메뉴 건너뛰기




Volumn 16, Issue 12, 2010, Pages

Ghrelin inhibits apoptosis induced by palmitate in rat aortic endothelial cells

Author keywords

Apoptosis; Endothelial injury; Ghrelin; PI3K AKt; Reactive oxygen species

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; GHRELIN; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

EID: 79751514534     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (3)

References (45)
  • 1
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormonerelasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Date Y, Kojima M, Hosoda H et al: Ghrelin, a novel growth hormonerelasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology, 2000; 141: 4255-61
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3
  • 2
    • 0034731310 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin: Two major forms of rat ghrelin peptide in gastrointestinal tissue
    • Hosoda H, Kojima M, Matsuo H, Kangawa K: Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun, 2000; 279: 909-13
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 909-913
    • Hosoda, H.1    Kojima, M.2    Matsuo, H.3    Kangawa, K.4
  • 3
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth hormone-relesasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y et al: Ghrelin is a growth hormone-relesasing acylated peptide from stomach. Nature, 1999; 402: 656-60
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3
  • 5
    • 12944304591 scopus 로고    scopus 로고
    • Ghrelin: More than a natural GH secretagogue and/or an orexigenic factor
    • Ghigo E, Broglio F, Arvat E et al: Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor. Clin Endocrinol, 2005; 62: 1-17
    • (2005) Clin Endocrinol , vol.62 , pp. 1-17
    • Ghigo, E.1    Broglio, F.2    Arvat, E.3
  • 6
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: Structure and function
    • Kojima M, Kangawa K: Ghrelin: structure and function. Physiol Rev, 2005: 85: 495-522
    • (2005) Physiol Rev , vol.85 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 7
    • 0034741715 scopus 로고    scopus 로고
    • Davenport AP: [125I-His(9)]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: Up-regulation of receptors with atherosclerosis
    • Katugampola SD, Pallikaros Z, Davenport AP: [125I-His(9)]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: up-regulation of receptors with atherosclerosis. Br J Pharmacol, 2001; 134: 143-49
    • (2001) Br J Pharmacol , vol.134 , pp. 143-149
    • Katugampola, S.D.1    Pallikaros, Z.2
  • 8
    • 41549084644 scopus 로고    scopus 로고
    • AMP-activated protein kinase activation by 5-Aminoimidazole-4-carboxamide-1-b-D-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression
    • Kim JE, Kim YW, Lee IK et al: AMP-activated protein kinase activation by 5-Aminoimidazole-4-carboxamide-1-b-D-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression. J Pharmacol Sci, 2008; 106: 394-403
    • (2008) J Pharmacol Sci , vol.106 , pp. 394-403
    • Kim, J.E.1    Kim, Y.W.2    Lee, I.K.3
  • 9
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME: Cellular survival: a play in three Akts. Genes Dev, 1999; 13: 2905-27
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 10
    • 0034997845 scopus 로고    scopus 로고
    • Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
    • Pearson G, Robinson F, Beers GT et al: Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endoc Rev, 2001; 22: 153-83
    • (2001) Endoc Rev , vol.22 , pp. 153-183
    • Pearson, G.1    Robinson, F.2    Beers, G.T.3
  • 11
    • 33845910446 scopus 로고    scopus 로고
    • Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation
    • Chung H, Kim E, Lee DH et al: Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation. Endocrinology, 2007; 148: 148-59
    • (2007) Endocrinology , vol.148 , pp. 148-159
    • Chung, H.1    Kim, E.2    Lee, D.H.3
  • 12
    • 33846435771 scopus 로고    scopus 로고
    • Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic b-cells and human islets: Involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling
    • Granata R, Settanni F, Biancone L et al: Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic b-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling. Endocrinology, 2007; 148: 512-29
    • (2007) Endocrinology , vol.148 , pp. 512-529
    • Granata, R.1    Settanni, F.2    Biancone, L.3
  • 13
    • 33846851996 scopus 로고    scopus 로고
    • Mitochondria play an important role in 17b-estradiol attenuation of H2O2-induced rat endothelial cell apoptosis
    • Lu A, Frink M, Choudhry MA et al: Mitochondria play an important role in 17b-estradiol attenuation of H2O2-induced rat endothelial cell apoptosis. Am J Physiol Endocrinol Metab, 2007; 292: 585-93
    • (2007) Am J Physiol Endocrinol Metab , vol.292 , pp. 585-593
    • Lu, A.1    Frink, M.2    Choudhry, M.A.3
  • 14
    • 0028956550 scopus 로고
    • Regulators of cell death
    • Korsmeyer SJ: Regulators of cell death. Trends Genet, 1995; 11: 101-5
    • (1995) Trends Genet , vol.11 , pp. 101-105
    • Korsmeyer, S.J.1
  • 15
    • 0023369786 scopus 로고
    • Isolation of rat aortic endothelial cells by primary explant techniques and their phenotypic modulation by defined substrata
    • McGuire PG, Orkin RW: Isolation of rat aortic endothelial cells by primary explant techniques and their phenotypic modulation by defined substrata. La Invest, 1987; 57: 94-105
    • (1987) La Invest , vol.57 , pp. 94-105
    • McGuire, P.G.1    Orkin, R.W.2
  • 16
    • 33947391701 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase mediates palmitate-induced apoptosis but not inhibitor of nuclear factor- B degradation in human coronary artery endothelial cells
    • Chai W, Liu Z: P38 mitogen-activated protein kinase mediates palmitate-induced apoptosis but not inhibitor of nuclear factor- B degradation in human coronary artery endothelial cells. Endocrinology, 2007; 148: 1622-28
    • (2007) Endocrinology , vol.148 , pp. 1622-16228
    • Chai, W.1    Liu, Z.2
  • 17
    • 0037164747 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
    • Baldanzi G, Filigheddu N, Cutrupi S et al: Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol, 2002; 159: 1029-37
    • (2002) J Cell Biol , vol.159 , pp. 1029-1037
    • Baldanzi, G.1    Filigheddu, N.2    Cutrupi, S.3
  • 18
    • 0033765672 scopus 로고    scopus 로고
    • High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells
    • Inoguchi T, Li P, Umeda F et al: High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes, 2000; 49: 1939-45
    • (2000) Diabetes , vol.49 , pp. 1939-1945
    • Inoguchi, T.1    Li, P.2    Umeda, F.3
  • 19
    • 6344285417 scopus 로고    scopus 로고
    • Endothelial cell superoxide generation: Regulation and relevance for cardiovascular pathophysiology
    • Li JM, Shah AM: Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. Am J Physiol Regul Integr Comp Physiol, 2004; 287: 1014-30
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.287 , pp. 1014-1030
    • Li, J.M.1    Shah, A.M.2
  • 20
    • 0029862706 scopus 로고    scopus 로고
    • Mitochondrial control of nuclear apoptosis
    • Zamzami N, Susin SA, Marchetti P et al: Mitochondrial control of nuclear apoptosis. J Exp Med, 1996; 183: 1533-44
    • (1996) J Exp Med , vol.183 , pp. 1533-1544
    • Zamzami, N.1    Susin, S.A.2    Marchetti, P.3
  • 21
    • 0032422488 scopus 로고    scopus 로고
    • Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
    • Narita M, Shimizu S, Ito T et al: Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci USA, 1998; 95: 14681-86
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14681-14686
    • Narita, M.1    Shimizu, S.2    Ito, T.3
  • 22
    • 4544235733 scopus 로고    scopus 로고
    • The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes
    • Kim MS, Yoon CY, Jang PG et al: The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes. Mo Endocrinol, 2004; 18: 2291-301
    • (2004) Mo Endocrinol , vol.18 , pp. 2291-2301
    • Kim, M.S.1    Yoon, C.Y.2    Jang, P.G.3
  • 23
    • 23844447768 scopus 로고    scopus 로고
    • Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells
    • Kim SW, Her SJ, Park SJ et al: Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells. Bone, 2005; 37: 359-69
    • (2005) Bone , vol.37 , pp. 359-369
    • Kim, S.W.1    Her, S.J.2    Park, S.J.3
  • 24
    • 68449105015 scopus 로고    scopus 로고
    • Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4
    • Hwang S, Moon M, Kim S et al: Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4. Endocri J, 2009; 56: 609-17
    • (2009) Endocri J , vol.56 , pp. 609-617
    • Hwang, S.1    Moon, M.2    Kim, S.3
  • 25
    • 48349103039 scopus 로고    scopus 로고
    • Ghrelin attenuates lipopolysaccharide-induced acute lung injury through NO pathway
    • Chen J, Liu X, Shu Q et al: Ghrelin attenuates lipopolysaccharide-induced acute lung injury through NO pathway. Med Sci Monit, 2008; 14 (7): BR141-BR46
    • (2008) Med Sci Monit , vol.14 , Issue.7
    • Chen, J.1    Liu, X.2    Shu, Q.3
  • 26
    • 67349227911 scopus 로고    scopus 로고
    • Ghrelin inhibits apoptosis induced by high glucose and sodium palmitate in adult rat cardiomyocytes through the PI3K-Akt signaling pathway
    • Kui L, Weiwei Z, Ling L et al: Ghrelin inhibits apoptosis induced by high glucose and sodium palmitate in adult rat cardiomyocytes through the PI3K-Akt signaling pathway. Regul Pept, 2009; 155: 62-69
    • (2009) Regul Pept , vol.155 , pp. 62-69
    • Kui, L.1    Weiwei, Z.2    Ling, L.3
  • 27
    • 1942473108 scopus 로고    scopus 로고
    • Plasma ghrelin concentrations are decreased in insulinresistant obese adults relative to equally obese insulinsensitive controls
    • McLaughlin T, Abbasi F, Lamendola C et al: Plasma ghrelin concentrations are decreased in insulinresistant obese adults relative to equally obese insulinsensitive controls. J Clini Endocrinol Metab, 2004; 89: 1630-35
    • (2004) J Clini Endocrinol Metab , vol.89 , pp. 1630-1635
    • McLaughlin, T.1    Abbasi, F.2    Lamendola, C.3
  • 28
    • 0141643291 scopus 로고    scopus 로고
    • Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes
    • Poykko SM, Kellokoski E, Horkko S et al: Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes, 2003; 52: 2546-53
    • (2003) Diabetes , vol.52 , pp. 2546-2553
    • Poykko, S.M.1    Kellokoski, E.2    Horkko, S.3
  • 29
    • 33645837808 scopus 로고    scopus 로고
    • Ghrelin-induced gastro protection against ischemia-reperfusion injury involves an activation of sensory afferent nerves and hyperemia mediated by nitric oxide
    • Konturek PC, Brzozowski T, Walter B et al: Ghrelin-induced gastro protection against ischemia-reperfusion injury involves an activation of sensory afferent nerves and hyperemia mediated by nitric oxide. Eur J Pharmacol, 2006; 536: 171-81
    • (2006) Eur J Pharmacol , vol.536 , pp. 171-181
    • Konturek, P.C.1    Brzozowski, T.2    Walter, B.3
  • 30
    • 29644442884 scopus 로고    scopus 로고
    • Ghrelin against alendronate-induced gastric damage in rats
    • Iseri SO, Sener G, Yuksel M et al: Ghrelin against alendronate-induced gastric damage in rats. J Endocrinol, 2005; 187: 399-406
    • (2005) J Endocrinol , vol.187 , pp. 399-406
    • Iseri, S.O.1    Sener, G.2    Yuksel, M.3
  • 31
    • 34548427342 scopus 로고    scopus 로고
    • Effect of ghrelin on human endothelial cells apoptosis induced by high glucose
    • Zhao H, Liu G, Wang Q et al: Effect of ghrelin on human endothelial cells apoptosis induced by high glucose. Biochem Biophys Res Commun, 2007; 362: 677-81
    • (2007) Biochem Biophys Res Commun , vol.362 , pp. 677-681
    • Zhao, H.1    Liu, G.2    Wang, Q.3
  • 32
    • 77950368247 scopus 로고    scopus 로고
    • Ghrelin inhibits cell apoptosis induced by lipotoxicity in pancreatic b-cell line
    • Wei W, Dan Z, Hong Z et al: Ghrelin inhibits cell apoptosis induced by lipotoxicity in pancreatic b-cell line. Regul Pept, 2010; 161: 43-50
    • (2010) Regul Pept , vol.161 , pp. 43-50
    • Wei, W.1    Dan, Z.2    Hong, Z.3
  • 33
    • 0036050908 scopus 로고    scopus 로고
    • Palmitate-induced apoptosis of microvascular endothelial cells and pericytes
    • Yamagishi S, Okamoto T, Amano S et al: Palmitate-induced apoptosis of microvascular endothelial cells and pericytes. Mol Med, 2002; 8: 179-84
    • (2002) Mol Med , vol.8 , pp. 179-184
    • Yamagishi, S.1    Okamoto, T.2    Amano, S.3
  • 34
    • 0034077189 scopus 로고    scopus 로고
    • Roles of caspases in apoptosis, development, andcytokine maturation revealed by homozygous gene deficiencies
    • Wang J, Lenardo MJ: Roles of caspases in apoptosis, development, andcytokine maturation revealed by homozygous gene deficiencies. J Cell Sci, 2000; 113: 753-57
    • (2000) J Cell Sci , vol.113 , pp. 753-757
    • Wang, J.1    Lenardo, M.J.2
  • 35
    • 0034704134 scopus 로고    scopus 로고
    • Expression of constitutively active phosphatidylinositol 3-kinase inhibits activation of caspase 3 and apoptosis of cardiac muscle cells
    • Wu W, Lee WL, Wu YY et al: Expression of constitutively active phosphatidylinositol 3-kinase inhibits activation of caspase 3 and apoptosis of cardiac muscle cells. J Biol Chem, 2000; 275: 40113-19
    • (2000) J Biol Chem , vol.275 , pp. 40113-40119
    • Wu, W.1    Lee, W.L.2    Wu, Y.Y.3
  • 36
    • 34247371033 scopus 로고    scopus 로고
    • Cell survival, cell death and cell cycle pathways areinterconnected: Implications for cancer therapy
    • Maddika S, Ande SR, Panigrahi S et al: Cell survival, cell death and cell cycle pathways areinterconnected: implications for cancer therapy. Drug Resist Updat, 2007; 10: 13-29
    • (2007) Drug Resist Updat , vol.10 , pp. 13-29
    • Maddika, S.1    Ande, S.R.2    Panigrahi, S.3
  • 37
    • 37549027147 scopus 로고    scopus 로고
    • The volumesensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and ERK 1/2
    • d'Anglemont de Tassigny A, Berdeaux A, Souktani R et al: The volumesensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and ERK 1/2. Eur J Heart Fail, 2008; 10: 39-46
    • (2008) Eur J Heart Fail , vol.10 , pp. 39-46
    • de Tassigny, D.A.1    Berdeaux, A.2    Souktani, R.3
  • 38
    • 65849373134 scopus 로고    scopus 로고
    • Angiopoietin-1 protects mesenchymal stem cells against serum deprivation and hypoxia-induced apoptosis through the PI3K/Akt pathway
    • Liu XB, Jiang J, Gui C et al: Angiopoietin-1 protects mesenchymal stem cells against serum deprivation and hypoxia-induced apoptosis through the PI3K/Akt pathway. Acta Pharmacol Sin, 2008; 29: 815-22
    • (2008) Acta Pharmacol Sin , vol.29 , pp. 815-822
    • Liu, X.B.1    Jiang, J.2    Gui, C.3
  • 39
    • 54049141243 scopus 로고    scopus 로고
    • Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation
    • Rossi F, Castelli A, Bianco MJ et al: Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation. Peptides, 2008; 29: 2046-51
    • (2008) Peptides , vol.29 , pp. 2046-2051
    • Rossi, F.1    Castelli, A.2    Bianco, M.J.3
  • 40
    • 0034939115 scopus 로고    scopus 로고
    • The role of oxidative stress in the onset and progression of diabetes and its complications: A summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society
    • Rosen P, Nawroth PP, King G et al: The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society. Diabetes Metab Res Rev, 2001; 17: 189-212
    • (2001) Diabetes Metab Res Rev , vol.17 , pp. 189-212
    • Rosen, P.1    Nawroth, P.P.2    King, G.3
  • 41
    • 0036478970 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species in cell death signaling
    • Fleury C, Mignotte B, Vayssiere JL: Mitochondrial reactive oxygen species in cell death signaling. Biochimie, 2002; 84: 131-41
    • (2002) Biochimie , vol.84 , pp. 131-141
    • Fleury, C.1    Mignotte, B.2    Vayssiere, J.L.3
  • 42
    • 0034641936 scopus 로고    scopus 로고
    • Apoptosis in the nervous system
    • Yuan J, Yankner BA: Apoptosis in the nervous system. Nature, 2000; 407: 802-9
    • (2000) Nature , vol.407 , pp. 802-809
    • Yuan, J.1    Yankner, B.A.2
  • 43
    • 0035039678 scopus 로고    scopus 로고
    • A structural view of mitochondria-mediated apoptosis
    • Shi Y: A structural view of mitochondria-mediated apoptosis. Nat Struct Biol, 2001; 8: 394-401
    • (2001) Nat Struct Biol , vol.8 , pp. 394-401
    • Shi, Y.1
  • 44
    • 0032191654 scopus 로고    scopus 로고
    • TNF-alpha activates atleast two apoptotic signaling cascades
    • Sidoti-de Fraisse C, Rincheval V, Risler Y et al: TNF-alpha activates atleast two apoptotic signaling cascades. Oncogene, 1998; 17: 1639-51
    • (1998) Oncogene , vol.17 , pp. 1639-1651
    • Sidoti-De fraisse, C.1    Rincheval, V.2    Risler, Y.3
  • 45
    • 9444243810 scopus 로고    scopus 로고
    • Shift of the cellular oxidationreduction potential in neural cells expressing Bcl-2
    • Ellerby LM, Ellerby HM, Park SM et al: Shift of the cellular oxidationreduction potential in neural cells expressing Bcl-2. J Neurochem, 1996; 67: 1259-67
    • (1996) J Neurochem , vol.67 , pp. 1259-1267
    • Ellerby, L.M.1    Ellerby, H.M.2    Park, S.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.