LH-induced steroidogenesis in the mouse ovary, but not testis, requires matrix metalloproteinase 2- and 9-mediated cleavage of upregulated EGF receptor ligands

Biology of Reproduction

Volumn 93, Issue 3, 2015, Pages

  Light, Allison ^a   Hammes, Stephen R ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Amphiregulin; Granulosa cells; Matrix metalloproteinase; Ovary; Steroid hormones steroid hormone receptors; Steroidogenesis; Testis

Indexed keywords

AMPHIREGULIN; CHORIONIC GONADOTROPIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIREGULIN; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; LUTEINIZING HORMONE; NEUTROPHIL COLLAGENASE; STROMELYSIN; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; AREG PROTEIN, MOUSE; EGFR PROTEIN, MOUSE; EPIDERMAL GROWTH FACTOR DERIVATIVE; EREG PROTEIN, MOUSE; LIGAND; MMP2 PROTEIN, MOUSE; MMP9 PROTEIN, MOUSE; STEROID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CYTOKINE RELEASE; ENZYME ACTIVITY; FEMALE; GRANULOSA CELL; HORMONE DETERMINATION; LEYDIG CELL; MALE; MOUSE; NONHUMAN; OVARY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; STEROIDOGENESIS; TESTIS; ZYMOGRAPHY; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; PRIMARY CELL CULTURE; UPREGULATION;

AMPHIREGULIN; ANIMALS; EGF FAMILY OF PROTEINS; EPIREGULIN; FEMALE; GRANULOSA CELLS; LEYDIG CELLS; LIGANDS; LUTEINIZING HORMONE; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; OVARY; PRIMARY CELL CULTURE; RECEPTOR, EPIDERMAL GROWTH FACTOR; STEROIDS; TESTIS; UP-REGULATION;

EID: 84943339429     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.115.130971     Document Type: Article

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