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Volumn 19, Issue 7, 2011, Pages 1263-1272

Nonredundant roles of IL-10 and TGF-Β in suppression of immune responses to hepatic AAV-factor IX gene transfer

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BLOOD CLOTTING FACTOR 9; IMMUNOGLOBULIN G1 ANTIBODY; INTERLEUKIN 10; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

EID: 79959981724     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.33     Document Type: Article
Times cited : (55)

References (45)
  • 1
    • 70349110562 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses
    • Gao, G, Wang, Q, Calcedo, R, Mays, L, Bell, P, Wang, L et al. (2009). Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses. Hum Gene Ther 20: 930-942.
    • (2009) Hum Gene Ther , vol.20 , pp. 930-942
    • Gao, G.1    Wang, Q.2    Calcedo, R.3    Mays, L.4    Bell, P.5    Wang, L.6
  • 2
    • 59649122961 scopus 로고    scopus 로고
    • Long-term correction of inhibitor-prone hemophilia B dogs treated with liverdirected AAV2-mediated factor IX gene therapy
    • Niemeyer, GP, Herzog, RW, Mount, J, Arruda, VR, Tillson, DM, Hathcock, J et al. (2009). Long-term correction of inhibitor-prone hemophilia B dogs treated with liverdirected AAV2-mediated factor IX gene therapy. Blood 113: 797-806.
    • (2009) Blood , vol.113 , pp. 797-806
    • Niemeyer, G.P.1    Herzog, R.W.2    Mount, J.3    Arruda, V.R.4    Tillson, D.M.5    Hathcock, J.6
  • 3
    • 70349878469 scopus 로고    scopus 로고
    • Impact of the underlying mutation and the route of vector administration on immune responses to factor IX in gene therapy for hemophilia B
    • Cao, O, Hoffman, BE, Moghimi, B, Nayak, S, Cooper, M, Zhou, S et al. (2009). Impact of the underlying mutation and the route of vector administration on immune responses to factor IX in gene therapy for hemophilia B. Mol Ther 17: 1733-1742.
    • (2009) Mol Ther , vol.17 , pp. 1733-1742
    • Cao, O.1    Hoffman, B.E.2    Moghimi, B.3    Nayak, S.4    Cooper, M.5    Zhou, S.6
  • 4
    • 21244476011 scopus 로고    scopus 로고
    • AAV-mediated gene transfer for treatment of hemophilia
    • DOI 10.2174/1566523054065048
    • Wang, L and Herzog, RW (2005). AAV-mediated gene transfer for treatment of hemophilia. Curr Gene Ther 5: 349-360. (Pubitemid 40895019)
    • (2005) Current Gene Therapy , vol.5 , Issue.3 , pp. 349-360
    • Wang, L.1    Herzog, R.W.2
  • 5
    • 68949192624 scopus 로고    scopus 로고
    • Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver
    • Breous, E, Somanathan, S, Vandenberghe, LH and Wilson, JM (2009). Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver. Hepatology 50: 612-621.
    • (2009) Hepatology , vol.50 , pp. 612-621
    • Breous, E.1    Somanathan, S.2    Vandenberghe, L.H.3    Wilson, J.M.4
  • 6
    • 77950520150 scopus 로고    scopus 로고
    • BALB/c mice show impaired hepatic tolerogenic response following AAV gene transfer to the liver
    • Breous, E, Somanathan, S and Wilson, JM (2010). BALB/c mice show impaired hepatic tolerogenic response following AAV gene transfer to the liver. Mol Ther 18: 766-774.
    • (2010) Mol Ther , vol.18 , pp. 766-774
    • Breous, E.1    Somanathan, S.2    Wilson, J.M.3
  • 7
    • 33645240071 scopus 로고    scopus 로고
    • Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells
    • Dobrzynski, E, Fitzgerald, JC, Cao, O, Mingozzi, F, Wang, L and Herzog, RW (2006). Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells. Proc Natl Acad Sci USA 103: 4592-4597.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4592-4597
    • Dobrzynski, E.1    Fitzgerald, J.C.2    Cao, O.3    Mingozzi, F.4    Wang, L.5    Herzog, R.W.6
  • 9
    • 0035080378 scopus 로고    scopus 로고
    • Intravenous administration of an E1/E3-deleted adenoviral vector induces tolerance to factor IX in C57BL/6 mice
    • DOI 10.1038/sj.gt.3301409
    • Fields, PA, Armstrong, E, Hagstrom, JN, Arruda, VR, Murphy, ML, Farrell, JP et al. (2001). Intravenous administration of an E1/E3-deleted adenoviral vector induces tolerance to factor IX in C57BL/6 mice. Gene Ther 8: 354-361. (Pubitemid 32243465)
    • (2001) Gene Therapy , vol.8 , Issue.5 , pp. 354-361
    • Fields, P.A.1    Armstrong, E.2    Hagstrom, J.N.3    Arruda, V.R.4    Murphy, M.L.5    Farrell, J.P.6    High, K.A.7    Herzog, R.W.8
  • 10
    • 69249219148 scopus 로고    scopus 로고
    • Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T-cells
    • Nayak, S, Cao, O, Hoffman, BE, Cooper, M, Zhou, S, Atkinson, MA et al. (2009). Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T-cells. J Thromb Haemost 7: 1523-1532.
    • (2009) J Thromb Haemost , vol.7 , pp. 1523-1532
    • Nayak, S.1    Cao, O.2    Hoffman, B.E.3    Cooper, M.4    Zhou, S.5    Atkinson, M.A.6
  • 12
    • 34547498762 scopus 로고    scopus 로고
    • + T cells in tolerance to the transgene product following hepatic in vivo gene transfer
    • DOI 10.1182/blood-2007-02-073304
    • Cao, O, Dobrzynski, E, Wang, L, Nayak, S, Mingle, B, Terhorst, C et al. (2007). Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer. Blood 110: 1132-1140. (Pubitemid 47281408)
    • (2007) Blood , vol.110 , Issue.4 , pp. 1132-1140
    • Cao, O.1    Dobrzynski, E.2    Wang, L.3    Nayak, S.4    Mingle, B.5    Terhorst, C.6    Herzog, R.W.7
  • 13
    • 68249139909 scopus 로고    scopus 로고
    • Distinct regulatory roles of transforming growth factor-beta and interleukin-4 in the development and maintenance of natural and induced CD4+ CD25+ Foxp3+ regulatory T cells
    • Prochazkova, J, Fric, J, Pokorna, K, Neuwirth, A, Krulova, M, Zajicova, A et al. (2009). Distinct regulatory roles of transforming growth factor-beta and interleukin-4 in the development and maintenance of natural and induced CD4+ CD25+ Foxp3+ regulatory T cells. Immunology 128(1 Suppl): e670-e678.
    • (2009) Immunology , vol.128 , Issue.1 SUPPL.
    • Prochazkova, J.1    Fric, J.2    Pokorna, K.3    Neuwirth, A.4    Krulova, M.5    Zajicova, A.6
  • 14
    • 68349130302 scopus 로고    scopus 로고
    • Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: Implications for antigen presentation and immunotoxicity
    • Martino, AT, Nayak, S, Hoffman, BE, Cooper, M, Liao, G, Markusic, DM et al. (2009). Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity. PLoS ONE 4: e6376.
    • (2009) PLoS ONE , vol.4
    • Martino, A.T.1    Nayak, S.2    Hoffman, B.E.3    Cooper, M.4    Liao, G.5    Markusic, D.M.6
  • 15
    • 68349125271 scopus 로고    scopus 로고
    • Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer
    • Cooper, M, Nayak, S, Hoffman, BE, Terhorst, C, Cao, O and Herzog, RW (2009). Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer. Hum Gene Ther 20: 767-776.
    • (2009) Hum Gene Ther , vol.20 , pp. 767-776
    • Cooper, M.1    Nayak, S.2    Hoffman, B.E.3    Terhorst, C.4    Cao, O.5    Herzog, R.W.6
  • 16
    • 68849126246 scopus 로고    scopus 로고
    • Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity
    • Sanjabi, S, Zenewicz, LA, Kamanaka, M and Flavell, RA (2009). Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity. Curr Opin Pharmacol 9: 447-453.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 447-453
    • Sanjabi, S.1    Zenewicz, L.A.2    Kamanaka, M.3    Flavell, R.A.4
  • 17
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva, M and O'Garra, A (2010). The regulation of IL-10 production by immune cells. Nat Rev Immunol 10: 170-181.
    • (2010) Nat Rev Immunol , vol.10 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 18
    • 21244487991 scopus 로고    scopus 로고
    • Major role of local immune responses in antibody formation to factor IX in AAV gene transfer
    • DOI 10.1038/sj.gt.3302539, PII 3302539
    • Wang, L, Cao, O, Swalm, B, Dobrzynski, E, Mingozzi, F and Herzog, RW (2005). Major role of local immune responses in antibody formation to factor IX in AAV gene transfer. Gene Ther 12: 1453-1464. (Pubitemid 41486134)
    • (2005) Gene Therapy , vol.12 , Issue.19 , pp. 1453-1464
    • Wang, L.1    Cao, O.2    Swalm, B.3    Dobrzynski, E.4    Mingozzi, F.5    Herzog, R.W.6
  • 19
    • 71849089195 scopus 로고    scopus 로고
    • Coexpression of TGF-beta1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity
    • Presser, K, Schwinge, D, Wegmann, M, Huber, S, Schmitt, S, Quaas, A et al. (2008). Coexpression of TGF-beta1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity. J Immunol 181: 7751-7758.
    • (2008) J Immunol , vol.181 , pp. 7751-7758
    • Presser, K.1    Schwinge, D.2    Wegmann, M.3    Huber, S.4    Schmitt, S.5    Quaas, A.6
  • 20
    • 77449107574 scopus 로고    scopus 로고
    • Blockade of TGF-beta enhances tumor vaccine efficacy mediated by CD8(+) T cells
    • Takaku, S, Terabe, M, Ambrosino, E, Peng, J, Lonning, S, McPherson, JM et al. (2010). Blockade of TGF-beta enhances tumor vaccine efficacy mediated by CD8(+) T cells. Int J Cancer 126: 1666-1674.
    • (2010) Int J Cancer , vol.126 , pp. 1666-1674
    • Takaku, S.1    Terabe, M.2    Ambrosino, E.3    Peng, J.4    Lonning, S.5    McPherson, J.M.6
  • 21
    • 17844402285 scopus 로고    scopus 로고
    • TGF-β1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells
    • Ahmadzadeh, M and Rosenberg, SA (2005). TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells. J Immunol 174: 5215-5223. (Pubitemid 40593159)
    • (2005) Journal of Immunology , vol.174 , Issue.9 , pp. 5215-5223
    • Ahmadzadeh, M.1    Rosenberg, S.A.2
  • 22
    • 65449136307 scopus 로고    scopus 로고
    • A central role for induced regulatory T cells in tolerance induction in experimental colitis
    • Haribhai, D, Lin, W, Edwards, B, Ziegelbauer, J, Salzman, NH, Carlson, MR et al. (2009). A central role for induced regulatory T cells in tolerance induction in experimental colitis. J Immunol 182: 3461-3468.
    • (2009) J Immunol , vol.182 , pp. 3461-3468
    • Haribhai, D.1    Lin, W.2    Edwards, B.3    Ziegelbauer, J.4    Salzman, N.H.5    Carlson, M.R.6
  • 23
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton, AM, Korty, PE, Tran, DQ, Wohlfert, EA, Murray, PE, Belkaid, Y et al. (2010). Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol 184: 3433-3441.
    • (2010) J Immunol , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3    Wohlfert, E.A.4    Murray, P.E.5    Belkaid, Y.6
  • 24
    • 0036170938 scopus 로고    scopus 로고
    • + regulatory T cells through GITR breaks immunological self-tolerance
    • DOI 10.1038/ni759
    • Shimizu, J, Yamazaki, S, Takahashi, T, Ishida, Y and Sakaguchi, S (2002). Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 3: 135-142. (Pubitemid 34141443)
    • (2002) Nature Immunology , vol.3 , Issue.2 , pp. 135-142
    • Shimizu, J.1    Yamazaki, S.2    Takahashi, T.3    Ishida, Y.4    Sakaguchi, S.5
  • 25
    • 77955279163 scopus 로고    scopus 로고
    • Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation
    • Cohen, AD, Schaer, DA, Liu, C, Li, Y, Hirschhorn-Cymmerman, D, Kim, SC et al. (2010). Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation. PLoS ONE 5: e10436.
    • (2010) PLoS ONE , vol.5
    • Cohen, A.D.1    Schaer, D.A.2    Liu, C.3    Li, Y.4    Hirschhorn-Cymmerman, D.5    Kim, S.C.6
  • 26
    • 77954056473 scopus 로고    scopus 로고
    • GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T-cells
    • Liao, G, Nayak, S, Regueiro, JR, Berger, SB, Detre, C, Romero, X et al. (2010). GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T-cells. Int Immunol 22: 259-270.
    • (2010) Int Immunol , vol.22 , pp. 259-270
    • Liao, G.1    Nayak, S.2    Regueiro, J.R.3    Berger, S.B.4    Detre, C.5    Romero, X.6
  • 27
    • 65949102083 scopus 로고    scopus 로고
    • Hepatic gene transfer as a means of tolerance induction to transgene products
    • LoDuca, PA, Hoffman, BE and Herzog, RW (2009). Hepatic gene transfer as a means of tolerance induction to transgene products. Curr Gene Ther 9: 104-114.
    • (2009) Curr Gene Ther , vol.9 , pp. 104-114
    • Loduca, P.A.1    Hoffman, B.E.2    Herzog, R.W.3
  • 28
    • 0034151775 scopus 로고    scopus 로고
    • Role of vector in activation of T cell subsets in immune responses against the secreted transgene product factor IX
    • Fields, PA, Kowalczyk, DW, Arruda, VR, Armstrong, E, McCleland, ML, Hagstrom, JN et al. (2000). Role of vector in activation of T cell subsets in immune responses against the secreted transgene product factor IX. Mol Ther 1: 225-235.
    • (2000) Mol Ther , vol.1 , pp. 225-235
    • Fields, P.A.1    Kowalczyk, D.W.2    Arruda, V.R.3    Armstrong, E.4    McCleland, M.L.5    Hagstrom, J.N.6
  • 29
    • 77951055907 scopus 로고    scopus 로고
    • Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice
    • Verma, D, Moghimi, B, LoDuca, PA, Singh, HD, Hoffman, BE, Herzog, RW et al. (2010). Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice. Proc Natl Acad Sci USA 107: 7101-7106.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 7101-7106
    • Verma, D.1    Moghimi, B.2    Loduca, P.A.3    Singh, H.D.4    Hoffman, B.E.5    Herzog, R.W.6
  • 30
    • 0037589022 scopus 로고    scopus 로고
    • Neonatal or hepatocyte growth factor-potentiated adult gene therapy with a retroviral vector results in therapeutic levels of canine factor IX for hemophilia B
    • DOI 10.1182/blood-2002-10-3050
    • Xu, L, Gao, C, Sands, MS, Cai, SR, Nichols, TC, Bellinger, DA et al. (2003). Neonatal or hepatocyte growth factor-potentiated adult gene therapy with a retroviral vector results in therapeutic levels of canine factor IX for hemophilia B. Blood 101: 3924-3932. (Pubitemid 36857868)
    • (2003) Blood , vol.101 , Issue.10 , pp. 3924-3932
    • Xu, L.1    Gao, C.2    Sands, M.S.3    Cai, S.-R.4    Nichols, T.C.5    Bellinger, D.A.6    Raymer, R.A.7    McCorquodale, S.8    Ponder, K.P.9
  • 31
    • 58149200168 scopus 로고    scopus 로고
    • IL-10 and TGFbeta redundantly protect against severe liver injury and mortality during acute schistosomiasis
    • Herbert, DR, Orekov, T, Perkins, C and Finkelman, FD (2008). IL-10 and TGFbeta redundantly protect against severe liver injury and mortality during acute schistosomiasis. J Immunol 181: 7214-7220.
    • (2008) J Immunol , vol.181 , pp. 7214-7220
    • Herbert, D.R.1    Orekov, T.2    Perkins, C.3    Finkelman, F.D.4
  • 32
    • 56349093347 scopus 로고    scopus 로고
    • IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
    • Dardalhon, V, Awasthi, A, Kwon, H, Galileos, G, Gao, W, Sobel, RA et al. (2008). IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol 9: 1347-1355.
    • (2008) Nat Immunol , vol.9 , pp. 1347-1355
    • Dardalhon, V.1    Awasthi, A.2    Kwon, H.3    Galileos, G.4    Gao, W.5    Sobel, R.A.6
  • 34
    • 34247271308 scopus 로고    scopus 로고
    • Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
    • DOI 10.1038/ni1437, PII NI1437
    • Williams, LM and Rudensky, AY (2007). Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 8: 277-284. (Pubitemid 46745377)
    • (2007) Nature Immunology , vol.8 , Issue.3 , pp. 277-284
    • Williams, L.M.1    Rudensky, A.Y.2
  • 35
    • 73949157699 scopus 로고    scopus 로고
    • In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance
    • Annoni, A, Brown, BD, Cantore, A, Sergi, LS, Naldini, L and Roncarolo, MG (2009). In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance. Blood 114: 5152-5161.
    • (2009) Blood , vol.114 , pp. 5152-5161
    • Annoni, A.1    Brown, B.D.2    Cantore, A.3    Sergi, L.S.4    Naldini, L.5    Roncarolo, M.G.6
  • 36
    • 76349113832 scopus 로고    scopus 로고
    • Immunomodulatory gene therapy prevents antibody formation and lethal hypersensitivity reactions in murine pompe disease
    • Sun, B, Kulis, MD, Young, SP, Hobeika, AC, Li, S, Bird, A et al. (2010). Immunomodulatory gene therapy prevents antibody formation and lethal hypersensitivity reactions in murine pompe disease. Mol Ther 18: 353-360.
    • (2010) Mol Ther , vol.18 , pp. 353-360
    • Sun, B.1    Kulis, M.D.2    Young, S.P.3    Hobeika, A.C.4    Li, S.5    Bird, A.6
  • 37
    • 0141755413 scopus 로고    scopus 로고
    • Long-term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti-inflammatory effect
    • DOI 10.1053/jhep.2003.50427
    • Nelson, DR, Tu, Z, Soldevila-Pico, C, Abdelmalek, M, Zhu, H, Xu, YL et al. (2003). Long-term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti-inflammatory effect. Hepatology 38: 859-868. (Pubitemid 37221669)
    • (2003) Hepatology , vol.38 , Issue.4 , pp. 859-868
    • Nelson, D.R.1    Tu, Z.2    Soldevila-Pico, C.3    Abdelmalek, M.4    Zhu, H.5    Xu, Y.L.6    Cabrera, R.7    Liu, C.8    Davis, G.L.9
  • 39
    • 2142645808 scopus 로고    scopus 로고
    • - T Cells through Foxp3 Induction and Down-Regulation of Smad7
    • Fantini, MC, Becker, C, Monteleone, G, Pallone, F, Galle, PR and Neurath, MF (2004). Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25-T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 172: 5149-5153. (Pubitemid 38542009)
    • (2004) Journal of Immunology , vol.172 , Issue.9 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3    Pallone, F.4    Galle, P.R.5    Neurath, M.F.6
  • 40
    • 33745978399 scopus 로고    scopus 로고
    • Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    • DOI 10.1016/j.immuni.2006.04.015, PII S1074761306003025
    • Mempel, TR, Pittet, MJ, Khazaie, K, Weninger, W, Weissleder, R, von Boehmer, H et al. (2006). Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity 25: 129-141. (Pubitemid 44066829)
    • (2006) Immunity , vol.25 , Issue.1 , pp. 129-141
    • Mempel, T.R.1    Pittet, M.J.2    Khazaie, K.3    Weninger, W.4    Weissleder, R.5    Von Boehmer, H.6    Von Andrian, U.H.7
  • 41
    • 3843137257 scopus 로고    scopus 로고
    • + T-cell anergy and deletion by in vivo viral gene transfer
    • DOI 10.1182/blood-2004-03-0847
    • Dobrzynski, E, Mingozzi, F, Liu, YL, Bendo, E, Cao, O, Wang, L et al. (2004). Induction of antigen-specific CD4+ T-cell anergy and deletion by in vivo viral gene transfer. Blood 104: 969-977. (Pubitemid 39038015)
    • (2004) Blood , vol.104 , Issue.4 , pp. 969-977
    • Dobrzynski, E.1    Mingozzi, F.2    Liu, Y.-L.3    Bendo, E.4    Cao, O.5    Wang, L.6    Herzog, R.W.7
  • 42
    • 77950384133 scopus 로고    scopus 로고
    • CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice
    • Miao, CH, Harmeling, BR, Ziegler, SF, Yen, BC, Torgerson, T, Chen, L et al. (2009). CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice. Blood 114: 4034-4044.
    • (2009) Blood , vol.114 , pp. 4034-4044
    • Miao, C.H.1    Harmeling, B.R.2    Ziegler, S.F.3    Yen, B.C.4    Torgerson, T.5    Chen, L.6
  • 43
    • 0034151775 scopus 로고    scopus 로고
    • Role of vector in activation of T cell subsets in immune responses against the secreted transgene product factor IX
    • Fields, PA, Kowalczyk, DW, Arruda, VR, Armstrong, E, McCleland, ML, Hagstrom, JN et al. (2000). Role of vector in activation of T cell subsets in immune responses against the secreted transgene product factor IX. Mol Ther 1: 225-235.
    • (2000) Mol Ther , vol.1 , pp. 225-235
    • Fields, P.A.1    Kowalczyk, D.W.2    Arruda, V.R.3    Armstrong, E.4    McCleland, M.L.5    Hagstrom, J.N.6
  • 45
    • 0037229304 scopus 로고    scopus 로고
    • Optimized production of high-titer recombinant adeno-associated virus in roller bottles
    • Liu, YL, Wagner, K, Robinson, N, Sabatino, D, Margaritis, P, Xiao, W et al. (2003). Optimized production of high-titer recombinant adeno-associated virus in roller bottles. Biotechniques 34: 184-189. (Pubitemid 36070918)
    • (2003) BioTechniques , vol.34 , Issue.1 , pp. 184-189
    • Liu, Y.-L.1    Wagner, K.2    Robinson, N.3    Sabatino, D.4    Margaritis, P.5    Xiao, W.6    Herzog, R.W.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.