Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia

Circulation Research

Volumn 116, Issue 7, 2015, Pages 1120-1132

  Cai, Yujun ^a   Nagel, David J ^a   Zhou, Qian ^a   Cygnar, Katherine D ^c   Zhao, Haiqing ^c   Li, Faqian ^b   Pi, Xinchun ^d   Knight, Peter A ^a   Yan, Chen ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b Laboratory Medicine   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cyclic nucleotide phosphodiesterases, type 1C; Neointima formation; Smooth muscle cell

Indexed keywords

ADENOVIRUS VECTOR; ADENYLATE CYCLASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP PHOSPHODIESTERASE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1C; FORSKOLIN; GROWTH FACTOR RECEPTOR; IC 86340; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MEMBRANE PROTEIN; PHOSPHODIESTERASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TRANSMEMBRANE ADENYLATE CYCLASE; UNCLASSIFIED DRUG; VASCULAR TARGETING AGENT; CYCLIC AMP; LRP1 PROTEIN, HUMAN; PDE1C PROTEIN, HUMAN; PDE1C PROTEIN, MOUSE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; BLOOD VESSEL INJURY; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CORONARY ARTERY; DRUG POTENTIATION; EMBRYO; ENDOCYTOSIS; ENDOSOME; EX VIVO STUDY; EXPLANT; GENE EXPRESSION; GENETIC SCREENING; HEART MUSCLE CONTRACTILITY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MONOTHERAPY; MOUSE; NEOINTIMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; SAPHENOUS VEIN; SIGNAL TRANSDUCTION; VASCULAR DISEASE; VASCULAR REMODELING; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CAROTID ARTERY INJURY; CELL CULTURE; CELL DIVISION; CELL MOTION; CYTOLOGY; DEFICIENCY; ENZYME INDUCTION; ENZYMOLOGY; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN ANALYSIS; RAT; RNA INTERFERENCE; SMOOTH MUSCLE CELL; SPRAGUE DAWLEY RAT; VASCULAR SMOOTH MUSCLE;

ANIMALS; CAROTID ARTERY INJURIES; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 1; ENDOCYTOSIS; ENZYME INDUCTION; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-1; LYSOSOMES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEOINTIMA; PROTEIN INTERACTION MAPPING; PROTEIN STABILITY; PROTEOLYSIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84942981204     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.304408     Document Type: Article

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