Differential miRNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 5, 2011, Pages

  Heneghan, H M ^a   Miller, Nicola ^a   McAnena, O J ^a   O'Brien, T ^a   Kerin, M J ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOSYLATED HEMOGLOBIN; MICRORNA;

ABDOMINAL FAT; ARTICLE; BLOOD LEVEL; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE LOCATION; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; MOLECULAR PATHOLOGY; OBESITY; OMENTAL ADIPOSE TISSUE; OMENTUM; PRIORITY JOURNAL; RNA ANALYSIS; RNA EXTRACTION; SUBCUTANEOUS FAT; TISSUE DISTRIBUTION; TISSUE SPECIFICITY;

ADIPOSE TISSUE; BIOLOGICAL MARKERS; BODY MASS INDEX; GASTRIC BYPASS; GUANIDINES; HUMANS; MICROARRAY ANALYSIS; MICRORNAS; OBESITY; OBESITY, MORBID; OMENTUM; PHENOLS; PILOT PROJECTS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT, ABDOMINAL;

EID: 79955671859     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-2701     Document Type: Article

References (20)

1. Alfredo Martínez J, Martínez-Hernandez A, Enríquez L, Moreno-Aliaga MJ, Moreno-Moreno MJ, Marti A 2007 Genetics of obesity. Public Health Nutr 10:1138-1144 (Pubitemid 350085202)
2. Ruderman NB, Saha AK 2006 Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Obesity (Silver Spring) 14(Suppl 1):25S-33S
3. Gabrielsson BG, Johansson JM, Jennische E, Jernås M, Itoh Y, Peltonen M, Olbers T, Lönn L, Lönroth H, Sjöström L, Carlsson B, Carlsson LM, Lönn M 2002 Depot-specific expression of fibroblast growth factors in human adipose tissue. Obes Res 10:608-616 (Pubitemid 135688259)
4. Jackson RJ, Standart N 2007 How do microRNAs regulate gene expression? Sci STKE 2007:re1
5. Lee RC, Feinbaum RL, Ambros V 1993 The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843-854
6. Lewis BP, Burge CB, Bartel DP 2005 Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15-20 (Pubitemid 40094598)
7. Sonkoly E, Ståhle M, Pivarcsi A 2008 MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation. Semin Cancer Biol 18:131-140
8. Erson AE, Petty EM 2008 MicroRNAs in development and disease. Clin Genet 74:296-306
9. Friedman JM, Jones PA 2009 MicroRNAs: critical mediators of differentiation, development and disease. Swiss Med Wkly 139:466-472
10. Mizoguchi A, Mizoguchi E 2008 Inflammatory bowel disease, past, present and future: lessons from animal models. J Gastroenterol 43:1-17 (Pubitemid 351324980)
11. Furer V, Greenberg JD, Attur M, Abramson SB, Pillinger MH 2010 The role of microRNA in rheumatoid arthritis and other autoimmune diseases. Clin Immunol 136:1-15
12. Bala S, Marcos M, Szabo G 2009 Emerging role of microRNAs in liver diseases. World J Gastroenterol 15:5633-5640
13. Heneghan HM, Miller N, Kerin MJ 2009 Role of microRNAs in obesity and the metabolic syndrome. Obes Rev 11:354-361
14. Klöting N, Berthold S, Kovacs P, Schön MR, Fasshauer M, Ruschke K, Stumvoll M, Blüher M 2009 MicroRNA expression in human omental and subcutaneous adipose tissue. PLoS One 4:e4699
15. Mellios N, Huang HS, Grigorenko A, Rogaev E, Akbarian S 2008 A set of differentially expressed miRNAs, including miR-30a-5p, acts as post-transcriptional inhibitors of BDNF in prefrontal cortex. Hum Mol Genet 17:3030-3042
16. Zhao E, Keller MP, Rabaglia ME, Oler AT, Stapleton DS, Schueler KL, Neto EC, Moon JY, Wang P, Wang IM, Lum PY, Ivanovska I, Cleary M, Greenawalt D, Tsang J, Choi YJ, Kleinhanz R, Shang J, Zhou YP, Howard AD, Zhang BB, Kendziorski C, Thornberry NA, Yandell BS, Schadt EE, Attie AD 2009 Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mamm Genome 20:476-485
17. Wang Q, Li YC, Wang J, Kong J, Qi Y, Quigg RJ, Li X 2008 miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci USA 105:2889-2894 (Pubitemid 351723639)
18. Mayr B, Montminy M 2001 Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2:599-609 (Pubitemid 33674011)
19. Cao L, Lin EJ, Cahill MC, Wang C, Liu X, During MJ 2009 Molecular therapy of obesity and diabetes by a physiological autoregulatory approach. Nat Med 15:447-454
20. Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, Wilson M, Wang X, Shelton J, Shingara J, Chin L, Brown D, Slack FJ 2007 The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res 67:7713-7722 (Pubitemid 47281364)