메뉴 건너뛰기




Volumn 7, Issue 1, 2015, Pages

Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN[1-42]; BIOLOGICAL MARKER; INTERLEUKIN 6; TAU PROTEIN; IL6 PROTEIN, HUMAN; SNCA PROTEIN, HUMAN;

EID: 84942940978     PISSN: None     EISSN: 17589193     Source Type: Journal    
DOI: 10.1186/s13195-015-0145-y     Document Type: Article
Times cited : (21)

References (62)
  • 1
    • 33847020433 scopus 로고    scopus 로고
    • Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells
    • Nakanishi M, Niidome T, Matsuda S, Akaike A, Kihara T, Sugimoto H. Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells. Eur J Neurosci. 2007;25:649-58. doi:10.1111/j.1460-9568.2007.05309.x.
    • (2007) Eur J Neurosci. , vol.25 , pp. 649-658
    • Nakanishi, M.1    Niidome, T.2    Matsuda, S.3    Akaike, A.4    Kihara, T.5    Sugimoto, H.6
  • 2
    • 77957241894 scopus 로고    scopus 로고
    • Astrocyte-derived interleukin-6 promotes specific neuronal differentiation of neural progenitor cells from adult hippocampus
    • Oh J, McCloskey MA, Blong CC, Bendickson L, Nilsen-Hamilton M, Sakaguchi DS. Astrocyte-derived interleukin-6 promotes specific neuronal differentiation of neural progenitor cells from adult hippocampus. J Neurosci Res. 2010;88:2798-809. doi:10.1002/jnr.22447.
    • (2010) J Neurosci Res. , vol.88 , pp. 2798-2809
    • Oh, J.1    McCloskey, M.A.2    Blong, C.C.3    Bendickson, L.4    Nilsen-Hamilton, M.5    Sakaguchi, D.S.6
  • 3
    • 12344331668 scopus 로고    scopus 로고
    • Interleukin-6 protects cultured cerebellar granule neurons against glutamate-induced neurotoxicity
    • Peng YP, Qiu YH, Lu JH, Wang JJ. Interleukin-6 protects cultured cerebellar granule neurons against glutamate-induced neurotoxicity. Neurosci Lett. 2005;374:192-6. doi:10.1016/j.neulet.2004.10.069.
    • (2005) Neurosci Lett. , vol.374 , pp. 192-196
    • Peng, Y.P.1    Qiu, Y.H.2    Lu, J.H.3    Wang, J.J.4
  • 4
    • 1542407681 scopus 로고    scopus 로고
    • Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices
    • Pizzi M, Sarnico I, Boroni F, Benarese M, Dreano M, Garotta G, et al. Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices. Mol Cell Neurosci. 2004;25:301-11. doi:10.1016/j.mcn.2003.10.022.
    • (2004) Mol Cell Neurosci. , vol.25 , pp. 301-311
    • Pizzi, M.1    Sarnico, I.2    Boroni, F.3    Benarese, M.4    Dreano, M.5    Garotta, G.6
  • 5
    • 58149360818 scopus 로고    scopus 로고
    • Interleukin-6 protects cerebellar granule neurons from NMDA-induced neurotoxicity
    • Wang XC, Qiu YH, Peng YP. Interleukin-6 protects cerebellar granule neurons from NMDA-induced neurotoxicity. Sheng Li Xue Bao. 2007;59:150-6.
    • (2007) Sheng Li Xue Bao. , vol.59 , pp. 150-156
    • Wang, X.C.1    Qiu, Y.H.2    Peng, Y.P.3
  • 6
    • 0029620390 scopus 로고
    • Interleukin-1 and tumor necrosis factor-α synergistically mediate neurotoxicity: Involvement of nitric oxide and of N-methyl-D-aspartate receptors
    • Chao CC, Hu S, Ehrlich L, Peterson PK. Interleukin-1 and tumor necrosis factor-α synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors. Brain Behav Immun. 1995;9:355-65.
    • (1995) Brain Behav Immun. , vol.9 , pp. 355-365
    • Chao, C.C.1    Hu, S.2    Ehrlich, L.3    Peterson, P.K.4
  • 8
    • 0028298627 scopus 로고
    • Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice
    • Steffensen SC, Campbell IL, Henriksen SJ. Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice. Brain Res. 1994;652:149-53.
    • (1994) Brain Res. , vol.652 , pp. 149-153
    • Steffensen, S.C.1    Campbell, I.L.2    Henriksen, S.J.3
  • 9
    • 0037079993 scopus 로고    scopus 로고
    • Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6
    • Vallières L, Campbell IL, Gage FH, Sawchenko PE. Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. J Neurosci. 2002;22:486-92.
    • (2002) J Neurosci. , vol.22 , pp. 486-492
    • Vallières, L.1    Campbell, I.L.2    Gage, F.H.3    Sawchenko, P.E.4
  • 10
    • 33748324658 scopus 로고    scopus 로고
    • Prenatal exposure to interleukin-6 results in hypertension and alterations in the renin-angiotensin system of the rat
    • Samuelsson AM, Alexanderson C, Mölne J, Haraldsson B, Hansell P, Holmäng A. Prenatal exposure to interleukin-6 results in hypertension and alterations in the renin-angiotensin system of the rat. J Physiol. 2006;575:855-67. doi:10.1113/jphysiol.2006.111260.
    • (2006) J Physiol. , vol.575 , pp. 855-867
    • Samuelsson, A.M.1    Alexanderson, C.2    Mölne, J.3    Haraldsson, B.4    Hansell, P.5    Holmäng, A.6
  • 12
    • 33750936288 scopus 로고    scopus 로고
    • Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers
    • Sparkman NL, Buchanan JB, Heyen JR, Chen J, Beverly JL, Johnson RW. Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers. J Neurosci. 2006;26:10709-16. doi:10.1523/JNEUROSCI.3376-06.2006.
    • (2006) J Neurosci. , vol.26 , pp. 10709-10716
    • Sparkman, N.L.1    Buchanan, J.B.2    Heyen, J.R.3    Chen, J.4    Beverly, J.L.5    Johnson, R.W.6
  • 13
    • 84911409757 scopus 로고    scopus 로고
    • Interleukin-6 predicts short-term global functional decline in the oldest old: Results from the BELFRAIL study
    • Adriaensen W, Matheï C, Vaes B, van Pottelbergh G, Wallemacq P, Degryse JM. Interleukin-6 predicts short-term global functional decline in the oldest old: results from the BELFRAIL study. Age (Dordr). 2014;36:9723. doi:10.1007/s11357-014-9723-3.
    • (2014) Age (Dordr) , vol.36 , pp. 9723
    • Adriaensen, W.1    Matheï, C.2    Vaes, B.3    Van Pottelbergh, G.4    Wallemacq, P.5    Degryse, J.M.6
  • 14
    • 77950354771 scopus 로고    scopus 로고
    • Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: The Edinburgh type 2 diabetes study
    • Marioni RE, Strachan MW, Reynolds RM, Lowe GD, Mitchell RJ, Fowkes FG, et al. Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes. 2010;59:710-3. doi:10.2337/db09-1163.
    • (2010) Diabetes , vol.59 , pp. 710-713
    • Marioni, R.E.1    Strachan, M.W.2    Reynolds, R.M.3    Lowe, G.D.4    Mitchell, R.J.5    Fowkes, F.G.6
  • 15
    • 0037072285 scopus 로고    scopus 로고
    • Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging
    • Weaver JD, Huang MH, Albert M, Harris T, Rowe JW, Seeman TE. Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging. Neurology. 2002;59:371-8.
    • (2002) Neurology , vol.59 , pp. 371-378
    • Weaver, J.D.1    Huang, M.H.2    Albert, M.3    Harris, T.4    Rowe, J.W.5    Seeman, T.E.6
  • 16
    • 30644477450 scopus 로고    scopus 로고
    • Interleukin-6 is associated with cognitive function: The Northern Manhattan Study
    • Wright CB, Sacco RL, Rundek T, Delman J, Rabbani L, Elkind M. Interleukin-6 is associated with cognitive function: the Northern Manhattan Study. J Stroke Cerebrovasc Dis. 2006;15:34-8. doi:10.1016/j.jstrokecerebrovasdis.2005.08.009.
    • (2006) J Stroke Cerebrovasc Dis. , vol.15 , pp. 34-38
    • Wright, C.B.1    Sacco, R.L.2    Rundek, T.3    Delman, J.4    Rabbani, L.5    Elkind, M.6
  • 17
    • 67649406060 scopus 로고    scopus 로고
    • Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity
    • Lindqvist D, Janelidze S, Hagell P, Erhardt S, Samuelsson M, Minthon L, et al. Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity. Biol Psychiatry. 2009;66:287-92. doi:10.1016/j.biopsych.2009.01.030.
    • (2009) Biol Psychiatry , vol.66 , pp. 287-292
    • Lindqvist, D.1    Janelidze, S.2    Hagell, P.3    Erhardt, S.4    Samuelsson, M.5    Minthon, L.6
  • 18
    • 84901586086 scopus 로고    scopus 로고
    • Potential biomarkers relating pathological proteins, neuroinflammatory factors and free radicals in PD patients with cognitive impairment: A cross-sectional study
    • Yu SY, Zuo LJ, Wang F, Chen ZJ, Hu Y, Wang YJ, et al. Potential biomarkers relating pathological proteins, neuroinflammatory factors and free radicals in PD patients with cognitive impairment: a cross-sectional study. BMC Neurol. 2014;14:113. doi:10.1186/1471-2377-14-113.
    • (2014) BMC Neurol. , vol.14 , pp. 113
    • Yu, S.Y.1    Zuo, L.J.2    Wang, F.3    Chen, Z.J.4    Hu, Y.5    Wang, Y.J.6
  • 19
    • 0029051259 scopus 로고
    • Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients
    • Huell M, Strauss S, Volk B, Berger M, Bauer J. Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients. Acta Neuropathol. 1995;89:544-51.
    • (1995) Acta Neuropathol. , vol.89 , pp. 544-551
    • Huell, M.1    Strauss, S.2    Volk, B.3    Berger, M.4    Bauer, J.5
  • 20
    • 0030014561 scopus 로고    scopus 로고
    • The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease
    • Hull M, Strauss S, Berger M, Volk B, Bauer J. The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease. Behav Brain Res. 1996;78:37-41.
    • (1996) Behav Brain Res. , vol.78 , pp. 37-41
    • Hull, M.1    Strauss, S.2    Berger, M.3    Volk, B.4    Bauer, J.5
  • 21
    • 33746310315 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Blennow K, de Leon MJ, Zetterberg H. Alzheimer's disease. Lancet. 2006;368:387-403. doi:10.1016/S0140-6736(06)69113-7.
    • (2006) Lancet , vol.368 , pp. 387-403
    • Blennow, K.1    De Leon, M.J.2    Zetterberg, H.3
  • 22
    • 16344382456 scopus 로고    scopus 로고
    • Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains
    • Imamura K, Hishikawa N, Ono K, Suzuki H, Sawada M, Nagatsu T, et al. Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains. Acta Neuropathol. 2005;109:141-50. doi:10.1007/s00401-004-0919-y.
    • (2005) Acta Neuropathol. , vol.109 , pp. 141-150
    • Imamura, K.1    Hishikawa, N.2    Ono, K.3    Suzuki, H.4    Sawada, M.5    Nagatsu, T.6
  • 23
    • 33144489150 scopus 로고    scopus 로고
    • Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium
    • McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65:1863-72.
    • (2005) Neurology , vol.65 , pp. 1863-1872
    • McKeith, I.G.1    Dickson, D.W.2    Lowe, J.3    Emre, M.4    O'Brien, J.T.5    Feldman, H.6
  • 24
    • 84883771075 scopus 로고    scopus 로고
    • Cerebrospinal fluid inflammatory markers in Parkinson's disease - Associations with depression, fatigue, and cognitive impairment
    • Lindqvist D, Hall S, Surova Y, Nielsen HM, Janelidze S, Brundin L, et al. Cerebrospinal fluid inflammatory markers in Parkinson's disease - associations with depression, fatigue, and cognitive impairment. Brain Behav Immun. 2013;33:183-9. doi:10.1016/j.bbi.2013.07.007.
    • (2013) Brain Behav Immun. , vol.33 , pp. 183-189
    • Lindqvist, D.1    Hall, S.2    Surova, Y.3    Nielsen, H.M.4    Janelidze, S.5    Brundin, L.6
  • 25
    • 32544435900 scopus 로고    scopus 로고
    • Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: A follow-up study
    • Hansson O, Zetterberg H, Buchhave P, Londos E, Blennow K, Minthon L. Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol. 2006;5:228-34. doi:10.1016/S1474-4422(06)70355-6.
    • (2006) Lancet Neurol. , vol.5 , pp. 228-234
    • Hansson, O.1    Zetterberg, H.2    Buchhave, P.3    Londos, E.4    Blennow, K.5    Minthon, L.6
  • 26
    • 84926147246 scopus 로고    scopus 로고
    • Physical exercise in MCI elderly promotes reduction of proinflammatory cytokines and improvements on cognition and BDNF peripheral levels
    • Nascimento CM, Pereira JR, de Andrade LP, Garuffi M, Talib LL, Forlenza OV, et al. Physical exercise in MCI elderly promotes reduction of proinflammatory cytokines and improvements on cognition and BDNF peripheral levels. Curr Alzheimer Res. 2014;11:799-805.
    • (2014) Curr Alzheimer Res. , vol.11 , pp. 799-805
    • Nascimento, C.M.1    Pereira, J.R.2    De Andrade, L.P.3    Garuffi, M.4    Talib, L.L.5    Forlenza, O.V.6
  • 27
    • 0034008318 scopus 로고    scopus 로고
    • Synergistic effects of interleukin-1β, interleukin-6, and tumor necrosis factor-α: Centralmonoamine, corticosterone, and behavioral variations
    • Brebner K, Hayley S, Zacharko R, Merali Z, Anisman H. Synergistic effects of interleukin-1β, interleukin-6, and tumor necrosis factor-α: centralmonoamine, corticosterone, and behavioral variations. Neuropsychopharmacology. 2000;22:566-80. doi:10.1016/S0893-133X(99)00166-9.
    • (2000) Neuropsychopharmacology , vol.22 , pp. 566-580
    • Brebner, K.1    Hayley, S.2    Zacharko, R.3    Merali, Z.4    Anisman, H.5
  • 28
    • 70349570588 scopus 로고    scopus 로고
    • Systemic inflammation and disease progression in Alzheimer disease
    • Holmes C, Cunningham C, Zotova E, Woolford J, Dean C, Kerr S, et al. Systemic inflammation and disease progression in Alzheimer disease. Neurology. 2009;73:768-74. doi:10.1212/WNL.0b013e3181b6bb95.
    • (2009) Neurology , vol.73 , pp. 768-774
    • Holmes, C.1    Cunningham, C.2    Zotova, E.3    Woolford, J.4    Dean, C.5    Kerr, S.6
  • 30
    • 0029417080 scopus 로고
    • Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
    • Blum-Degen D, Müller T, Kuhn W, Gerlach M, Przuntek H, Riederer P. Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci Lett. 1995;202:17-20.
    • (1995) Neurosci Lett. , vol.202 , pp. 17-20
    • Blum-Degen, D.1    Müller, T.2    Kuhn, W.3    Gerlach, M.4    Przuntek, H.5    Riederer, P.6
  • 31
    • 20344393856 scopus 로고    scopus 로고
    • 1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia
    • 1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia. Neurosci Lett. 2005;383:12-6. doi:10.1016/j.neulet.2005.03.051.
    • (2005) Neurosci Lett. , vol.383 , pp. 12-16
    • Jia, J.P.1    Meng, R.2    Sun, Y.X.3    Sun, W.J.4    Ji, X.M.5    Jia, L.F.6
  • 32
    • 0343569927 scopus 로고    scopus 로고
    • Increased cerebrospinal fluid Fas (Apo-1) levels in Alzheimer's disease: Relationship with IL-6 concentrations
    • Martínez M, Fernández-Vivancos E, Frank A, De la Fuente M, Hernanz A. Increased cerebrospinal fluid Fas (Apo-1) levels in Alzheimer's disease: relationship with IL-6 concentrations. Brain Res. 2000;869:216-9.
    • (2000) Brain Res. , vol.869 , pp. 216-219
    • Martínez, M.1    Fernández-Vivancos, E.2    Frank, A.3    De La-Fuente, M.4    Hernanz, A.5
  • 33
    • 0028938729 scopus 로고
    • Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia
    • Yamada K, Kono K, Umegaki H, Iguchi A, Fukatsu T, Nakashima N, et al. Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia. Neurosci Lett. 1995;186:219-21.
    • (1995) Neurosci Lett. , vol.186 , pp. 219-221
    • Yamada, K.1    Kono, K.2    Umegaki, H.3    Iguchi, A.4    Fukatsu, T.5    Nakashima, N.6
  • 34
    • 0032981238 scopus 로고    scopus 로고
    • Unchanged levels of interleukins, neopterin, interferon-γ and tumor necrosis factor-α in cerebrospinal fluid of patients with dementia of the Alzheimer type
    • Engelborghs S, De Brabander M, De Cree J, D'Hooge R, Geerts H, Verhaegen H, et al. Unchanged levels of interleukins, neopterin, interferon-γ and tumor necrosis factor-α in cerebrospinal fluid of patients with dementia of the Alzheimer type. Neurochem Int. 1999;34:523-30.
    • (1999) Neurochem Int. , vol.34 , pp. 523-530
    • Engelborghs, S.1    De Brabander, M.2    De Cree, J.3    D'Hooge, R.4    Geerts, H.5    Verhaegen, H.6
  • 35
    • 0344333426 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients
    • März P, Heese K, Hock C, Golombowski S, Müller-Spahn F, Rose-John S, et al. Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients. Neurosci Lett. 1997;239:29-32.
    • (1997) Neurosci Lett. , vol.239 , pp. 29-32
    • März, P.1    Heese, K.2    Hock, C.3    Golombowski, S.4    Müller-Spahn, F.5    Rose-John, S.6
  • 36
    • 0042421736 scopus 로고    scopus 로고
    • Cerebrospinal fluid markers in dementia with Lewy bodies compared with Alzheimer disease
    • Gómez-Tortosa E, Gonzalo I, Fanjul S, Sainz MJ, Cantarero S, Cemillán C, et al. Cerebrospinal fluid markers in dementia with Lewy bodies compared with Alzheimer disease. Arch Neurol. 2003;60:1218-22. doi:10.1001/archneur.60.9.1218.
    • (2003) Arch Neurol. , vol.60 , pp. 1218-1222
    • Gómez-Tortosa, E.1    Gonzalo, I.2    Fanjul, S.3    Sainz, M.J.4    Cantarero, S.5    Cemillán, C.6
  • 38
    • 84872189834 scopus 로고    scopus 로고
    • Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy
    • Wennström M, Surova Y, Hall S, Nilsson C, Minthon L, Boström F, et al. Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy. PLoS One. 2013;8:e53250. doi:10.1371/journal.pone.0053250.
    • (2013) PLoS One , vol.8 , pp. e53250
    • Wennström, M.1    Surova, Y.2    Hall, S.3    Nilsson, C.4    Minthon, L.5    Boström, F.6
  • 39
    • 84870465485 scopus 로고
    • 4th ed. Washington, DC: American Psychiatric Press
    • American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Press; 1994.
    • (1994) Diagnostic and Statistical Manual of Mental Disorders
  • 40
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939-44.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 41
    • 0006164301 scopus 로고    scopus 로고
    • Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the Consortium on DLB international workshop
    • McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB international workshop. Neurology. 1996;47:1113-24.
    • (1996) Neurology , vol.47 , pp. 1113-1124
    • McKeith, I.G.1    Galasko, D.2    Kosaka, K.3    Perry, E.K.4    Dickson, D.W.5    Hansen, L.A.6
  • 42
    • 0016823810 scopus 로고
    • "Mini-mental state": A practical method for grading the cognitive state of patients for the clinician
    • Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-98.
    • (1975) J Psychiatr Res. , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 43
    • 84858136734 scopus 로고    scopus 로고
    • Altered CSF orexin and alpha-synuclein levels in dementia patients
    • Wennström M, Londos E, Minthon L, Nielsen HM. Altered CSF orexin and alpha-synuclein levels in dementia patients. J Alzheimers Dis. 2012;29:125-32. doi:10.3233/JAD-2012-111655.
    • (2012) J Alzheimers Dis. , vol.29 , pp. 125-132
    • Wennström, M.1    Londos, E.2    Minthon, L.3    Nielsen, H.M.4
  • 44
  • 45
    • 0030855888 scopus 로고    scopus 로고
    • Serum interleukin-6 levels correlate with the severity of dementia in Down syndrome and in Alzheimer's disease
    • Kálmán J, Juhász A, Laird G, Dickens P, Járdánházy T, Rimanóczy A, et al. Serum interleukin-6 levels correlate with the severity of dementia in Down syndrome and in Alzheimer's disease. Acta Neurol Scand. 1997;96:236-40.
    • (1997) Acta Neurol Scand. , vol.96 , pp. 236-240
    • Kálmán, J.1    Juhász, A.2    Laird, G.3    Dickens, P.4    Járdánházy, T.5    Rimanóczy, A.6
  • 46
    • 0034051068 scopus 로고    scopus 로고
    • Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty
    • Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med. 2000;51:245-70. doi:10.1146/annurev.med.51.1.245.
    • (2000) Annu Rev Med. , vol.51 , pp. 245-270
    • Ershler, W.B.1    Keller, E.T.2
  • 48
    • 78549294808 scopus 로고    scopus 로고
    • Association between male gender and cortical Lewy body pathology in large autopsy series
    • Nelson PT, Schmitt FA, Jicha GA, Kryscio RJ, Abner EL, Smith CD, et al. Association between male gender and cortical Lewy body pathology in large autopsy series. J Neurol. 2010;257:1875-81. doi:10.1007/S00415-010-5630-4.
    • (2010) J Neurol. , vol.257 , pp. 1875-1881
    • Nelson, P.T.1    Schmitt, F.A.2    Jicha, G.A.3    Kryscio, R.J.4    Abner, E.L.5    Smith, C.D.6
  • 49
    • 84989182833 scopus 로고    scopus 로고
    • Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease
    • Hansson O, Hall S, Ohrfelt A, Zetterberg H, Blennow K, Minthon L, et al. Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease. Alzheimers Res Ther. 2014;6:25. doi:10.1186/alzrt255.
    • (2014) Alzheimers Res Ther. , vol.6 , pp. 25
    • Hansson, O.1    Hall, S.2    Ohrfelt, A.3    Zetterberg, H.4    Blennow, K.5    Minthon, L.6
  • 50
    • 77953716788 scopus 로고    scopus 로고
    • Differential levels of α-synuclein, β-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease
    • Kasuga K, Tokutake T, Ishikawa A, Uchiyama T, Tokuda T, Onodera O, et al. Differential levels of α-synuclein, β-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2010;81:608-10. doi:10.1136/jnnp.2009.197483.
    • (2010) J Neurol Neurosurg Psychiatry , vol.81 , pp. 608-610
    • Kasuga, K.1    Tokutake, T.2    Ishikawa, A.3    Uchiyama, T.4    Tokuda, T.5    Onodera, O.6
  • 51
    • 79951720856 scopus 로고    scopus 로고
    • α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: A cohort study
    • A published erratum appears in Lancet Neurol. 2011;10:297
    • Mollenhauer B, Locascio JJ, Schulz-Schaeffer W, Sixel-Döring F, Trenkwalder C, Schlossmacher MG. α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study. Lancet Neurol. 2011;10:230-40. doi:10.1016/S1474-4422(11)70014-X. A published erratum appears in Lancet Neurol. 2011;10:297.
    • (2011) Lancet Neurol. , vol.10 , pp. 230-240
    • Mollenhauer, B.1    Locascio, J.J.2    Schulz-Schaeffer, W.3    Sixel-Döring, F.4    Trenkwalder, C.5    Schlossmacher, M.G.6
  • 52
    • 79960613150 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau/α-synuclein ratio in Parkinson's disease and degenerative dementias
    • Parnetti L, Chiasserini D, Bellomo G, Giannandrea D, De Carlo C, Qureshi MM, et al. Cerebrospinal fluid tau/α-synuclein ratio in Parkinson's disease and degenerative dementias. Mov Disord. 2011;26:1428-35. doi:10.1002/mds.23670.
    • (2011) Mov Disord. , vol.26 , pp. 1428-1435
    • Parnetti, L.1    Chiasserini, D.2    Bellomo, G.3    Giannandrea, D.4    De Carlo, C.5    Qureshi, M.M.6
  • 53
    • 84865756966 scopus 로고    scopus 로고
    • α-Synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease
    • Tateno F, Sakakibara R, Kawai T, Kishi M, Murano T. α-Synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease. Alzheimer Dis Assoc Disord. 2012;26:213-6. doi:10.1097/WAD.0b013e31823899cc.
    • (2012) Alzheimer Dis Assoc Disord. , vol.26 , pp. 213-216
    • Tateno, F.1    Sakakibara, R.2    Kawai, T.3    Kishi, M.4    Murano, T.5
  • 54
    • 49449105990 scopus 로고    scopus 로고
    • Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration
    • Mollenhauer B, Cullen V, Kahn I, Krastins B, Outeiro TF, Pepivani I, et al. Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Exp Neurol. 2008;213:315-25. doi:10.1016/j.expneurol.2008.06.004.
    • (2008) Exp Neurol. , vol.213 , pp. 315-325
    • Mollenhauer, B.1    Cullen, V.2    Kahn, I.3    Krastins, B.4    Outeiro, T.F.5    Pepivani, I.6
  • 55
    • 84911130038 scopus 로고    scopus 로고
    • Reduced α-synuclein in cerebrospinal fluid in synucleinopathies: Evidence from a meta-analysis
    • Sako W, Murakami N, Izumi Y, Kaji R. Reduced α-synuclein in cerebrospinal fluid in synucleinopathies: evidence from a meta-analysis. Mov Disord. 2014;29:1599-605. doi:10.1002/mds.26036.
    • (2014) Mov Disord. , vol.29 , pp. 1599-1605
    • Sako, W.1    Murakami, N.2    Izumi, Y.3    Kaji, R.4
  • 56
    • 58149374375 scopus 로고    scopus 로고
    • CSF α-synuclein levels in dementia with Lewy bodies and Alzheimer's disease
    • Noguchi-Shinohara M, Tokuda T, Yoshita M, Kasai T, Ono K, Nakagawa M, et al. CSF α-synuclein levels in dementia with Lewy bodies and Alzheimer's disease. Brain Res. 2009;1251:1-6. doi:10.1016/j.brainres.2008.11.055.
    • (2009) Brain Res. , vol.1251 , pp. 1-6
    • Noguchi-Shinohara, M.1    Tokuda, T.2    Yoshita, M.3    Kasai, T.4    Ono, K.5    Nakagawa, M.6
  • 57
    • 60349122813 scopus 로고    scopus 로고
    • Cerebrospinal fluid α-synuclein does not discriminate between dementia disorders
    • Spies PE, Melis RJ, Sjögren MJ, Rikkert MG, Verbeek MM. Cerebrospinal fluid α-synuclein does not discriminate between dementia disorders. J Alzheimers Dis. 2009;16:363-9. doi:10.3233/JAD-2009-0955.
    • (2009) J Alzheimers Dis. , vol.16 , pp. 363-369
    • Spies, P.E.1    Melis, R.J.2    Sjögren, M.J.3    Rikkert, M.G.4    Verbeek, M.M.5
  • 58
    • 84896730461 scopus 로고    scopus 로고
    • The diagnostic value of CSF α-synuclein in the differential diagnosis of dementia with Lewy bodies vs normal subjects and patients with Alzheimer's disease
    • Kapaki E, Paraskevas GP, Emmanouilidou E, Vekrellis K. The diagnostic value of CSF α-synuclein in the differential diagnosis of dementia with Lewy bodies vs normal subjects and patients with Alzheimer's disease. PLoS One. 2013;8, e81654. doi:10.1371/journal.pone.0081654.
    • (2013) PLoS One , vol.8 , pp. e81654
    • Kapaki, E.1    Paraskevas, G.P.2    Emmanouilidou, E.3    Vekrellis, K.4
  • 59
    • 84902692007 scopus 로고    scopus 로고
    • Glimepiride reduces CD14 expression and cytokine secretion from macrophages
    • Ingham V, Williams A, Bate C. Glimepiride reduces CD14 expression and cytokine secretion from macrophages. J Neuroinflammation. 2014;11:115. doi:10.1186/1742-2094-11-115.
    • (2014) J Neuroinflammation , vol.11 , pp. 115
    • Ingham, V.1    Williams, A.2    Bate, C.3
  • 60
    • 20144389524 scopus 로고    scopus 로고
    • Aggregated α-synuclein activates microglia: A process leading to disease progression in Parkinson's disease
    • Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, et al. Aggregated α-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005;19:533-42. doi:10.1096/fj.04-2751com.
    • (2005) FASEB J. , vol.19 , pp. 533-542
    • Zhang, W.1    Wang, T.2    Pei, Z.3    Miller, D.S.4    Wu, X.5    Block, M.L.6
  • 61
    • 84912113143 scopus 로고    scopus 로고
    • Complex deregulation and expression of cytokines and mediators of the immune response in Parkinson's disease brain is region dependent
    • Garcia-Esparcia P, Llorens F, Carmona M, Ferrer I. Complex deregulation and expression of cytokines and mediators of the immune response in Parkinson's disease brain is region dependent. Brain Pathol. 2014;24:584-98. doi:10.1111/bpa.12137.
    • (2014) Brain Pathol. , vol.24 , pp. 584-598
    • Garcia-Esparcia, P.1    Llorens, F.2    Carmona, M.3    Ferrer, I.4
  • 62
    • 0031857454 scopus 로고    scopus 로고
    • Interleukin-6 levels in cerebrospinal fluid inversely correlate to severity of Parkinson's disease
    • Müller T, Blum-Degen D, Przuntek H, Kuhn W. Interleukin-6 levels in cerebrospinal fluid inversely correlate to severity of Parkinson's disease. Acta Neurol Scand. 1998;98:142-4.
    • (1998) Acta Neurol Scand. , vol.98 , pp. 142-144
    • Müller, T.1    Blum-Degen, D.2    Przuntek, H.3    Kuhn, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.