Wu Y, Qin X, He L, Wang J, et al. Cohort profile: the Fangshan Cohort Study of cardiovascular epidemiology in Beijing, China. J Epidemiol. 2014; 24: 84-93.
    • (2014) J Epidemiol , vol.24 , pp. 84-93
    • Wu, N.1    Tang, X.2    Wu, Y.3    Qin, X.4    He, L.5    Wang, J.6
  • 5
    • 84911411164 scopus 로고    scopus 로고
    • Obesity prevalence in colombian adults is increasing fastest in lower socio-economic status groups and urban residents: Results from two nationally representative surveys
    • Kasper NM, Herran OF, Villamor E. Obesity prevalence in Colombian adults is increasing fastest in lower socio-economic status groups and urban residents: results from two nationally representative surveys. Public Health Nutr. 2014; 17: 2398-2406.
    • (2014) Public Health Nutr , vol.17 , pp. 2398-2406
    • Kasper, N.M.1    Herran, O.F.2    Villamor, E.3
  • 6
    • 84858776574 scopus 로고    scopus 로고
    • Micrornas in metabolism and metabolic disorders
    • Rottiers V, Naar AM. MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol. 2012; 13: 239-250.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 239-250
    • Rottiers, V.1    Naar, A.M.2
  • 7
    • 84875224308 scopus 로고    scopus 로고
    • Micrornas in adipose tissue: Their role in adipogenesis and obesity
    • Hilton C, Neville MJ, Karpe F. MicroRNAs in adipose tissue: their role in adipogenesis and obesity. Int J Obes (Lond) 2013; 37: 325-332.
    • (2013) Int J Obes (Lond , vol.37 , pp. 325-332
    • Hilton, C.1    Neville, M.J.2    Karpe, F.3
  • 9
    • 79953317808 scopus 로고    scopus 로고
    • Obesity-induced overexpression of mirna-143 inhibits insulin-stimulated akt activation and impairs glucose metabolism
    • Jordan SD, Kruger M, Willmes DM, Redemann N, Wunderlich FT, Bronneke HS, et al. Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat Cell Biol. 2011; 13: 434-446.
    • (2011) Nat Cell Biol , vol.13 , pp. 434-446
    • Jordan, S.D.1    Kruger, M.2    Willmes, D.M.3    Redemann, N.4    Wunderlich, F.T.5    Bronneke, H.S.6
  • 10
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    • Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol. 2008; 9: 367-377.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3    Czech, M.P.4
  • 11
    • 77951117713 scopus 로고    scopus 로고
    • Role of micrornas in obesity and the metabolic syndrome
    • Heneghan HM, Miller N, Kerin MJ. Role of microRNAs in obesity and the metabolic syndrome. Obes Rev. 2010; 11: 354-361.
    • (2010) Obes Rev , vol.11 , pp. 354-361
    • Heneghan, H.M.1    Miller, N.2    Kerin, M.J.3
  • 12
    • 79954532462 scopus 로고    scopus 로고
    • Micrornas in adipogenesis and as therapeutic targets for obesity
    • Alexander R, Lodish H, Sun L. MicroRNAs in adipogenesis and as therapeutic targets for obesity. Expert Opin Ther Targets. 2011; 15: 623-636.
    • (2011) Expert Opin Ther Targets , vol.15 , pp. 623-636
    • Alexander, R.1    Lodish, H.2    Sun, L.3
  • 13
    • 84881129444 scopus 로고    scopus 로고
    • Role of microrna-21 in regulating 3t3-l1 adipocyte differentiation and adiponectin expression
    • Kang M, Yan LM, Zhang WY, Li YM, Tang AZ, Ou HS. Role of microRNA-21 in regulating 3T3-L1 adipocyte differentiation and adiponectin expression. Mol Biol Rep. 2013; 40: 5027-5034.
    • (2013) Mol Biol Rep , vol.40 , pp. 5027-5034
    • Kang, M.1    Yan, L.M.2    Zhang, W.Y.3    Li, Y.M.4    Tang, A.Z.5    Ou, H.S.6
  • 14
    • 79960565215 scopus 로고    scopus 로고
    • Small RNA sequencing reveals mir-642a-3p as a novel adipocyte-specific microRNA and mir-30 as a key regulator of human adipogenesis
    • Zaragosi LE, Wdziekonski B, Brigand KL, Villageois P, Mari B, Waldmann R, et al. Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis. Genome Biol. 2011; 12: R64.
    • (2011) Genome Biol , vol.12 , pp. R64
    • Zaragosi, L.E.1    Wdziekonski, B.2    Brigand, K.L.3    Villageois, P.4    Mari, B.5    Waldmann, R.6
  • 16
    • 84884941624 scopus 로고    scopus 로고
    • Microrna-146b promotes adipogenesis by suppressing the sirt1-foxo1 cascade
    • Ahn J, Lee H, Jung CH, Jeon TI, Ha TY. MicroRNA-146b promotes adipogenesis by suppressing the SIRT1-FOXO1 cascade. EMBO Mol Med. 2013; 5: 1602-1612.
    • (2013) EMBO Mol Med , vol.5 , pp. 1602-1612
    • Ahn, J.1    Lee, H.2    Jung, C.H.3    Jeon, T.I.4    Ha, T.Y.5
  • 17
    • 76349089521 scopus 로고    scopus 로고
    • Mir-27a is a negative regulator of adipocyte differentiation via suppressing ppargamma expression
    • Kim SY, Kim AY, Lee HW, Son YH, Lee GY, Lee JW, et al. MiR-27a is a negative regulator of adipocyte differentiation via suppressing PPARgamma expression. Biochem Biophys Res Commun. 2010; 392: 323-328.
    • (2010) Biochem Biophys Res Commun , vol.392 , pp. 323-328
    • Kim, S.Y.1    Kim, A.Y.2    Lee, H.W.3    Son, Y.H.4    Lee, G.Y.5    Lee, J.W.6
  • 18
    • 84892803671 scopus 로고    scopus 로고
    • Microrna-344 inhibits 3t3-l1 cell differentiation via targeting gsk3beta of wnt/beta-catenin signaling pathway
    • Chen H, Wang S, Chen L, Chen Y, Wu M, Zhang Y, et al. MicroRNA-344 inhibits 3T3-L1 cell differentiation via targeting GSK3beta of Wnt/beta-catenin signaling pathway. FEBS Lett. 2014; 588: 429-435.
    • (2014) FEBS Lett , vol.588 , pp. 429-435
    • Chen, H.1    Wang, S.2    Chen, L.3    Chen, Y.4    Wu, M.5    Zhang, Y.6
  • 19
    • 84894581857 scopus 로고    scopus 로고
    • A novel negative regulator of adipogenesis: Microrna-363
    • Chen L, Cui J, Hou J, Long J, Li C, Liu L A novel negative regulator of adipogenesis: microRNA-363. Stem Cells. 2014; 32: 510-520.
    • (2014) Stem Cells , vol.32 , pp. 510-520
    • Chen, L.1    Cui, J.2    Hou, J.3    Long, J.4    Li, C.5    Liu, L.6
  • 21
    • 79955671859 scopus 로고    scopus 로고
    • Differential mirna expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers
    • Heneghan HM, Miller N, McAnena OJ, O'Brien T, Kerin MJ. Differential miRNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers. J Clin Endocrinol Metab. 2011; 96: E846-E850.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. E846-E850
    • Heneghan, H.M.1    Miller, N.2    McAnena, O.J.3    O'Brien, T.4    Kerin, M.J.5
  • 23
    • 84887612129 scopus 로고    scopus 로고
    • The role of microrna-26b in human adipocyte differentiation and proliferation
    • Song G, Xu G, Ji C, Shi C, Shen Y, Chen L, et al. The role of microRNA-26b in human adipocyte differentiation and proliferation. Gene. 2014; 533: 481-487.
    • (2014) Gene , vol.533 , pp. 481-487
    • Song, G.1    Xu, G.2    Ji, C.3    Shi, C.4    Shen, Y.5    Chen, L.6
  • 24
    • 0034079122 scopus 로고    scopus 로고
    • High glucose and glucosamine induce insulin resistance via different mechanisms in 3t3-l1 adipocytes
    • Nelson BA, Robinson KA, Buse MG. High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes. Diabetes. 2000; 49: 981-991.
    • (2000) Diabetes , vol.49 , pp. 981-991
    • Nelson, B.A.1    Robinson, K.A.2    Buse, M.G.3
  • 25
    • 12944302597 scopus 로고    scopus 로고
    • Globular adiponectin increases glut4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells
    • Ceddia RB, Somwar R, Maida A, Fang X, Bikopoulos G, Sweeney G. Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells. Diabetologia. 2005; 48: 132-139.
    • (2005) Diabetologia , vol.48 , pp. 132-139
    • Ceddia, R.B.1    Somwar, R.2    Maida, A.3    Fang, X.4    Bikopoulos, G.5    Sweeney, G.6
  • 26
    • 84875886326 scopus 로고    scopus 로고
    • Functional screen analysis reveals mir-26b and mir-128 as central regulators of pituitary somatomammotrophic tumor growth through activation of the ptenakt pathway
    • Palumbo T, Faucz FR, Azevedo M, Xekouki P, Iliopoulos D, Stratakis CA. Functional screen analysis reveals miR-26b and miR-128 as central regulators of pituitary somatomammotrophic tumor growth through activation of the PTENAKT pathway. Oncogene. 2013; 32: 1651-1659.
    • (2013) Oncogene , vol.32 , pp. 1651-1659
    • Palumbo, T.1    Faucz, F.R.2    Azevedo, M.3    Xekouki, P.4    Iliopoulos, D.5    Stratakis, C.A.6
  • 27
    • 65549144017 scopus 로고    scopus 로고
    • Micrornas induced during adipogenesis that accelerate fat cell development are downregulated in obesity
    • Xie H, Lim B, Lodish HF. MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes. 2009; 58: 1050-1057.
    • (2009) Diabetes , vol.58 , pp. 1050-1057
    • Xie, H.1    Lim, B.2    Lodish, H.F.3
  • 28
    • 84878401701 scopus 로고    scopus 로고
    • Modulation of hsa-mir-26b levels following adipokine stimulation
    • Xu G, Ji C, Shi C, Fu H, Zhu L, Xu L, et al. Modulation of hsa-miR-26b levels following adipokine stimulation. Mol Biol Rep. 2013; 40: 3577-3582.
    • (2013) Mol Biol Rep , vol.40 , pp. 3577-3582
    • Xu, G.1    Ji, C.2    Shi, C.3    Fu, H.4    Zhu, L.5    Xu, L.6
  • 29
    • 84901407428 scopus 로고    scopus 로고
    • Expression of microrna-26b, an obesity-related microrna, is regulated by free fatty acids, glucose, dexamethasone and growth hormone in human adipocytes
    • Xu G, Shi C, Ji C, Song G, Chen L, Yang L, et al. Expression of microRNA-26b, an obesity-related microRNA, is regulated by free fatty acids, glucose, dexamethasone and growth hormone in human adipocytes. Mol Med Rep. 2014; 10: 223-228.
    • (2014) Mol Med Rep , vol.10 , pp. 223-228
    • Xu, G.1    Shi, C.2    Ji, C.3    Song, G.4    Chen, L.5    Yang, L.6
  • 31
    • 84874715061 scopus 로고    scopus 로고
    • Obesity-induced overexpression of mir-802 impairs glucose metabolism through silencing of Hnf1b
    • Kornfeld JW, Baitzel C, Konner AC, Nicholls HT, Vogt MC, Herrmanns K, et al. Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature. 2013; 494: 111-115.
    • (2013) Nature , vol.494 , pp. 111-115
    • Kornfeld, J.W.1    Baitzel, C.2    Konner, A.C.3    Nicholls, H.T.4    Vogt, M.C.5    Herrmanns, K.6
  • 32
    • 24144441285 scopus 로고    scopus 로고
    • Point: Visceral adiposity is causally related to insulin resistance
    • Lebovitz HE, Banerji MA. Point: visceral adiposity is causally related to insulin resistance. Diabetes Care. 2005; 28: 2322-2325.
    • (2005) Diabetes Care , vol.28 , pp. 2322-2325
    • Lebovitz, H.E.1    Banerji, M.A.2
  • 33
    • 34347351228 scopus 로고    scopus 로고
    • Abdominal visceral and subcutaneous adipose tissue compartments: Association with metabolic risk factors in the framingham heart study
    • Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation. 2007; 116: 39-48.
    • (2007) Circulation , vol.116 , pp. 39-48
    • Fox, C.S.1    Massaro, J.M.2    Hoffmann, U.3    Pou, K.M.4    Maurovich-Horvat, P.5    Liu, C.Y.6
  • 34
    • 84885406105 scopus 로고    scopus 로고
    • Mir-26b is downregulated in carcinoma-Associated fibroblasts from er-positive breast cancers leading to enhanced cell migration and invasion
    • Verghese ET, Drury R, Green CA, Holliday DL, Lu X, Nash C, et al. Mir-26b is downregulated in carcinoma-Associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion. J Pathol. 2013; 231: 388-399.
    • (2013) J Pathol , vol.231 , pp. 388-399
    • Verghese, E.T.1    Drury, R.2    Green, C.A.3    Holliday, D.L.4    Lu, X.5    Nash, C.6
  • 35
    • 79251563156 scopus 로고    scopus 로고
    • Role of microrna-26b in glioma development and its mediated regulation on Epha2
    • Wu N, Zhao X, Liu M, Liu H, Yao W, Zhang Y, et al. Role of microRNA-26b in glioma development and its mediated regulation on Epha2. PloS one. 2011; 6: e16264.
    • (2011) PloS One , vol.6 , pp. e16264
    • Wu, N.1    Zhao, X.2    Liu, M.3    Liu, H.4    Yao, W.5    Zhang, Y.6
  • 37
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of us adults
    • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. N Engl J Med. 2003; 348: 1625-1638.
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 39
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: Insights into insulin action
    • Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol. 2006; 7: 85-96.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 40
    • 20444487358 scopus 로고    scopus 로고
    • Pten, but not ship2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/akt pathway in 3t3-l1 adipocytes
    • Tang X, Powelka AM, Soriano NA, Czech MP, Guilherme A. PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes. J Biol Chem. 2005; 280: 22523-22529.
    • (2005) J Biol Chem , vol.280 , pp. 22523-22529
    • Tang, X.1    Powelka, A.M.2    Soriano, N.A.3    Czech, M.P.4    Guilherme, A.5
  • 41
    • 14844340146 scopus 로고    scopus 로고
    • Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking pten in adipose tissue
    • Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking Pten in adipose tissue. Mol Cell Biol. 2005; 25: 2498-2510.
    • (2005) Mol Cell Biol , vol.25 , pp. 2498-2510
    • Kurlawalla-Martinez, C.1    Stiles, B.2    Wang, Y.3    Devaskar, S.U.4    Kahn, B.B.5    Wu, H.6
  • 42
    • 10744222107 scopus 로고    scopus 로고
    • Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]
    • Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, et al. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci USA. 2004; 101: 2082-2087.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2082-2087
    • Stiles, B.1    Wang, Y.2    Stahl, A.3    Bassilian, S.4    Lee, W.P.5    Kim, Y.J.6
  • 43
    • 33645217126 scopus 로고    scopus 로고
    • Selective deletion of pten in pancreatic beta cells leads to increased islet mass and resistance to stz-induced diabetes
    • Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, et al. Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol. 2006; 26: 2772-2781.
    • (2006) Mol Cell Biol , vol.26 , pp. 2772-2781
    • Stiles, B.L.1    Kuralwalla-Martinez, C.2    Guo, W.3    Gregorian, C.4    Wang, Y.5    Tian, J.6
  • 44
  • 46
    • 0242541686 scopus 로고    scopus 로고
    • Association of the polymorphisms in the 5'-untranslated region of pten gene with type 2 diabetes in a Japanese population
    • Ishihara H, Sasaoka T, Kagawa S, Murakami S, Fukui K, Kawagishi Y, et al. Association of the polymorphisms in the 5'-untranslated region of Pten gene with type 2 diabetes in a Japanese population. FEBS Lett. 2003; 554: 450-454.
    • (2003) FEBS Lett , vol.554 , pp. 450-454
    • Ishihara, H.1    Sasaoka, T.2    Kagawa, S.3    Murakami, S.4    Fukui, K.5    Kawagishi, Y.6
  • 48
    • 84986587264 scopus 로고    scopus 로고
    • A combinatorial microrna therapeutics approach to suppressing non-small cell lung cancer
    • Kasinski AL, Kelnar K, Stahlhut C, Orellana E, Zhao J, Shimer E, et al A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer. Oncogene. 2015; 34: 3547-3555.
    • (2015) Oncogene , vol.34 , pp. 3547-3555
    • Kasinski, A.L.1    Kelnar, K.2    Stahlhut, C.3    Orellana, E.4    Zhao, J.5    Shimer, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.