Diminished MTORC1-Dependent JNK Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction

Cell Reports

Volumn 12, Issue 12, 2015, Pages 2009-2020

  Wong, Ching On ^a   Palmieri, Michela ^b   Li, Jiaxing ^c   Akhmedov, Dmitry ^a   Chao, Yufang ^a   Broadhead, Geoffrey T ^a   Zhu, Michael X ^a,d   Berdeaux, Rebecca ^a,d   Collins, Catherine A ^c   Sardiello, Marco ^b   Venkatachalam, Kartik ^a,d  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b TEXAS CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALECTINIB; ANAPLASTIC LYMPHOMA KINASE; GUANOSINE TRIPHOSPHATASE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE PROTEIN; RAG GTPASE; RHEB PROTEIN; S6 KINASE; STRESS ACTIVATED PROTEIN KINASE; TRPML PROTEIN; UNCLASSIFIED DRUG; DLK1 PROTEIN, MOUSE; DROSOPHILA PROTEIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MULTIPROTEIN COMPLEX; PROTEIN INTAKE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE; WALLENDA PROTEIN, DROSOPHILA;

AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; FRUIT FLY MODEL; GENETIC TRANSCRIPTION; LYSOSOME STORAGE DISEASE; MOUSE; MOUSE MODEL; NERVE FIBER GROWTH; NEUROMUSCULAR SYNAPSE; NEURONAL CEROID LIPOFUSCINOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DIET; PROTEIN PHOSPHORYLATION; SYNAPTOGENESIS; ADMINISTRATION AND DOSAGE; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DROSOPHILA MELANOGASTER; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LYSOSOME; METABOLISM; NEUROMUSCULAR JUNCTION; PATHOLOGY; PHOSPHORYLATION; PROTEIN INTAKE; SIGNAL TRANSDUCTION; SYNAPSE;

ANIMALS; DIETARY PROTEINS; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSOSOMAL STORAGE DISEASES, NERVOUS SYSTEM; LYSOSOMES; MAP KINASE KINASE 4; MAP KINASE KINASE KINASES; MICE; MULTIPROTEIN COMPLEXES; NEUROMUSCULAR JUNCTION; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SYNAPSES; TOR SERINE-THREONINE KINASES;

EID: 84942824523     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.08.047     Document Type: Article

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