Chromosome segregation regulation in human zygotes: Altered mitotic histone phosphorylation dynamics underlying centromeric targeting of the chromosomal passenger complex

Human Reproduction

Volumn 30, Issue 10, 2015, Pages 2275-2291

  Van De Werken, C ^a   Avo Santos, M ^a,b,c   Laven, J S E ^a   Eleveld, C ^a   Fauser, B C J M ^b   Lens, S M A ^b   Baart, E B ^a  

^a University Medical Center   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c REINIER DE GRAAF HOSPITAL   (Netherlands)

Author keywords

Aneuploidy; Aurora kinase; Bub1 kinase; Chromosomesegregation; Haspin kinase; Histone phosphorylation; Humanembryoresearch; Zygote

Indexed keywords

AURORA A KINASE; AURORA C KINASE; BUB1 RELATED PROTEIN; HISTONE H2A; HISTONE H3; AURORA B KINASE; BUB1 PROTEIN, HUMAN; CELL CYCLE PROTEIN; GSG2 PROTEIN, HUMAN; HISTONE; PROTEIN SERINE THREONINE KINASE; SGOL1 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ARTICLE; BLASTOCYST; CELL NUCLEUS MEMBRANE; CENTROMERE; CHROMOSOME ARM; CHROMOSOME SEGREGATION; EMBRYO; ENZYME ACTIVITY; EPIGENETICS; FEEDBACK SYSTEM; FERTILIZATION IN VITRO; GENE EXPRESSION; HISTONE PHOSPHORYLATION; HUMAN; IMMUNOFLUORESCENCE; IMMUNOLOCALIZATION; M PHASE CELL CYCLE CHECKPOINT; METAPHASE; METAPHASE CHROMOSOME; MITOSIS; PREIMPLANTATION EMBRYO; PROMETAPHASE; SOMATIC CELL; TIME LAPSE IMAGING; U2OS CELL LINE; ZYGOTE; CHROMOSOME; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; ULTRASTRUCTURE;

AURORA KINASE B; AURORA KINASE C; BLASTOCYST; CELL CYCLE PROTEINS; CENTROMERE; CHROMOSOME SEGREGATION; CHROMOSOMES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HISTONES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICROSCOPY, FLUORESCENCE; MITOSIS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; TIME-LAPSE IMAGING; ZYGOTE;

EID: 84943236278     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dev186     Document Type: Article

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