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Volumn 212, Issue 5, 2015, Pages 793-802

Rapid and profound shifts in the vaginal microbiota following antibiotic treatment for bacterial vaginosis

Author keywords

Bacterial vaginosis; Gardnerella vaginalis; Lactobacillus; Mathematical modeling; Metronidazole; qPCR; Vaginal microbiota

Indexed keywords

METRONIDAZOLE; ANTIINFECTIVE AGENT;

EID: 84943329147     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv079     Document Type: Article
Times cited : (94)

References (50)
  • 1
    • 84874479365 scopus 로고    scopus 로고
    • Implications of the human microbiome project for epidemiology
    • Foxman B, Rosenthal M. Implications of the human microbiome project for epidemiology. Am J Epidemiol 2013; 177:197-201.
    • (2013) Am J Epidemiol , vol.177 , pp. 197-201
    • Foxman, B.1    Rosenthal, M.2
  • 2
    • 84861964370 scopus 로고    scopus 로고
    • Is it time for a metagenomic basis of therapeutics?
    • Haiser HJ, Turnbaugh PJ. Is it time for a metagenomic basis of therapeutics? Science 2012; 336:1253-5.
    • (2012) Science , vol.336 , pp. 1253-1255
    • Haiser, H.J.1    Turnbaugh, P.J.2
  • 3
    • 37349024986 scopus 로고    scopus 로고
    • The prevalence of bacterial vaginosis in the United States 2001-2004; Associations with symptoms, sexual behaviors, and reproductive health
    • Koumans EH, Sternberg M, Bruce C, et al. The prevalence of bacterial vaginosis in the United States, 2001-2004; associations with symptoms, sexual behaviors, and reproductive health. Sex Transm Dis 2007; 34: 864-9.
    • (2007) Sex Transm Dis , vol.34 , pp. 864-869
    • Koumans, E.H.1    Sternberg, M.2    Bruce, C.3
  • 4
    • 0029562793 scopus 로고
    • Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant
    • Hillier SL, Nugent RP, Eschenbach DA, et al. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. N Engl J Med 1995; 333:1737-42.
    • (1995) N Engl J Med , vol.333 , pp. 1737-1742
    • Hillier, S.L.1    Nugent, R.P.2    Eschenbach, D.A.3
  • 5
    • 0029939375 scopus 로고    scopus 로고
    • The preterm prediction study: Fetal fibronectin, bacterial vaginosis, and peripartum infection
    • Goldenberg RL, Thom E, Moawad AH, Johnson F, Roberts J, Cartis SN. The preterm prediction study: Fetal fibronectin, bacterial vaginosis, and peripartum infection. Obstet Gynecol 1996; 87:656-60.
    • (1996) Obstet Gynecol , vol.87 , pp. 656-660
    • Goldenberg, R.L.1    Thom, E.2    Moawad, A.H.3    Johnson, F.4    Roberts, J.5    Cartis, S.N.6
  • 6
    • 0036710564 scopus 로고    scopus 로고
    • Lower genital tract infection and endometritis: Insight into subclinical pelvic inflammatory disease
    • Wiesenfeld HC, Hillier SL, Krohn MA, et al. Lower genital tract infection and endometritis: Insight into subclinical pelvic inflammatory disease. Obstet Gynecol 2002; 100:456-63.
    • (2002) Obstet Gynecol , vol.100 , pp. 456-463
    • Wiesenfeld, H.C.1    Hillier, S.L.2    Krohn, M.A.3
  • 7
    • 24344459109 scopus 로고    scopus 로고
    • A cluster analysis of bacterial vaginosis-associated microflora and pelvic inflammatory disease
    • Ness RB, Kip KE, Hillier SL, et al. A cluster analysis of bacterial vaginosis-associated microflora and pelvic inflammatory disease. Am J Epidemiol 2005; 162:585-90.
    • (2005) Am J Epidemiol , vol.162 , pp. 585-590
    • Ness, R.B.1    Kip, K.E.2    Hillier, S.L.3
  • 8
    • 0026570913 scopus 로고
    • Incidence of pelvic inflammatory disease after 1st-trimester legal-abortion in women with bacterial vaginosis after treatment with metronidazole-a double-blind, randomized study
    • Larsson PG, Platzchristensen JJ, Thejls H, Forsum U, Pahlson C. Incidence of pelvic inflammatory disease after 1st-trimester legal-abortion in women with bacterial vaginosis after treatment with metronidazole-a double-blind, randomized study. Am J Obstet Gynecol 1992; 166: 100-3.
    • (1992) Am J Obstet Gynecol , vol.166 , pp. 100-103
    • Larsson, P.G.1    Platzchristensen, J.J.2    Thejls, H.3    Forsum, U.4    Pahlson, C.5
  • 9
    • 18244398661 scopus 로고    scopus 로고
    • Genital tract shedding of herpes simplex virus type 2 in women: Effects of hormonal contraception, bacterial vaginosis, and vaginal group B Streptococcus colonization
    • Cherpes TL, Melan MA, Kant JA, Cosentino LA, Meyn LA, Hillier SL. Genital tract shedding of herpes simplex virus type 2 in women: effects of hormonal contraception, bacterial vaginosis, and vaginal group B Streptococcus colonization. Clin Infect Dis 2005; 40:1422-8.
    • (2005) Clin Infect Dis , vol.40 , pp. 1422-1428
    • Cherpes, T.L.1    Melan, M.A.2    Kant, J.A.3    Cosentino, L.A.4    Meyn, L.A.5    Hillier, S.L.6
  • 10
    • 0037370081 scopus 로고    scopus 로고
    • Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection
    • Wiesenfeld HC, Hillier SL, Krohn MA, Landers DV, Sweet RL. Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection. Clin Infect Dis 2003; 36:663-8.
    • (2003) Clin Infect Dis , vol.36 , pp. 663-668
    • Wiesenfeld, H.C.1    Hillier, S.L.2    Krohn, M.A.3    Landers, D.V.4    Sweet, R.L.5
  • 11
    • 20144367468 scopus 로고    scopus 로고
    • Effects of bacterial vaginosis and other genital infections on the natural history of human papillomavirus infection among HIV-1-infected and high-risk HIV-1-uninfected women
    • Watts DH, Fazarri SM, Minkoff H. Effects of bacterial vaginosis and other genital infections on the natural history of human papillomavirus infection among HIV-1-infected and high-risk HIV-1-uninfected women. J Infect Dis 2005; 191:1129-39.
    • (2005) J Infect Dis , vol.191 , pp. 1129-1139
    • Watts, D.H.1    Fazarri, S.M.2    Minkoff, H.3
  • 12
    • 0032710330 scopus 로고    scopus 로고
    • Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition
    • Martin HL, Richardson BA, Nyange PM, et al. Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition. J Infect Dis 1999; 180:1863-8.
    • (1999) J Infect Dis , vol.180 , pp. 1863-1868
    • Martin, H.L.1    Richardson, B.A.2    Nyange, P.M.3
  • 13
    • 7344236840 scopus 로고    scopus 로고
    • Bacterial vaginosis and disturbances of vaginal flora: Association with increased acquisition of HIV
    • Taha TE, Hoover DR, Dallabetta GA, et al. Bacterial vaginosis and disturbances of vaginal flora: association with increased acquisition of HIV. AIDS 1998; 12:1699-706.
    • (1998) AIDS , vol.12 , pp. 1699-1706
    • Taha, T.E.1    Hoover, D.R.2    Dallabetta, G.A.3
  • 14
    • 33845945332 scopus 로고    scopus 로고
    • Prevalence of bacterial vaginosis-2001-2004 national health and nutrition examination survey data
    • Allsworth JE, Peipert JF. Prevalence of bacterial vaginosis-2001-2004 National Health and Nutrition Examination Survey data. Obstet Gynecol 2007; 109:114-20.
    • (2007) Obstet Gynecol , vol.109 , pp. 114-120
    • Allsworth, J.E.1    Peipert, J.F.2
  • 15
    • 84911001601 scopus 로고    scopus 로고
    • Molecular analysis of the relationship between specific vaginal bacteria and bacterial vaginosis metronidazole therapy failure
    • Wang B, Xiao BB, Shang CG, et al. Molecular analysis of the relationship between specific vaginal bacteria and bacterial vaginosis metronidazole therapy failure. Eur J Clin Microbiol Infect Dis 2014; 33:1749-56.
    • (2014) Eur J Clin Microbiol Infect Dis , vol.33 , pp. 1749-1756
    • Wang, B.1    Xiao, B.B.2    Shang, C.G.3
  • 16
    • 84922318971 scopus 로고    scopus 로고
    • Interplay between the temporal dynamics of the vaginal microbiota and human papillomavirus detection
    • Brotman RM, Shardell MD, Gajer P, et al. Interplay between the temporal dynamics of the vaginal microbiota and human papillomavirus detection. J Infect Dis 2014; 210:1723-33.
    • (2014) J Infect Dis , vol.210 , pp. 1723-1733
    • Brotman, R.M.1    Shardell, M.D.2    Gajer, P.3
  • 17
    • 84860720391 scopus 로고    scopus 로고
    • Temporal dynamics of the human vaginal microbiota
    • Gajer P, Brotman RM, Bai G, et al. Temporal dynamics of the human vaginal microbiota. Sci Transl Med 2012; 4:132ra52.
    • (2012) Sci Transl Med , vol.4 , pp. 132ra52
    • Gajer, P.1    Brotman, R.M.2    Bai, G.3
  • 18
    • 82355193794 scopus 로고    scopus 로고
    • Longitudinal study of the dynamics of vaginal microflora during two consecutive menstrual cycles
    • Santiago GL, Cools P, Verstraelen H, et al. Longitudinal study of the dynamics of vaginal microflora during two consecutive menstrual cycles. PLoS One 2011; 6:e28180.
    • (2011) PLoS One , vol.6 , pp. e28180
    • Santiago, G.L.1    Cools, P.2    Verstraelen, H.3
  • 19
    • 77956314273 scopus 로고    scopus 로고
    • Temporal variability of human vaginal bacteria and relationship with bacterial vaginosis
    • Srinivasan S, Liu C, Mitchell CM, et al. Temporal variability of human vaginal bacteria and relationship with bacterial vaginosis. PLoS One 2010; 5:e10197.
    • (2010) PLoS One , vol.5 , pp. e10197
    • Srinivasan, S.1    Liu, C.2    Mitchell, C.M.3
  • 21
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1-infected compartments during combination therapy
    • Perelson AS, Essunger P, Cao Y, et al. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 1997; 387:188-91.
    • (1997) Nature , vol.387 , pp. 188-191
    • Perelson, A.S.1    Essunger, P.2    Cao, Y.3
  • 22
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
    • Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 1996; 271:1582-6.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5
  • 23
    • 0033589745 scopus 로고    scopus 로고
    • Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis
    • Ramratnam B, Bonhoeffer S, Binley J, et al. Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet 1999; 354:1782-5.
    • (1999) Lancet , vol.354 , pp. 1782-1785
    • Ramratnam, B.1    Bonhoeffer, S.2    Binley, J.3
  • 24
    • 77953013128 scopus 로고    scopus 로고
    • Rapid emergence of protease inhibitor resistance in hepatitis C virus
    • Rong L, Dahari H, Ribeiro RM, Perelson AS. Rapid emergence of protease inhibitor resistance in hepatitis C virus. Sci Transl Med 2010; 2:30ra2.
    • (2010) Sci Transl Med , vol.2 , pp. 30ra2
    • Rong, L.1    Dahari, H.2    Ribeiro, R.M.3    Perelson, A.S.4
  • 25
    • 84883724515 scopus 로고    scopus 로고
    • Mucosal HSV-2 specific CD8+ T-Cells represent containment of prior viral shedding rather than a correlate of future protection
    • Schiffer JT. Mucosal HSV-2 specific CD8+ T-Cells represent containment of prior viral shedding rather than a correlate of future protection. Front Immunol 2013; 4:209.
    • (2013) Front Immunol , vol.4 , pp. 209
    • Schiffer, J.T.1
  • 26
    • 84887501416 scopus 로고    scopus 로고
    • Rapid viral expansion and short drug half-life explain the incomplete effectiveness of current herpes simplex virus-2 directed antiviral agents
    • Schiffer JT, Swan D, Corey L, Wald A. Rapid viral expansion and short drug half-life explain the incomplete effectiveness of current herpes simplex virus-2 directed antiviral agents. Antimicrob Agents Chemother 2013; 57:5820-9.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 5820-5829
    • Schiffer, J.T.1    Swan, D.2    Corey, L.3    Wald, A.4
  • 29
    • 62749193862 scopus 로고    scopus 로고
    • Changes in vaginal bacterial concentrations with intravaginal metronidazole therapy for bacterial vaginosis as assessed by quantitative PCR
    • Fredricks DN, Fiedler TL, Thomas KK, Mitchell CM, Marrazzo JM. Changes in vaginal bacterial concentrations with intravaginal metronidazole therapy for bacterial vaginosis as assessed by quantitative PCR. J Clin Microbiol 2009; 47:721-6.
    • (2009) J Clin Microbiol , vol.47 , pp. 721-726
    • Fredricks, D.N.1    Fiedler, T.L.2    Thomas, K.K.3    Mitchell, C.M.4    Marrazzo, J.M.5
  • 30
    • 0026088584 scopus 로고
    • Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation
    • Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol 1991; 29:297-301.
    • (1991) J Clin Microbiol , vol.29 , pp. 297-301
    • Nugent, R.P.1    Krohn, M.A.2    Hillier, S.L.3
  • 31
  • 32
    • 56849106496 scopus 로고    scopus 로고
    • The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing
    • Dethlefsen L, Huse S, Sogin ML, Relman DA. The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol 2008; 6:e280.
    • (2008) PLoS Biol , vol.6 , pp. e280
    • Dethlefsen, L.1    Huse, S.2    Sogin, M.L.3    Relman, D.A.4
  • 34
    • 33646942950 scopus 로고    scopus 로고
    • High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence
    • Bradshaw CS, Morton AN, Hocking J, et al. High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. J Infect Dis 2006; 193:1478-86.
    • (2006) J Infect Dis , vol.193 , pp. 1478-1486
    • Bradshaw, C.S.1    Morton, A.N.2    Hocking, J.3
  • 36
    • 37349022421 scopus 로고    scopus 로고
    • An adherent Gardnerella vaginalis biofilm persists on the vaginal epithelium after standard therapy with oral metronidazole
    • Swidsinski A, Mendling W, Loening-Baucke V, et al. An adherent Gardnerella vaginalis biofilm persists on the vaginal epithelium after standard therapy with oral metronidazole. Am J Obstet Gynecol 2008; 198: 97.e1-6.
    • (2008) Am J Obstet Gynecol , vol.198 , pp. 97e1-97e6
    • Swidsinski, A.1    Mendling, W.2    Loening-Baucke, V.3
  • 37
    • 84871809900 scopus 로고    scopus 로고
    • The biofilm in bacterial vaginosis: Implications for epidemiology, diagnosis and treatment
    • Verstraelen H, Swidsinski A. The biofilm in bacterial vaginosis: implications for epidemiology, diagnosis and treatment. Curr Opin Infect Dis 2013; 26:86-9.
    • (2013) Curr Opin Infect Dis , vol.26 , pp. 86-89
    • Verstraelen, H.1    Swidsinski, A.2
  • 38
    • 84899104426 scopus 로고    scopus 로고
    • High-dose vaginal maintenance metronidazole for recurrent bacterial vaginosis: A pilot study
    • Aguin T, Akins RA, Sobel JD. High-dose vaginal maintenance metronidazole for recurrent bacterial vaginosis: a pilot study. Sex Transm Dis 2014; 41:290-1.
    • (2014) Sex Transm Dis , vol.41 , pp. 290-291
    • Aguin, T.1    Akins, R.A.2    Sobel, J.D.3
  • 39
    • 0027481272 scopus 로고
    • Nitroimidazole drugs-action and resistance mechanisms. II. Mechanisms of resistance
    • Edwards DI. Nitroimidazole drugs-action and resistance mechanisms. II. Mechanisms of resistance. J Antimicrob Chemother 1993; 31:201-10.
    • (1993) J Antimicrob Chemother , vol.31 , pp. 201-210
    • Edwards, D.I.1
  • 40
    • 84906416296 scopus 로고
    • Pharmacokinetics of metronidazole and its principal metabolites and their activity against Gardnerella vaginalis
    • Easmon CS, Ison CA, Kaye CM, Timewell RM, Dawson SG. Pharmacokinetics of metronidazole and its principal metabolites and their activity against Gardnerella vaginalis. Br J Vener Dis 1982; 58:246-9.
    • (1982) Br J Vener Dis , vol.58 , pp. 246-249
    • Easmon, C.S.1    Ison, C.A.2    Kaye, C.M.3    Timewell, R.M.4    Dawson, S.G.5
  • 41
    • 84862501725 scopus 로고    scopus 로고
    • Bacterial communities in women with bacterial vaginosis: High resolution phylogenetic analyses reveal relationships of microbiota to clinical criteria
    • Srinivasan S, Hoffman NG, Morgan MT, et al. Bacterial Communities in Women with Bacterial Vaginosis: High Resolution Phylogenetic Analyses Reveal Relationships of Microbiota to Clinical Criteria. PLoS One 2012; 7:e37818.
    • (2012) PLoS One , vol.7 , pp. e37818
    • Srinivasan, S.1    Hoffman, N.G.2    Morgan, M.T.3
  • 42
    • 79961198113 scopus 로고    scopus 로고
    • The genital econiche: Focus on microbiota and bacterial vaginosis
    • Danielsson D, Teigen PK, Moi H. The genital econiche: focus on microbiota and bacterial vaginosis. Ann N Y Acad Sci 2011; 1230:48-58.
    • (2011) Ann N y Acad Sci , vol.1230 , pp. 48-58
    • Danielsson, D.1    Teigen, P.K.2    Moi, H.3
  • 43
    • 77951774144 scopus 로고    scopus 로고
    • Quantitative PCR assessments of bacterial species in women with and without bacterial vaginosis
    • Zozaya-Hinchliffe M, Lillis R, Martin DH, Ferris MJ. Quantitative PCR assessments of bacterial species in women with and without bacterial vaginosis. J Clin Microbiol 2010; 48:1812-9.
    • (2010) J Clin Microbiol , vol.48 , pp. 1812-1819
    • Zozaya-Hinchliffe, M.1    Lillis, R.2    Martin, D.H.3    Ferris, M.J.4
  • 44
    • 33947255745 scopus 로고    scopus 로고
    • Cultivationindependent analysis of changes in bacterial vaginosis flora following metronidazole treatment
    • Ferris MJ, Norori J, Zozaya-Hinchliffe M, Martin DH. Cultivationindependent analysis of changes in bacterial vaginosis flora following metronidazole treatment. J Clin Microbiol 2007; 45:1016-8.
    • (2007) J Clin Microbiol , vol.45 , pp. 1016-1018
    • Ferris, M.J.1    Norori, J.2    Zozaya-Hinchliffe, M.3    Martin, D.H.4
  • 45
    • 84877970230 scopus 로고    scopus 로고
    • The microbiota of the human genitourinary tract: Trying to see the forest through the trees
    • Martin DH, Zozaya M, Lillis R, Miller J, Ferris MJ. The microbiota of the human genitourinary tract: trying to see the forest through the trees. Trans Am Clin Climatol Assoc 2012; 123:242-56.
    • (2012) Trans Am Clin Climatol Assoc , vol.123 , pp. 242-256
    • Martin, D.H.1    Zozaya, M.2    Lillis, R.3    Miller, J.4    Ferris, M.J.5
  • 46
    • 67650642119 scopus 로고    scopus 로고
    • Longitudinal analysis of the vaginal microflora in pregnancy suggests that L. Crispatus promotes the stability of the normal vaginal microflora and that L. Gasseri and/or L. Iners are more conducive to the occurrence of abnormal vaginal microflora
    • Verstraelen H, Verhelst R, Claeys G, De Backer E, Temmerman M, Vaneechoutte M. Longitudinal analysis of the vaginal microflora in pregnancy suggests that L. crispatus promotes the stability of the normal vaginal microflora and that L. gasseri and/or L. iners are more conducive to the occurrence of abnormal vaginal microflora. BMC Microbiol 2009; 9:116.
    • (2009) BMC Microbiol , vol.9 , pp. 116
    • Verstraelen, H.1    Verhelst, R.2    Claeys, G.3    De Backer, E.4    Temmerman, M.5    Vaneechoutte, M.6
  • 47
    • 84872260955 scopus 로고    scopus 로고
    • Vaginal microbiome: Rethinking health and disease
    • Ma B, Forney LJ, Ravel J. Vaginal microbiome: rethinking health and disease. Annu Rev Microbiol 2012; 66:371-89.
    • (2012) Annu Rev Microbiol , vol.66 , pp. 371-389
    • Ma, B.1    Forney, L.J.2    Ravel, J.3
  • 48
    • 77956490376 scopus 로고    scopus 로고
    • Molecular analysis of the diversity of vaginal microbiota associated with bacterial vaginosis
    • Ling Z, Kong J, Liu F, et al. Molecular analysis of the diversity of vaginal microbiota associated with bacterial vaginosis. BMC Genomics 2010; 11:488.
    • (2010) BMC Genomics , vol.11 , pp. 488
    • Ling, Z.1    Kong, J.2    Liu, F.3
  • 49
    • 0025859599 scopus 로고
    • Comparison of the bactericidal activity of clindamycin and metronidazole against cefoxitin-susceptible and cefoxitin-resistant isolates of the Bacteroides fragilis group
    • Stratton CW, Weeks LS, Aldridge KE. Comparison of the bactericidal activity of clindamycin and metronidazole against cefoxitin-susceptible and cefoxitin-resistant isolates of the Bacteroides fragilis group. Diagn Microbiol Infect Dis 1991; 14:377-82.
    • (1991) Diagn Microbiol Infect Dis , vol.14 , pp. 377-382
    • Stratton, C.W.1    Weeks, L.S.2    Aldridge, K.E.3
  • 50
    • 0026773843 scopus 로고
    • Inhibitory and bactericidal activity of selected beta-lactam agents alone and in combination with beta-lactamase inhibitors compared with that of cefoxitin and metronidazole against cefoxitin-susceptible and cefoxitin-resistant isolates of the Bacteroides fragilis group
    • Stratton CW, Weeks LS, Aldridge KE. Inhibitory and bactericidal activity of selected beta-lactam agents alone and in combination with beta-lactamase inhibitors compared with that of cefoxitin and metronidazole against cefoxitin-susceptible and cefoxitin-resistant isolates of the Bacteroides fragilis group. Diagn Microbiol Infect Dis 1992; 15:321-30.
    • (1992) Diagn Microbiol Infect Dis , vol.15 , pp. 321-330
    • Stratton, C.W.1    Weeks, L.S.2    Aldridge, K.E.3


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