Interleukin-6 predicts short-term global functional decline in the oldest old: results from the BELFRAIL study

Age

Volumn 36, Issue 6, 2014, Pages 1-14

  Adriaensen, Wim ^a,b   Matheï, Catharina ^a   Vaes, Bert ^a,b   van Pottelbergh, Gijs ^a   Wallemacq, Pierre ^c   Degryse, Jean Marie ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Chronic inflammation; Global functional decline; IL 6; Oldest old; Risk indicator

Indexed keywords

ACUTE PHASE PROTEIN; ANTIINFLAMMATORY AGENT; CYTOKINE; GROWTH FACTOR; INTERLEUKIN 6; AUTACOID;

ACUTE PHASE PROTEIN BLOOD LEVEL; AGED; ARTICLE; BELGIUM; CHRONIC INFLAMMATION; COGNITIVE DEFECT; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE BLOOD LEVEL; DEPRESSION; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; FUNCTIONAL ASSESSMENT; FUNCTIONAL DISEASE; FUNCTIONAL STATUS; GROWTH FACTOR BLOOD LEVEL; HUMAN; INTERLEUKIN 6 BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; OBSERVATIONAL STUDY; PHYSICAL CAPACITY; PHYSICAL DISABILITY; PHYSICAL PERFORMANCE; POPULATION RESEARCH; PREDICTION; PREDICTIVE VALUE; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; REFERENCE VALUE; RISK ASSESSMENT; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; VERY ELDERLY; AGING; BLOOD; COGNITION DISORDERS; COMPARATIVE STUDY; DAILY LIFE ACTIVITY; GERIATRIC ASSESSMENT; MENTAL CAPACITY; METABOLISM; PHYSIOLOGY; PROCEDURES; PSYCHOLOGY; STATISTICAL MODEL; TIME;

ACTIVITIES OF DAILY LIVING; AGED, 80 AND OVER; AGING; BELGIUM; COGNITION DISORDERS; COHORT STUDIES; FEMALE; GERIATRIC ASSESSMENT; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; LOGISTIC MODELS; MALE; MENTAL COMPETENCY; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RISK ASSESSMENT; TIME FACTORS;

EID: 84911409757     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-014-9723-3     Document Type: Article

References (42)

1. Adriaensen W, Mathei C, van Pottelbergh G, Vaes B, Legrand D, Wallemacq P, Degryse JM (2014) Significance of serum immune markers in identification of global functional impairment in the oldest old: cross-sectional results from the BELFRAIL study. Age (Dordr) 36(1):457–467. doi:10.1007/s11357-013-9558-3
2. Alexandraki K, Piperi C, Kalofoutis C, Singh J, Alaveras A, Kalofoutis A (2006) Inflammatory process in type 2 diabetes: the role of cytokines. Ann N Y Acad Sci 1084:89–117. doi:10.1196/annals.1372.039
3. Badolato R, Oppenheim J (1995) Role of cytokines, acute-phase proteins, and chemokines in the progression of rheumatoid arthritis. Semin Arthritis Rheum 26(2):526–538
4. Banks W, Kastin A, Broadwell R (1995) Passage of cytokines across the blood-brain barrier. Neuroimmunomodulation 2(4):241–248
5. Baune BT, Ponath G, Golledge J, Varga G, Arolt V, Rothermundt M, Berger K (2008) Association between IL-8 cytokine and cognitive performance in an elderly general population—the MEMO-Study. Neurobiol Aging 29(6):937–944. doi:10.1016/j.neurobiolaging.2006.12.003
6. Beenakker K, Ling C, Meskers C, de Craen A, Stijnen T, Westendorp R, Maier A (2010) Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state. Ageing Res Rev 9(4):431–436. doi:10.1016/j.arr.2010.05.005
7. Bremmer MA, Beekman AT, Deeg DJ, Penninx BW, Dik MG, Hack CE, Hoogendijk WJ (2008) Inflammatory markers in late-life depression: results from a population-based study. J Affect Disord 106(3):249–255. doi:10.1016/j.jad.2007.07.002
8. Brinkley TE, Leng X, Miller ME, Kitzman DW, Pahor M, Berry MJ, Marsh AP, Kritchevsky SB, Nicklas BJ (2009) Chronic inflammation is associated with low physical function in older adults across multiple comorbidities. J Gerontol A Biol Sci Med Sci 64(4):455–461. doi:10.1093/gerona/gln038
9. Charlson M, Pompei P, Ales K, MacKenzie C (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373–383
10. Christian LM, Glaser R, Porter K, Malarkey WB, Beversdorf D, Kiecolt-Glaser JK (2011) Poorer self-rated health is associated with elevated inflammatory markers among older adults. Psychoneuroendocrinology 36(10):1495–1504. doi:10.1016/j.psyneuen.2011.04.003
11. Cohen H, Pieper C, Harris T, Rao K, Currie M (1997) The association of plasma IL-6 levels with functional disability in community-dwelling elderly. J Gerontol A: Biol Med Sci 52(4):M201–M208
12. Dik MG, Jonker C, Hack CE, Smit JH, Comijs HC, Eikelenboom P (2005) Serum inflammatory proteins and cognitive decline in older persons. Neurology 64(8):1371–1377. doi:10.1212/01.WNL.0000158281.08946.68
13. Dimopoulos N, Piperi C, Psarra V, Lea RW, Kalofoutis A (2008) Increased plasma levels of 8-iso-PGF2alpha and IL-6 in an elderly population with depression. Psychiatry Res 161(1):59–66. doi:10.1016/j.psychres.2007.07.019
14. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctot KL (2010) A meta-analysis of cytokines in major depression. Biol Psychiatry 67(5):446–457. doi:10.1016/j.biopsych.2009.09.033
15. Economos A, Wright CB, Moon YP, Rundek T, Rabbani L, Paik MC, Sacco RL, Elkind MS (2013) Interleukin 6 plasma concentration associates with cognitive decline: the northern Manhattan study. Neuroepidemiology 40(4):253–259. doi:10.1159/000343276
16. Ferrucci L, Harris T, Guralnik J, Tracy R, Corti M, Cohen H, Penninx B, Pahor M, Wallace R, Havlik R (1999) Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc 47(6):639–646
17. Ferrucci L, Penninx B, Volpato S, Harris T, Bandeen-Roche K, Balfour J, Leveille S, Fried L, Md J (2002) Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J Am Geriatr Soc 50(12):1947–1954
18. Gimeno D, Marmot MG, Singh-Manoux A (2008) Inflammatory markers and cognitive function in middle-aged adults: the Whitehall II study. Psychoneuroendocrinology 33(10):1322–1334. doi:10.1016/j.psyneuen.2008.07.006
19. Gimeno D, Kivimaki M, Brunner EJ, Elovainio M, De Vogli R, Steptoe A, Kumari M, Lowe GD, Rumley A, Marmot MG, Ferrie JE (2009) Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychol Med 39(3):413–423. doi:10.1017/S0033291708003723
20. Harris T, Ferrucci L, Tracy R, Corti M, Wacholder S, Ettinger WJ, Heimovitz H, Cohen H, Wallace R (1999) Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med 106(5):506–512
21. Joppa P, Petrasova D, Stancak B, Tkacova R (2006) Systemic inflammation in patients with COPD and pulmonary hypertension. Chest 130(2):326–333. doi:10.1378/chest.130.2.326
22. Legrand D, Adriaensen W, Vaes B, Mathei C, Wallemacq P, Degryse J (2013) The relationship between grip strength and muscle mass (MM), inflammatory biomarkers and physical performance in community-dwelling very old persons. Arch Gerontol Geriatr 57(3):345–351. doi:10.1016/j.archger.2013.06.003
23. Lumley T, Diehr P, Emerson S, Chen L (2002) The importance of the normality assumption in large public health data sets. Annu Rev Public Health 23:151–169. doi:10.1146/annurev.publheath.23.100901.140546
24. McAfoose J, Baune B (2009) Evidence for a cytokine model of cognitive function. Neurosci Biobehav Rev 33(3):355–366
25. Mooijaart SP, Sattar N, Trompet S, Lucke J, Stott DJ, Ford I, Jukema JW, Westendorp RG, de Craen AJ (2013) Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study. J Intern Med 274(1):77–85. doi:10.1111/joim.12052
26. Penninx B, Kritchevsky S, Newman A, Nicklas B, Simonsick E, Rubin S, Nevitt M, Visser M, Harris T, Pahor M (2004) Inflammatory markers and incident mobility limitation in the elderly. J Am Geriatr Soc 52(7):1105–1113
27. Picotte M, Campbell CG, Thorland WG (2009) Day-to-day variation in plasma interleukin-6 concentrations in older adults. Cytokine 47(3):162–165. doi:10.1016/j.cyto.2009.05.007
28. Rao K, Pieper C, Currie M, Cohen H (1994) Variability of plasma IL-6 and crosslinked fibrin dimers over time in community dwelling elderly subjects. Am J Clin Pathol 102(6):802–805
29. Roubenoff R, Hughes V (2000) Sarcopenia: current concepts. J Gerontol A: Biol Med Sci 55(12):M716–M724
30. Schaap LA, Pluijm SM, Deeg DJ, Harris TB, Kritchevsky SB, Newman AB, Colbert LH, Pahor M, Rubin SM, Tylavsky FA, Visser M (2009) Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strength. J Gerontol A Biol Sci Med Sci 64(11):1183–1189. doi:10.1093/gerona/glp097
31. Schram MT, Euser SM, de Craen AJ, Witteman JC, Frolich M, Hofman A, Jolles J, Breteler MM, Westendorp RG (2007) Systemic markers of inflammation and cognitive decline in old age. J Am Geriatr Soc 55(5):708–716. doi:10.1111/j.1532-5415.2007.01159.x
32. Singh T, Newman AB (2011) Inflammatory markers in population studies of aging. Ageing Res Rev 10(3):319–329. doi:10.1016/j.arr.2010.11.002
33. Speer D, Greenbaum P (1995) Five methods for computing significant individual client change and improvement rates: support for an individual growth curve approach. J Consult Clin Psychol 63(6):1044–1048
34. Stenholm S, Maggio M, Lauretani F, Bandinelli S, Ceda G, Di Iorio A, Giallauria F, Guralnik J, Ferrucci L (2010) Anabolic and catabolic biomarkers as predictors of muscle strength decline: the InCHIANTI study. Rejuvenation Res 13(1):3–11. doi:10.1089/rej.2009.0891
35. Taaffe D, Harris T, Ferrucci L, Rowe J, Seeman T (2000) Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur Studies of Successful Aging. J Gerontol A: Biol Med Sci 55A(12):M709–M715
36. Vaes B, Pasquet A, Wallemacq P, Rezzoug N, Mekouar H, Olivier PA, Legrand D, Mathei C, Van Pottelbergh G, Degryse J (2010) The BELFRAIL (BFC80+) study: a population-based prospective cohort study of the very elderly in Belgium. BMC Geriatr 10:39. doi:10.1186/1471-2318-10-39
37. van den Biggelaar AH, Gussekloo J, de Craen AJ, Frolich M, Stek ML, van der Mast RC, Westendorp RG (2007) Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age. Exp Gerontol 42(7):693–701. doi:10.1016/j.exger.2007.01.011
38. Vasan R, Sullivan L, D’Agostino R, Roubenoff R, Harris T, Sawyer D, Levy D, Wilson P (2003) Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study. Ann Intern Med 139(8):642–648
39. Verghese J, Holtzer R, Oh-Park M, Derby CA, Lipton RB, Wang C (2011) Inflammatory markers and gait speed decline in older adults. J Gerontol A Biol Sci Med Sci 66(10):1083–1089. doi:10.1093/gerona/glr099
40. Weaver JD, Huang MH, Albert M, Harris T, Rowe JW, Seeman TE (2002) Interleukin-6 and risk of cognitive decline: MacArthur Studies of Successful Aging. Neurology 59(3):371–378. doi:10.1212/wnl.59.3.371
41. Wright C, Sacco R, Rundek T, Delman J, Rabbani L, Elkind M (2006) Interleukin-6 is associated with cognitive function: the Northern Manhattan Study. J Stroke Cerebrovasc Dis 15(1):34–38
42. Yudkin J, Kumari M, Humphries S, Mohamed-Ali V (2000) Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 148(2):209–214