Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling pathways and the inactivation of cyclin A, cyclin B and cyclin e

Cell Communication and Signaling

Volumn 11, Issue 1, 2013, Pages

  Zhang, Zhenzhen ^a   Gong, Yuehua ^a   Guo, Ying ^a   Hai, Yanan ^a   Yang, Hao ^a   Yang, Shi ^a   Liu, Yang ^a   Ma, Meng ^a   Liu, Linhong ^a   Li, Zheng ^a   Gao, Wei Qiang ^a   He, Zuping ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Key Laboratory of Reproductive Medicine   (China)

Author keywords

Direct transdifferentiation; ERK1 2 and Smad2 3 signaling pathways; Function; Hepatic stem cells; Mature hepatocytes; Morphology and phenotype; Spermatogonial stem cells

Indexed keywords

ALBUMIN; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYCLIN A; CYCLIN B; CYCLIN E; CYTOCHROME P450 1A2; HEPATOCYTE NUCLEAR FACTOR 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSACTIVATOR PROTEIN; ALBUMINOID; SMAD2 PROTEIN, MOUSE; SMAD3 PROTEIN, MOUSE;

ALB GENE; ARTICLE; CELL FUNCTION; CELL MATURATION; CELL STRUCTURE; CELL TRANSDIFFERENTIATION; CK17 GENE; CK18 GENE; CK7 GENE; CK8 GENE; CONTROLLED STUDY; CYP1A2 GENE; GENE EXPRESSION; GENE FUNCTION; HNF3B GENE; HUMAN; HUMAN CELL; LIVER CELL; LIVER DEVELOPMENT; NUCLEAR REPROGRAMMING; OV6 GENE; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPERMATOGONIUM; TAT GENE; TTR GENE; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; MALE; METABOLISM; MOUSE; PHYSIOLOGY; STEM CELL;

ALBUMINS; ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; CYCLIN A; CYCLIN B; CYCLIN E; HEPATOCYTES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; PHENOTYPE; SMAD2 PROTEIN; SMAD3 PROTEIN; SPERMATOGONIA; STEM CELLS;

EID: 84884183623     PISSN: None     EISSN: 1478811X     Source Type: Journal    
DOI: 10.1186/1478-811X-11-67     Document Type: Article

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