Integration of high-content screening and untargeted metabolomics for comprehensive functional annotation of natural product libraries

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 39, 2015, Pages 11999-12004

  Kurita, Kenji L ^a   Glassey, Emerson ^a   Linington, Roger G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SIMON FRASER UNIVERSITY   (Canada)

Author keywords

Bioactive small molecules; Image based screening; Informatics; Metabolomics; Natural products

Indexed keywords

NATURAL PRODUCT; QUINOCINNOLINOMYCIN A; QUINOCINNOLINOMYCIN B; QUINOCINNOLINOMYCIN C; QUINOCINNOLINOMYCIN D; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT;

ANALYTIC METHOD; ARTICLE; COMPOUND ACTIVITY MAPPING; CYTOLOGY; ENDOPLASMIC RETICULUM STRESS; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; METABOLOMICS; MOLECULAR LIBRARY; PHENOTYPE; PRIORITY JOURNAL; PROBABILITY; PROTEIN UNFOLDING; DATA BASE; DRUG DEVELOPMENT; IMAGE PROCESSING; INFORMATION PROCESSING; PROCEDURES; STANDARDS;

BIOLOGICAL PRODUCTS; DATA CURATION; DATABASES AS TOPIC; DRUG DISCOVERY; HELA CELLS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; METABOLOMICS;

EID: 84942876357     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1507743112     Document Type: Article

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