Short-term antibiotic treatment has differing long- term impacts on the human throat and gut microbiome

PLoS ONE

Volumn 5, Issue 3, 2010, Pages

  Jakobsson, Hedvig E ^a,b   Jernberg, Cecilia ^a   Andersson, Anders F ^a,c   Sjölund Karlsson, Maria ^a   Jansson, Janet K ^d,e   Engstrand, Lars ^a,b  

^a SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

^d SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^e LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CLARITHROMYCIN; METRONIDAZOLE; OLIGONUCLEOTIDE; OMEPRAZOLE; RNA 16S;

ANTIBIOTIC RESISTANCE; ARTICLE; CASE CONTROL STUDY; DRUG EFFECT; DYSPEPSIA; FECES; GASTROINTESTINAL TRACT; GENETICS; HUMAN; MICROBIOLOGY; PHARYNX; PHYLOGENY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TIME;

ANTI-BACTERIAL AGENTS; CASE-CONTROL STUDIES; CLARITHROMYCIN; DRUG RESISTANCE, MICROBIAL; DYSPEPSIA; FECES; GASTROINTESTINAL TRACT; HUMANS; METRONIDAZOLE; OLIGONUCLEOTIDES; OMEPRAZOLE; PHARYNX; PHYLOGENY; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RNA, RIBOSOMAL, 16S; TIME FACTORS;

EID: 78049494788     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009836     Document Type: Article

References (45)

1. Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, et al. (2009) Bacterial community variation in human body habitats across space and time. Science 326: 1694-1697.
2. Gibson GR, Roberfroid MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 125: 1401-1412.
3. Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, et al. (2006) Metagenomic analysis of the human distal gut microbiome. Science 312: 1355-1359.
4. Round JL, Mazmanian SK (2009) The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol.
5. Guarner F (2006) Enteric flora in health and disease. Digestion 73 Suppl 1: 5-12.
6. Hooper LV (2004) Bacterial contributions to mammalian gut development. Trends Microbiol 12: 129-134.
7. Adamsson I, Nord CE, Lundquist P, Sjostedt S, Edlund C (1999) Comparative effects of omeprazole, amoxycillin plus metronidazole versus omeprazole, clarithromycin plus metronidazole on the oral, gastric and intestinal microflora in Helicobacter pylori-infected patients. J Antimicrob Chemother 44: 629-640.
8. Jernberg C, Lofmark S, Edlund C, Jansson JK (2007) Long-term ecological impacts of antibiotic administration on the human intestinal microbiota. Isme J 1: 56-66.
9. Sjölund M, Tano E, Blaser MJ, Andersson DI, Engstrand L (2005) Persistence of resistant Staphylococcus epidermidis after single course of clarithromycin. Emerg Infect Dis 11: 1389-1393.
10. Sjölund M, Wreiber K, Andersson DI, Blaser MJ, Engstrand L (2003) Longterm persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pylori. Ann Intern Med 139: 483-487.
11. Jakobsson H, Wreiber K, Fall K, Fjelstad B, Nyren O, et al. (2007) Macrolide resistance in the normal microbiota after Helicobacter pylori treatment. Scand J Infect Dis 39: 757-763.
12. Sullivan A, Edlund C, Nord CE (2001) Effect of antimicrobial agents on the ecological balance of human microflora. Lancet Infect Dis 1: 101-114.
13. Courvalin P (1994) Transfer of antibiotic resistance genes between gram-positive and gram-negative bacteria. Antimicrob Agents Chemother 38: 1447-1451.
14. Graham DY (2000) Therapy of Helicobacter pylori: current status and issues. Gastroenterology 118: S2-8.
15. de Boer WA, Tytgat GN (2000) Regular review: treatment of Helicobacter pylori infection. Bmj 320: 31-34.
16. Dunn BE, Cohen H, Blaser MJ (1997) Helicobacter pylori. Clin Microbiol Rev 10: 720-741.
17. Jönsson M, Qvarnström Y, Engstrand L, Swedberg G (2005) Clarithromycin treatment selects for persistent macrolide-resistant bacteria in throat commensal flora. Int J Antimicrob Agents 25: 68-74.
18. Roberts MC (2008) Update on macrolide-lincosamide-streptogramin, ketolide, and oxazolidinone resistance genes. FEMS Microbiol Lett 282: 147-159.
19. Portillo A, Ruiz-Larrea F, Zarazaga M, Alonso A, Martinez JL, et al. (2000) Macrolide resistance genes in Enterococcus spp. Antimicrob Agents Chemother 44: 967-971.
20. Buhling A, Radun D, Muller WA, Malfertheiner P (2001) Influence of anti-Helicobacter triple-therapy with metronidazole, omeprazole and clarithromycin on intestinal microflora. Aliment Pharmacol Ther 15: 1445-1452.
21. Tanaka J, Fukuda Y, Shintani S, Hori K, Tomita T, et al. (2005) Influence of antimicrobial treatment for Helicobacter pylori infection on the intestinal microflora in Japanese macaques. J Med Microbiol 54: 309-314.
22. Suau A, Bonnet R, Sutren M, Godon JJ, Gibson GR, et al. (1999) Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut. Appl Environ Microbiol 65: 4799-4807.
23. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, et al. (2005) Diversity of the human intestinal microbial flora. Science 308: 1635-1638.
24. Andersson AF, Lindberg M, Jakobsson H, Bäckhed F, Nyren P, et al. (2008) Comparative analysis of human gut microbiota by barcoded pyrosequencing. PLoS ONE 3: e2836.
25. Ley RE, Peterson DA, Gordon JI (2006) Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 124: 837-848.
26. Pei Z, Bini EJ, Yang L, Zhou M, Francois F, et al. (2004) Bacterial biota in the human distal esophagus. Proc Natl Acad Sci U S A 101: 4250-4255.
27. Bik EM, Eckburg PB, Gill SR, Nelson KE, Purdom EA, et al. (2006) Molecular analysis of the bacterial microbiota in the human stomach. Proc Natl Acad Sci U S A 103: 732-737.
28. Franks AH, Harmsen HJ, Raangs GC, Jansen GJ, Schut F, et al. (1998) Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes. Appl Environ Microbiol 64: 3336-3345.
29. Jernberg C, Sullivan A, Edlund C, Jansson JK (2005) Monitoring of antibioticinduced alterations in the human intestinal microflora and detection of probiotic strains by use of terminal restriction fragment length polymorphism. Appl Environ Microbiol 71: 501-506.
30. Donskey CJ, Hujer AM, Das SM, Pultz NJ, Bonomo RA, et al. (2003) Use of denaturing gradient gel electrophoresis for analysis of the stool microbiota of hospitalized patients. J Microbiol Methods 54: 249-256.
31. Tannock GW, Munro K, Harmsen HJ, Welling GW, Smart J, et al. (2000) Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20. Appl Environ Microbiol 66: 2578-2588.
32. Zoetendal EG, Akkermans AD, De Vos WM (1998) Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria. Appl Environ Microbiol 64: 3854-3859.
33. Krogius-Kurikka L, Kassinen A, Paulin L, Corander J, Makivuokko H, et al. (2009) Sequence analysis of percent G+C fraction libraries of human faecal bacterial DNA reveals a high number of Actinobacteria. BMC Microbiol 9: 68.
34. Kassinen A, Krogius-Kurikka L, Makivuokko H, Rinttila T, Paulin L, et al. (2007) The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology 133: 24-33.
35. Moore WE, Moore LH (1995) Intestinal floras of populations that have a high risk of colon cancer. Appl Environ Microbiol 61: 3202-3207.
36. Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, et al. (2009) A core gut microbiome in obese and lean twins. Nature 457: 480-484.
37. Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE (2005) Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 43: 5721-5732.
38. Williams JD, Maskell JP, Shain H, Chrysos G, Sefton AM, et al. (1992) Comparative in-vitro activity of azithromycin, macrolides (erythromycin, clarithromycin and spiramycin) and streptogramin RP 59500 against oral organisms. J Antimicrob Chemother 30: 27-37.
39. Dethlefsen L, Huse S, Sogin ML, Relman DA (2008) The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol 6: e280.
40. Löfmark S, Jernberg C, Jansson JK, Edlund C (2006) Clindamycin-induced enrichment and long-term persistence of resistant Bacteroides spp. and resistance genes. J Antimicrob Chemother 58: 1160-1167.
41. Cresti S, Lattanzi M, Zanchi A, Montagnani F, Pollini S, et al. (2002) Resistance determinants and clonal diversity in group A streptococci collected during a period of increasing macrolide resistance. Antimicrob Agents Chemother 46: 1816-1822.
42. Cole JR, Chai B, Farris RJ, Wang Q, Kulam-Syed-Mohideen AS, et al. (2007) The ribosomal database project (RDP-II): introducing myRDP space and quality controlled public data. Nucleic Acids Res 35: D169-172.
43. Weisburg WG, Barns SM, Pelletier DA, Lane DJ (1991) 16S ribosomal DNA amplification for phylogenetic study. J Bacteriol 173: 697-703.
44. Muyzer G, de Waal EC, Uitterlinden AG (1993) Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. Appl Environ Microbiol 59: 695-700.
45. Hayek LCaMAB (1996) Surveying natural populations. New York: Columbia University Press.