메뉴 건너뛰기




Volumn 9, Issue , 2015, Pages 5385-5396

Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice

Author keywords

Apoptosis; Autophagy; Inflammation; PI3K Akt pathway

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CASPASE 8; CASPASE 9; CONCANAVALIN A; CYTOKINE; GHRELIN; MICROTUBULE ASSOCIATED PROTEIN 1; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN LC3; SODIUM CHLORIDE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; APOPTOSIS REGULATORY PROTEIN; AUTACOID;

EID: 84943195934     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S89096     Document Type: Article
Times cited : (36)

References (33)
  • 1
    • 0026643743 scopus 로고
    • A T cell-dependent experimental liver injury in mice inducible by concanavalin A
    • Tiegs G, Hentschel J, Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest. 1992;90(1):196-203.
    • (1992) J Clin Invest , vol.90 , Issue.1 , pp. 196-203
    • Tiegs, G.1    Hentschel, J.2    Wendel, A.3
  • 2
    • 75149129437 scopus 로고    scopus 로고
    • CD4 T cells in hepatic immune tolerance
    • Carambia A, Herkel J. CD4 T cells in hepatic immune tolerance. J Autoimmun. 2010;34(1):23-28.
    • (2010) J Autoimmun , vol.34 , Issue.1 , pp. 23-28
    • Carambia, A.1    Herkel, J.2
  • 3
    • 0033694155 scopus 로고    scopus 로고
    • Importance of Kupffer cells for T-cell-dependent liver injury in mice
    • Schümann J, Wolf D, Pahl A, et al. Importance of Kupffer cells for T-cell-dependent liver injury in mice. Am J Pathol. 2000;157(5):1671-1683.
    • (2000) Am J Pathol , vol.157 , Issue.5 , pp. 1671-1683
    • Schümann, J.1    Wolf, D.2    Pahl, A.3
  • 4
    • 0034598156 scopus 로고    scopus 로고
    • Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis
    • Kaneko Y, Harada M, Kawano T, et al. Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J Exp Med. 2000;191(1):105-114.
    • (2000) J Exp Med , vol.191 , Issue.1 , pp. 105-114
    • Kaneko, Y.1    Harada, M.2    Kawano, T.3
  • 5
    • 0031958385 scopus 로고    scopus 로고
    • Concanavalin A-induced liver cell damage: Activation of intracellular pathways triggered by tumor necrosis factor in mice
    • Trautwein C, Rakemann T, Brenner DA, et al. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Gastroenterology. 1998;114(5):1035-1045.
    • (1998) Gastroenterology , vol.114 , Issue.5 , pp. 1035-1045
    • Trautwein, C.1    Rakemann, T.2    Brenner, D.A.3
  • 6
    • 0030017301 scopus 로고    scopus 로고
    • Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A
    • Küsters S, Gantner F, Künstle G, Tiegs G. Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology. 1996;111(2):462-471.
    • (1996) Gastroenterology , vol.111 , Issue.2 , pp. 462-471
    • Küsters, S.1    Gantner, F.2    Künstle, G.3    Tiegs, G.4
  • 7
    • 77958109232 scopus 로고    scopus 로고
    • Opposite effects of high and low doses of interleukin-2 on T cell-mediated hepatitis in mice (Interleukin-2 on hepatitis)
    • Zhang X, Wei HX, Rui S, Wei H, Tian Z. Opposite effects of high and low doses of interleukin-2 on T cell-mediated hepatitis in mice (interleukin-2 on hepatitis). Hepatol Int. 2010;4(3):641-648.
    • (2010) Hepatol Int , vol.4 , Issue.3 , pp. 641-648
    • Zhang, X.1    Wei, H.X.2    Rui, S.3    Wei, H.4    Tian, Z.5
  • 8
    • 84907549904 scopus 로고    scopus 로고
    • Dexmedetomidine premedication attenuates concanavalin A-induced hepatitis in mice
    • Wang H, Hu B, Zou Y, et al. Dexmedetomidine premedication attenuates concanavalin A-induced hepatitis in mice. J Toxicol Sci. 2014;39(5):755-764.
    • (2014) J Toxicol Sci , vol.39 , Issue.5 , pp. 755-764
    • Wang, H.1    Hu, B.2    Zou, Y.3
  • 9
    • 84908055402 scopus 로고    scopus 로고
    • Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis
    • Cheng P, Chen K, Xia Y, et al. Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis. Drug Des Devel Ther. 2014;8:1277-1286.
    • (2014) Drug Des Devel Ther , vol.8 , pp. 1277-1286
    • Cheng, P.1    Chen, K.2    Xia, Y.3
  • 10
    • 77949350918 scopus 로고    scopus 로고
    • Immunological aspects and therapeutic significance of an autoantibody against histone H1 in a rat model of concanavalin A-induced hepatitis
    • Nakano T, Goto S, Lai CY, et al. Immunological aspects and therapeutic significance of an autoantibody against histone H1 in a rat model of concanavalin A-induced hepatitis. Immunology. 2010;129(4):547-555.
    • (2010) Immunology , vol.129 , Issue.4 , pp. 547-555
    • Nakano, T.1    Goto, S.2    Lai, C.Y.3
  • 11
    • 84874861922 scopus 로고    scopus 로고
    • The protective effect of intrasplenic transplantation of Ad-IL-18BP/IL-4 gene-modified fetal hepatocytes on Con A-induced hepatitis in mice
    • Shao X, Qian Y, Xu C, et al. The protective effect of intrasplenic transplantation of Ad-IL-18BP/IL-4 gene-modified fetal hepatocytes on Con A-induced hepatitis in mice. PLoS One. 2013;8(3):e58836.
    • (2013) Plos One , vol.8 , Issue.3 , pp. 58836
    • Shao, X.1    Qian, Y.2    Xu, C.3
  • 12
    • 84907481151 scopus 로고    scopus 로고
    • Anti-apoptotic BCL-2 family proteins in acute neural injury
    • Anilkumar U, Prehn JH. Anti-apoptotic BCL-2 family proteins in acute neural injury. Front Cell Neurosci. 2014;8:281.
    • (2014) Front Cell Neurosci , vol.8 , pp. 281
    • Anilkumar, U.1    Prehn, J.H.2
  • 13
    • 43949123866 scopus 로고    scopus 로고
    • Autophagy in the liver
    • Yin XM, Ding WX, Gao W. Autophagy in the liver. Hepatology. 2008;47(5):1773-1785.
    • (2008) Hepatology , vol.47 , Issue.5 , pp. 1773-1785
    • Yin, X.M.1    Ding, W.X.2    Gao, W.3
  • 14
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: A double-edged sword
    • Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science. 2004;306(5698):990-995.
    • (2004) Science , vol.306 , Issue.5698 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 15
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656-660.
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 16
    • 0037383867 scopus 로고    scopus 로고
    • Ghrelin in chronic liver disease
    • Tacke F, Brabant G, Kruck E, et al. Ghrelin in chronic liver disease. J Hepatol. 2003;38(4):447-454.
    • (2003) J Hepatol , vol.38 , Issue.4 , pp. 447-454
    • Tacke, F.1    Brabant, G.2    Kruck, E.3
  • 17
    • 23844457178 scopus 로고    scopus 로고
    • Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo
    • Momota H, Nerio E, Holland EC. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res. 2005;65(16):7429-7435.
    • (2005) Cancer Res , vol.65 , Issue.16 , pp. 7429-7435
    • Momota, H.1    Nerio, E.2    Holland, E.C.3
  • 18
    • 84931089430 scopus 로고    scopus 로고
    • Prediction of risk for hepatocellular carcinoma by response of serum α-fetoprotein to entecavir therapy
    • Yang SW, Kim GH, Chung JW, et al. Prediction of risk for hepatocellular carcinoma by response of serum α-fetoprotein to entecavir therapy. J Gastroenterol Hepatol. 2015;30(7):1175-1182.
    • (2015) J Gastroenterol Hepatol , vol.30 , Issue.7 , pp. 1175-1182
    • Yang, S.W.1    Kim, G.H.2    Chung, J.W.3
  • 19
    • 34247371033 scopus 로고    scopus 로고
    • Cell survival, cell death and cell cycle pathways are interconnected: Implications for cancer therapy
    • Maddika S, Ande SR, Panigrahi S, et al. Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist Updat. 2007;10(1-2):13-29.
    • (2007) Drug Resist Updat , vol.10 , Issue.1-2 , pp. 13-29
    • Maddika, S.1    E, S.R.2    Panigrahi, S.3
  • 20
    • 84922534932 scopus 로고    scopus 로고
    • Fenofibrate pre-treatment suppressed inflammation by activating phosphoinositide 3 kinase/protein kinase B (PI3K/Akt) signaling in renal ischemia-reperfusion injury
    • Yang FJ, He YH, Zhou JH. Fenofibrate pre-treatment suppressed inflammation by activating phosphoinositide 3 kinase/protein kinase B (PI3K/Akt) signaling in renal ischemia-reperfusion injury. J Huazhong Univ Sci Technolog Med Sci. 2015;35(1):58-63.
    • (2015) J Huazhong Univ Sci Technolog Med Sci , vol.35 , Issue.1 , pp. 58-63
    • Yang, F.J.1    He, Y.H.2    Zhou, J.H.3
  • 21
    • 84890210617 scopus 로고    scopus 로고
    • Changes of PI3K/AKT/BCL2 signaling proteins in congenital Giant Nevi: Melanocytes contribute to their increased survival and integrity
    • Drukker L, Margulis A, Chaouat M, Levitzki R, Maiorenko E, Ben Bassat H. Changes of PI3K/AKT/BCL2 signaling proteins in congenital Giant Nevi: melanocytes contribute to their increased survival and integrity. J Recept Signal Transduct Res. 2013;33(6):359-366.
    • (2013) J Recept Signal Transduct Res , vol.33 , Issue.6 , pp. 359-366
    • Drukker, L.1    Margulis, A.2    Chaouat, M.3    Levitzki, R.4    Maiorenko, E.5    Ben Bassat, H.6
  • 22
    • 84878619468 scopus 로고    scopus 로고
    • Administration of ghrelin improves inflammation, oxidative stress, and apoptosis during and after non-alcoholic fatty liver disease development
    • Li Y, Hai J, Li L, et al. Administration of ghrelin improves inflammation, oxidative stress, and apoptosis during and after non-alcoholic fatty liver disease development. Endocrine. 2013;43(2):376-386.
    • (2013) Endocrine , vol.43 , Issue.2 , pp. 376-386
    • Li, Y.1    Hai, J.2    Li, L.3
  • 23
    • 84922830506 scopus 로고    scopus 로고
    • Ghrelin alleviates early brain injury after subarachnoid hemorrhage via the PI3K/Akt signaling pathway
    • Hao XK, Wu W, Wang CX, et al. Ghrelin alleviates early brain injury after subarachnoid hemorrhage via the PI3K/Akt signaling pathway. Brain Res. 2014;1587:15-22.
    • (2014) Brain Res , vol.1587 , pp. 15-22
    • Hao, X.K.1    Wu, W.2    Wang, C.X.3
  • 24
    • 77950600619 scopus 로고    scopus 로고
    • Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans
    • Moreno M, Chaves JF, Sancho-Bru P, et al. Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans. Hepatology. 2010;51(3):974-985.
    • (2010) Hepatology , vol.51 , Issue.3 , pp. 974-985
    • Moreno, M.1    Chaves, J.F.2    Sancho-Bru, P.3
  • 25
    • 79751514534 scopus 로고    scopus 로고
    • Ghrelin inhibits apoptosis induced by palmitate in rat aortic endothelial cells
    • Zhang D, Wang W, Zhou D, et al. Ghrelin inhibits apoptosis induced by palmitate in rat aortic endothelial cells. Med Sci Monit. 2010;16(12):BR396-BR403.
    • (2010) Med Sci Monit , vol.16 , Issue.12
    • Zhang, D.1    Wang, W.2    Zhou, D.3
  • 26
    • 0037066587 scopus 로고    scopus 로고
    • Neuroendocrine and peripheral activities of ghrelin: Implications in metabolism and obesity
    • Muccioli G, Tschöp M, Papotti M, Deghenghi R, Heiman M, Ghigo E. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol. 2002;440(2-3):235-254.
    • (2002) Eur J Pharmacol , vol.440 , Issue.2-2 , pp. 235-254
    • Muccioli, G.1    Tschöp, M.2    Papotti, M.3    Deghenghi, R.4    Heiman, M.5    Ghigo, E.6
  • 27
    • 54049141243 scopus 로고    scopus 로고
    • Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation
    • Rossi F, Castelli A, Bianco MJ, Bertone C, Brama M, Santiemma V. Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation. Peptides. 2008;29(11):2046-2051.
    • (2008) Peptides , vol.29 , Issue.11 , pp. 2046-2051
    • Rossi, F.1    Castelli, A.2    Bianco, M.J.3    Bertone, C.4    Brama, M.5    Santiemma, V.6
  • 28
    • 84884707343 scopus 로고    scopus 로고
    • Ghrelin inhibits the apoptosis of MC3T3-E1 cells through ERK and AKT signaling pathway
    • Liang QH, Liu Y, Wu SS, Cui RR, Yuan LQ, Liao EY. Ghrelin inhibits the apoptosis of MC3T3-E1 cells through ERK and AKT signaling pathway. Toxicol Appl Pharmacol. 2013;272(3):591-597.
    • (2013) Toxicol Appl Pharmacol , vol.272 , Issue.3 , pp. 591-597
    • Liang, Q.H.1    Liu, Y.2    Wu, S.S.3    Cui, R.R.4    Yuan, L.Q.5    Liao, E.Y.6
  • 29
    • 0029862706 scopus 로고    scopus 로고
    • Mitochondrial control of nuclear apoptosis
    • Zamzami N, Susin SA, Marchetti P, et al. Mitochondrial control of nuclear apoptosis. J Exp Med. 1996;183(4):1533-1544.
    • (1996) J Exp Med , vol.183 , Issue.4 , pp. 1533-1544
    • Zamzami, N.1    Susin, S.A.2    Marchetti, P.3
  • 30
    • 0032422488 scopus 로고    scopus 로고
    • Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
    • Narita M, Shimizu S, Ito T, et al. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci U S A. 1998;95(25):14681-14686.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.25 , pp. 14681-14686
    • Narita, M.1    Shimizu, S.2    Ito, T.3
  • 31
    • 84908055402 scopus 로고    scopus 로고
    • Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis
    • Cheng P, Chen K, Xia Y, et al. Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis. Drug Des Devel Ther. 2014;8:1277-1286.
    • (2014) Drug Des Devel Ther , vol.8 , pp. 1277-1286
    • Cheng, P.1    Chen, K.2    Xia, Y.3
  • 33
    • 84875892111 scopus 로고    scopus 로고
    • Autophagy as a stress-response and quality-control mechanism: Implications for cell injury and human disease
    • Murrow L, Debnath J. Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease. Annu Rev Pathol. 2013;8:105-137.
    • (2013) Annu Rev Pathol , vol.8 , pp. 105-137
    • Murrow, L.1    Debnath, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.