Silver nanoparticles induce tight junction disruption and astrocyte neurotoxicity in a rat blood-brain barrier primary triple coculture model

International Journal of Nanomedicine

Volumn 10, Issue , 2015, Pages 6105-6119

  Xu, Liming ^a,b   Dan, Mo ^a   Shao, Anliang ^a   Cheng, Xiang ^a,c   Zhang, Cuiping ^d   Ayokel, Robert A ^e   Takemura, Taro ^f   Hanagata, Nobutaka ^f   Niwa, Masami ^g,h   Watanabe, Daisuke ^g,h  

^a NATIONAL INSTITUTES FOR FOOD AND DRUG CONTROL   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c SOUTHWEST JIAOTONG UNIVERSITY   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

^e University of Kentucky   (United States)

^f NATIONAL INSTITUTE FOR MATERIALS SCIENCE   (Japan)

^g NAGASAKI UNIVERSITY   (Japan)

^h PharmaCo Cell Co Ltd   (Japan)

Author keywords

Ag nanoparticles; Antioxidant defense; Astrocytes; BBB model; Global gene expression analysis

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; NUCLEAR RECEPTOR NUR77; POLYSTYRENE; PROTEIN ZO1; SILVER NANOPARTICLE; THIOREDOXIN INTERACTING PROTEIN; TIGHT JUNCTION PROTEIN; METAL NANOPARTICLE; SILVER;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; CAPILLARY ENDOTHELIAL CELL; CELL EXPANSION; CELL ULTRASTRUCTURE; CELL VACUOLE; COCULTURE; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; ELECTRIC RESISTANCE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ASSOCIATION; INFLAMMATION; MEMBRANE PERMEABILITY; NEUROTOXICITY; NONHUMAN; PERICYTE; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; TIGHT JUNCTION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; BRAIN; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION PROFILING; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSPORT AT THE CELLULAR LEVEL; VASCULAR ENDOTHELIUM;

ANIMALS; ASTROCYTES; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; COCULTURE TECHNIQUES; ENDOTHELIUM, VASCULAR; GENE EXPRESSION PROFILING; METAL NANOPARTICLES; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, BIOLOGICAL; RATS; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SILVER; TIGHT JUNCTIONS;

EID: 84943146331     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S85265     Document Type: Article

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