Dexmedetomidine premedication attenuates concanavalin a-induced hepatitis in mice

Journal of Toxicological Sciences

Volumn 39, Issue 5, 2014, Pages 755-764

  Wang, Haibin ^a,b   Hu, Baoji ^a,c   Zou, Yun ^a   Bo, Lulong ^a   Wang, Jun ^a   Li, Jinbao ^a   Luo, Yan ^b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c FUDAN UNIVERSITY PUDONG MEDICAL CENTER   (China)

Author keywords

Concanavalin A; Dexmedetomidine; Hepatitis; Inflammation response

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CONCANAVALIN A; DEXMEDETOMIDINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; AUTACOID; CYTOKINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; HEPATITIS; HISTOPATHOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BLOOD; C57BL MOUSE; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY, CHRONIC; IMMUNOLOGY; LIVER; METABOLISM; PHOSPHORYLATION;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CHEMOKINE CXCL10; CONCANAVALIN A; CYTOKINES; DEXMEDETOMIDINE; DRUG-INDUCED LIVER INJURY, CHRONIC; INFLAMMATION MEDIATORS; LIVER; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; PHOSPHORYLATION;

EID: 84907549904     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.39.755     Document Type: Article

References (42)

1. Bozza, M., Bliss J.L., Maylor R., Erickson J., Donnelly L., Bouchard P., Dorner A.J. and Trepicchio W.L. (1999): Inter-leukin-11 reduces T-cell-dependent experimental liver injury in mice. Hepatology, 30, 1441-1447.
2. Cai, Y., Xu H., Yan J., Zhang L. and Lu Y. (2014): Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury. Mol. Med. Rep., 9, 1542-1550.
3. Cao, L., Zou Y., Zhu J., Fan X. and Li J. (2013): Ginsenoside Rg1 attenuates concanavalin A-induced hepatitis in mice through inhibition of cytokine secretion and lymphocyte infiltration. Mol. Cell. Biochem., 380, 203-210.
4. Cao, Q., Batey R., Pang G. and Clancy R. (1999): Ethanol-altered liver-associated T cells mediate liver injury in rats administered Concanavalin A (Con A) or lipopolysaccharide (LPS). Alcohol. Clin. Exp. Res., 23, 1660-1667.
5. Chisari, F.V. and Ferrari C. (1995): Hepatitis B virus immunopatho-genesis. Annu. Rev. Immunol., 13, 29-60.
6. Czaja, A.J. and Freese D.K.; American Association for the Study of Liver Disease (2002): Diagnosis and treatment of autoimmune hepatitis. Hepatology, 36, 479-497.
7. Diao, H., Kon S., Iwabuchi K., Kimura C., Morimoto J., Ito D., Segawa T., Maeda M., Hamuro J., Nakayama T., Taniguchi M., Yagita H., Van Kaer L., Onóe K., Denhardt D., Rittling S. and Uede T. (2004): Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. Immunity, 21, 539-550.
8. Doolin, E.J., Strande L.F., Chen M.K., Kain M.S. and Hewitt C.W. (1999): The effect of leukocyte infiltration on apoptosis in an in vitro thermal injury bioartificial living skin equivalent model. J. Burn. Care. Rehabil., 20, 374-376.
9. Fiorucci, S., Mencarelli A., Palazzetti B., Del Soldato P., Morelli A. and Ignarro L.J. (2001): An NO derivative of ursodeoxychol-ic acid protects against Fas-mediated liver injury by inhibiting caspase activity. Proc. Natl. Acad. Sci. USA, 98, 2652-2657.
10. Fiorucci, S., Santucci L., Antonelli E., Distrutti E., Del Sero G., Morelli O., Romani L., Federici B., Del Soldato P. and Morelli A. (2000): NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokines. Gastroenterology, 118, 404-421.
11. Gantner, F., Leist M., Lohse A.W., Germann P.G. and Tiegs G. (1995): Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology, 21, 190-198.
12. Kage, M. (2007): Pathology of autoimmune liver diseases in children. Hepatol. Res., 37 Suppl. 3, S502-508.
13. Kato, J., Okamoto T., Motoyama H., Uchiyama R., Kirchhofer D., Van Rooijen N., Enomoto H., Nishiguchi S., Kawada N., Fujimoto J. and Tsutsui H. (2013): Interferon-gamma-mediat-ed tissue factor expression contributes to T-cell-mediated hepatitis through induction of hypercoagulation in mice. Hepatology, 57, 362-372.
14. Kawasaki, T., Kawasaki C., Ueki M., Hamada K., Habe K. and Sata T. (2013): Dexmedetomidine suppresses proinflammatory mediator production in human whole blood in vitro. J. Trauma. Acute Care Surg., 74, 1370-1375.
15. Kimura, K., Ando K., Ohnishi H., Ishikawa T., Kakumu S., Takemura M., Muto Y. and Moriwaki H. (1999): Immun-opathogenesis of hepatic fibrosis in chronic liver injury induced by repeatedly administered concanavalin A. Int. Immunol., 11, 1491-1500.
16. Kita, H., Mackay I.R., Van De Water J. and Gershwin M.E. (2001): The lymphoid liver: considerations on pathways to autoimmune injury. Gastroenterology, 120, 1485-1501.
17. Ksontini, R., Colagiovanni D.B., Josephs M.D., Edwards, C.K., Tannahill C.L., Solorzano C.C., Norman J., Denham W., Clare-Salzler M., MacKay S.L. and Moldawer L.L. (1998): Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis. J. Immunol., 160, 4082-4089.
18. Kunstle, G., Hentze H., Germann P.G., Tiegs G., Meergans T. and Wendel A. (1999): Concanavalin A hepatotoxicity in mice: tumor necrosis factor-mediated organ failure independent of cas-pase-3-like protease activation. Hepatology, 30, 1241-1251.
19. Kusters, S., Gantner F., Kunstle G. and Tiegs G. (1996): Interfer-on gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology, 111, 462-471.
20. Livak, K.J. and Schmittgen T.D. (2001): Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Del-ta Delta C(T)) Method. Methods, 25, 402-408.
21. Madden, C.J., Tupone D., Cano G. and Morrison S.F. (2013): α2 Adrenergic receptor-mediated inhibition of thermogenesis. J. Neurosci., 33, 2017-2028.
22. Okamoto, T., Kobayashi T., Tsuzuike N. and Hara K. (1998a): Induction of CPP32-like activity and inhibition of interleukin 1beta converting enzyme activity in the liver of a mouse conca-navalin A-induced hepatitis model. Jpn. J. Pharmacol., 77, 257-259.
23. Okamoto, T., Nakano Y., Asakura W., Kobayashi T., Tsuzuike N. and Hara K. (1998b): Expression of cytokine mRNA in extrahe-patic organs in a mouse concanavalin A-hepatitis model. Jpn. J. Pharmacol., 77, 219-225.
24. Reagan-Shaw, S., Nihal M. and Ahmad N. (2008): Dose translation from animal to human studies revisited. FASEB J., 22, 659-661.
25. Sakamoto, T., Ezure T., Lunz J., Murase N., Tsuji H., Fung J.J. and Demetris A.J. (2000): Concanavalin A simultaneously primes liver hematopoietic and epithelial progenitor cells for parallel expansion during liver regeneration after partial hepate-ctomy in mice. Hepatology, 32, 256-267.
26. Sarra, M., Cupi M.L., Bernardini R., Ronchetti G., Monteleone I., Ranalli M., Franzè E., Rizzo A., Colantoni A., Caprioli F., Maggioni M., Gambacurta A., Mattei M., Macdonald T.T., Pallone F. and Monteleone G. (2013): IL-25 prevents and cures fulminant hepatitis in mice through a myeloid-derived suppressor cell-dependent mechanism. Hepatology, 58, 1436-1450.
27. Sass, G., Koerber K., Bang R., Guehring H. and Tiegs G. (2001): Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice. J. Clin. Invest., 107, 439-447.
28. Schümann, J., Wolf D., Pahl A., Brune K., Papadopoulos T., van Rooijen N. and Tiegs G. (2000): Importance of Kupffer cells for T-cell-dependent liver injury in mice. Am. J. Pathol., 157, 1671-1683.
29. Shao, X., Qian Y., Xu C., Hong B., Xu W., Shen L., Jin C., Wu Z., Tong X. and Yao H. (2013): The protective effect of intras-plenic transplantation of Ad-IL-18BP/IL-4 gene-modified fetal hepatocytes on ConA-induced hepatitis in mice. PLoS One, 8, e58836.
30. Shirin, H., Dotan I., Papa M., Maaravi Y., Aeed H., Zaidel L., Matas Z., Bruck R., Moss S.F., Halpern Z. and Oren R. (1999): Inhibition of concanavalin A-induced acute T cell dependent hepatic damage in mice by hypothyroidism. Liver, 19, 206-211.
31. Tiegs, G., Hentschel J. and Wendel A. (1992): A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest., 90, 196-203.
32. Tu, C.T., Han B., Liu H.C. and Zhang S.C. (2011): Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression. Mol. Cell. Biochem., 358, 53-60.
33. van der Meer, W., van Gelder W., de Keijzer R. and Willems H. (2007): The divergent morphological classification of variant lymphocytes in blood smears. J. Clin. Pathol., 60, 838-839.
34. Varthaman, A., Khallou-Laschet J., Clement M., Fornasa G., Kim H.J., Gaston A.T., Dussiot M., Caligiuri G., Herbelin A., Kaveri S., Cantor H. and Nicoletti A. (2010): Control of T cell reactivation by regulatory Qa-1-restricted CD8+ T cells. J. Immunol., 184, 6585-6591.
35. Wang, H.-X., Liu M., Weng S.-Y., Li J.-J., Xie C., He H.-L., Guan W., Yuan Y.-S. and Gao J. (2012): Immune mechanisms of Concanavalin A model of autoimmune hepatitis. World J. Gastroenterol., 18, 119-125.
36. Wang, Z.X., Huang C.Y., Hua Y.P., Huang W.Q., Deng L.H. and Liu K.X. (2014): Dexmedetomidine reduces intestinal and hepatic injury after hepatectomy with inflow occlusion under general anaesthesia: a randomized controlled trial. Br. J. Anaesth., 112, 1055-1064.
37. Wolf, D., Hallmann R., Sass G., Sixt M., Küsters S., Fregien B., Trautwein C. and Tiegs G. (2001): TNF-alpha-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. J. Immunol., 166, 1300-1307.
38. Wu, Y., Liu Y., Huang H., Zhu Y., Zhang Y., Lu F., Zhou C., Huang L., Li X. and Zhou C. (2013): Dexmedetomidine inhibits inflammatory reaction in lung tissues of septic rats by suppressing TLR4/NF-κB pathway. Mediators. Inflamm., 2013, 562154.
39. Yang, C.L., Tsai P.S. and Huang C.J. (2008): Effects of dexme-detomidine on regulating pulmonary inflammation in a rat model of ventilator-induced lung injury. Acta. Anaesthesiol. Taiwan, 46, 151-159.
40. Zhang, S., Liang R., Luo W., Liu C., Wu X., Gao Y., Hao J., Cao G., Chen X., Wei J., Xia S., Li Z., Wen T., Wu Y., Zhou X., Wang P., Zhao L., Wu Z., Xiong S., Gao X., Gao X., Chen Y., Ge Q., Tian Z. and Yin Z. (2013): High susceptibility to liver injury in IL-27 p28 conditional knockout mice involves intrinsic interferon-γ dysregulation of CD4+ T cells. Hepatology, 57, 1620-1631.
41. Zhang, X., Wei H.X., Rui S., Wei H. and Tian Z. (2010): Opposite effects of high and low doses of interleukin-2 on T cell-mediated hepatitis in mice (interleukin-2 on hepatitis). Hepatol. Int., 4, 641-648.
42. Zhu, J., Wang J., Sheng Y., Zou Y., Bo L., Wang F., Lou J., Fan X., Bao R., Wu Y., Chen F., Deng X. and Li J. (2012): Baica-lin improves survival in a murine model of polymicrobial sepsis via suppressing inflammatory response and lymphocyte apopto-sis. PLoS One, 7, e35523.