Frizzled 4 is required for retinal angiogenesis and maintenance of the blood-retina barrier

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 9, 2011, Pages 6452-6461

  Paes, Kim T ^a   Wang, Ernest ^a   Henze, Kathy ^a   Vogel, Peter ^a   Read, Robert ^a   Suwanichkul, Adisak ^a   Kirkpatrick, Laura L ^a   Potter, David ^a   Newhouse, Matthew M ^a   Rice, Dennis S ^a  

^a LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; FRIZZLED 4; FRIZZLED PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1.99.25; UNCLASSIFIED DRUG; WNT3A PROTEIN; EYE PROTEIN; FZD4 PROTEIN, MOUSE; G PROTEIN COUPLED RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; NDPH PROTEIN, MOUSE; NERVE PROTEIN; NEUTRALIZING ANTIBODY; OXYGEN; VERY LOW DENSITY LIPOPROTEIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD RETINA BARRIER; CELL DIFFERENTIATION; CONTROLLED STUDY; ENDOTHELIUM CELL; EXTRAVASATION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MOUSE; NEWBORN; NONHUMAN; OXYGEN INDUCED RETINOPATHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA DISEASE; RETINA NEOVASCULARIZATION; RETINAL ANGIOMATOUS PROLIFERATION; RETINOPATHY; SINGLE DRUG DOSE; ANGIOGENESIS; ANIMAL; C57BL MOUSE; CAPILLARY PERMEABILITY; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; MALE; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; RETINA BLOOD VESSEL;

ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, NEUTRALIZING; BLOOD-RETINAL BARRIER; CAPILLARY PERMEABILITY; DISEASE MODELS, ANIMAL; EYE PROTEINS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FRIZZLED RECEPTORS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOVASCULARIZATION, PHYSIOLOGIC; NERVE TISSUE PROTEINS; OXYGEN; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LDL; RETINAL NEOVASCULARIZATION; RETINAL VESSELS;

EID: 80054027552     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-7146     Document Type: Article

References (27)

1. Cattelino A, Liebner S, Gallini R, et al. The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol. 2003; 162:1111-1122.
2. Daneman R, Agalliu D, Zhou L, Kuhnert F, Kuo CJ, Barres BA. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A. 2009;106:641-646.
3. Liebner S, Corada M, Bangsow T, et al. Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol. 2008; 183:409-417.
4. Stenman JM, Rajagopal J, Carroll TJ, Ishibashi M, McMahon J, McMahon AP. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science. 2008; 322:1247-1250.
5. van Amerongen R, Nusse R. Towards an integrated view of Wnt signaling in development. Development. 2009;136:3205-3214.
6. Tam SJ, Watts RJ. Connecting vascular and nervous system development: angiogenesis and the blood-brain barrier. Annu Rev Neurosci. 2010;33:379-408.
7. Ye X, Wang Y, Nathans J. The Norrin/Frizzled4 signaling pathway in retinal vascular development and disease. Trends Mol Med. 2010;16:417-425.
8. Junge HJ, Yang S, Burton JB, et al. TSPAN12 regulates retinal vascular development by promoting Norrin-but not Wnt-induced FZD4/beta-catenin signaling. Cell. 2009;139:299-311.
9. Ye X, Wang Y, Cahill H, et al. Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell. 2009;139:285-298.
10. Wang Y, Huso D, Cahill H, Ryugo D, Nathans J. Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene. J Neurosci. 2001;21: 4761-4771.
11. Xu Q, Wang Y, Dabdoub A, et al. Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a highaffinity ligand-receptor pair. Cell. 2004;116:883-895.
12. Wattler S, Kelly M, Nehls M. Construction of gene targeting vectors from lambda KOS genomic libraries. BioTechniques. 1999;26: 1150-1156, 1158, 1160.
13. Smith LE, Wesolowski E, McLellan A, et al. Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci. 1994;35:101-111.
14. Heckenlively JR, Hawes NL, Friedlander M, et al. Mouse model of subretinal neovascularization with choroidal anastomosis. Retina. 2003;23:518-522.
15. Pierce EA, Foley ED, Smith LE. Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch Ophthalmol. 1996;114:1219-1228.
16. Pierce EA, Avery RL, Foley ED, Aiello LP, Smith LE. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci U S A. 1995;92:905-909.
17. Luhmann UF, Lin J, Acar N, et al. Role of the Norrie disease pseudoglioma gene in sprouting angiogenesis during development of the retinal vasculature. Invest Ophthalmol Vis Sci. 2005;46: 3372-3382.
18. Rice DS, Curran T. Role of the reelin signaling pathway in central nervous system development. Annu Rev Neurosci. 2001;24:1005-1039.
19. Yannuzzi LA, Negrao S, Iida T, et al. Retinal angiomatous proliferation in age-related macular degeneration. Retina. 2001;21:416-434.
20. Chen Y, Hu Y, Lu K, Flannery JG, Ma JX. Very low density lipoprotein receptor, a negative regulator of the wnt signaling pathway and choroidal neovascularization. J Biol Chem. 2007;282: 34420-34428.
21. Dorrell MI, Aguilar E, Jacobson R, et al. Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress. J Clin Invest. 2009;119:611-623.
22. Ohlmann A, Seitz R, Braunger B, Seitz D, Bosl MR, Tamm ER. Norrin promotes vascular regrowth after oxygen-induced retinal vessel loss and suppresses retinopathy in mice. J Neurosci. 2010; 30:183-193.
23. Hallmann R, Mayer DN, Berg EL, Broermann R, Butcher EC. Novel mouse endothelial cell surface marker is suppressed during differentiation of the blood brain barrier. Dev Dyn. 1995;202:325-332.
24. Stewart PA, Wiley MJ. Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: a study using quail-chick transplantation chimeras. Dev Biol. 1981;84:183-192.
25. Ye X, Smallwood P, Nathans J. Expression of the Norrie disease gene (Ndp) in developing and adult mouse eye, ear, and brain. Gene Expr Patterns. 2010;11:151-155.
26. Janzer RC, Raff MC. Astrocytes induce blood-brain barrier properties in endothelial cells. Nature. 1987;325:253-257.
27. Tout S, Chan-Ling T, Hollander H, Stone J. The role of Muller cells in the formation of the blood-retinal barrier. Neuroscience. 1993; 55:291-301.