Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing

Brain, Behavior, and Immunity

Volumn 48, Issue , 2015, Pages 205-221

  Schaafsma, W ^a   Zhang, X ^a   van Zomeren, K C ^a   Jacobs, S ^a   Georgieva, P B ^b   Wolf, S A ^b   Kettenmann, H ^b   Janova, H ^c   Saiepour, N ^c   Hanisch, U K ^c,d   Meerlo, P ^e   van den Elsen, P J ^f,g   Brouwer, N ^a   Boddeke, H W G M ^a   Eggen, B J L ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d UNIVERSITY OF LEIPZIG   (Germany)

^e UNIVERSITY OF GRONINGEN   (Netherlands)

^f LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^g VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Endotoxin tolerance; Epigenetic silencing; Innate immunity; Microglia

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; HISTONE H3; INTERLEUKIN 1BETA; NITRIC OXIDE; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR ALPHA; HISTONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; RELB PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CHROMATIN IMMUNOPRECIPITATION; ENVIRONMENTAL EXPOSURE; EPIGENETICS; FEMALE; GENE SILENCING; HISTONE MODIFICATION; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; MEMORY CONSOLIDATION; MENTAL PERFORMANCE; MICROGLIA; MICROGLIA BACTERIUM LIPOPOLYSACCHARIDE PRECONDITIONING; MOUSE; NERVE CELL CULTURE; NEUROMODULATION; NONHUMAN; PHAGOCYTOSIS; PHENOTYPE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; SPATIAL LEARNING; ANIMAL; DRUG EFFECTS; GENETIC EPIGENESIS; GENETICS; METABOLISM;

ANIMALS; EPIGENESIS, GENETIC; GENE SILENCING; HISTONES; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NF-KAPPA B; PROMOTER REGIONS, GENETIC; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84942991826     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2015.03.013     Document Type: Article

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