Nodal signaling via an autocrine pathway promotes proliferation of mouse spermatogonial stem/progenitor cells through Smad2/3 and Oct-4 activation

Stem Cells

Volumn 27, Issue 10, 2009, Pages 2580-2590

  Zuping, He ^a   Jiji, Jiang ^a   Kokkinaki, Maria ^a   Dym, Martin ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Autocrine signaling; Nodal; Oct 4; Proliferation; Smad2 3 pathway; Spermatogonial stem progenitor cells

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; BROXURIDINE; CYCLIN D1; CYCLIN E; GROWTH FACTOR; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN NODAL; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GERM CELL; IMMUNOCYTOCHEMISTRY; MALE; MOLECULAR MECHANICS; MOUSE; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SERTOLI CELL; SIGNAL TRANSDUCTION; SPERMATOGENESIS; SPERMATOGONIAL STEM CELL; SPERMATOGONIUM; STEM CELL; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; AUTOCRINE COMMUNICATION; BENZAMIDES; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CYCLINS; DIOXOLES; MALE; MICE; MICE, INBRED BALB C; NODAL PROTEIN; OCTAMER TRANSCRIPTION FACTOR-3; RECEPTORS, CELL SURFACE; RNA INTERFERENCE; RNA, MESSENGER; SMAD2 PROTEIN; SPERMATOGENESIS; SPERMATOGONIA; STEM CELLS;

EID: 70350228794     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.198     Document Type: Article

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