Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2

BMC Nephrology

Volumn 9, Issue 1, 2008, Pages

  Felekkis, Kyriacos N ^a   Koupepidou, Panayiota ^a   Kastanos, Evdokia ^a   Witzgall, Ralph ^b   Bai, Chang Xi ^c   Li, Li ^d   Tsiokas, Leonidas ^c   Gretz, Norbert ^d   Deltas, Constantinos ^a  

^a UNIVERSITY OF CYPRUS   (Cyprus)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; MUTANT PROTEIN; POLYCYSTIN 1; POLYCYSTIN 2; PROTEIN P21; PROTEIN P57; STAT1 PROTEIN; CDK2 PROTEIN, RAT; CYCLIN DEPENDENT KINASE INHIBITOR 1C; HYBRID PROTEIN; P21 ACTIVATED KINASE; PAK1 PROTEIN, RAT; POLYCYSTIC KIDNEY DISEASE 2 PROTEIN; POLYCYSTIN; STAT1 PROTEIN, RAT;

ANIMAL CELL; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CELL LINE; CELL PROLIFERATION; CELL STRAIN HEK293; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE CELL; NONHUMAN; RAT; SIGNAL TRANSDUCTION; TRANSGENIC RAT; AMINO ACID SUBSTITUTION; ANIMAL; BIOSYNTHESIS; CELL DIVISION; CELL MEMBRANE POTENTIAL; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; KIDNEY TUBULE; METABOLISM; MISSENSE MUTATION; PATCH CLAMP; PATHOLOGY; PHYSIOLOGY; POINT MUTATION; TRANSGENIC ANIMAL;

AMINO ACID SUBSTITUTION; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL DIVISION; CELL LINE; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P57; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; KIDNEY TUBULES; MEMBRANE POTENTIALS; MUTATION, MISSENSE; P21-ACTIVATED KINASES; PATCH-CLAMP TECHNIQUES; POINT MUTATION; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TRANSFECTION; TRPP CATION CHANNELS;

EID: 51649086198     PISSN: None     EISSN: 14712369     Source Type: Journal    
DOI: 10.1186/1471-2369-9-10     Document Type: Article

References (47)

1. Autosomal dominant polycystic kidney disease. PA Gabow, N Engl J Med 1993 329 5 332 342 10.1056/NEJM199307293290508 8321262
2. Genetic evidence for a trans-heterozygous model for cystogenesis in autosomal dominant polycystic kidney disease. M Koptides R Mean K Demetriou A Pierides CC Deltas, Hum Mol Genet 2000 9 3 447 452 10.1093/hmg/9.3.447 10655555
3. Germinal and somatic mutations in the PKD2 gene of renal cysts in autosomal dominant polycystic kidney disease. M Koptides C Hadjimichael P Koupepidou A Pierides C Constantinou Deltas, Hum Mol Genet 1999 8 3 509 513 10.1093/hmg/8.3.509 9949210
4. The pathology of human renal cystic disease. PD Wilson D Falkenstein, Curr Top Pathol 1995 88 1 50 7614844
5. Cyst formation and growth in autosomal dominant polycystic kidney disease. JJ Grantham JL Geiser AP Evan, Kidney Int 1987 31 5 1145 1152 10.1038/ki.1987.121 3599654
6. Mechanism of progression in autosomal dominant polycystic kidney disease. J Grantham, Kidney Int Suppl 1997 63 S93 S97 9407432
7. Polycystic kidney disease in SBM transgenic mice: role of c-myc in disease induction and progression. M Trudel L Barisoni J Lanoix V D'Agati, Am J Pathol 1998 152 1 219 229 9422539
8. Increased epithelial cell proliferation and abnormal extracellular matrix in rat polycystic kidney disease. K Ramasubbu N Gretz S Bachmann, J Am Soc Nephrol 1998 9 6 937 945 9621276
9. Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. P Delmas H Nomura X Li M Lakkis Y Luo Y Segal JM Fernandez-Fernandez P Harris AM Frischauf DA Brown J Zhou, J Biol Chem 2002 277 13 11276 11283 10.1074/jbc.M110483200 11786542
10. Interaction between RGS7 and polycystin. E Kim T Arnould L Sellin T Benzing N Comella O Kocher L Tsiokas VP Sukhatme G Walz, Proc Natl Acad Sci USA 1999 96 11 6371 6376 10339594 10.1073/pnas.96.11.6371
11. The polycystic kidney disease 1 gene product modulates Wnt signaling. E Kim T Arnould LK Sellin T Benzing MJ Fan W Gruning SY Sokol I Drummond G Walz, J Biol Chem 1999 274 8 4947 4953 10.1074/jbc.274.8.4947 9988738
12. Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins. SC Parnell BS Magenheimer RL Maser CA Zien AM Frischauf JP Calvet, J Biol Chem 2002 277 22 19566 19572 10.1074/jbc.M201875200 11912216
13. PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. AK Bhunia K Piontek A Boletta L Liu F Qian PN Xu FJ Germino GG Germino, Cell 2002 109 2 157 168 10.1016/S0092-8674(02)00716-X 12007403
14. Voltage dependence and pH regulation of human polycystin-2-mediated cation channel activity. S Gonzalez-Perrett M Batelli K Kim M Essafi G Timpanaro N Moltabetti IL Reisin MA Arnaout HF Cantiello, J Biol Chem 2002 277 28 24959 24966 10.1074/jbc.M105084200 11991947
15. Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2. T Arnould L Sellin T Benzing L Tsiokas HT Cohen E Kim G Walz, Mol Cell Biol 1999 19 5 3423 3434 10207066
16. Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Y Luo PM Vassilev X Li Y Kawanabe J Zhou, Mol Cell Biol 2003 23 7 2600 2607 12640140 10.1128/MCB.23.7.2600-2607.2003
17. Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. X Li Y Luo PG Starremans CA McNamara Y Pei J Zhou, Nat Cell Biol 2005 7 12 1202 1212 10.1038/ncb1326 16311606
18. Polycystin-2 regulates proliferation and branching morphogenesis in kidney epithelial cells. DH Grimm A Karihaloo Y Cai S Somlo LG Cantley MJ Caplan, J Biol Chem 2006 281 1 137 144 10.1074/jbc.M507845200 16278216
19. A truncated polycystin-2 protein causes polycystic kidney disease and retinal degeneration in transgenic rats. AR Gallagher S Hoffmann N Brown A Cedzich S Meruvu D Podlich Y Feng V Konecke U de Vries HP Hammes N Gretz R Witzgall, J Am Soc Nephrol 2006 17 10 2719 2730 10.1681/ASN.2005090979 16943309
20. PKD2 functions as an epidermal growth factor-activated plasma membrane channel. R Ma WP Li D Rundle J Kong HI Akbarali L Tsiokas, Mol Cell Biol 2005 25 18 8285 8298 16135816 10.1128/MCB.25.18.8285-8298.2005
21. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. KN Felekkis RP Narsimhan R Near AF Castro Y Zheng LA Quilliam A Lerner, Mol Cancer Res 2005 3 1 32 41 15671247
22. Hepatitis C virus core functions as a suppressor of cyclin-dependent kinase-activating kinase and impairs cell cycle progression. K Okhkawa H Ishida F Nakanishi A Hosui K Ueda T Takehara M Hori N Hayashi, J Biol Chem 2004 279 11719 11726 10.1074/jbc.M308560200 14711830
23. Faster rates of post-puberty kidney deterioration in males is correlated with elevated oxidative stress in males vs females at early puberty. L Li SN Boehn X Yu Q Zhang M Kenzelmann D Techel SA Mohamed P Jakob B Kraenzlin S Hoffmann N Gretz, BMC Genomics 2007 8 221 17620128 10.1186/1471-2164-8-221
24. A systematic statistical linear modeling approach to oligonucleotide array experiments. TM Chu B Weir R Wolfinger, Math Biosci 2002 176 1 35 51 10.1016/S0025-5564(01)00107-9 11867082
25. Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. M Dai P Wang AD Boyd G Kostov B Athey EG Jones WE Bunney RM Myers TP Speed H Akil SJ Watson F Meng, Nucleic Acids Res 2005 33 20 e175 16284200 10.1093/nar/gni179
26. PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein. T Mochizuki G Wu T Hayashi SL Xenophontos B Veldhuisen JJ Saris DM Reynolds Y Cai PA Gabow A Pierides WJ Kimberling MH Breuning CC Deltas DJ Peters S Somlo, Science 1996 272 5266 1339 1342 10.1126/science.272.5266.1339 8650545
27. Polycystin-1 activates and stabilizes the polycystin-2 channel. GM Xu S Gonzalez-Perrett M Essafi GA Timpanaro N Montalbetti MA Arnaout HF Cantiello, J Biol Chem 2003 278 3 1457 1462 10.1074/jbc.M209996200 12407099
28. Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X. XZ Chen Y Segal N Basora L Guo JB Peng H Babakhanlou PM Vassilev EM Brown MA Hediger J Zhou, Biochem Biophys Res Commun 2001 282 5 1251 1256 10.1006/bbrc.2001.4720 11302751
29. Polycystin-2 is an intracellular calcium release channel. P Koulen Y Cai L Geng Y Maeda S Nishimura R Witzgall BE Ehrlich S Somlo, Nat Cell Biol 2002 4 3 191 197 10.1038/ncb754 11854751
30. Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel. S Gonzalez-Perrett K Kim C Ibarra AE Damiano E Zotta M Batelli PC Harris IL Reisin MA Arnaout HF Cantiello, Proc Natl Acad Sci USA 2001 98 3 1182 1187 11252306 10.1073/pnas.021456598
31. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. K Hanaoka F Qian A Boletta AK Bhunia K Piontek L Tsiokas VP Sukhatme WB Guggino GG Germino, Nature 2000 408 6815 990 994 10.1038/35050128 11140688
32. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. SM Nauli FJ Alenghat Y Luo E Williams P Vassilev X Li AE Elia W Lu EM Brown SJ Quinn DE Ingber J Zhou, Nat Genet 2003 33 2 129 137 10.1038/ng1076 12514735
33. Characteristics of a human cell line transformed by DNA from Adenovirus type 5. FL Graham J Smiley WC Russell R Nairn, J Gen Virol 1977 36 59 72 10.1099/0022-1317-36-1-59 886304
34. Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells. G Shaw S Morse M Ararat FL Graham, Faseb J 2002 16 8 869 871 11967234
35. Transgenic mice expressing tamoxifen-inducible Cre for somatic gene modification in renal epithelial cells. IS Lantinga-van Leeuwen WN Leonhard A van de Wal MH Breuning S Verbeek E de Heer DJ Peters, Genesis 2006 44 5 225 232 10.1002/dvg.20207 16652363
36. Cdk inhibitors in development and cancer. JW Harper SJ Elledge, Curr Opin Genet Dev 1996 6 1 56 64 10.1016/S0959-437X(96)90011-8 8791491
37. Cancer cell cycles. CJ Sherr, Science 1996 274 5293 1672 1677 10.1126/science.274.5293.1672 8939849
38. Role of the INK4a locus in tumor suppression and cell mortality. M Serrano H Lee L Chin C Cordon-Cardo D Beach RA DePinho, Cell 1996 85 1 27 37 10.1016/S0092-8674(00)81079-X 8620534
39. p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels. JY Park WE Schutzer JN Lindsley SP Bagby TT Oyama S Anderson RH Weiss, BMC Nephrol 2007 8 12 17714589 10.1186/1471-2369-8-12
40. Cell bilogy of polycystin-2. L Tsiokas S Kim EC Ong, Cell Signal 2007 19 3 444 453 17084592 10.1016/j.cellsig.2006.09.005
41. A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. K Piontek LF Menezes MA Garcia-Gonzalez DL Huso GG Germino, Nat Med 2007 13 12 1490 1495 10.1038/nm1675 17965720
42. Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants. J Sullivan-Brown J Schottenfeld N Okabe CL Hostetter FC Serluca SY Thiberge RD Burdine, Dev Biol 2007 18178183
43. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. MH Lee I Reynisdottir J Massague, Genes Dev 1995 9 6 639 649 10.1101/gad.9.6.639 7729683
44. p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. S Matsuoka MC Edwards C Bai S Parker P Zhang A Baldini JW Harper SJ Elledge, Genes Dev 1995 9 6 650 662 10.1101/gad.9.6.650 7729684
45. Induction of p57(KIP2) expression by p73beta. E Blint AC Phillips S Kozlov CL Stewart KH Vousden, Proc Natl Acad Sci USA 2002 99 6 3529 3534 11891335 10.1073/pnas.062491899
46. A role of p73 in mitotic exit. P Merlo M Fulco A Costanzo R Mangiacasale S Strano G Blandino Y Taya P Lavia M Levrero, J Biol Chem 2005 280 34 30354 30360 10.1074/jbc.M500635200 15985436
47. E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells. G Rothschild X Zhao A Iavarone A Lasorella, Mol Cell Biol 2006 26 11 4351 4361 16705184 10.1128/MCB.01743-05