메뉴 건너뛰기




Volumn 4, Issue JUL, 2013, Pages

Mucosal HSV2 specific CD8+ T-cells represent containment of prior viral shedding rather than a correlate of future protection

Author keywords

CD8+ T cells; HSV 2; Mathematical modeling; Mucosal immunology; Tissue resident memory cells

Indexed keywords

ARTICLE; CD8+ T LYMPHOCYTE; HERPES SIMPLEX VIRUS 2; HUMAN; IMMUNE RESPONSE; IMMUNOTHERAPY; MATHEMATICAL MODEL; MUCOSA; PHENOTYPE; POLYMERASE CHAIN REACTION; RISK; SIMULATION; VIRAL CLEARANCE; VIROGENESIS; VIRUS INFECTIVITY; VIRUS REPLICATION; VIRUS SHEDDING;

EID: 84883724515     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00209     Document Type: Article
Times cited : (23)

References (35)
  • 1
    • 0029135197 scopus 로고
    • Virologic characteristics of subclinical and symptomatic genital herpes infections
    • doi:10.1056/NEJM199509213331205
    • Wald A, Zeh J, Selke S, Ashley RL, Corey L. Virologic characteristics of subclinical and symptomatic genital herpes infections. N Engl J Med (1995) 333:770-5. doi:10.1056/NEJM199509213331205
    • (1995) N Engl J Med , vol.333 , pp. 770-775
    • Wald, A.1    Zeh, J.2    Selke, S.3    Ashley, R.L.4    Corey, L.5
  • 2
    • 0034704798 scopus 로고    scopus 로고
    • Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons
    • doi:10.1056/NEJM200003233421203
    • Wald A, Zeh J, Selke S, Warren T, Ryncarz A, Ashley R, et al. Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons. N Engl J Med (2000) 342:844-50. doi:10.1056/NEJM200003233421203
    • (2000) N Engl J Med , vol.342 , pp. 844-850
    • Wald, A.1    Zeh, J.2    Selke, S.3    Warren, T.4    Ryncarz, A.5    Ashley, R.6
  • 3
    • 0028945292 scopus 로고
    • Herpes simplex virus type 2 meningitis in the absence of genital lesions: improved recognition with use of the polymerase chain reaction
    • doi:10.1093/clinids/20.4.842
    • Schlesinger Y, Tebas P, Gaudreault-Keener M, Buller RS, Storch GA. Herpes simplex virus type 2 meningitis in the absence of genital lesions: improved recognition with use of the polymerase chain reaction. Clin Infect Dis (1995) 20:842-8. doi:10.1093/clinids/20.4.842
    • (1995) Clin Infect Dis , vol.20 , pp. 842-848
    • Schlesinger, Y.1    Tebas, P.2    Gaudreault-Keener, M.3    Buller, R.S.4    Storch, G.A.5
  • 4
    • 33750016788 scopus 로고    scopus 로고
    • Herpes simplex virus encephalitis in human UNC-93B deficiency
    • doi:10.1126/science.1128346
    • Casrouge A, Zhang SY, Eidenschenk C, Jouanguy E, Puel A, Yang K, et al. Herpes simplex virus encephalitis in human UNC-93B deficiency. Science (2006) 314:308-12. doi:10.1126/science.1128346
    • (2006) Science , vol.314 , pp. 308-312
    • Casrouge, A.1    Zhang, S.Y.2    Eidenschenk, C.3    Jouanguy, E.4    Puel, A.5    Yang, K.6
  • 5
    • 84055190795 scopus 로고    scopus 로고
    • Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency
    • doi:10.1172/JCI59259
    • Sancho-Shimizu V, Perez de Diego R, Lorenzo L, Halwani R, Alangari A, Israelsson E, et al. Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency. J Clin Invest (2011) 121:4889-902. doi:10.1172/JCI59259
    • (2011) J Clin Invest , vol.121 , pp. 4889-4902
    • Sancho-Shimizu, V.1    Perez de Diego, R.2    Lorenzo, L.3    Halwani, R.4    Alangari, A.5    Israelsson, E.6
  • 6
    • 0029847966 scopus 로고    scopus 로고
    • High frequency of CD8+ cytotoxic T-lymphocyte precursors specific for herpes simplex viruses in persons with genital herpes
    • Posavad CM, Koelle DM, Corey L. High frequency of CD8+ cytotoxic T-lymphocyte precursors specific for herpes simplex viruses in persons with genital herpes. J Virol (1996) 70:8165-8.
    • (1996) J Virol , vol.70 , pp. 8165-8168
    • Posavad, C.M.1    Koelle, D.M.2    Corey, L.3
  • 7
    • 3943108785 scopus 로고    scopus 로고
    • Frequent reactivation of herpes simplex virus among HIV-1-infected patients treated with highly active antiretroviral therapy
    • doi:10.1086/422755
    • Posavad CM, Wald A, Kuntz S, Huang ML, Selke S, Krantz E, et al. Frequent reactivation of herpes simplex virus among HIV-1-infected patients treated with highly active antiretroviral therapy. J Infect Dis (2004) 190:693-6. doi:10.1086/422755
    • (2004) J Infect Dis , vol.190 , pp. 693-696
    • Posavad, C.M.1    Wald, A.2    Kuntz, S.3    Huang, M.L.4    Selke, S.5    Krantz, E.6
  • 8
    • 70849099812 scopus 로고    scopus 로고
    • CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help
    • doi:10.1038/nature08511
    • Nakanishi Y, Lu B, Gerard C, Iwasaki A. CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help. Nature (2009) 462:510-3. doi:10.1038/nature08511
    • (2009) Nature , vol.462 , pp. 510-513
    • Nakanishi, Y.1    Lu, B.2    Gerard, C.3    Iwasaki, A.4
  • 9
    • 65249134069 scopus 로고    scopus 로고
    • Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
    • doi:10.1038/ni.1718
    • Gebhardt T, Wakim LM, Eidsmo L, Reading PC, Heath WR, Carbone FR. Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat Immunol (2009) 10:524-30. doi:10.1038/ni.1718
    • (2009) Nat Immunol , vol.10 , pp. 524-530
    • Gebhardt, T.1    Wakim, L.M.2    Eidsmo, L.3    Reading, P.C.4    Heath, W.R.5    Carbone, F.R.6
  • 10
    • 78651078119 scopus 로고    scopus 로고
    • Rapid recruitment and activation of CD8+ T cells after herpes simplex virus type 1 skin infection
    • doi:10.1038/icb.2010.66
    • Stock AT, Jones CM, Heath WR, Carbone FR. Rapid recruitment and activation of CD8+ T cells after herpes simplex virus type 1 skin infection. Immunol Cell Biol (2011) 89:143-8. doi:10.1038/icb.2010.66
    • (2011) Immunol Cell Biol , vol.89 , pp. 143-148
    • Stock, A.T.1    Jones, C.M.2    Heath, W.R.3    Carbone, F.R.4
  • 11
    • 84857473338 scopus 로고    scopus 로고
    • Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection
    • doi:10.4049/jimmunol.1102719
    • Mackay LK, Wakim L, van Vliet CJ, Jones CM, Mueller SN, Bannard O, et al. Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection. J Immunol (2012) 188:2173-8. doi:10.4049/jimmunol.1102719
    • (2012) J Immunol , vol.188 , pp. 2173-2178
    • Mackay, L.K.1    Wakim, L.2    van Vliet, C.J.3    Jones, C.M.4    Mueller, S.N.5    Bannard, O.6
  • 12
    • 68349146396 scopus 로고    scopus 로고
    • Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition
    • doi:10.1038/nm.2006
    • Zhu J, Hladik F, Woodward A, Klock A, Peng T, Johnston C, et al. Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition. Nat Med (2009) 15:886-92. doi:10.1038/nm.2006
    • (2009) Nat Med , vol.15 , pp. 886-892
    • Zhu, J.1    Hladik, F.2    Woodward, A.3    Klock, A.4    Peng, T.5    Johnston, C.6
  • 13
    • 33947424353 scopus 로고    scopus 로고
    • Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation
    • doi:10.1084/jem.20061792
    • Zhu J, Koelle D, Cao J, Vazquez J, Huang M, Hladik F, et al. Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation. J Exp Med (2007) 204:595-603. doi:10.1084/jem.20061792
    • (2007) J Exp Med , vol.204 , pp. 595-603
    • Zhu, J.1    Koelle, D.2    Cao, J.3    Vazquez, J.4    Huang, M.5    Hladik, F.6
  • 14
    • 84869077019 scopus 로고    scopus 로고
    • An effector phenotype of CD8+ T cells at the junction epithelium during clinical quiescence of herpes simplex virus 2 infection
    • doi:10.1128/JVI.01237-12
    • Peng T, Zhu J, Phasouk K, Koelle DM, Wald A, Corey L. An effector phenotype of CD8+ T cells at the junction epithelium during clinical quiescence of herpes simplex virus 2 infection. J Virol (2012) 86: 10587-96. doi:10.1128/JVI.01237-12
    • (2012) J Virol , vol.86 , pp. 10587-96
    • Peng, T.1    Zhu, J.2    Phasouk, K.3    Koelle, D.M.4    Wald, A.5    Corey, L.6
  • 15
    • 84878130297 scopus 로고    scopus 로고
    • Immune surveillance by CD8alphaalpha+ skin-resident T cells in human herpes virus infection
    • doi:10.1038/nature12110
    • Zhu J, Peng T, Johnston C, Phasouk K, Kask AS, Klock A, et al. Immune surveillance by CD8alphaalpha+ skin-resident T cells in human herpes virus infection. Nature (2013) 497:494-7. doi:10.1038/nature12110
    • (2013) Nature , vol.497 , pp. 494-497
    • Zhu, J.1    Peng, T.2    Johnston, C.3    Phasouk, K.4    Kask, A.S.5    Klock, A.6
  • 16
    • 84869082967 scopus 로고    scopus 로고
    • A vaccine strategy that protects against genital herpes by establishing local memory T cells
    • doi:10.1038/nature11522
    • Shin H, Iwasaki A. A vaccine strategy that protects against genital herpes by establishing local memory T cells. Nature (2012) 491:463-7. doi:10.1038/nature11522
    • (2012) Nature , vol.491 , pp. 463-467
    • Shin, H.1    Iwasaki, A.2
  • 17
    • 84870377041 scopus 로고    scopus 로고
    • Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen
    • doi:10.1073/pnas.1208927109
    • Ariotti S, Beltman JB, Chodaczek G, Hoekstra ME, van Beek AE, Gomez-Eerland R, et al. Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen. Proc Natl Acad Sci U S A (2012) 109:19739-44. doi:10.1073/pnas.1208927109
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 19739-44
    • Ariotti, S.1    Beltman, J.B.2    Chodaczek, G.3    Hoekstra, M.E.4    van Beek, A.E.5    Gomez-Eerland, R.6
  • 18
    • 56249122247 scopus 로고    scopus 로고
    • CD8(+) T-cell attenuation of cutaneous herpes simplex virus infection reduces the average viral copy number of the ensuing latent infection
    • doi:10.1038/icb.2008.47
    • Wakim LM, Jones CM, Gebhardt T, Preston CM, Carbone FR. CD8(+) T-cell attenuation of cutaneous herpes simplex virus infection reduces the average viral copy number of the ensuing latent infection. Immunol Cell Biol (2008) 86:666-75. doi:10.1038/icb.2008.47
    • (2008) Immunol Cell Biol , vol.86 , pp. 666-675
    • Wakim, L.M.1    Jones, C.M.2    Gebhardt, T.3    Preston, C.M.4    Carbone, F.R.5
  • 19
    • 78650499757 scopus 로고    scopus 로고
    • Mucosal host immune response predicts the severity and duration of herpes simplex virus -2 genital tract shedding episodes
    • doi:10.1073/pnas.1006614107
    • Schiffer JT, Abu-Raddad L, Mark KE, Zhu J, Selke S, Koelle DM, et al. Mucosal host immune response predicts the severity and duration of herpes simplex virus -2 genital tract shedding episodes. Proc Natl Acad Sci U S A (2010) 107:18973-8. doi:10.1073/pnas.1006614107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 18973-8
    • Schiffer, J.T.1    Abu-Raddad, L.2    Mark, K.E.3    Zhu, J.4    Selke, S.5    Koelle, D.M.6
  • 20
    • 79960850488 scopus 로고    scopus 로고
    • The kinetics of mucosal herpes simplex virus-2 infection in humans: evidence for rapid viral-host interactions
    • doi:10.1093/infdis/jir314
    • Schiffer JT, Wald A, Selke S, Corey L, Magaret A. The kinetics of mucosal herpes simplex virus-2 infection in humans: evidence for rapid viral-host interactions. J Infect Dis (2011) 204:554-61. doi:10.1093/infdis/jir314
    • (2011) J Infect Dis , vol.204 , pp. 554-561
    • Schiffer, J.T.1    Wald, A.2    Selke, S.3    Corey, L.4    Magaret, A.5
  • 21
    • 79851487778 scopus 로고    scopus 로고
    • Persistent genital herpes simplex virus-2 shedding years following the first clinical episode
    • doi:10.1093/infdis/jiq035
    • Phipps W, Saracino M, Magaret A, Selke S, Remington M, Huang ML, et al. Persistent genital herpes simplex virus-2 shedding years following the first clinical episode. J Infect Dis (2011) 203:180-7. doi:10.1093/infdis/jiq035
    • (2011) J Infect Dis , vol.203 , pp. 180-187
    • Phipps, W.1    Saracino, M.2    Magaret, A.3    Selke, S.4    Remington, M.5    Huang, M.L.6
  • 22
    • 84879050128 scopus 로고    scopus 로고
    • Rapid localized spread and immunologic containment define herpes simplex virus-2 reactivation in the human genital tract
    • doi:10.7554/eLife.00288
    • Schiffer JT, Swan D, Al Sallaq R, Magaret A, Johnston C, Mark KE, et al. Rapid localized spread and immunologic containment define herpes simplex virus-2 reactivation in the human genital tract. Elife (2013) 2:e00288. doi:10.7554/eLife.00288
    • (2013) Elife , vol.2
    • Schiffer, J.T.1    Swan, D.2    Al Sallaq, R.3    Magaret, A.4    Johnston, C.5    Mark, K.E.6
  • 23
    • 79953848750 scopus 로고    scopus 로고
    • Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection
    • doi:10.1001/jama.2011.420
    • Tronstein E, Johnston C, Huang ML, Selke S, Magaret A, Warren T, et al. Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection. JAMA (2011) 305:1441-9. doi:10.1001/jama.2011.420
    • (2011) JAMA , vol.305 , pp. 1441-1449
    • Tronstein, E.1    Johnston, C.2    Huang, M.L.3    Selke, S.4    Magaret, A.5    Warren, T.6
  • 24
    • 77953919549 scopus 로고    scopus 로고
    • Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model
    • doi:10.1126/scitranslmed.3000193
    • Schiffer JT, Abu-Raddad L, Mark KE, Zhu J, Selke S, Magaret A, et al. Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model. Sci Transl Med (2009) 1:7ra16. doi:10.1126/scitranslmed.3000193
    • (2009) Sci Transl Med , vol.1
    • Schiffer, J.T.1    Abu-Raddad, L.2    Mark, K.E.3    Zhu, J.4    Selke, S.5    Magaret, A.6
  • 25
    • 75749156216 scopus 로고    scopus 로고
    • Overlapping reactivations of herpes simplex virus type 2 in the genital and perianal mucosa
    • doi:10.1086/650302
    • Tata S, Johnston C, Huang ML, Selke S, Magaret A, Corey L, et al. Overlapping reactivations of herpes simplex virus type 2 in the genital and perianal mucosa. J Infect Dis (2010) 201:499-504. doi:10.1086/650302
    • (2010) J Infect Dis , vol.201 , pp. 499-504
    • Tata, S.1    Johnston, C.2    Huang, M.L.3    Selke, S.4    Magaret, A.5    Corey, L.6
  • 26
    • 54749135281 scopus 로고    scopus 로고
    • Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults
    • doi:10.1086/591913
    • Mark KE, Wald A, Magaret AS, Selke S, Olin L, Huang ML, et al. Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults. J Infect Dis (2008) 198:1141-9. doi:10.1086/591913
    • (2008) J Infect Dis , vol.198 , pp. 1141-1149
    • Mark, K.E.1    Wald, A.2    Magaret, A.S.3    Selke, S.4    Olin, L.5    Huang, M.L.6
  • 28
    • 33947373530 scopus 로고    scopus 로고
    • Optimizing PCR positivity criterion for detection of herpes simplex virus DNA on skin and mucosa
    • doi:10.1128/JCM.01405-06
    • Magaret A, Wald A, Huang M, Selke S, Corey L. Optimizing PCR positivity criterion for detection of herpes simplex virus DNA on skin and mucosa. J Clin Microbiol (2007) 45:1618-20. doi:10.1128/JCM.01405-06
    • (2007) J Clin Microbiol , vol.45 , pp. 1618-1620
    • Magaret, A.1    Wald, A.2    Huang, M.3    Selke, S.4    Corey, L.5
  • 29
    • 80054693148 scopus 로고    scopus 로고
    • Detailed analysis of mucosal herpes simplex virus-2 replication kinetics with and without antiviral therapy
    • doi:10.1093/jac/dkr346
    • Schiffer JT, Magaret A, Selke S, Corey L, Wald A. Detailed analysis of mucosal herpes simplex virus-2 replication kinetics with and without antiviral therapy. J Antimicrob Chemother (2011) 66:2593-600. doi:10.1093/jac/dkr346
    • (2011) J Antimicrob Chemother , vol.66 , pp. 2593-2600
    • Schiffer, J.T.1    Magaret, A.2    Selke, S.3    Corey, L.4    Wald, A.5
  • 30
    • 0037322288 scopus 로고    scopus 로고
    • Herpes simplex virus gE/gI expressed in epithelial cells interferes with cell-to-cell spread
    • doi:10.1128/JVI.77.4.2686-2695.2003
    • Collins WJ, Johnson DC. Herpes simplex virus gE/gI expressed in epithelial cells interferes with cell-to-cell spread. J Virol (2003) 77:2686-95. doi:10.1128/JVI.77.4.2686-2695.2003
    • (2003) J Virol , vol.77 , pp. 2686-2695
    • Collins, W.J.1    Johnson, D.C.2
  • 31
    • 53749095611 scopus 로고    scopus 로고
    • Noncytotoxic lytic granule-mediated CD8+ T cell inhibition of HSV-1 reactivation from neuronal latency
    • doi:10.1126/science.1164164
    • Knickelbein JE, Khanna KM, Yee MB, Baty CJ, Kinchington PR, Hendricks RL. Noncytotoxic lytic granule-mediated CD8+ T cell inhibition of HSV-1 reactivation from neuronal latency. Science (2008) 322:268-71. doi:10.1126/science.1164164
    • (2008) Science , vol.322 , pp. 268-271
    • Knickelbein, J.E.1    Khanna, K.M.2    Yee, M.B.3    Baty, C.J.4    Kinchington, P.R.5    Hendricks, R.L.6
  • 32
    • 73849086201 scopus 로고    scopus 로고
    • Identification of viral microRNAs expressed in human sacral ganglia latently infected with herpes simplex virus 2
    • doi:10.1128/JVI.01712-09
    • Umbach JL, Wang K, Tang S, Krause PR, Mont EK, Cohen JI, et al. Identification of viral microRNAs expressed in human sacral ganglia latently infected with herpes simplex virus 2. J Virol (2010) 84:1189-92. doi:10.1128/JVI.01712-09
    • (2010) J Virol , vol.84 , pp. 1189-1192
    • Umbach, J.L.1    Wang, K.2    Tang, S.3    Krause, P.R.4    Mont, E.K.5    Cohen, J.I.6
  • 33
    • 84875208257 scopus 로고    scopus 로고
    • Rapid host immune response and viral dynamics in herpes simplex virus-2 infection
    • doi:10.1038/nm.3103
    • Schiffer JT, Corey L. Rapid host immune response and viral dynamics in herpes simplex virus-2 infection. Nat Med (2013) 19:280-90. doi:10.1038/nm.3103
    • (2013) Nat Med , vol.19 , pp. 280-290
    • Schiffer, J.T.1    Corey, L.2
  • 34
    • 35848969753 scopus 로고    scopus 로고
    • Duration of humoral immunity to common viral and vaccine antigens
    • doi:10.1056/NEJMoa066092
    • Amanna IJ, Carlson NE, Slifka MK. Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med (2007) 357:1903-15. doi:10.1056/NEJMoa066092
    • (2007) N Engl J Med , vol.357 , pp. 1903-1915
    • Amanna, I.J.1    Carlson, N.E.2    Slifka, M.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.