Expression of IL-37 contributes to the immunosuppressive property of human CD4 + CD25 + regulatory T cells

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Shuai, Xu ^a,b   Wei Min, Li ^b   Tong, Ya Lin ^c   Dong, Ning ^a   Sheng, Zhi Yong ^a   Yao, Yong Ming ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b 309TH HOSPITAL OF PLA   (China)

^c 181St Hospital of PLA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL10 PROTEIN, HUMAN; IL37 PROTEIN, HUMAN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA;

CELL DIFFERENTIATION; COCULTURE; CYTOLOGY; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; IMMUNOMODULATION; LYMPHOCYTE ACTIVATION; METABOLISM; PHENOTYPE; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

BIOMARKERS; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; CTLA-4 ANTIGEN; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; HUMANS; IMMUNOMODULATION; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; PHENOTYPE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 84942865248     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep14478     Document Type: Article

References (43)

1. Gershon, R. K. & Kondo, K. Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology. 18, 723-737 (1970).
2. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-Tolerance maintained by activated T cells expressing IL-2 receptor alpha chains CD25: breakdown of a single mechanism of self-Tolerance causes various autoimmune diseases. J Immunol. 155, 1151-1164 (1995).
3. Asano, M., Toda, M., Sakaguchi, N. & Sakaguchi, S. Autoimmune disease as a consequence of developmental abnormality of a T-cell subpopulation. J Exp Med. 184, 387-396 (1996).
4. Sakaguchi, S., Setoguchi, R., Yagi, H. & Nomura, T. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in selftolerance and autoimmune disease. Curr Top Microbiol Immunol. 305, 51-66 (2006).
5. Jonuleit, H., Schmitt, E. & Stassen, M. Identification and functional characterization of human CD4+CD25+ T cells with regulatory properties isolated from peripheral blood. J Exp Med. 193, 1285-1294 (2001).
6. Fontenot, J. D., Gavin, M. A. & Rudensky, A. Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 4, 330-336 (2003).
7. Fontenot, J. D. et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity. 22, 329-341 (2005).
8. Crellin, N. K. et al. Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells. J. Immunol. 175, 8051-8059 (2005).
9. Becker, C., Fantini, M. C. & Neurath, M. F. TGF-beta as a T cell regulator in colitis and colon cancer. Cytokine Growth Factor Rev. 17, 97-106 (2006).
10. Feuerer, M., Hill, J. A., Mathis, D. & Benoist, C. Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol. 10, 689-695 (2009).
11. Dinarello, C. A. The IL-1 family and inflammatory diseases. Clin Exp Rheumatol. 20, S1-13 (2002).
12. Nold, M. F. et al. IL-37 is a fundamental inhibitor of innate immunity. Nat lmmunol. 11, 1014-1022 (2010).
13. Akdis, M. et al. Interleukins, 1 to 37, and interferon-γ : receptors, functions, and roles in disease. Allergy Clin Immunol. 3, 701-721 (2011).
14. Boraschi, D. et al. IL-37: a new anti-inflammatory cytokine of the IL-1 family. Eur Cytokine Netw. 22, 127-147 (2011).
15. McNamee, E. N. et al. Interleukin 37 expression protects mice from colitis. Proc Natl Acad Sci USA. 108, 16711-16716 (2011).
16. Alexander, R. M. et al. Adipose and liver expression of interleukin (IL)-1 family members in morbid obesity and effects of weight loss. Mol Med. 7, 840-845 (2011).
17. Bulau, A. M. et al. In vivo expression of interleukin-37 reduces local and systemic inflammation in concanavalin A-induced hepatitis. Scientific World J. 11, 2480-2490 (2011).
18. Gao, W. et al. Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-l2-dependent adaptive and profound antitumor immunity. J Immunol. 170, l07-113 (2003).
19. Luo, Y. et al. Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells. Proc Natl Acad Sci USA. 111, 15178-15183 (2014).
20. Bufer, P. et al. A complex of the IL-1 homologue IL-1 F7b and IL-18-binding protein reduces IL-18 activity through binding to the IL-18BP. Proc Natl Acad Sci USA. 21, 13723-13728 (2002).
21. Boraschi, D. & Dinarello, C. A. IL-18 in autoimmunity. Eur Cytokine Netw. 17, 224-252 (2006).
22. Kumar, S. et al. Interleukin-1F7b (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7b binds to the IL-18 receptor but does not induce IFN-γ production. Cytokine. 8, 61-71 (2002).
23. Huang, L. F. et al. The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats. Shock. 31, 322-329 (2009).
24. Kumar, S. et al. Identification and initial characterization of four novel members of the interleukin-1 family. J Biol Chem. 275, 10308-10314 (2000).
25. Bulau, A. M. et al. Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses. Proc Natl Acad Sci USA. 111, 2650-2655 (2014).
26. Quirk, S. & Agrawal D. K. Immunobiology of IL-37: mechanism of action and clinical perspectives. Expert Rev Clin Immunol. 10, 1703-1709 (2014).
27. Zhao, J. J. et al. Interleukin-37 mediates the antitumor activity in hepatocellular carcinoma: role for CD57+ NK cells. Sci Rep. 4, 5177 (2014).
28. Nold, P. C. et al. IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction. Nat Immunol. 16, 354-365 (2015).
29. Li, S. et al. Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8. Proc Natl Acad Sci USA. 112, 2497-2502 (2015).
30. Belkaid, Y. & Rouse, B. T. Natural regulatory T cells in infectious disease. Nat Immunol. 6, 353-360 (2005).
31. Halvorsen, E. C., Mahmoud, S. M. & Bennewith, K. L. Emerging roles of regulatory T cells in tumour progression and metastasis. Cancer Metastasis Rev. 33, 1025-1041 (2014).
32. Raghavan, S. & Holmgren, J. CD4+CD25+Tregs suppressor T cells regulate pathogen induced inflammation and disease. FEMS Immunol Med Microbiol. 44, 121-127 (2005).
33. Lan, Q. et al. Induced Foxp3(+ ) regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases? J Mol Cell Biol. 4, 22-28 (2012).
34. Sojka, D. K., Hughson, A. & Fowell, D. J. CTLA-4 is required by CD4+CD25+Treg to control CD4+ T-cell lymphopenia-induced proliferation. Eur J Immunol. 39, 1544-1551 (2009).
35. Hoffman, B. E. et al. Nonredundant roles of IL-10 and TGF-beta in suppression of immune responses to hepatic AAV-factor IX gene transfer. Mol Ther. 19, 1263-1272 (2011).
36. Suri-Payer, E., Amar, A. Z., Thornton, A. M. & Shevach, E. M. CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol. 160, 1212-1218 (1998).
37. Akdis, C. A. & Akdis, M. Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs. J Clin Invest. 124, 4678-4680 (2014).
38. Akdis, M. & Akdis C. A. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol. 119, 780-791 (2007).
39. Zhang, Y., Zhang, Y., Gu, W. & Sun, B. Th1/Th2 cell's function in immune system. Adv Exp Med Biol. 841, 45-65 (2014).
40. Larche, M., Akdis, C. A. & Valenta R. Immunological mechanisms of allergen specific immunotherapy. Nat Rev Immunol. 6, 761-771 (2006).
41. Singh, M. P., Rai, A. K. & Singh, S. M. Gender dimorphism in the progressive in vivo growth of a T cell lymphoma: involvement of cytokines and gonadal hormones. J Reprod Immunol. 65, 17-32 (2005).
42. Zhang,Y. et al. The potential effect and mechanism of high-mobility group box 1 protein on regulatory T cell-mediated immunosuppression. J Interferon Cytokine Res. 31, 249-257 (2011).
43. Hu, Y. et al. Isolation, amplification and identification of human natural CD4+CD25+ regulatory T cells in vitro. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 39, 818-824 (2014).