Roles of different pools of the mitotic checkpoint complex and the mechanisms of their disassembly

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 26, 2013, Pages 10568-10573

  Eytan, Esther ^a   Sitry Shevah, Danielle ^a   Teichner, Adar ^a   Hershko, Avram ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; CELL CYCLE PROTEIN 20; PROTEIN MAD2;

ARTICLE; CELL CYCLE CHECKPOINT; CELL FREE SYSTEM; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; UBIQUITINATION; XENOPUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CALCIUM-BINDING PROTEINS; CELL CYCLE PROTEINS; CELL-FREE SYSTEM; FEMALE; HELA CELLS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; OOCYTES; PROTEIN-SERINE-THREONINE KINASES; REPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASE COMPLEXES; XENOPUS; XENOPUS PROTEINS;

EID: 84879538760     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1308928110     Document Type: Article

References (27)

1. Musacchio A, Salmon ED (2007) The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 8(5):379-393.
2. Kim S, Yu H (2011) Mutual regulation between the spindle checkpoint and APC/C. Semin Cell Dev Biol 22(6):551-558.
3. Murray AW (2011) A brief history of error. Nat Cell Biol 13(10):1178-1182.
4. Sudakin V, Chan GKT, Yen TJ (2001) Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J Cell Biol 154(5):925-936.
5. Reddy SK, Rape M, Margansky WA, Kirschner MW (2007) Ubiquitination by the anaphasepromoting complex drives spindle checkpoint inactivation. Nature 446(7138):921-925.
6. Stegmeier F, et al. (2007) Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature 446(7138):876-881.
7. Nilsson J, Yekezare M, Minshull J, Pines J (2008) The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction. Nat Cell Biol 10(12):1411-1420.
8. Foster SA, Morgan DO (2012) The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell 47(6):921-932.
9. Uzunova K, et al. (2012) APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Nat Struct Mol Biol 19(11):1116-1123.
10. Jia L, et al. (2011) Defining pathways of spindle checkpoint silencing: Functional redundancy between Cdc20 ubiquitination and p31(comet). Mol Biol Cell 22(22): 4227-4235.
11. Pan J, Chen RH (2004) Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae. Genes Dev 18(12):1439-1451.
12. King EM, van der Sar SJ, Hardwick KG (2007) Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint. PLoS ONE 2(4):e342.
13. Ge S, Skaar JR, Pagano M (2009) APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation. Cell Cycle 8(1):167-171.
14. Varetti G, Guida C, Santaguida S, Chiroli E, Musacchio A (2011) Homeostatic control of mitotic arrest. Mol Cell 44(5):710-720.
15. Braunstein I, Miniowitz S, Moshe Y, Hershko A (2007) Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint. Proc Natl Acad Sci USA 104(12):4870-4875.
16. Eytan E, et al. (2008) Two different mitotic checkpoint inhibitors of the anaphasepromoting complex/cyclosome antagonize the action of the activator Cdc20. Proc Natl Acad Sci USA 105(27):9181-9185.
17. Miniowitz-Shemtov S, Teichner A, Sitry-Shevah D, Hershko A (2010) ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint. Proc Natl Acad Sci USA 107(12):5351-5356.
18. Habu T, Kim SH, Weinstein J, Matsumoto T (2002) Identification of a MAD2-binding protein, CMT2, and its role in mitosis. EMBO J 21(23):6419-6428.
19. Xia G, et al. (2004) Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. EMBO J 23(15):3133-3143.
20. Teichner A, et al. (2011) p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process. Proc Natl Acad Sci USA 108(8):3187-3192.
21. Miniowitz-Shemtov S, et al. (2012) Role of phosphorylation of Cdc20 in p31(comet)- stimulated disassembly of the mitotic checkpoint complex. Proc Natl Acad Sci USA 109(21):8056-8060.
22. Lara-Gonzalez P, Scott MIF, Diez M, Sen O, Taylor SS (2011) BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. J Cell Sci 124(Pt 24): 4332-4345.
23. Ciechanover A, Ben-Saadon R (2004) N-terminal ubiquitination: More protein substrates join in. Trends Cell Biol 14(3):103-106.
24. Kulukian A, Han JS, Cleveland DW (2009) Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. Dev Cell 16(1):105-117.
25. Minshull J, Sun H, Tonks NK, Murray AW (1994) A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts. Cell 79(3):475-486.
26. Murray AW (1991) Cell cycle extracts. Methods Cell Biol 36:581-605.
27. Sudakin V, Shteinberg M, Ganoth D, Hershko J, Hershko A (1997) Binding of activated cyclosome to p13(suc1). Use for affinity purification. J Biol Chem 272(29): 18051-18059.