Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons

Nature Neuroscience

Volumn 12, Issue 4, 2009, Pages 454-462

  Cygnar, Katherine D ^a   Zhao, Haiqing ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; PHOSPHODIESTERASE I;

ARTICLE; BRAIN NERVE CELL; CELLULAR DISTRIBUTION; ENZYME ACTIVITY; EUKARYOTIC FLAGELLUM; NOCICEPTIVE STIMULATION; NONHUMAN; OLFACTOMETRY; OLFACTORY MEMORY; PRIORITY JOURNAL; WILD TYPE;

1-METHYL-3-ISOBUTYLXANTHINE; ADAPTATION, PHYSIOLOGICAL; ANIMALS; CALCIUM; CALMODULIN; COMPUTER SIMULATION; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 1; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DOSE-RESPONSE RELATIONSHIP, DRUG; EVOKED POTENTIALS; MICE; MICE, KNOCKOUT; OLFACTORY MUCOSA; OLFACTORY RECEPTOR NEURONS; PENTANOLS; PHOSPHODIESTERASE INHIBITORS; REACTION TIME;

EID: 63649146754     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2289     Document Type: Article

References (38)

1. Firestein, S., Shepherd, G.M. & Werblin, F.S. Time course of the membrane current underlying sensory transduction in salamander olfactory receptor neurones. J. Physiol. (Lond.) 430, 135-158 (1990).
2. Lowe, G. & Gold, G.H. The spatial distributions of odorant sensitivity and odorantinduced currents in salamander olfactory receptor cells. J. Physiol. (Lond.) 442, 147-168 (1991).
3. Firestein, S. How the olfactory sys tem makes sense of scents. Nature 413, 211-218 (2001).
4. Ma, M. Encoding olfactory signals via multiple chemosensory systems. Crit. Rev. Biochem. Mol. Biol. 42, 463-480 (2007).
5. Kurahashi, T. & Yau, K.W. Co-existence of cationic and chloride components in odorantinduced current of vertebrate olfactory receptor cells. Nature 363, 71-74 (1993).
6. Kleene, S.J. Origin of the chloride current in olfactory transduction. Neuron 11, 123-132 (1993).
7. Lowe, G. & Gold, G.H. Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells. Nature 366, 283-286 (1993).
8. Reisert, J., Bauer, P.J., Yau, K.W. & Frings, S. The Ca-activated Cl channel and its control in rat olfactory receptor neurons. J. Gen. Physiol. 122, 349-363 (2003).
9. Firestein, S., Darrow, B. & Shepherd, G.M. Activation of the sensory current in salamander olfactory receptor neurons depends on a G protein-mediated cAMP second messenger system. Neuron 6, 825-835 (1991).
10. Boekhoff, I. & Breer, H. Termination of second messenger signaling in olfaction. Proc. Natl. Acad. Sci. USA 89, 471-474 (1992).
11. Yan, C. et al. Mole cular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. Proc. Natl. Acad. Sci. USA 92, 9677-9681 (1995).
12. Yan, C., Zhao, A.Z., Bentley, J.K. & Beavo, J.A. The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissuespecific manner. J. Biol. Chem. 271, 25699-25706 (1996).
13. Cherry, J.A. & Davis, R.L. A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons. J. Neurobiol. 28, 102-113 (1995).
14. Juilfs, D.M. et al. A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway. Proc. Natl. Acad. Sci. USA 94, 3388-3395 (1997).
15. Conti, M. & Beavo, J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu. Rev. Biochem. 76, 481-511 (2007).
16. Borisy, F.F. et al. Calcium/calmodulin-activated phosphodiesterase expressed in olfactory receptor neurons. J. Neurosci. 12, 915-923 (1992).
17. Scott, J.W. & Scott- Johnson, P.E. The electroolfactogram: a review of its history and uses. Microsc. Res. Tech. 58, 152-160 (2002).
18. 2+/CaM via the B1b subunit affects response termination, but not sensitivity to recurring stimulation. Neuron 58, 374-386 (2008).
19. 2+/calmodulin kinase II. J. Neurosci. 19, RC19 (1999).
20. Zufall, F. & Leinders-Zufall, T. The cellular and molecular basis of odor adaptation. Chem. Senses 25, 473-481 (2000).
21. Boccaccio, A., Lagostena, L., Hagen, V. & Menini, A. Fast adaptation in mouse olfactory sensory neurons does not require the activity of phosphodiesterase. J. Gen. Physiol. 128, 171-184 (2006).
22. Chen, C., Nakamura, T. & Koutalos, Y. Cyclic AMP diffusion coefficient in frog olfactory cilia. Biophys. J. 76, 2861-2867 (1999).
23. Kaupp, U.B. & Seifert, R. Cyclic nucleotide-gated ion channels. Physiol. Rev. 82, 769-824 (2002).
24. 2+ extrusion governs response recovery in frog olfactory receptor cells. J. Gen. Physiol. 112, 529-535 (1998).
25. Willoughby, D. & Cooper, D.M. Live-cell imaging of cAMP dynamics. Nat. Methods 5, 29-36 (2008).
26. Leinders-Zufall, T. et al. Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proc. Natl. Acad. Sci. USA 104, 14507-14512 (2007).
27. 2 by an olfactory subsystem in the mouse. Science 317, 953-957 (2007).
28. Wong, S.T. et al. Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. Neuron 27, 487-497 (2000).
29. Ma, M., Chen, W.R. & Shepherd, G.M. Electrophysiological characterization of rat and mouse olfactory receptor neurons from an intact epithelial preparation. J. Neurosci. Methods 92, 31-40 (1999).
30. Kurahashi, T. Activation by odorants of cation-selective conductance in the olfactory receptor cell isolated from the newt. J. Physiol. (Lond.) 419, 177-192 (1989).
31. Firestein, S. & Werblin, F. Odor-induced membrane currents in vertebrate-olfactory receptor neurons. Science 244, 79-82 (1989).
32. Wei, J. et al. Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in neurons: a mechanism for attenuation of olfactory signals. Neuron 21, 495-504 (1998).
33. 2+- calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons. Nature 368, 545-548 (1994).
34. Kurahashi, T. & Menini, A. Mechanism of odorant adaptation in the olfactory receptor cell. Nature 385, 725-729 (1997).
35. Bradley, J., Reuter, D. & Frings, S. Facilitation of calmodulin-mediated odor adaptation by cAMP-gated channel subunits. Science 294, 2176-2178 (2001).
36. 2+-calmodulin-dependent odor adaptation. Science 294, 2172-2175 (2001).
37. Anholt, R.R., Aebi, U. & Snyder, S.H. A partially purified preparation of isolated chemosensory cilia from the olfactory epithelium of the bullfrog, Rana catesbeiana. J. Neurosci. 6, 1962-1969 (1986).
38. Zhao, H. et al. Functional expression of a mammalian odorant receptor. Science 279, 237-242 (1998).