Inhibition of matrix Metalloproteinase-9 with doxycycline reduces pancreatitis-associated lung injury

Digestion

Volumn 80, Issue 2, 2009, Pages 65-73

  Sochor, Markus ^a   Richter, Sabine ^a   Schmidt, Anja ^a   Hempel, Silke ^a   Hopt, Ulrich T ^a   Keck, Tobias ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Acute pancreatitis; Doxycycline; Lung injury; Matrix metalloproteinase 9; Polymorphonuclear neutrophil granulocytes

Indexed keywords

DOXYCYCLINE; GELATINASE B;

ACUTE HEMORRHAGIC PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATELECTASIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; ENZYME INHIBITION; HISTOPATHOLOGY; LUNG EDEMA; LUNG HEMORRHAGE; LUNG INJURY; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; CELL CULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; DOXYCYCLINE; MALE; MATRIX METALLOPROTEINASE 9; NEUTROPHIL INFILTRATION; NEUTROPHILS; PANCREATITIS; RATS; RATS, INBRED LEW; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 66149130698     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000212080     Document Type: Article

References (32)

1. Imrie CW, Ferguson JC, Murphy D, Blumgart LH: Arterial hypoxia in acute pancreatitis. Br J Surg 1977; 64: 185-188.
2. Ranson JH, Turner JW, Roses DF, Rifkind KM, Spencer FC: Respiratory complications in acute pancreatitis. Ann Surg 1974; 179: 557-566.
3. Guice KS, Oldham KT, Johnson KJ, Kunkel RG, Morganroth ML, Ward PA: Pancreatitis-induced acute lung injury. An ARDS model. Ann Surg 1988; 208: 71-77.
4. Gross V, Leser HG, Heinisch A, Scholmerich J: Inflammatory mediators and cytokines -new aspects of the pathophysiology and assessment of severity of acute pancreatitis? Hepatogastroenterology 1993; 40: 522-530.
5. Bhatia M, Saluja AK, Hofbauer B, Lee HS, Frossard JL, Steer ML: The effects of neutrophil depletion on a completely noninvasive model of acute pancreatitis-associated lung injury. Int J Pancreatol 1998; 24: 77-83.
6. Closa D, Sabater L, Fernandez-Cruz L, Prats N, Gelpi E, Rosello-Catafau J: Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver. Ann Surg 1999; 229: 230-236.
7. Hartwig W, Werner J, Jimenez RE, Z'Graggen K, Weimann J, Lewandrowski KB, Warshaw AL, Fernandez-del Castillo C: Trypsin and activation of circulating trypsinogen contribute to pancreatitis-associated lung injury. Am J Physiol 1999; 277:G1008-G1016.
8. Guice KS, Oldham KT, Caty MG, Johnson KJ, Ward PA: Neutrophil-dependent, oxygen-radical mediated lung injury associated with acute pancreatitis. Ann Surg 1989; 210: 740-747.
9. Martinez-Hernandez A, Amenta PS: The basement membrane in pathology. Lab Invest 1983; 48: 656-677.
10. Keck T, Balcom JHT, Fernandez-del Castillo C, Antoniu BA, Warshaw AL: Matrix metalloproteinase-9 promotes neutrophil migration and alveolar capillary leakage in pancreatitis-associated lung injury in the rat. Gastroenterology 2002; 122: 188-201.
11. Norman J: The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg 1998; 175: 76-83.
12. Golub LM, Ramamurthy NS, McNamara TF, Greenwald RA, Rifkin BR: Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs. Crit Rev Oral Biol Med 1991; 2: 297-321.
13. Burns FR, Stack MS, Gray RD, Paterson CA: Inhibition of purified collagenase from alkali-burned rabbit corneas. Invest Ophthalmol Vis Sci 1989; 30: 1569-1575.
14. Lee CZ, Xu B, Hashimoto T, McCulloch CE, Yang GY, Young WL: Doxycycline suppresses cerebral matrix metalloproteinase-9 and angiogenesis induced by focal hyperstimulation of vascular endothelial growth factor in a mouse model. Stroke 2004; 35: 1715-1719.
15. Schmidt J, Rattner DW, Lewandrowski K, Compton CC, Mandavilli U, Knoefel WT, Warshaw AL: A better model of acute pancreatitis for evaluating therapy. Ann Surg 1992; 215: 44-56.
16. Yekebas EF, Strate T, Zolmajd S, Eisenberger CF, Erbersdobler A, Saalmuller A, Steffani K, Busch C, Elsner HA, Engelhardt M, Gillesen A, Meins J, The M, Knoefel WT, Izbicki JR: Impact of different modalities of continuous venovenous hemofiltration on sepsis-induced alterations in experimental pancreatitis. Kidney Int 2002; 62: 1806-1818.
17. Hartwig W, Carter EA, Jimenez RE, Jones R, Fischman AJ, Fernandez-Del Castillo C, Warshaw AL: Neutrophil metabolic activity but not neutrophil sequestration reflects the development of pancreatitis-associated lung injury. Crit Care Med 2002; 30: 2075-2082.
18. Keck T, Richter S, Jargon D, Hopt UT, Benz S: Pancreatitis induces premature release of neutrophils from the bone marrow, subsequent pulmonary sequestration and lung injury (abstract). Pancreas 2003; 27: 390.
19. Werner J, Z'Graggen K, Fernandez-del Castillo C, Lewandrowski KB, Compton CC, Warshaw AL: Specific therapy for local and systemic complications of acute pancreatitis with monoclonal antibodies against ICAM-1. Ann Surg 1999; 229: 834-840; discussion 841-1832
20. Adamson IY, King GM, Young L: Influence of extracellular matrix and collagen components on alveolar type 2 cell morphology and function. In Vitro Cell Dev Biol 1989; 25: 494-502.
21. Ricou B, Nicod L, Lacraz S, Welgus HG, Suter PM, Dayer JM: Matrix metalloproteinases and TIMP in acute respiratory distress syndrome. Am J Respir Crit Care Med 1996; 154: 346-352.
22. Bhatia M, Brady M, Zagorski J, Christmas SE, Campbell F, Neoptolemos JP, Slavin J: Treatment with neutralising antibody against cytokine induced neutrophil chemoattractant (CINC) protects rats against acute pancreatitis associated lung injury. Gut 2000; 47: 838-844.
23. Curci JA, Petrinec D, Liao S, Golub LM, Thompson RW: Pharmacologic suppression of experimental abdominal aortic aneurysms: a comparison of doxycycline and four chemically modified tetracyclines. J Vasc Surg 1998; 28: 1082-1093.
24. Frossard JL, Saluja A, Bhagat L, Lee HS, Bhatia M, Hofbauer B, Steer ML: The role of intercellular adhesion molecule 1 and neutrophils in acute pancreatitis and pancreatitis-associated lung injury. Gastroenterology 1999; 116: 694-701.
25. Grewal HP, Kotb M, el Din AM, Ohman M, Salem A, Gaber L, Gaber AO: Induction of tumor necrosis factor in severe acute pancreatitis and its subsequent reduction after hepatic passage. Surgery 1994; 115: 213-221.
26. Amin AR, Attur MG, Thakker GD, Patel PD, Vyas PR, Patel RN, Patel IR, Abramson SB: A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc Natl Acad Sci USA 1996; 93: 14014-14019.
27. Vollmar B, Menger MD: Microcirculatory dysfunction in acute pancreatitis. A new concept of pathogenesis involving vasomotion-associated arteriolar constriction and dilation. Pancreatology 2003; 3: 181-190.
28. Steer ML: Frank Brooks memorial lecture: The early intraacinar cell events which occur during acute pancreatitis. Pancreas 1998; 17: 31-37.
29. Makela A, Kuusi T, Schroder T: Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro. Scand J Clin Lab Invest 1997; 57: 401-407.
30. Bernard GR: Sepsis trials. Intersection of investigation, regulation, funding, and practice. Am J Respir Crit Care Med 1995; 152: 4-10.
31. Renner IG, Savage WT 3rd, Pantoja JL, Renner VJ: Death due to acute pancreatitis. A retrospective analysis of 405 autopsy cases. Dig Dis Sci 1985; 30: 1005-1018.
32. Bhatia M, Brady M, Shokuhi S, Christmas S, Neoptolemos JP, Slavin J: Inflammatory mediators in acute pancreatitis. J Pathol 2000; 190: 117-125.