Expression of microRNA-26b, an obesity-related microRNA, is regulated by free fatty acids, glucose, dexamethasone and growth hormone in human adipocytes

Molecular Medicine Reports

Volumn 10, Issue 1, 2014, Pages 223-228

  Xu, Guangfeng ^a,b   Shi, Chunmei ^b   Ji, Chenbo ^b   Song, Guixian ^b   Chen, Ling ^b   Yang, Lei ^b   Zhao, Yaping ^a   Guo, Xirong ^b  

^a The 82nd Hospital of the People's Liberation Army   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Adipocyte; Dexamethasone; Free fatty acids; Glucose; Growth hormone; microRNA 26b

Indexed keywords

ARACHIDONIC ACID; DEXAMETHASONE; FATTY ACID; GLUCOSE; GROWTH HORMONE; LAURIC ACID; LINOLEIC ACID; MICRORNA; MICRORNA 26B; MYRISTIC ACID; OLEIC ACID; UNCLASSIFIED DRUG; MIRN26A MICRORNA, HUMAN;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; ENERGY RESOURCE; GENE EXPRESSION; HUMAN; HUMAN CELL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID STORAGE; OBESITY; PROADIPOCYTE; ADIPOCYTE; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; TIME;

ADIPOCYTES; CELLS, CULTURED; DEXAMETHASONE; FATTY ACIDS, NONESTERIFIED; GENE EXPRESSION REGULATION; GLUCOSE; GROWTH HORMONE; HUMANS; INSULIN RESISTANCE; MICRORNAS; OBESITY; TIME FACTORS;

EID: 84901407428     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2204     Document Type: Article

References (30)

1. Basham P, Luik J, Jeffery RW, et al: Is the obesity epidemic exaggerated? Yes. BMJ 336: 244, 2008.
2. Haslam DW and James WP: Obesity. Lancet 366: 1197-1209, 2005. (Pubitemid 41393598)
3. Gregoire FM, Smas CM and Sul HS: Understanding adipocyte differentiation. Physiol Rev 78: 783-809, 1998. (Pubitemid 28340604)
4. Kassi E, Pervanidou P, Kaltsas G and Chrousos G: Metabolic syndrome: definitions and controversies. BMC Med 9: 48, 2011.
5. Lubrano C, Saponara M, Barbaro G, et al: Relationships between body fat distribution, epicardial fat and obstructive sleep apnea in obese patients with and without metabolic syndrome. PloS One 7: e47059, 2012.
6. Lee MJ and Fried SK: Glucocorticoids antagonize tumor necrosis factor-α-stimulated lipolysis and resistance to the antilipolytic effect of insulin in human adipocytes. Am J Physiol Endocrinol Metab 303: E1126-E1133, 2012.
7. Morita J, Hakuno F, Hizuka N, Takahashi S and Takano K: Growth hormone (GH) or insulin-like growth factor (IGF)-I represses 11beta-hydroxysteroid dehydrogenase type 1 (HSD1) mRNA expression in 3T3-L1 cells and its activity in their homogenates. Endocr J 56: 561-570, 2009.
8. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
9. Esau C, Kang X, Peralta E, et al: MicroRNA-143 regulates adipocyte differentiation. J Biol Chem 279: 52361-52365, 2004. (Pubitemid 39656612)
10. Wang Q, Li YC, Wang J, et al: miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci USA 105: 2889-2894, 2008. (Pubitemid 351723639)
11. Arora H, Qureshi R, Park AK and Park WY: Coordinated regulation of ATF2 by miR-26b in γ-irradiated lung cancer cells. PloS One 6: e23802, 2011.
12. Li J, Kong X, Zhang J, Luo Q, Li X and Fang L: MiRNA-26b inhibits proliferation by targeting PTGS2 in breast cancer. Cancer Cell Int 13: 7, 2013.
13. Han M, Yang Z, Sayed D, et al: GATA4 expression is primarily regulated via a miR-26b-dependent post-transcriptional mechanism during cardiac hypertrophy. Cardiovasc Res 93: 645-654, 2012.
14. Klöting N, Berthold S, Kovacs P, et al: MicroRNA expression in human omental and subcutaneous adipose tissue. PloS One 4: e4699, 2009.
15. Kajimoto K, Naraba H and Iwai N: MicroRNA and 3T3-L1 pre-adipocyte differentiation. RNA 12: 1626-1632, 2006. (Pubitemid 44316027)
16. Xu G, Ji C, Shi C, et al: Modulation of hsa-miR-26b levels following adipokine stimulation. Mol Biol Rep 40: 3577-3582, 2013.
17. Ebbeling CB, Pawlak DB and Ludwig DS: Childhood obesity: public-health crisis, common sense cure. Lancet 360: 473-482, 2002. (Pubitemid 34880150)
18. Lobstein T, Baur L and Uauy R; IASO International Obesity TaskForce: Obesity in children and young people: a crisis in public health. Obes Rev 5 (Suppl 1): 4-104, 2004. (Pubitemid 38967209)
19. Rosen ED and Spiegelman BM: Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444: 847-853, 2006. (Pubitemid 46024991)
20. Galic S, Oakhill JS and Steinberg GR: Adipose tissue as an endocrine organ. Mol Cell Endocrinol 316: 129-139, 2010.
21. Ambros V: The functions of animal microRNAs. Nature 431: 350-355, 2004.
22. Zhao E, Keller MP, Rabaglia ME, et al: Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mamm Genome 20: 476-485, 2009.
23. Dill H, Linder B, Fehr A and Fischer U: Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2. Genes Dev 26: 25-30, 2012.
24. Bergman RN and Ader M: Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol Metab 11: 351-356, 2000.
25. Boden G: Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46: 3-10, 1997.
26. Kahn SE, Hull RL and Utzschneider KM: Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444: 840-846, 2006. (Pubitemid 46024990)
27. Fried SK, Russell CD, Grauso NL, et al: Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men. J Clin Invest 92: 2191-2198, 1993. (Pubitemid 23333523)
28. Lee MJ, Gong DW, Burkey BF and Fried SK: Pathways regulated by glucocorticoids in omental and subcutaneous human adipose tissues: a microarray study. Am J Physiol Endocrinol Metab 300: E571-E580, 2011.
29. Yu CY, Mayba O, Lee JV, et al: Genome-wide analysis of glucocorticoid receptor binding regions in adipocytes reveal gene network involved in triglyceride homeostasis. PloS One 5: e15188, 2010.
30. Gravhølt CH, Schmitz O, Simonsen L, Bülow J, Christiansen JS and Møller N: Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue. Am J Physiol 277: E848-E854, 1999.