Molecular analysis of the relationship between specific vaginal bacteria and bacterial vaginosis metronidazole therapy failure

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 33, Issue 10, 2014, Pages 1749-1756

  Wang, B ^a   Xiao, B B ^a   Shang, C G ^a   Wang, K ^b   Na, R S ^a   Nu, X X ^a   Liao, Q ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b Xingtai Maternal and Child Health Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

METRONIDAZOLE; AGENTS USED INTRAVAGINALLY; ANTIINFECTIVE AGENT;

ACTINOMYCETALES; ADULT; ARTICLE; BACTERIUM; BACTERIUM DETECTION; BURKHOLDERIA; CLOSTRIDIUM; CORIOBACTERIALES; CORYNEBACTERIUM; DRUG TREATMENT FAILURE; FACKLAMIA; FEMALE; HUMAN; INCIDENCE; INTRAUTERINE CONTRACEPTIVE DEVICE; LACTOBACILLUS CRISPATUS; LACTOBACILLUS PENTOSUS; MAJOR CLINICAL STUDY; MEGASPHAERA; PORPHYROMONADACEAE; PORPHYROMONAS; PYROSEQUENCING; VAGINA DISCHARGE; VAGINA FLORA; VAGINITIS; VEILLONELLA; ADOLESCENT; ANIMAL; BIOTA; CLASSIFICATION; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; INTRAVAGINAL DRUG ADMINISTRATION; ISOLATION AND PURIFICATION; LACTOBACILLUS; MICROBIOLOGY; MIDDLE AGED; TREATMENT FAILURE; VAGINOSIS, BACTERIAL; YOUNG ADULT;

ADMINISTRATION, INTRAVAGINAL; ADOLESCENT; ADULT; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; BIOTA; FEMALE; HUMANS; LACTOBACILLUS; METRONIDAZOLE; MIDDLE AGED; TREATMENT FAILURE; VAGINAL CREAMS, FOAMS, AND JELLIES; VAGINOSIS, BACTERIAL; YOUNG ADULT;

EID: 84911001601     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-014-2128-5     Document Type: Article

References (45)

1. Schwebke JR (2009) New concepts in the etiology of bacterial vaginosis. Curr Infect Dis Rep 11(2):143–147
2. Koumans EH, Sternberg M, Bruce C, McQuillan G, Kendrick J, Sutton M et al (2007) The prevalence of bacterial vaginosis in the United States, 2001–2004; associations with symptoms, sexual behaviors, and reproductive health. Sex Transm Dis 34(11):864–869
3. Fredricks DN, Fiedler TL, Marrazzo JM (2005) Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med 353(18):1899–1911
4. Ling Z, Kong J, Liu F, Zhu H, Chen X, Wang Y et al (2010) Molecular analysis of the diversity of vaginal microbiota associated with bacterial vaginosis. BMC Genomics 11:488
5. Schellenberg JJ, Card CM, Ball TB, Mungai JN, Irungu E, Kimani J et al (2012) Bacterial vaginosis, HIV serostatus and T-cell subset distribution in a cohort of East African commercial sex workers: retrospective analysis. AIDS 26(3):387–393
6. King CC, Jamieson DJ, Wiener J, Cu-Uvin S, Klein RS, Rompalo AM et al (2011) Bacterial vaginosis and the natural history of human papillomavirus. Infect Dis Obstet Gynecol 2011:319460
7. Cohen CR, Lingappa JR, Baeten JM, Ngayo MO, Spiegel CA, Hong T et al (2012) Bacterial vaginosis associated with increased risk of female-to-male HIV-1 transmission: a prospective cohort analysis among African couples. PLoS Med 9(6):e1001251
8. Hillier SL, Nugent RP, Eschenbach DA, Krohn MA, Gibbs RS, Martin DH et al (1995) Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med 333(26):1737–1742
9. Myer L, Denny L, Telerant R, Souza Md, Wright TC Jr, Kuhn L (2005) Bacterial vaginosis and susceptibility to HIV infection in South African women: a nested case–control study. J Infect Dis 192(8):1372–1380
10. Ness RB, Kip KE, Hillier SL, Soper DE, Stamm CA, Sweet RL et al (2005) A cluster analysis of bacterial vaginosis-associated microflora and pelvic inflammatory disease. Am J Epidemiol 162(6):585–590
11. Ferris DG, Litaker MS, Woodward L, Mathis D, Hendrich J (1995) Treatment of bacterial vaginosis: a comparison of oral metronidazole, metronidazole vaginal gel, and clindamycin vaginal cream. J Fam Pract 41(5):443–449
12. Bunge KE, Beigi RH, Meyn LA, Hillier SL (2009) The efficacy of retreatment with the same medication for early treatment failure of bacterial vaginosis. Sex Transm Dis 36(11):711–713
13. Livengood CH 3rd, Soper DE, Sheehan KL, Fenner DE, Martens MG, Nelson AL et al (1999) Comparison of once-daily and twice-daily dosing of 0.75% metronidazole gel in the treatment of bacterial vaginosis. Sex Transm Dis 26(3):137–142
14. Fischbach F, Petersen EE, Weissenbacher ER, Martius J, Hosmann J, Mayer H (1993) Efficacy of clindamycin vaginal cream versus oral metronidazole in the treatment of bacterial vaginosis. Obstet Gynecol 82(3):405–410
15. Bradshaw CS, Morton AN, Hocking J, Garland SM, Morris MB, Moss LM et al (2006) High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. J Infect Dis 193(11):1478–1486
16. Klatt TE, Cole DC, Eastwood DC, Barnabei VM (2010) Factors associated with recurrent bacterial vaginosis. J Reprod Med 55(1–2):55–61
17. Bradshaw CS, Morton AN, Hocking J, Garland SM, Morris MB, Moss LM et al (2006) High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. J Infect Dis 193(11):1478–1486
18. Marrazzo JM, Thomas KK, Agnew K, Ringwood K (2010) Prevalence and risks for bacterial vaginosis in women who have sex with women. Sex Transm Dis 37(5):335–339
19. Bradshaw CS, Vodstrcil LA, Hocking JS, Law M, Pirotta M, Garland SM et al (2013) Recurrence of bacterial vaginosis is significantly associated with posttreatment sexual activities and hormonal contraceptive use. Clin Infect Dis 56(6):777–786
20. Fredricks DN, Fiedler TL, Thomas KK, Mitchell CM, Marrazzo JM (2009) Changes in vaginal bacterial concentrations with intravaginal metronidazole therapy for bacterial vaginosis as assessed by quantitative PCR. J Clin Microbiol 47(3):721–726
21. Marrazzo JM, Thomas KK, Fiedler TL, Ringwood K, Fredricks DN (2008) Relationship of specific vaginal bacteria and bacterial vaginosis treatment failure in women who have sex with women. Ann Intern Med 149(1):20–28
22. Nugent RP, Krohn MA, Hillier SL (1991) Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol 29(2):297–301
23. Marrazzo JM, Martin DH, Watts DH, Schulte J, Sobel JD, Hillier SL et al (2010) Bacterial vaginosis: identifying research gaps proceedings of a workshop sponsored by DHHS/NIH/NIAID. Sex Transm Dis 37(12):732–744
24. Margulies M, Egholm M, Altman WE, Attiya S, Bader JS, Bemben LA et al (2005) Genome sequencing in microfabricated high-density picolitre reactors. Nature 437(7057):376–380
25. Hamady M, Walker JJ, Harris JK, Gold NJ, Knight R (2008) Error-correcting barcoded primers for pyrosequencing hundreds of samples in multiplex. Nat Methods 5(3):235–237
26. Turovskiy Y, Sutyak Noll K, Chikindas ML (2011) The aetiology of bacterial vaginosis. J Appl Microbiol 110(5):1105–1128
27. Pavlova SI, Kiliç AO, Mou SM, Tao L (1997) Phage infection in vaginal lactobacilli: an in vitro study. Infect Dis Obstet Gynecol 5(1):36–44
28. Pavlova SI, Tao L (2000) Induction of vaginal Lactobacillus phages by the cigarette smoke chemical benzo[a]pyrene diol epoxide. Mutat Res 466(1):57–62
29. Damelin LH, Paximadis M, Mavri-Damelin D, Birkhead M, Lewis DA, Tiemessen CT (2011) Identification of predominant culturable vaginal Lactobacillus species and associated bacteriophages from women with and without vaginal discharge syndrome in South Africa. J Med Microbiol 60(Pt 2):180–183
30. Hale LP, Swidsinski A, Mendling W (2006) Bacteria associated with bacterial vaginosis. N Engl J Med 354(2):202–203, author reply 202–203
31. Beigi RH, Austin MN, Meyn LA, Krohn MA, Hillier SL (2004) Antimicrobial resistance associated with the treatment of bacterial vaginosis. Am J Obstet Gynecol 191(4):1124–1129
32. Meltzer MC, Desmond RA, Schwebke JR (2008) Association of mobiluncus curtisii with recurrence of bacterial vaginosis. Sex Transm Dis 35(6):611–613
33. Nagaraja P (2008) Antibiotic resistance of Gardnerella vaginalis in recurrent bacterial vaginosis. Indian J Med Microbiol 26(2):155–157
34. Menard JP, Fenollar F, Raoult D, Boubli L, Bretelle F (2012) Self-collected vaginal swabs for the quantitative real-time polymerase chain reaction assay of Atopobium vaginae and Gardnerella vaginalis and the diagnosis of bacterial vaginosis. Eur J Clin Microbiol Infect Dis 31(4):513–518
35. Swidsinski A, Mendling W, Loening-Baucke V, Swidsinski S, Dörffel Y, Scholze J et al (2008) An adherent Gardnerella vaginalis biofilm persists on the vaginal epithelium after standard therapy with oral metronidazole. Am J Obstet Gynecol 198(1):97.e1–97.e6
36. Sobel JD, Ferris D, Schwebke J, Nyirjesy P, Wiesenfeld HC, Peipert J et al (2006) Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis. Am J Obstet Gynecol 194(5):1283–1289
37. Schwebke JR, Desmond RA (2007) A randomized trial of the duration of therapy with metronidazole plus or minus azithromycin for treatment of symptomatic bacterial vaginosis. Clin Infect Dis 44(2):213–219
38. Ness RB, Hillier SL, Richter HE, Soper DE, Stamm C, McGregor J et al (2002) Douching in relation to bacterial vaginosis, lactobacilli, and facultative bacteria in the vagina. Obstet Gynecol 100(4):765
39. Hassan WM, Lavreys L, Chohan V, Richardson BA, Mandaliya K, Ndinya-Achola JO et al (2007) Associations between intravaginal practices and bacterial vaginosis in Kenyan female sex workers without symptoms of vaginal infections. Sex Transm Dis 34(6):384–388
40. Holzman C, Leventhal JM, Qiu H, Jones NM, Wang J; BV Study Group (2001) Factors linked to bacterial vaginosis in nonpregnant women. Am J Public Health 91(10):1664–1670
41. Madden T, Grentzer JM, Secura GM, Allsworth JE, Peipert JF (2012) Risk of bacterial vaginosis in users of the intrauterine device: a longitudinal study. Sex Transm Dis 39(3):217–222
42. Sanchez S, Garcia PJ, Thomas KK, Catlin M, Holmes KK (2004) Intravaginal metronidazole gel versus metronidazole plus nystatin ovules for bacterial vaginosis: a randomized controlled trial. Am J Obstet Gynecol 191(6):1898–1906
43. Fethers KA, Fairley CK, Morton A, Hocking JS, Hopkins C, Kennedy LJ et al (2009) Early sexual experiences and risk factors for bacterial vaginosis. J Infect Dis 200(11):1662–1670
44. Fethers K, Twin J, Fairley CK, Fowkes FJ, Garland SM, Fehler G et al (2012) Bacterial vaginosis (BV) candidate bacteria: associations with BV and behavioural practices in sexually-experienced and inexperienced women. PLoS One 7(2):e30633
45. Evans AL, Scally AJ, Wellard SJ, Wilson JD (2007) Prevalence of bacterial vaginosis in lesbians and heterosexual women in a community setting. Sex Transm Infect 83(6):470–475