Efficient Conversion of Spermatogonial Stem Cells to Phenotypic and Functional Dopaminergic Neurons via the PI3K/Akt and P21/Smurf2/Nolz1 Pathway

Molecular Neurobiology

Volumn 52, Issue 3, 2015, Pages 1654-1669

  Yang, Hao ^a   Liu, Yang ^a   Hai, Yanan ^a   Guo, Ying ^a   Yang, Shi ^a   Li, Zheng ^a   Gao, Wei Qiang ^a   He, Zuping ^a,b,c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics   (China)

^c Shanghai Key Laboratory of Reproductive Medicine   (China)

Author keywords

Direct conversion; Dopamine release; Dopaminergic neurons; Electrophysiology activity; p21 Smurf2 Nolz1; Phenotype; PI3K Akt; Spermatogonial stem cells; Synapse formation

Indexed keywords

DOPAMINE; GROWTH FACTOR; NOLZ1 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN P21; SMURF2 PROTEIN; UNCLASSIFIED DRUG; ONCOPROTEIN; SMURF2 PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL GROWTH; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; ELECTROPHYSIOLOGY; FLOW CYTOMETRY; MESENCEPHALON; MESENCHYMAL STEM CELL; MOUSE; NERVE CELL; NONHUMAN; OLFACTORY ENSHEATHING CELL; PARKINSON DISEASE; PHENOTYPE; PLURIPOTENT STEM CELL; QUALITY OF LIFE; SPERMATOGONIUM; STEM CELL; WESTERN BLOTTING; ADULT STEM CELL; ANIMAL; BAGG ALBINO MOUSE; CYTOLOGY; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ADULT STEM CELLS; ANIMALS; DOPAMINE; DOPAMINERGIC NEURONS; MESENCEPHALON; MICE, INBRED BALB C; NEUROGENESIS; ONCOGENE PROTEIN V-AKT; PHENOTYPE; PHOSPHATIDYLINOSITOL 3-KINASES; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES;

EID: 84942827142     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8966-4     Document Type: Article

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