메뉴 건너뛰기




Volumn 33, Issue 6, 2013, Pages 359-366

Changes of PI3K/AKT/BCL2 signaling proteins in congenital Giant Nevi: Melanocytes contribute to their increased survival and integrity

Author keywords

Apoptosis; Cell growth; CGN; Melanocytes; PI3K AKT BCL2; Signaling pathways

Indexed keywords

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHR; WNT PROTEIN;

EID: 84890210617     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.3109/10799893.2013.838785     Document Type: Article
Times cited : (14)

References (43)
  • 1
    • 8644266840 scopus 로고    scopus 로고
    • Classification of congenital melanocytic naevi and malignant transformation: A review of the literature
    • Zaal LH, Mooi WJ, Sillevis Smitt JH, van der Horst CM. Classification of congenital melanocytic naevi and malignant transformation: a review of the literature. Br J Plast Surg 2004; 57:707-19.
    • (2004) Br J Plast Surg , vol.57 , pp. 707-719
    • Zaal, L.H.1    Mooi, W.J.2    Sillevis Smitt, J.H.3    Van Der Horst, C.M.4
  • 2
    • 24644464206 scopus 로고    scopus 로고
    • Congenital melanocytic nevi: Clinical and histopathologic features, risk of melanoma, and clinical management
    • Tannous ZS, Mihm Jr MC, Sober AJ, Duncan LM. Congenital melanocytic nevi: clinical and histopathologic features, risk of melanoma, and clinical management. J Am Acad Dermatol 2005; 52:197-203.
    • (2005) J Am Acad Dermatol , vol.52 , pp. 197-203
    • Tannous, Z.S.1    Mihm Jr., M.C.2    Sober, A.J.3    Duncan, L.M.4
  • 3
    • 41449115202 scopus 로고    scopus 로고
    • Congenital melanocytic nevi: Treatment modalities and management options
    • Marghoob AA, Borrego JP, Halpern AC. Congenital melanocytic nevi: treatment modalities and management options. Semin Cutan Med Surg 2007;26:231-40.
    • (2007) Semin Cutan Med Surg , vol.26 , pp. 231-240
    • Marghoob, A.A.1    Borrego, J.P.2    Halpern, A.C.3
  • 6
    • 0142184344 scopus 로고    scopus 로고
    • Large congenital melanocytic nevi may reflect paradominant inheritance implying allelic loss
    • Danarti R, König A, Happle R. Large congenital melanocytic nevi may reflect paradominant inheritance implying allelic loss. Eur J Dermatol 2003;13:430-2.
    • (2003) Eur J Dermatol , vol.13 , pp. 430-432
    • Danarti, R.1    König, A.2    Happle, R.3
  • 7
    • 33744535687 scopus 로고    scopus 로고
    • Genetic alterations in melanocytic tumors
    • Takata M, Saida T. Genetic alterations in melanocytic tumors. J Dermatol Sci 2006;43:1-10.
    • (2006) J Dermatol Sci , vol.43 , pp. 1-10
    • Takata, M.1    Saida, T.2
  • 8
    • 84865052493 scopus 로고    scopus 로고
    • Human giant congenital melanocytic nevus exhibits potential proteomic alterations leading to melanotumorigenesis
    • Kim HK, Kim YK, Song IS, et al. Human giant congenital melanocytic nevus exhibits potential proteomic alterations leading to melanotumorigenesis. Proteome Sci 2012;10:50.
    • (2012) Proteome Sci , vol.10 , pp. 50
    • Kim, H.K.1    Kim, Y.K.2    Song, I.S.3
  • 9
    • 74349114086 scopus 로고    scopus 로고
    • Molecular pathogenesis of malignant melanoma: A different perspective from the studies of melanocytic nevus and acral melanoma
    • Takata M, Murata H, Saida T. Molecular pathogenesis of malignant melanoma: a different perspective from the studies of melanocytic nevus and acral melanoma. Pigment Cell Melanoma Res 2010;23: 64-71.
    • (2010) Pigment Cell Melanoma Res , vol.23 , pp. 64-71
    • Takata, M.1    Murata, H.2    Saida, T.3
  • 10
    • 77957985035 scopus 로고    scopus 로고
    • Interface of signal transduction inhibition and immunotherapy in melanoma
    • Shada AL, Molhoek KR, Slingluff Jr CL. Interface of signal transduction inhibition and immunotherapy in melanoma. Cancer J 2010;16:360-6.
    • (2010) Cancer J , vol.16 , pp. 360-366
    • Shada, A.L.1    Molhoek, K.R.2    Slingluff Jr., C.L.3
  • 11
    • 77949430065 scopus 로고    scopus 로고
    • The Akt/PKB family of protein kinases: A review of small molecule inhibitors and progress towards target validation: A 2009 update
    • Lindsley CW. The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation: a 2009 update. Curr Top Med Chem 2010;10:458-77.
    • (2010) Curr Top Med Chem , vol.10 , pp. 458-477
    • Lindsley, C.W.1
  • 12
    • 5044240701 scopus 로고    scopus 로고
    • PI3K mediates protection against TRAIL-induced apoptosis in primary human melanocytes
    • Larribere L, Khaled M, Tartare-Deckert S, et al. PI3K mediates protection against TRAIL-induced apoptosis in primary human melanocytes. Cell Death Differ 2004;11:1084-91.
    • (2004) Cell Death Differ , vol.11 , pp. 1084-1091
    • Larribere, L.1    Khaled, M.2    Tartare-Deckert, S.3
  • 13
    • 6344269718 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt-dependent and -independent protection against apoptosis in normal human melanocytes
    • Oka M, Kageyama A, Fukunaga M, et al. Phosphatidylinositol 3-kinase/Akt-dependent and -independent protection against apoptosis in normal human melanocytes. J Invest Dermatol 2004;123: 930-6.
    • (2004) J Invest Dermatol , vol.123 , pp. 930-936
    • Oka, M.1    Kageyama, A.2    Fukunaga, M.3
  • 14
    • 34249661591 scopus 로고    scopus 로고
    • Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity
    • Fang D, Hawke D, Zheng Y, et al. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem 2007;282:11221-9.
    • (2007) J Biol Chem , vol.282 , pp. 11221-11229
    • Fang, D.1    Hawke, D.2    Zheng, Y.3
  • 15
    • 33847417986 scopus 로고    scopus 로고
    • Overexpression of Akt converts radial growth melanoma to vertical growth melanoma
    • Govindarajan B, Sligh JE, Vincent BJ, et al. Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. J Clin Invest 2007;117:719-29.
    • (2007) J Clin Invest , vol.117 , pp. 719-729
    • Govindarajan, B.1    Sligh, J.E.2    Vincent, B.J.3
  • 16
    • 49049103833 scopus 로고    scopus 로고
    • Wnt signaling and cancer development: Therapeutic implication
    • Paul S, Dey A. Wnt signaling and cancer development: therapeutic implication. Neoplasma 2008;55:165-76.
    • (2008) Neoplasma , vol.55 , pp. 165-176
    • Paul, S.1    Dey, A.2
  • 17
    • 77956266718 scopus 로고    scopus 로고
    • A re-evaluation of the ''oncogenic'' nature of Wnt/beta-catenin signaling in melanoma and other cancers
    • Lucero OM, Dawson DW, Moon RT, Chien AJ. A re-evaluation of the ''oncogenic'' nature of Wnt/beta-catenin signaling in melanoma and other cancers. Curr Oncol Rep 2010;12: 314-18.
    • (2010) Curr Oncol Rep , vol.12 , pp. 314-318
    • Lucero, O.M.1    Dawson, D.W.2    Moon, R.T.3    Chien, A.J.4
  • 18
    • 4544313842 scopus 로고    scopus 로고
    • The AG1478 tyrosine kinase inhibitor is an effective suppressor of leiomyoma cell growth
    • Shushan A, Rojansky N, Laufer N, et al. The AG1478 tyrosine kinase inhibitor is an effective suppressor of leiomyoma cell growth. Hum Reprod 2004;19:1957-67.
    • (2004) Hum Reprod , vol.19 , pp. 1957-1967
    • Shushan, A.1    Rojansky, N.2    Laufer, N.3
  • 19
    • 14444280165 scopus 로고    scopus 로고
    • Inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes
    • Ben-Bassat H, Rosenbaum-Mitrani S, Hartzstark Z, et al. Inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes. Cancer Res 1997;57:3741-50.
    • (1997) Cancer Res , vol.57 , pp. 3741-3750
    • Ben-Bassat, H.1    Rosenbaum-Mitrani, S.2    Hartzstark, Z.3
  • 20
    • 67649415934 scopus 로고    scopus 로고
    • Melanoma: Molecular pathogenesis and emerging target therapies
    • Russo AE, Torrisi E, Bevelacqua Y, et al. Melanoma: molecular pathogenesis and emerging target therapies. Int J Oncol 2009;34: 1481-9.
    • (2009) Int J Oncol , vol.34 , pp. 1481-1489
    • Russo, A.E.1    Torrisi, E.2    Bevelacqua, Y.3
  • 21
    • 77953542075 scopus 로고    scopus 로고
    • Signaling pathways in melanosome biogenesis and pathology
    • Schiaffino MV. Signaling pathways in melanosome biogenesis and pathology. Int J Biochem Cell Biol 2010;42:1094-104.
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 1094-1104
    • Schiaffino, M.V.1
  • 22
    • 28444450214 scopus 로고    scopus 로고
    • Enhanced cell survival of melanocyte spheroids in serum starvation condition
    • Lin SJ, Jee SH, Hsiao WC, et al. Enhanced cell survival of melanocyte spheroids in serum starvation condition. Biomaterials 2006;27:1462-69.
    • (2006) Biomaterials , vol.27 , pp. 1462-1469
    • Lin, S.J.1    Jee, S.H.2    Hsiao, W.C.3
  • 23
    • 38549111246 scopus 로고    scopus 로고
    • Overcoming apoptosis deficiency of melanoma-hope for new therapeutic approaches
    • Eberle J, Kurbanov BM, Hossini AM, et al. Overcoming apoptosis deficiency of melanoma-hope for new therapeutic approaches. Drug Resist Update 2007;10:218-34.
    • (2007) Drug Resist Update , vol.10 , pp. 218-234
    • Eberle, J.1    Kurbanov, B.M.2    Hossini, A.M.3
  • 24
    • 67749086812 scopus 로고    scopus 로고
    • The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma
    • Madhunapantula SV, Robertson GP. The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma. Pigment Cell Melanoma Res 2009;22:400-19.
    • (2009) Pigment Cell Melanoma Res , vol.22 , pp. 400-419
    • Madhunapantula, S.V.1    Robertson, G.P.2
  • 25
    • 34447626493 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3: A key regulator of cellular fate
    • Forde JE, Dale TC. Glycogen synthase kinase 3: a key regulator of cellular fate. Cell Mol Life Sci 2007;64:1930-44.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 1930-1944
    • Forde, J.E.1    Dale, T.C.2
  • 26
    • 33748299477 scopus 로고    scopus 로고
    • The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways
    • Beurel E, Jope RS. The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog Neurobiol 2006;79:173-89.
    • (2006) Prog Neurobiol , vol.79 , pp. 173-189
    • Beurel, E.1    Jope, R.S.2
  • 27
    • 0035477424 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and beta-catenin pathways
    • Satyamoorthy K, Li G, Vaidya B, et al. Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and beta-catenin pathways. Cancer Res 2001;61:7318-24.
    • (2001) Cancer Res , vol.61 , pp. 7318-7324
    • Satyamoorthy, K.1    Li, G.2    Vaidya, B.3
  • 28
    • 0038003956 scopus 로고    scopus 로고
    • Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty
    • Burgering BM, Medema RH. Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty. J Leukoc Biol 2003;73:689-701.
    • (2003) J Leukoc Biol , vol.73 , pp. 689-701
    • Burgering, B.M.1    Medema, R.H.2
  • 29
    • 77952672913 scopus 로고    scopus 로고
    • Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells
    • Zanella F, Renner O, García B, et al. Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells. Oncogene 2010;29:2973-82.
    • (2010) Oncogene , vol.29 , pp. 2973-2982
    • Zanella, F.1    Renner, O.2    García, B.3
  • 30
    • 36249026528 scopus 로고    scopus 로고
    • Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development
    • Delmas V, Beermann F, Martinozzi S, et al. Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development. Genes Dev 2007;21:2923-35.
    • (2007) Genes Dev , vol.21 , pp. 2923-2935
    • Delmas, V.1    Beermann, F.2    Martinozzi, S.3
  • 32
    • 33745559424 scopus 로고    scopus 로고
    • Bak (and Bax) to the future - Of primary melanoma prognosis?
    • Leverkus M, Gollnick H. ''Bak (and Bax) to the future'' - of primary melanoma prognosis? J Invest Dermatol 2006;126: 1212-24.
    • (2006) J Invest Dermatol , vol.126 , pp. 1212-1224
    • Leverkus, M.1    Gollnick, H.2
  • 33
    • 0034062695 scopus 로고    scopus 로고
    • Antiapoptotic bcl-2 and bcl-xL in advanced malignant melanoma
    • Leiter U, Schmid RM, Kaskel P, et al. Antiapoptotic bcl-2 and bcl-xL in advanced malignant melanoma. Arch Dermatol Res 2000; 292:225-32.
    • (2000) Arch Dermatol Res , vol.292 , pp. 225-232
    • Leiter, U.1    Schmid, R.M.2    Kaskel, P.3
  • 34
    • 33947598446 scopus 로고    scopus 로고
    • Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma
    • Zhuang L, Lee CS, Scolyer RA, et al. Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma. Mod Pathol 2007;20:416-26.
    • (2007) Mod Pathol , vol.20 , pp. 416-426
    • Zhuang, L.1    Lee, C.S.2    Scolyer, R.A.3
  • 35
    • 0142029990 scopus 로고    scopus 로고
    • The role of Bcl-2 family members in the progression of cutaneous melanoma
    • Bush JA, Li G. The role of Bcl-2 family members in the progression of cutaneous melanoma. Clin Exp Metastasis 2003;20:531-9.
    • (2003) Clin Exp Metastasis , vol.20 , pp. 531-539
    • Bush, J.A.1    Li, G.2
  • 36
    • 77957122174 scopus 로고    scopus 로고
    • The engine driving the ship: Metabolic steering of cell proliferation and death
    • Buchakjian MR, Kornbluth S. The engine driving the ship: metabolic steering of cell proliferation and death. Nat Rev Mol Cell Biol 2010;11:715-27.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 715-727
    • Buchakjian, M.R.1    Kornbluth, S.2
  • 37
    • 34247171828 scopus 로고    scopus 로고
    • GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN
    • Huang W, Chang HY, Fei T, et al. GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene 2007;26:2471-82.
    • (2007) Oncogene , vol.26 , pp. 2471-2482
    • Huang, W.1    Chang, H.Y.2    Fei, T.3
  • 38
    • 0035092418 scopus 로고    scopus 로고
    • Expression of cyclins and cyclin dependent kinases in human benign and malignant melanocytic lesions
    • Georgieva J, Sinha P, Schadendorf D. Expression of cyclins and cyclin dependent kinases in human benign and malignant melanocytic lesions. J Clin Pathol 2001;54: 229-35.
    • (2001) J Clin Pathol , vol.54 , pp. 229-235
    • Georgieva, J.1    Sinha, P.2    Schadendorf, D.3
  • 40
    • 67650458544 scopus 로고    scopus 로고
    • Active Notch1 confers a transformed phenotype to primary human melanocytes
    • Pinnix CC, Lee JT, Liu ZJ, et al. Active Notch1 confers a transformed phenotype to primary human melanocytes. Cancer Res 2009;69:5312-20.
    • (2009) Cancer Res , vol.69 , pp. 5312-5320
    • Pinnix, C.C.1    Lee, J.T.2    Liu, Z.J.3
  • 41
    • 27644490306 scopus 로고    scopus 로고
    • Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression
    • Balint K, Xiao M, Pinnix CC, et al. Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest 2005;115:3166-76.
    • (2005) J Clin Invest , vol.115 , pp. 3166-3176
    • Balint, K.1    Xiao, M.2    Pinnix, C.C.3
  • 42
    • 33646257783 scopus 로고    scopus 로고
    • Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression
    • Liu ZJ, Xiao M, Balint K, et al. Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression. Cancer Res 2006;66:4182-90.
    • (2006) Cancer Res , vol.66 , pp. 4182-4190
    • Liu, Z.J.1    Xiao, M.2    Balint, K.3
  • 43
    • 55849139852 scopus 로고    scopus 로고
    • Notch1 is an effector of Akt and hypoxia in melanoma development
    • Bedogni B, Warneke JA, Nickoloff BJ, et al. Notch1 is an effector of Akt and hypoxia in melanoma development. J Clin Invest 2008; 118:3660-70.
    • (2008) J Clin Invest , vol.118 , pp. 3660-3670
    • Bedogni, B.1    Warneke, J.A.2    Nickoloff, B.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.