Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

Cell Reports

Volumn 13, Issue 1, 2015, Pages 157-167

  Gooding, Jessica R ^a   Jensen, Mette V ^a   Dai, Xiaoqing ^b   Wenner, Brett R ^a   Lu, Danhong ^a   Arumugam, Ramamani ^a   Ferdaoussi, Mourad ^b   MacDonald, Patrick E ^b   Newgard, Christopher B ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLOSUCCINATE; ADENYLOSUCCINATE LYASE; ADENYLOSUCCINATE SYNTHASE; GLUCOSE; INOSINE PHOSPHATE; INSULIN; PURINE; SUCCINIC ACID DERIVATIVE; SUMO 1 PROTEIN; UNCLASSIFIED DRUG; ADENOSINE PHOSPHATE; ENZYME INHIBITOR; GUANINE; MYCOPHENOLIC ACID; PROTEINASE; SENP1 PROTEIN, HUMAN;

832 13 CELL LINE; ARTICLE; BIOSYNTHESIS; CELL DAMAGE; CONTROLLED STUDY; ENZYME INHIBITION; EXOCYTOSIS; GLUCOSE METABOLISM; GLUCOSE STIMULATED INSULIN SECRETION; HUMAN; HUMAN CELL; INSULIN RELEASE; INSULINOMA CELL LINE; METABOLITE; METABOLOMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURINE METABOLISM; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METABOLOME; PATCH CLAMP TECHNIQUE; PATHOLOGY; PRIMARY CELL CULTURE; RAT; SECRETION (PROCESS); SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

ADENOSINE MONOPHOSPHATE; ADENYLOSUCCINATE LYASE; ADENYLOSUCCINATE SYNTHASE; ANIMALS; CELL LINE, TUMOR; DIABETES MELLITUS, TYPE 2; ENDOPEPTIDASES; ENZYME INHIBITORS; EXOCYTOSIS; GENE EXPRESSION REGULATION; GLUCOSE; GUANINE; HUMANS; INOSINE MONOPHOSPHATE; INSULIN; INSULIN-SECRETING CELLS; METABOLOME; MYCOPHENOLIC ACID; PATCH-CLAMP TECHNIQUES; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84943246526     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.08.072     Document Type: Article

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